hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09446.1

Complex Portal: CPX-12026

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
NELFCD	Negative elongation factor C/D (NELF-C/D) (TH1-like protein)	5	UniProt NCBI
NELFE	Negative elongation factor E (NELF-E) (RNA-binding protein RD)	5	UniProt NCBI
GPR137B	Integral membrane protein GPR137B (Transmembrane 7 superfamily member 1 protein)	5	UniProt NCBI
NELFA	Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein)	5	UniProt NCBI
XYLT1	Xylosyltransferase 1 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase I) (XT-I) (XylT-I)	5	UniProt NCBI
TMEM141	Transmembrane protein 141	2	UniProt NCBI
IGHMBP2	DNA-binding protein SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase IGHMBP2) (Glial factor 1) (GF-1) (Immunoglobulin mu-binding protein 2)	5	UniProt NCBI
NELFB	Negative elongation factor B (NELF-B) (Cofactor of BRCA1)	5	UniProt NCBI
ICA1	Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (Islet cell autoantigen p69) (ICAp69) (p69)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:2598	5.38212907005e-12	0.444444444444	NELFE NELFB NELFCD NELFA	NELF complex (Negative elongation factor complex)
CORUM:281	5.38212907005e-12	0.444444444444	NELFE NELFB NELFCD NELFA	NELF complex (Negative elongation factor complex)
GO:0032021	3.31539150715e-09	0.444444444444	NELFE NELFB NELFCD NELFA	NELF complex
WP:WP5365	1.05510345548e-07	0.444444444444	NELFE NELFB NELFCD NELFA	4p16 3 copy number variation
REAC:R-HSA-167242	1.14373512426e-07	0.444444444444	NELFE NELFB NELFCD NELFA	Abortive elongation of HIV-1 transcript in the absence of Tat
WP:WP3414	1.42712411928e-07	0.444444444444	NELFE NELFB NELFCD NELFA	Initiation of transcription and translation elongation at the HIV 1 LTR
REAC:R-HSA-167238	4.2755177006e-07	0.444444444444	NELFE NELFB NELFCD NELFA	Pausing and recovery of Tat-mediated HIV elongation
REAC:R-HSA-167243	4.2755177006e-07	0.444444444444	NELFE NELFB NELFCD NELFA	Tat-mediated HIV elongation arrest and recovery
REAC:R-HSA-167290	5.60712805559e-07	0.444444444444	NELFE NELFB NELFCD NELFA	Pausing and recovery of HIV elongation
REAC:R-HSA-167158	5.60712805559e-07	0.444444444444	NELFE NELFB NELFCD NELFA	Formation of the HIV-1 Early Elongation Complex
REAC:R-HSA-113418	5.60712805559e-07	0.444444444444	NELFE NELFB NELFCD NELFA	Formation of the Early Elongation Complex
REAC:R-HSA-167287	5.60712805559e-07	0.444444444444	NELFE NELFB NELFCD NELFA	HIV elongation arrest and recovery
KEGG:03250	1.30507907331e-06	0.444444444444	NELFE NELFB NELFCD NELFA	Viral life cycle - HIV-1
REAC:R-HSA-167246	1.74050956917e-06	0.444444444444	NELFE NELFB NELFCD NELFA	Tat-mediated elongation of the HIV-1 transcript
REAC:R-HSA-167200	1.74050956917e-06	0.444444444444	NELFE NELFB NELFCD NELFA	Formation of HIV-1 elongation complex containing HIV-1 Tat
REAC:R-HSA-167169	1.74050956917e-06	0.444444444444	NELFE NELFB NELFCD NELFA	HIV Transcription Elongation
REAC:R-HSA-167152	2.10976803376e-06	0.444444444444	NELFE NELFB NELFCD NELFA	Formation of HIV elongation complex in the absence of HIV Tat
GO:0034244	3.30963071989e-06	0.444444444444	NELFE NELFB NELFCD NELFA	negative regulation of transcription elongation by RNA polymerase II
REAC:R-HSA-112382	6.11717158058e-06	0.444444444444	NELFE NELFB NELFCD NELFA	Formation of RNA Pol II elongation complex
REAC:R-HSA-75955	6.11717158058e-06	0.444444444444	NELFE NELFB NELFCD NELFA	RNA Polymerase II Transcription Elongation
REAC:R-HSA-6796648	8.07264008546e-06	0.444444444444	NELFE NELFB NELFCD NELFA	TP53 Regulates Transcription of DNA Repair Genes
GO:0032785	1.01062722265e-05	0.444444444444	NELFE NELFB NELFCD NELFA	negative regulation of DNA-templated transcription, elongation
REAC:R-HSA-167172	1.2573634848e-05	0.444444444444	NELFE NELFB NELFCD NELFA	Transcription of the HIV genome
REAC:R-HSA-674695	2.31277665371e-05	0.444444444444	NELFE NELFB NELFCD NELFA	RNA Polymerase II Pre-transcription Events
REAC:R-HSA-162599	0.000172409898389	0.444444444444	NELFE NELFB NELFCD NELFA	Late Phase of HIV Life Cycle
REAC:R-HSA-162587	0.000245601040752	0.444444444444	NELFE NELFB NELFCD NELFA	HIV Life Cycle
GO:0008023	0.000584421737577	0.444444444444	NELFE NELFB NELFCD NELFA	transcription elongation factor complex
REAC:R-HSA-162906	0.00143161155991	0.444444444444	NELFE NELFB NELFCD NELFA	HIV Infection
GO:0034243	0.00463414518632	0.444444444444	NELFE NELFB NELFCD NELFA	regulation of transcription elongation by RNA polymerase II
REAC:R-HSA-3700989	0.00765511426945	0.444444444444	NELFE NELFB NELFCD NELFA	Transcriptional Regulation by TP53
GO:0032784	0.0102944372343	0.444444444444	NELFE NELFB NELFCD NELFA	regulation of DNA-templated transcription elongation
GO:0006368	0.0121592546484	0.444444444444	NELFE NELFB NELFCD NELFA	transcription elongation by RNA polymerase II
GO:0006354	0.0230202913566	0.444444444444	NELFE NELFB NELFCD NELFA	DNA-templated transcription elongation

