hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09476.1
Complex Portal: CPX-17765
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RFC2 | Replication factor C subunit 2 (Activator 1 40 kDa subunit) (A1 40 kDa subunit) (Activator 1 subunit 2) (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40) | 5 | UniProt NCBI |
| ESF1 | ESF1 homolog (ABT1-associated protein) | 4 | UniProt NCBI |
| ATAD5 | ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein) | 5 | UniProt NCBI |
| RFC5 | Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) | 5 | UniProt NCBI |
| RFC4 | Replication factor C subunit 4 (Activator 1 37 kDa subunit) (A1 37 kDa subunit) (Activator 1 subunit 4) (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:278 | 2.80233355908e-09 | 0.6 | RFC2 RFC4 RFC5 | RFC core complex |
| CORUM:2200 | 1.12081835382e-08 | 0.6 | RFC2 RFC4 RFC5 | RFC2-5 subcomplex |
| CORUM:2201 | 1.12081835382e-08 | 0.6 | RFC2 RFC4 RFC5 | PCNA-RFC2-5 complex |
| CORUM:2799 | 2.80175822576e-08 | 0.6 | RFC2 RFC4 RFC5 | RFC complex |
| CORUM:2199 | 2.80175822576e-08 | 0.6 | RFC2 RFC4 RFC5 | CHTF18-RFC2-5 complex |
| CORUM:279 | 2.80175822576e-08 | 0.6 | RFC2 RFC4 RFC5 | RFC complex |
| CORUM:2797 | 2.80175822576e-08 | 0.6 | RFC2 RFC4 RFC5 | PCNA-CHL12-RFC2-5 complex |
| CORUM:2810 | 2.80175822576e-08 | 0.6 | RFC2 RFC4 RFC5 | RAD17-RFC complex |
| CORUM:2202 | 2.80175822576e-08 | 0.6 | RFC2 RFC4 RFC5 | CHTF18-RFC2-5 complex |
| CORUM:277 | 2.80175822576e-08 | 0.6 | RFC2 RFC4 RFC5 | RFC complex |
| CORUM:270 | 2.80175822576e-08 | 0.6 | RFC2 RFC4 RFC5 | RAD17-RFC complex |
| CORUM:266 | 2.80175822576e-08 | 0.6 | RFC2 RFC4 RFC5 | RAD17-RFC complex |
| CORUM:2203 | 5.60294116544e-08 | 0.6 | RFC2 RFC4 RFC5 | BRD4-RFC complex |
| CORUM:2804 | 9.80414034403e-08 | 0.6 | RFC2 RFC4 RFC5 | CTF18-cohesion-RFC complex |
| CORUM:274 | 1.56850139259e-07 | 0.6 | RFC2 RFC4 RFC5 | 9-1-1-RAD17-RFC complex |
| CORUM:268 | 1.56850139259e-07 | 0.6 | RFC2 RFC4 RFC5 | 9-1-1-RAD17-RFC complex |
| CORUM:1003 | 1.56850139259e-07 | 0.6 | RFC2 RFC4 RFC5 | RC complex (Replication competent complex) |
| CORUM:3070 | 1.56850139259e-07 | 0.6 | RFC2 RFC4 RFC5 | CTF18-cohesion-RFC-POLH complex |
| WP:WP5366 | 5.46288943065e-07 | 0.8 | RFC5 RFC2 RFC4 ATAD5 | NF1 copy number variation syndrome |
| REAC:R-HSA-69091 | 1.13468173222e-06 | 0.6 | RFC2 RFC4 RFC5 | Polymerase switching |
| REAC:R-HSA-69109 | 1.13468173222e-06 | 0.6 | RFC2 RFC4 RFC5 | Leading Strand Synthesis |
| KEGG:03430 | 1.64931336911e-06 | 0.6 | RFC2 RFC4 RFC5 | Mismatch repair |
| REAC:R-HSA-5656121 | 1.74530562074e-06 | 0.6 | RFC2 RFC4 RFC5 | Translesion synthesis by POLI |
| REAC:R-HSA-110312 | 1.74530562074e-06 | 0.6 | RFC2 RFC4 RFC5 | Translesion synthesis by REV1 |
| REAC:R-HSA-5655862 | 2.11908198931e-06 | 0.6 | RFC2 RFC4 RFC5 | Translesion synthesis by POLK |
| WP:WP531 | 2.13416177159e-06 | 0.6 | RFC2 RFC4 RFC5 | DNA mismatch repair |
| REAC:R-HSA-110320 | 3.01907146066e-06 | 0.6 | RFC2 RFC4 RFC5 | Translesion Synthesis by POLH |
| REAC:R-HSA-69186 | 3.55148388129e-06 | 0.6 | RFC2 RFC4 RFC5 | Lagging Strand Synthesis |
| REAC:R-HSA-5651801 | 4.14297217289e-06 | 0.6 | RFC2 RFC4 RFC5 | PCNA-Dependent Long Patch Base Excision Repair |
| KEGG:03030 | 6.64052632759e-06 | 0.6 | RFC2 RFC4 RFC5 | DNA replication |
| REAC:R-HSA-110373 | 7.16159413456e-06 | 0.6 | RFC2 RFC4 RFC5 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| REAC:R-HSA-5696397 | 7.16159413456e-06 | 0.6 | RFC2 RFC4 RFC5 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| REAC:R-HSA-174411 | 8.09488316343e-06 | 0.6 | RFC2 RFC4 RFC5 | Polymerase switching on the C-strand of the telomere |
| GO:0005663 | 9.61003071434e-06 | 0.6 | RFC2 RFC4 RFC5 | DNA replication factor C complex |
| KEGG:03410 | 1.14694346097e-05 | 0.6 | RFC2 RFC4 RFC5 | Base excision repair |
| REAC:R-HSA-110314 | 1.26352756558e-05 | 0.6 | RFC2 RFC4 RFC5 | Recognition of DNA damage by PCNA-containing replication complex |
| WP:WP466 | 1.3807096837e-05 | 0.6 | RFC2 RFC4 RFC5 | DNA replication |
| REAC:R-HSA-5656169 | 1.39876172793e-05 | 0.6 | RFC2 RFC4 RFC5 | Termination of translesion DNA synthesis |
| WP:WP4753 | 1.48411025729e-05 | 0.6 | RFC2 RFC4 RFC5 | Nucleotide excision repair |
| REAC:R-HSA-69190 | 1.54330255969e-05 | 0.6 | RFC2 RFC4 RFC5 | DNA strand elongation |
| REAC:R-HSA-174417 | 1.861537069e-05 | 0.6 | RFC2 RFC4 RFC5 | Telomere C-strand (Lagging Strand) Synthesis |
| REAC:R-HSA-9709570 | 1.861537069e-05 | 0.6 | RFC2 RFC4 RFC5 | Impaired BRCA2 binding to RAD51 |
| REAC:R-HSA-73933 | 2.03584684634e-05 | 0.6 | RFC2 RFC4 RFC5 | Resolution of Abasic Sites (AP sites) |
| REAC:R-HSA-5685938 | 2.03584684634e-05 | 0.6 | RFC2 RFC4 RFC5 | HDR through Single Strand Annealing (SSA) |
| REAC:R-HSA-176187 | 2.22069549267e-05 | 0.6 | RFC2 RFC4 RFC5 | Activation of ATR in response to replication stress |
| REAC:R-HSA-110313 | 2.62324018845e-05 | 0.6 | RFC2 RFC4 RFC5 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| REAC:R-HSA-5693616 | 2.84155131715e-05 | 0.6 | RFC2 RFC4 RFC5 | Presynaptic phase of homologous DNA pairing and strand exchange |
| KEGG:03420 | 2.86326141069e-05 | 0.6 | RFC2 RFC4 RFC5 | Nucleotide excision repair |
| REAC:R-HSA-9675136 | 3.07163147334e-05 | 0.6 | RFC2 RFC4 RFC5 | Diseases of DNA Double-Strand Break Repair |
| REAC:R-HSA-9701190 | 3.07163147334e-05 | 0.6 | RFC2 RFC4 RFC5 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function |
| REAC:R-HSA-5696400 | 3.31378787787e-05 | 0.6 | RFC2 RFC4 RFC5 | Dual Incision in GG-NER |
| REAC:R-HSA-5693579 | 3.5683276241e-05 | 0.6 | RFC2 RFC4 RFC5 | Homologous DNA Pairing and Strand Exchange |
| REAC:R-HSA-73893 | 5.03751582702e-05 | 0.6 | RFC2 RFC4 RFC5 | DNA Damage Bypass |
| GO:0003689 | 5.37995977657e-05 | 0.6 | RFC2 RFC4 RFC5 | DNA clamp loader activity |
| GO:0031390 | 5.37995977657e-05 | 0.6 | RFC2 RFC4 RFC5 | Ctf18 RFC-like complex |
