hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09414.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LAMB3 | Laminin subunit beta-3 (Epiligrin subunit bata) (Kalinin B1 chain) (Kalinin subunit beta) (Laminin B1k chain) (Laminin-5 subunit beta) (Nicein subunit beta) | 5 | UniProt NCBI |
| PXDN | Peroxidasin homolog (EC 1.11.2.-) (Melanoma-associated antigen MG50) (Peroxidasin 1) (hsPxd01) (Vascular peroxidase 1) (p53-responsive gene 2 protein) [Cleaved into: PXDN active fragment] | 5 | UniProt NCBI |
| PLAUR | Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (Monocyte activation antigen Mo3) (CD antigen CD87) | 5 | UniProt NCBI |
| LARGE1 | Xylosyl- and glucuronyltransferase LARGE1 (EC 2.4.-.-) (Acetylglucosaminyltransferase-like 1A) (Glycosyltransferase-like protein) (LARGE xylosyl- and glucuronyltransferase 1) [Includes: Alpha-1,3-xylosyltransferase LARGE1 (EC 2.4.2.-); Beta-1,3-glucuronyltransferase LARGE1 (EC 2.4.1.-)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0000557 | 0.0092117244708 | 0.5 | PXDN LARGE1 | Buphthalmos |
| HP:0007833 | 0.0100118295947 | 0.5 | PXDN LARGE1 | Anterior chamber synechiae |
| REAC:R-HSA-2022090 | 0.0110375739361 | 0.5 | LAMB3 PXDN | Assembly of collagen fibrils and other multimeric structures |
| HP:0001090 | 0.0246976114972 | 0.5 | PXDN LARGE1 | Abnormally large globe |
| CORUM:7108 | 0.0249718442456 | 0.25 | PLAUR | IGF2R-PLAUR complex |
| REAC:R-HSA-1474290 | 0.0260384914588 | 0.5 | LAMB3 PXDN | Collagen formation |
| HP:0000593 | 0.0391604009626 | 0.5 | PXDN LARGE1 | Abnormal anterior chamber morphology |
| CORUM:7107 | 0.049938562206 | 0.25 | PLAUR | IGF2R-PLAUR-PLG complex |
| CORUM:7109 | 0.049938562206 | 0.25 | PLAUR | IGF2R-PLAUR-PLAU complex |
| CORUM:7112 | 0.049938562206 | 0.25 | PLAUR | PLAUR-PLAU complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PLAUR | LARGE1 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PLAUR | PXDN | 0.978 | 0.202 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| LAMB3 | PLAUR | 0.97 | 0.048 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| LARGE1 | PXDN | 0.325 | bioplex_WMM bioplex3_WMM WMM_only | |
| LAMB3 | PXDN | 0.206 | 0.346 | bioplex3_WMM WMM_only |
| LAMB3 | LARGE1 | 0.038 | bioplex3_WMM WMM_only |
Related Complexes