hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09442.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GBP3 | Guanylate-binding protein 3 (EC 3.6.5.-) (GTP-binding protein 3) (GBP-3) (Guanine nucleotide-binding protein 3) | 5 | UniProt NCBI |
| GBP5 | Guanylate-binding protein 5 (EC 3.6.5.-) (GBP-TA antigen) (GTP-binding protein 5) (GBP-5) (Guanine nucleotide-binding protein 5) | 5 | UniProt NCBI |
| GBP1 | Guanylate-binding protein 1 (EC 3.6.1.-) (EC 3.6.5.-) (GTP-binding protein 1) (GBP-1) (HuGBP-1) (hGBP1) (Guanine nucleotide-binding protein 1) (Interferon-induced guanylate-binding protein 1) | 5 | UniProt NCBI |
| GBP2 | Guanylate-binding protein 2 (EC 3.6.5.-) (GTP-binding protein 2) (GBP-2) (HuGBP-2) (Guanine nucleotide-binding protein 2) (Interferon-induced guanylate-binding protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0140639 | 1.31563155046e-10 | 1.0 | GBP5 GBP2 GBP3 GBP1 | positive regulation of pyroptosis |
| GO:0051715 | 3.94689465137e-10 | 1.0 | GBP5 GBP2 GBP3 GBP1 | cytolysis in another organism |
| GO:0019835 | 9.2094208532e-10 | 1.0 | GBP5 GBP2 GBP3 GBP1 | cytolysis |
| REAC:R-HSA-877300 | 1.23206013755e-07 | 1.0 | GBP5 GBP2 GBP3 GBP1 | Interferon gamma signaling |
| GO:0070269 | 1.92476895832e-07 | 1.0 | GBP5 GBP2 GBP3 GBP1 | pyroptosis |
| KEGG:04621 | 4.2673120168e-07 | 1.0 | GBP5 GBP2 GBP3 GBP1 | NOD-like receptor signaling pathway |
| GO:0031640 | 2.94517278885e-06 | 1.0 | GBP5 GBP2 GBP3 GBP1 | killing of cells of another organism |
| GO:0141061 | 2.94517278885e-06 | 1.0 | GBP5 GBP2 GBP3 GBP1 | disruption of cell in another organism |
| REAC:R-HSA-913531 | 3.6254700184e-06 | 1.0 | GBP5 GBP2 GBP3 GBP1 | Interferon Signaling |
| GO:0141060 | 4.29382669123e-06 | 1.0 | GBP5 GBP2 GBP3 GBP1 | disruption of anatomical structure in another organism |
| GO:0071346 | 1.56735133501e-05 | 1.0 | GBP5 GBP2 GBP3 GBP1 | cellular response to type II interferon |
| GO:0034341 | 4.16155309515e-05 | 1.0 | GBP5 GBP2 GBP3 GBP1 | response to type II interferon |
| GO:0001906 | 0.000255005574346 | 1.0 | GBP5 GBP2 GBP3 GBP1 | cell killing |
| REAC:R-HSA-1280215 | 0.000544985136876 | 1.0 | GBP5 GBP2 GBP3 GBP1 | Cytokine Signaling in Immune system |
| GO:0005525 | 0.000993378785041 | 1.0 | GBP5 GBP2 GBP3 GBP1 | GTP binding |
| GO:0032561 | 0.00156892706691 | 1.0 | GBP5 GBP2 GBP3 GBP1 | guanyl ribonucleotide binding |
| GO:0019001 | 0.00160144369006 | 1.0 | GBP5 GBP2 GBP3 GBP1 | guanyl nucleotide binding |
| GO:0140973 | 0.0028092043205 | 0.5 | GBP5 GBP2 | positive regulation of AIM2 inflammasome complex assembly |
| GO:0003924 | 0.00366770658506 | 1.0 | GBP5 GBP2 GBP3 GBP1 | GTPase activity |
| GO:0140971 | 0.00842684400117 | 0.5 | GBP5 GBP2 | regulation of AIM2 inflammasome complex assembly |
| GO:0043068 | 0.0120071462095 | 1.0 | GBP5 GBP2 GBP3 GBP1 | positive regulation of programmed cell death |
| GO:0071347 | 0.0159688263229 | 0.75 | GBP1 GBP3 GBP2 | cellular response to interleukin-1 |
| GO:0140970 | 0.0168521501606 | 0.5 | GBP5 GBP2 | AIM2 inflammasome complex assembly |
| GO:0017111 | 0.0191409054275 | 1.0 | GBP5 GBP2 GBP3 GBP1 | ribonucleoside triphosphate phosphatase activity |
| GO:0070555 | 0.0302857026499 | 0.75 | GBP1 GBP3 GBP2 | response to interleukin-1 |
| GO:0016462 | 0.0305291540849 | 1.0 | GBP5 GBP2 GBP3 GBP1 | pyrophosphatase activity |
| GO:0016817 | 0.0305291540849 | 1.0 | GBP5 GBP2 GBP3 GBP1 | hydrolase activity, acting on acid anhydrides |
| GO:0016818 | 0.0305291540849 | 1.0 | GBP5 GBP2 GBP3 GBP1 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| REAC:R-HSA-168256 | 0.032293648674 | 1.0 | GBP5 GBP2 GBP3 GBP1 | Immune System |
| GO:0035639 | 0.0326761482103 | 1.0 | GBP5 GBP2 GBP3 GBP1 | purine ribonucleoside triphosphate binding |
| GO:0071345 | 0.0376564867058 | 1.0 | GBP5 GBP2 GBP3 GBP1 | cellular response to cytokine stimulus |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GBP3 | GBP2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GBP3 | GBP1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GBP1 | GBP2 | 0.988 | 0.284 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GBP5 | GBP1 | 0.987 | 0.21 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GBP5 | GBP3 | 0.868 | bioplex_WMM bioplex3_WMM WMM_only | |
| GBP5 | GBP2 | 0.769 | 0.15 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes