hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09417.1

Complex Portal: CPX-11705

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
INA	Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (NF-66) (Neurofilament-66) (Neurofilament 5)	5	UniProt NCBI
NEFL	Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein)	5	UniProt NCBI
NEFM	Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein)	5	UniProt NCBI
KRT7	Keratin, type II cytoskeletal 7 (Cytokeratin-7) (CK-7) (Keratin-7) (K7) (Sarcolectin) (Type-II keratin Kb7)	5	UniProt NCBI
VIM	Vimentin	5	UniProt NCBI
IDE	Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)	5	UniProt NCBI
NES	Nestin	5	UniProt NCBI
NEFH	Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0045104	7.52838076699e-11	1.0	NEFL NEFM KRT7 INA VIM NES	intermediate filament cytoskeleton organization
GO:0045103	8.48945065214e-11	1.0	NEFL NEFM KRT7 INA VIM NES	intermediate filament-based process
GO:0005882	2.5125586413e-10	1.0	NEFL NEFM KRT7 INA VIM NES	intermediate filament
GO:0045111	2.8187089442e-09	1.0	NEFL NEFM KRT7 INA VIM NES	intermediate filament cytoskeleton
GO:0045109	2.70670481454e-08	0.833333333333	NEFM VIM KRT7 INA NEFL	intermediate filament organization
GO:0099160	1.92240082153e-06	0.5	NEFM INA NEFL	postsynaptic intermediate filament cytoskeleton
GO:0099571	1.92180881975e-05	0.5	NEFM INA NEFL	postsynaptic cytoskeleton
GO:0099513	2.68096414183e-05	1.0	NEFL NEFM KRT7 INA VIM NES	polymeric cytoskeletal fiber
GO:0005883	0.00010757157937	0.5	NEFM INA NEFL	neurofilament
GO:0099512	0.000149286254074	1.0	NEFL NEFM KRT7 INA VIM NES	supramolecular fiber
GO:0099081	0.000160956821667	1.0	NEFL NEFM KRT7 INA VIM NES	supramolecular polymer
WP:WP5417	0.000278673368084	0.5	NEFM NEFL NES	Cell lineage map for neuronal differentiation
GO:0005200	0.000999031924798	0.666666666667	NEFM VIM INA NEFL	structural constituent of cytoskeleton
HPA:0091032	0.00217264570231	0.5	NEFM INA NES	cerebellum; processes in molecular layer[>=Medium]
GO:0099080	0.00221939891188	1.0	NEFL NEFM KRT7 INA VIM NES	supramolecular complex
HPA:0091031	0.00262622558041	0.5	NEFM INA NES	cerebellum; processes in molecular layer[>=Low]
WP:WP4352	0.00400681842466	0.5	NEFM NEFL VIM	Ciliary landscape
WP:WP2447	0.00529013036744	0.333333333333	NEFM NEFL	Amyotrophic lateral sclerosis ALS
GO:0007010	0.00907384039353	1.0	NEFL NEFM KRT7 INA VIM NES	cytoskeleton organization
GO:0005198	0.0146483217905	0.833333333333	NEFM VIM KRT7 INA NEFL	structural molecule activity
WP:WP3680	0.0170615762461	0.333333333333	NEFM NEFL	Physico chemical features and toxicity associated pathways
GO:0033693	0.0210651876021	0.333333333333	NEFM NEFL	neurofilament bundle assembly
GO:0099184	0.0210651876021	0.333333333333	INA NEFL	structural constituent of postsynaptic intermediate filament cytoskeleton
GO:0097435	0.0346642437534	0.833333333333	NEFM VIM KRT7 INA NEFL	supramolecular fiber organization
HPA:0091043	0.0421652715576	0.333333333333	NEFM INA	cerebellum; processes in white matter[High]
HPA:0091033	0.0465379666742	0.333333333333	NEFM INA	cerebellum; processes in molecular layer[High]

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
NEFM	NES	1.0	0.116	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
NEFL	NEFM	0.999	0.236	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM
NEFM	VIM	0.999	0.296	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM
INA	NEFM	0.998	0.138	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM
NES	VIM	0.994	0.532833333333	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () treiber_WMM
NEFH	NEFM	0.994	0.126	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
IDE	NES	0.992	0.138	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein ()
INA	VIM	0.991	0.325107990434	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM
NEFL	NES	0.99	0.144	bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
IDE	VIM	0.987	0.194610526316	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM
INA	NES	0.984	0.114	bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
KRT7	VIM	0.964	0.402608695652	hein_WMM bioplex3_HEK293 boldt_WMM WMM_only
NEFL	VIM	0.956	0.286	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM
INA	NEFL	0.861	0.158	bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM
IDE	NEFM	0.861	0.082	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
IDE	NEFL	0.859	0.088	bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
IDE	INA	0.808	0.05	bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
NEFH	NEFL	0.72	0.21	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
NEFH	VIM	0.712	0.354832628115	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
INA	NEFH	0.609	0.108	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
INA	KRT7	0.38	0.136	bioplex3_HEK293 WMM_only
NEFH	NES	0.24	0.326	bioplex3_WMM WMM_only
NEFM	KRT7	0.239	0.226	bioplex3_HEK293 WMM_only
IDE	KRT7	0.232	0.058	hein_WMM WMM_only boldt_WMM
KRT7	NES	0.154	0.434	hein_WMM hein ()
NEFL	KRT7	0.112	0.2	bioplex3_HEK293 youn_WMM gupta_WMM WMM_only
IDE	NEFH	0.006	0.106	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM

Related Complexes

Genename	Complexes
INA	huMAP3_00659.1 huMAP3_07026.1 huMAP3_09417.1 huMAP3_10960.1 huMAP3_11715.1
NEFL	huMAP3_00659.1 huMAP3_07026.1 huMAP3_09417.1 huMAP3_10960.1 huMAP3_11715.1
NEFM	huMAP3_00659.1 huMAP3_06794.1 huMAP3_09417.1 huMAP3_10960.1 huMAP3_11715.1
KRT7	huMAP3_05156.1 huMAP3_07026.1 huMAP3_09417.1 huMAP3_10960.1 huMAP3_11715.1
VIM	huMAP3_05156.1 huMAP3_07026.1 huMAP3_09417.1 huMAP3_10960.1 huMAP3_11715.1
IDE	huMAP3_00335.1 huMAP3_05156.1 huMAP3_07026.1 huMAP3_09417.1 huMAP3_10960.1 huMAP3_11715.1 huMAP3_11831.1
NES	huMAP3_05156.1 huMAP3_07026.1 huMAP3_09417.1 huMAP3_10960.1 huMAP3_11715.1
NEFH	huMAP3_00659.1 huMAP3_06794.1 huMAP3_09417.1 huMAP3_10960.1 huMAP3_13014.1 huMAP3_15340.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09417.1

Complex Portal: CPX-11705