hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09409.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KLHL8 | Kelch-like protein 8 | 5 | UniProt NCBI |
| FUS | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | 5 | UniProt NCBI |
| TAF15 | TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1332 | 0.000648796245143 | 0.666666666667 | TAF15 FUS | Large Drosha complex |
| HP:0009067 | 0.00667190161012 | 0.666666666667 | TAF15 FUS | Progressive spinal muscular atrophy |
| HP:0008955 | 0.0075178385046 | 0.666666666667 | TAF15 FUS | Progressive distal muscular atrophy |
| HP:0033683 | 0.00888120343534 | 0.666666666667 | TAF15 FUS | Jaw hyperreflexia |
| HP:0025425 | 0.00888120343534 | 0.666666666667 | TAF15 FUS | Laryngospasm |
| KEGG:05202 | 0.00904723539575 | 0.666666666667 | TAF15 FUS | Transcriptional misregulation in cancer |
| HP:0030195 | 0.00985306624309 | 0.666666666667 | TAF15 FUS | Fatigable weakness of swallowing muscles |
| HPA:0440343 | 0.0104312831454 | 1.0 | KLHL8 FUS TAF15 | skeletal muscle; myocytes[High] |
| HP:0012473 | 0.0119478163599 | 0.666666666667 | TAF15 FUS | Tongue atrophy |
| HP:0025424 | 0.0119478163599 | 0.666666666667 | TAF15 FUS | Abnormal larynx physiology |
| HP:0007354 | 0.0130706759587 | 0.666666666667 | TAF15 FUS | Amyotrophic lateral sclerosis |
| HP:0002145 | 0.0142438401108 | 0.666666666667 | TAF15 FUS | Frontotemporal dementia |
| HP:0007269 | 0.0154672949612 | 0.666666666667 | TAF15 FUS | Spinal muscular atrophy |
| HP:0000217 | 0.0154672949612 | 0.666666666667 | TAF15 FUS | Xerostomia |
| HP:0030196 | 0.0173967419879 | 0.666666666667 | TAF15 FUS | Fatigable weakness of respiratory muscles |
| HP:0030192 | 0.0201452261528 | 0.666666666667 | TAF15 FUS | Fatigable weakness of bulbar muscles |
| HP:0007373 | 0.022338444757 | 0.666666666667 | TAF15 FUS | Motor neuron atrophy |
| HP:0002450 | 0.0313463863633 | 0.666666666667 | TAF15 FUS | Abnormal motor neuron morphology |
| HP:0002180 | 0.0340663843581 | 0.666666666667 | TAF15 FUS | Neurodegeneration |
| HP:0012757 | 0.0359423574679 | 0.666666666667 | TAF15 FUS | Abnormal neuron morphology |
| HP:0004326 | 0.045003983416 | 0.666666666667 | TAF15 FUS | Cachexia |
| CORUM:7518 | 0.0499402709677 | 0.333333333333 | KLHL8 | Ubiquitin E3 ligase (CUL3, KLHL8) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TAF15 | KLHL8 | 0.983 | 0.116 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| FUS | TAF15 | 0.955 | 0.666 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () treiber_WMM |
| FUS | KLHL8 | 0.127 | 0.146 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| KLHL8 | huMAP3_09409.1 huMAP3_15133.1 |
| FUS | huMAP3_05259.1 huMAP3_09409.1 huMAP3_14523.1 |
| TAF15 | huMAP3_05259.1 huMAP3_06354.1 huMAP3_08869.1 huMAP3_09409.1 huMAP3_09539.1 huMAP3_12158.1 huMAP3_14523.1 |