hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09432.1
Complex Portal: CPX-22242
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RPAIN | RPA-interacting protein (hRIP) | 5 | UniProt NCBI |
| RPA4 | Replication protein A 30 kDa subunit (RP-A p30) (Replication factor A protein 4) (RF-A protein 4) | 5 | UniProt NCBI |
| PARP1 | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | 5 | UniProt NCBI |
| HLTF | Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3) | 5 | UniProt NCBI |
| MACROD1 | ADP-ribose glycohydrolase MACROD1 (MACRO domain-containing protein 1) (O-acetyl-ADP-ribose deacetylase MACROD1) (EC 3.1.1.106) (Protein LRP16) ([Protein ADP-ribosylaspartate] hydrolase MACROD1) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD1) (EC 3.2.2.-) | 5 | UniProt NCBI |
| RPA2 | Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) | 5 | UniProt NCBI |
| RPA3 | Replication protein A 14 kDa subunit (RP-A p14) (Replication factor A protein 3) (RF-A protein 3) | 5 | UniProt NCBI |
| HMCES | Abasic site processing protein HMCES (EC 4.-.-.-) (Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein) (ES cell-specific 5hmC-binding protein) (Peptidase HMCES) (EC 3.4.-.-) (SRAP domain-containing protein 1) | 5 | UniProt NCBI |
| RPA1 | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1004 | 8.23819018485e-07 | 0.375 | RPA1 PARP1 RPA3 | RC complex during S-phase of cell cycle |
| CORUM:1005 | 1.17658221023e-06 | 0.375 | RPA1 PARP1 RPA3 | RC complex during G2/M-phase of cell cycle |
| GO:0005657 | 4.12240046619e-06 | 0.625 | RPA1 HMCES RPA3 RPA4 PARP1 | replication fork |
| KEGG:03430 | 9.3900725154e-06 | 0.375 | RPA1 RPA4 RPA3 | Mismatch repair |
| CORUM:5229 | 2.39226645298e-05 | 0.25 | RPA1 RPA3 | RPA complex |
| KEGG:03030 | 3.77309774533e-05 | 0.375 | RPA1 RPA4 RPA3 | DNA replication |
| KEGG:03440 | 5.21567264954e-05 | 0.375 | RPA1 RPA4 RPA3 | Homologous recombination |
| REAC:R-HSA-110373 | 5.23852014749e-05 | 0.375 | RPA1 PARP1 RPA3 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| KEGG:03460 | 9.70359180975e-05 | 0.375 | RPA1 RPA4 RPA3 | Fanconi anemia pathway |
| WP:WP466 | 0.000111638200677 | 0.375 | RPA1 RPA4 RPA3 | DNA replication |
| REAC:R-HSA-68962 | 0.000124011659906 | 0.375 | RPA1 RPA4 RPA3 | Activation of the pre-replicative complex |
| REAC:R-HSA-73933 | 0.000148687552241 | 0.375 | RPA1 PARP1 RPA3 | Resolution of Abasic Sites (AP sites) |
| GO:0043596 | 0.000150338896321 | 0.5 | RPA1 RPA3 RPA4 PARP1 | nuclear replication fork |
| KEGG:03420 | 0.000162137358357 | 0.375 | RPA1 RPA4 RPA3 | Nucleotide excision repair |
| CORUM:2222 | 0.000239030245992 | 0.25 | RPA1 RPA3 | BLM complex II |
| CORUM:2738 | 0.000239030245992 | 0.25 | RPA1 RPA3 | BLM complex II |
| REAC:R-HSA-5696400 | 0.000241797870321 | 0.375 | RPA1 PARP1 RPA3 | Dual Incision in GG-NER |
| GO:0006974 | 0.00025723002296 | 0.875 | RPA1 RPA3 HMCES RPA4 HLTF PARP1 MACROD1 | DNA damage response |
| REAC:R-HSA-5696395 | 0.000260330782854 | 0.375 | RPA1 PARP1 RPA3 | Formation of Incision Complex in GG-NER |
| WP:WP5114 | 0.000600026967084 | 0.375 | RPA1 PARP1 RPA3 | Nucleotide excision repair in xeroderma pigmentosum |
| CORUM:248 | 0.000859567015467 | 0.25 | RPA1 RPA3 | BRAFT complex |
| WP:WP2446 | 0.000984012141689 | 0.375 | HLTF RPA3 RPA1 | Retinoblastoma gene in cancer |
| CORUM:244 | 0.00131250845457 | 0.25 | RPA1 RPA3 | BRAFT complex |
| GO:0005662 | 0.00153551162834 | 0.375 | RPA1 RPA4 RPA3 | DNA replication factor A complex |
| REAC:R-HSA-73884 | 0.00158030541683 | 0.375 | RPA1 PARP1 RPA3 | Base Excision Repair |
| REAC:R-HSA-5696399 | 0.00206171621711 | 0.375 | RPA1 PARP1 RPA3 | Global Genome Nucleotide Excision Repair (GG-NER) |
| WP:WP4946 | 0.00223564396029 | 0.375 | RPA1 PARP1 RPA3 | DNA repair pathways full network |
