hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09450.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| JMJD6 | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (EC 1.14.11.-) (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) (Protein PTDSR) | 5 | UniProt NCBI |
| PUF60 | Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1) | 5 | UniProt NCBI |
| RBM25 | RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7) | 5 | UniProt NCBI |
| PRPF38A | Pre-mRNA-splicing factor 38A | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03040 | 0.000108396031683 | 0.75 | PUF60 RBM25 PRPF38A | Spliceosome |
| REAC:R-HSA-72163 | 0.00185188916926 | 0.75 | PUF60 RBM25 PRPF38A | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 0.002052480752 | 0.75 | PUF60 RBM25 PRPF38A | mRNA Splicing |
| REAC:R-HSA-72203 | 0.00469213914253 | 0.75 | PUF60 RBM25 PRPF38A | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0000377 | 0.005365870902 | 1.0 | PRPF38A PUF60 JMJD6 RBM25 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 0.005365870902 | 1.0 | PRPF38A PUF60 JMJD6 RBM25 | mRNA splicing, via spliceosome |
| GO:0000375 | 0.00569790407237 | 1.0 | PRPF38A PUF60 JMJD6 RBM25 | RNA splicing, via transesterification reactions |
| GO:0006397 | 0.0135620900865 | 1.0 | PRPF38A PUF60 JMJD6 RBM25 | mRNA processing |
| GO:0008380 | 0.0193524071449 | 1.0 | PRPF38A PUF60 JMJD6 RBM25 | RNA splicing |
| GO:0048024 | 0.0364824972322 | 0.75 | PUF60 JMJD6 RBM25 | regulation of mRNA splicing, via spliceosome |
| CORUM:351 | 0.047170241778 | 0.5 | PUF60 RBM25 | Spliceosome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| JMJD6 | RBM25 | 0.999 | 0.122 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| JMJD6 | PRPF38A | 0.996 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction boldt_WMM |
| PUF60 | JMJD6 | 0.993 | 0.126 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| PUF60 | RBM25 | 0.963 | 0.694 | bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| RBM25 | PRPF38A | 0.135 | 0.466 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction |
| PUF60 | PRPF38A | 0.117 | 0.564 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes