List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_09433.1

Confidence: Moderate High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
CHEK2	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2)	5	UniProt   NCBI
TP73	Tumor protein p73 (p53-like transcription factor) (p53-related protein)	5	UniProt   NCBI
TP63	Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-6803207	0.000190864539041	0.666666666667	TP73 TP63	TP53 Regulates Transcription of Caspase Activators and Caspases
WP:WP1742	0.000193548942551	0.666666666667	TP73 TP63	TP53 network
REAC:R-HSA-139915	0.00024538606603	0.666666666667	TP73 TP63	Activation of PUMA and translocation to mitochondria
REAC:R-HSA-5633007	0.000267736308591	1.0	CHEK2 TP63 TP73	Regulation of TP53 Activity
REAC:R-HSA-6804759	0.000374861161166	0.666666666667	TP73 TP63	Regulation of TP53 Activity through Association with Co-factors
REAC:R-HSA-6803211	0.000449812862905	0.666666666667	TP73 TP63	TP53 Regulates Transcription of Death Receptors and Ligands
REAC:R-HSA-6803205	0.000531572756485	0.666666666667	TP73 TP63	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
WP:WP2516	0.00079501095268	0.666666666667	CHEK2 TP73	ATM signaling pathway
REAC:R-HSA-6803204	0.0011650518872	0.666666666667	TP73 TP63	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
WP:WP3959	0.00149859190216	0.666666666667	CHEK2 TP73	DNA IR double strand breaks and cellular response via ATM
KEGG:04115	0.00153460242624	0.666666666667	CHEK2 TP73	p53 signaling pathway
REAC:R-HSA-114452	0.00296224002415	0.666666666667	TP73 TP63	Activation of BH3-only proteins
WP:WP254	0.00296720799434	0.666666666667	TP73 TP63	Apoptosis
REAC:R-HSA-3700989	0.00297633187542	1.0	CHEK2 TP63 TP73	Transcriptional Regulation by TP53
REAC:R-HSA-5633008	0.00478550282195	0.666666666667	TP73 TP63	TP53 Regulates Transcription of Cell Death Genes
REAC:R-HSA-109606	0.00902065028483	0.666666666667	TP73 TP63	Intrinsic Pathway for Apoptosis
HPA:0060843	0.0200666393919	0.666666666667	CHEK2 TP73	bronchus; basal cells[High]
HPA:0320843	0.0319527413287	0.666666666667	CHEK2 TP73	nasopharynx; basal cells[High]



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?	Evidence ?
TP63	CHEK2	0.987	0.172	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
TP73	TP63	0.986		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
TP73	CHEK2	0.26		bioplex_WMM     bioplex3_WMM     WMM_only





Related Complexes

Genename	Complexes
CHEK2	huMAP3_09433.1 huMAP3_11513.1
TP73	huMAP3_05193.1 huMAP3_09433.1
TP63	huMAP3_05193.1 huMAP3_09433.1 huMAP3_11513.1