| GO:0006310 | 0.00355755965791 | 0.625 | RPA1 HMCES RPA3 RPA4 PARP1 | DNA recombination |
| REAC:R-HSA-3371511 | 0.00367178411278 | 0.25 | RPA1 RPA3 | HSF1 activation |
| REAC:R-HSA-5696398 | 0.00455165033631 | 0.375 | RPA1 PARP1 RPA3 | Nucleotide Excision Repair |
| REAC:R-HSA-5358565 | 0.00505983974502 | 0.25 | RPA1 RPA3 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) |
| REAC:R-HSA-5358606 | 0.00505983974502 | 0.25 | RPA1 RPA3 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) |
| REAC:R-HSA-69166 | 0.00505983974502 | 0.25 | RPA1 RPA3 | Removal of the Flap Intermediate |
| REAC:R-HSA-5358508 | 0.00583667819665 | 0.25 | RPA1 RPA3 | Mismatch Repair |
| REAC:R-HSA-69183 | 0.00583667819665 | 0.25 | RPA1 RPA3 | Processive synthesis on the lagging strand |
| WP:WP531 | 0.00601773204474 | 0.25 | RPA1 RPA3 | DNA mismatch repair |
| REAC:R-HSA-5656121 | 0.00666866305696 | 0.25 | RPA1 RPA3 | Translesion synthesis by POLI |
| REAC:R-HSA-110312 | 0.00666866305696 | 0.25 | RPA1 RPA3 | Translesion synthesis by REV1 |
| REAC:R-HSA-174437 | 0.00755574884395 | 0.25 | RPA1 RPA3 | Removal of the Flap Intermediate from the C-strand |
| REAC:R-HSA-5655862 | 0.00755574884395 | 0.25 | RPA1 RPA3 | Translesion synthesis by POLK |
| GO:0003697 | 0.00766061600114 | 0.5 | RPA1 HMCES RPA4 RPA3 | single-stranded DNA binding |
| GO:0090734 | 0.00766061600114 | 0.5 | RPA1 RPA3 RPA4 PARP1 | site of DNA damage |
| REAC:R-HSA-5693538 | 0.00775010993696 | 0.375 | RPA1 PARP1 RPA3 | Homology Directed Repair |
| REAC:R-HSA-69206 | 0.00793113777729 | 0.375 | RPA1 RPA4 RPA3 | G1/S Transition |
| GO:0043601 | 0.00824905178996 | 0.375 | RPA1 RPA4 RPA3 | nuclear replisome |
| REAC:R-HSA-174414 | 0.00949504138694 | 0.25 | RPA1 RPA3 | Processive synthesis on the C-strand of the telomere |
| REAC:R-HSA-110320 | 0.00949504138694 | 0.25 | RPA1 RPA3 | Translesion Synthesis by POLH |
| REAC:R-HSA-69186 | 0.0105471572959 | 0.25 | RPA1 RPA3 | Lagging Strand Synthesis |
| GO:0030894 | 0.0108360428077 | 0.375 | RPA1 RPA4 RPA3 | replisome |
| REAC:R-HSA-69002 | 0.0114479048277 | 0.375 | RPA1 RPA4 RPA3 | DNA Replication Pre-Initiation |
| REAC:R-HSA-453279 | 0.0114479048277 | 0.375 | RPA1 RPA4 RPA3 | Mitotic G1 phase and G1/S transition |
| REAC:R-HSA-5651801 | 0.0116541924374 | 0.25 | RPA1 RPA3 | PCNA-Dependent Long Patch Base Excision Repair |
| REAC:R-HSA-5693532 | 0.0141950226766 | 0.375 | RPA1 PARP1 RPA3 | DNA Double-Strand Break Repair |
| GO:0033554 | 0.0151848602789 | 0.875 | RPA1 RPA3 HMCES RPA4 HLTF PARP1 MACROD1 | cellular response to stress |
| REAC:R-HSA-5696397 | 0.0166306183768 | 0.25 | RPA1 RPA3 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| REAC:R-HSA-69306 | 0.0189140309144 | 0.375 | RPA1 RPA4 RPA3 | DNA Replication |
| WP:WP4753 | 0.021360968316 | 0.25 | RPA1 RPA3 | Nucleotide excision repair |
| REAC:R-HSA-110314 | 0.0240813966337 | 0.25 | RPA1 RPA3 | Recognition of DNA damage by PCNA-containing replication complex |
| GO:0006259 | 0.0256033984124 | 0.75 | RPA1 RPA3 HMCES HLTF PARP1 RPA4 | DNA metabolic process |
| REAC:R-HSA-5656169 | 0.0257351328695 | 0.25 | RPA1 RPA3 | Termination of translesion DNA synthesis |
| REAC:R-HSA-69190 | 0.0274432906045 | 0.25 | RPA1 RPA3 | DNA strand elongation |
| REAC:R-HSA-174417 | 0.0310226901604 | 0.25 | RPA1 RPA3 | Telomere C-strand (Lagging Strand) Synthesis |
| REAC:R-HSA-9709570 | 0.0310226901604 | 0.25 | RPA1 RPA3 | Impaired BRCA2 binding to RAD51 |
| REAC:R-HSA-6783310 | 0.0328938418336 | 0.25 | RPA1 RPA3 | Fanconi Anemia Pathway |
| REAC:R-HSA-5685938 | 0.0328938418336 | 0.25 | RPA1 RPA3 | HDR through Single Strand Annealing (SSA) |
| REAC:R-HSA-176187 | 0.0348192347107 | 0.25 | RPA1 RPA3 | Activation of ATR in response to replication stress |
