List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_09419.1

Confidence: Moderate High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
EYA2	Eyes absent homolog 2 (EC 3.1.3.48)	5	UniProt   NCBI
EYA1	Eyes absent homolog 1 (EC 3.1.3.16) (EC 3.1.3.48)	5	UniProt   NCBI
EYA3	Eyes absent homolog 3 (EC 3.1.3.48)	5	UniProt   NCBI
SIX2	Homeobox protein SIX2 (Sine oculis homeobox homolog 2)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0140789	3.84480164306e-07	0.75	EYA2 EYA3 EYA1	histone phosphatase activity
GO:0140793	3.84480164306e-07	0.75	EYA2 EYA3 EYA1	histone H2AXY142 phosphatase activity
CORUM:7364	5.12628525639e-06	0.5	EYA1 SIX2	EYA1-SIX2 complex
REAC:R-HSA-5693565	7.99206750774e-05	0.75	EYA2 EYA3 EYA1	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
REAC:R-HSA-5693606	8.33911915483e-05	0.75	EYA2 EYA3 EYA1	DNA Double Strand Break Response
GO:1901099	0.000437924933217	0.75	EYA2 EYA3 EYA1	negative regulation of signal transduction in absence of ligand
GO:2001240	0.000437924933217	0.75	EYA2 EYA3 EYA1	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001239	0.000883305813556	0.75	EYA2 EYA3 EYA1	regulation of extrinsic apoptotic signaling pathway in absence of ligand
REAC:R-HSA-5693532	0.000897810107574	0.75	EYA2 EYA3 EYA1	DNA Double-Strand Break Repair
WP:WP5236	0.0027493593259	0.5	EYA1 SIX2	Markers of kidney cell lineage
WP:WP5053	0.0027493593259	0.5	EYA1 SIX2	Development of ureteric collection system
GO:0038034	0.00323764786551	0.75	EYA2 EYA3 EYA1	signal transduction in absence of ligand
GO:0097192	0.00323764786551	0.75	EYA2 EYA3 EYA1	extrinsic apoptotic signaling pathway in absence of ligand
REAC:R-HSA-73894	0.00653220236003	0.75	EYA2 EYA3 EYA1	DNA Repair
GO:2001237	0.0144970047051	0.75	EYA2 EYA3 EYA1	negative regulation of extrinsic apoptotic signaling pathway
GO:0004725	0.0248327141789	0.75	EYA2 EYA3 EYA1	protein tyrosine phosphatase activity
GO:0007501	0.0280843539964	0.5	EYA2 SIX2	mesodermal cell fate specification
GO:0001710	0.042122686785	0.5	EYA2 SIX2	mesodermal cell fate commitment
GO:2001236	0.0496619752722	0.75	EYA2 EYA3 EYA1	regulation of extrinsic apoptotic signaling pathway
CORUM:7363	0.049938562206	0.25	EYA1	EYA1-SIX1 complex



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?	Evidence ?
EYA2	SIX2	0.993		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
EYA1	SIX2	0.986		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
EYA3	SIX2	0.973	0.054	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
EYA1	EYA2	0.333		bioplex_WMM     bioplex3_WMM     WMM_only
EYA3	EYA2	0.333		bioplex_WMM     bioplex3_WMM     WMM_only
EYA3	EYA1	0.265		bioplex_WMM     bioplex3_WMM     WMM_only





Related Complexes

Genename	Complexes
EYA2	huMAP3_01386.1 huMAP3_05663.1 huMAP3_08067.1 huMAP3_08280.1 huMAP3_09419.1 huMAP3_10131.1 huMAP3_10248.1
EYA1	huMAP3_00974.1 huMAP3_07869.1 huMAP3_08067.1 huMAP3_08280.1 huMAP3_09419.1 huMAP3_10131.1 huMAP3_10205.1 huMAP3_12169.1 huMAP3_14496.1
EYA3	huMAP3_00067.1 huMAP3_01386.1 huMAP3_05663.1 huMAP3_08067.1 huMAP3_08280.1 huMAP3_08335.1 huMAP3_09419.1 huMAP3_10131.1 huMAP3_10248.1 huMAP3_12159.1
SIX2	huMAP3_01386.1 huMAP3_05663.1 huMAP3_08067.1 huMAP3_08280.1 huMAP3_09419.1 huMAP3_10131.1 huMAP3_10205.1 huMAP3_10248.1