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
NELFE	NELFB	1.0			hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction
NELFB	NELFA	1.0		structurally_consistent (Q8IXH7)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116
NELFCD	NELFE	1.0	0.56		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction
NELFE	NELFA	1.0	0.336		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM
NELFCD	NELFA	1.0	0.682	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116
NELFCD	NELFB	1.0		structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction
NELFE	IGHMBP2	1.0	0.05		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
IGHMBP2	NELFA	0.999	0.124		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
NELFCD	IGHMBP2	0.988	0.16		bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
NELFCD	TMEM141	0.984	0.046		bioplex3_HEK293 bioplex3_WMM WMM_only
NELFCD	XYLT1	0.979		mutually_exclusive (Q8WX92)	bioplex3_HEK293 bioplex3_WMM WMM_only
XYLT1	IGHMBP2	0.977			bioplex3_HEK293 bioplex3_WMM WMM_only
XYLT1	NELFB	0.977		structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM WMM_only
ICA1	NELFA	0.97	0.084		bioplex3_WMM bioplex3_HCT116 WMM_only
IGHMBP2	NELFB	0.966			bioplex_WMM bioplex3_WMM WMM_only
XYLT1	NELFA	0.955			bioplex3_HEK293 bioplex3_WMM WMM_only
NELFCD	GPR137B	0.95			bioplex3_HEK293 bioplex3_WMM WMM_only
NELFE	XYLT1	0.934			bioplex3_HEK293 bioplex3_WMM WMM_only
TMEM141	GPR137B	0.415			bioplex3_WMM WMM_only
ICA1	NELFCD	0.41	0.084		bioplex3_WMM WMM_only
ICA1	NELFB	0.364			bioplex3_WMM WMM_only
ICA1	IGHMBP2	0.356	0.074		bioplex3_WMM WMM_only
ICA1	NELFE	0.32	0.044		bioplex3_WMM WMM_only
NELFA	GPR137B	0.25			bioplex3_WMM WMM_only
TMEM141	NELFB	0.25			bioplex3_WMM WMM_only
TMEM141	IGHMBP2	0.25	0.128		bioplex3_WMM WMM_only
NELFB	GPR137B	0.25			bioplex3_WMM WMM_only
TMEM141	NELFA	0.25	0.018		bioplex3_WMM WMM_only
IGHMBP2	GPR137B	0.25			bioplex3_WMM WMM_only
NELFE	TMEM141	0.093	0.036		bioplex3_WMM WMM_only
NELFE	GPR137B	0.093			bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
NELFCD	huMAP3_01088.1 huMAP3_05354.1 huMAP3_09446.1
NELFE	huMAP3_01088.1 huMAP3_05354.1 huMAP3_09446.1
GPR137B	huMAP3_03084.1 huMAP3_05354.1 huMAP3_09446.1 huMAP3_09855.1 huMAP3_11452.1 huMAP3_11457.1 huMAP3_14385.1 huMAP3_14663.1
NELFA	huMAP3_01088.1 huMAP3_03668.1 huMAP3_05268.1 huMAP3_09446.1
XYLT1	huMAP3_01088.1 huMAP3_05354.1 huMAP3_09446.1
TMEM141	huMAP3_01088.1 huMAP3_05354.1 huMAP3_09446.1
IGHMBP2	huMAP3_01088.1 huMAP3_05354.1 huMAP3_09446.1
NELFB	huMAP3_01088.1 huMAP3_05354.1 huMAP3_09446.1
ICA1	huMAP3_01038.1 huMAP3_03668.1 huMAP3_05268.1 huMAP3_09446.1 huMAP3_12870.1 huMAP3_13177.1 huMAP3_13980.1 huMAP3_14705.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09446.1

Complex Portal: CPX-12026