| REAC:R-HSA-110313 | 0.0388325640363 | 0.25 | RPA1 RPA3 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| REAC:R-HSA-5693616 | 0.0409204105231 | 0.25 | RPA1 RPA3 | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-9701190 | 0.04306231829 | 0.25 | RPA1 RPA3 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function |
| REAC:R-HSA-9675136 | 0.04306231829 | 0.25 | RPA1 RPA3 | Diseases of DNA Double-Strand Break Repair |
| GO:0000724 | 0.0445000722229 | 0.5 | RPA1 RPA3 RPA4 PARP1 | double-strand break repair via homologous recombination |
| WP:WP45 | 0.0474159822822 | 0.25 | RPA1 RPA3 | G1 to S cell cycle control |
| REAC:R-HSA-5693579 | 0.0475081379956 | 0.25 | RPA1 RPA3 | Homologous DNA Pairing and Strand Exchange |
| GO:0000725 | 0.0491838271735 | 0.5 | RPA1 RPA3 RPA4 PARP1 | recombinational repair |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RPA3 | RPA2 | 1.0 | 0.958 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| RPA1 | RPA2 | 1.0 | 0.802 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| RPA3 | RPA1 | 1.0 | 0.658 |
mutually_exclusive (Q13156)
|
hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo gupta_WMM fraction boldt_WMM |
| RPA1 | RPAIN | 0.999 | 0.196 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RPA2 | RPAIN | 0.999 | 0.208 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RPA1 | RPA4 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RPAIN | RPA4 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RPA3 | RPA4 | 0.995 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MACROD1 | PARP1 | 0.991 | 0.166 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RPA3 | RPAIN | 0.989 | 0.288 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| HMCES | RPA1 | 0.988 | 0.08 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RPA2 | PARP1 | 0.985 | 0.424 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | |
| RPAIN | PARP1 | 0.983 | 0.226 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MACROD1 | RPA2 | 0.978 | 0.026 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| HLTF | RPA2 | 0.977 | 0.07 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| HLTF | RPA1 | 0.972 | 0.204166666667 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM treiber_WMM WMM_only | |
| RPA4 | PARP1 | 0.97 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| HMCES | RPA4 | 0.969 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| HMCES | RPA2 | 0.965 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| HLTF | PARP1 | 0.963 | 0.482857142857 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM treiber_WMM WMM_only | |
| HLTF | RPA3 | 0.957 | 0.048 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| RPA3 | HMCES | 0.957 | 0.072 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RPA2 | RPA4 | 0.931 |
mutually_exclusive (P35244)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MACROD1 | RPA1 | 0.841 | 0.052 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MACROD1 | RPA3 | 0.734 | 0.052 |
mutually_exclusive (P41208)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| HMCES | RPAIN | 0.643 | 0.034 | bioplex_WMM bioplex3_WMM WMM_only | |
| RPA1 | PARP1 | 0.605 | 0.63 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM | |
| HMCES | PARP1 | 0.355 | 0.144333333333 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| HLTF | RPAIN | 0.283 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only | |
| RPA3 | PARP1 | 0.242 | 0.42 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM | |
| HLTF | HMCES | 0.072 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only | |
| HLTF | MACROD1 | 0.067 | 0.036 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| HLTF | RPA4 | 0.024 | bioplex3_WMM bioplex3_HCT116 WMM_only |
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