| REAC:R-HSA-9675135 | 5.72260849506e-05 | 0.6 | RFC2 RFC4 RFC5 | Diseases of DNA repair |
| REAC:R-HSA-180786 | 6.46704304154e-05 | 0.6 | RFC2 RFC4 RFC5 | Extension of Telomeres |
| WP:WP5114 | 7.45653773707e-05 | 0.6 | RFC2 RFC4 RFC5 | Nucleotide excision repair in xeroderma pigmentosum |
| GO:1900262 | 8.06911104389e-05 | 0.6 | RFC2 RFC4 RFC5 | regulation of DNA-directed DNA polymerase activity |
| GO:1900264 | 8.06911104389e-05 | 0.6 | RFC2 RFC4 RFC5 | positive regulation of DNA-directed DNA polymerase activity |
| REAC:R-HSA-6782210 | 0.000123167229073 | 0.6 | RFC2 RFC4 RFC5 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6782135 | 0.000129211329951 | 0.6 | RFC2 RFC4 RFC5 | Dual incision in TC-NER |
| REAC:R-HSA-5685942 | 0.000141884912451 | 0.6 | RFC2 RFC4 RFC5 | HDR through Homologous Recombination (HRR) |
| CORUM:435 | 0.000204640425412 | 0.4 | RFC2 RFC4 | BASC (Ab 81) complex (BRCA1-associated genome surveillance complex) |
| REAC:R-HSA-73884 | 0.000217750033404 | 0.6 | RFC2 RFC4 RFC5 | Base Excision Repair |
| REAC:R-HSA-6781827 | 0.000226554396442 | 0.6 | RFC2 RFC4 RFC5 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| WP:WP4946 | 0.00027954510039 | 0.6 | RFC2 RFC4 RFC5 | DNA repair pathways full network |
| REAC:R-HSA-5696399 | 0.000284390695808 | 0.6 | RFC2 RFC4 RFC5 | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-69473 | 0.000327941222395 | 0.6 | RFC2 RFC4 RFC5 | G2/M DNA damage checkpoint |
| REAC:R-HSA-6804756 | 0.000351286759397 | 0.6 | RFC2 RFC4 RFC5 | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-5693607 | 0.00036336263669 | 0.6 | RFC2 RFC4 RFC5 | Processing of DNA double-strand break ends |
| GO:0008094 | 0.000365836607157 | 0.8 | RFC5 RFC2 RFC4 ATAD5 | ATP-dependent activity, acting on DNA |
| CORUM:434 | 0.00038189088864 | 0.4 | RFC2 RFC4 | BASC (Ab 80) complex (BRCA1-associated genome surveillance complex) |
| GO:0006275 | 0.000472796969853 | 0.8 | RFC5 RFC2 RFC4 ATAD5 | regulation of DNA replication |
| REAC:R-HSA-157579 | 0.000499618531598 | 0.6 | RFC2 RFC4 RFC5 | Telomere Maintenance |
| REAC:R-HSA-5696398 | 0.000630278165562 | 0.6 | RFC2 RFC4 RFC5 | Nucleotide Excision Repair |
| REAC:R-HSA-69239 | 0.000844385297839 | 0.6 | RFC2 RFC4 RFC5 | Synthesis of DNA |
| CORUM:433 | 0.000899678549321 | 0.4 | RFC2 RFC4 | BASC complex (BRCA1-associated genome surveillance complex) |
| REAC:R-HSA-5693567 | 0.000932817738425 | 0.6 | RFC2 RFC4 RFC5 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-73886 | 0.00102719141084 | 0.6 | RFC2 RFC4 RFC5 | Chromosome Maintenance |
| REAC:R-HSA-5693538 | 0.00107666549853 | 0.6 | RFC2 RFC4 RFC5 | Homology Directed Repair |
| GO:0017116 | 0.00147736290187 | 0.6 | RFC2 RFC4 RFC5 | single-stranded DNA helicase activity |
| REAC:R-HSA-5633007 | 0.00176342488404 | 0.6 | RFC2 RFC4 RFC5 | Regulation of TP53 Activity |
| REAC:R-HSA-5693532 | 0.0019808748776 | 0.6 | RFC2 RFC4 RFC5 | DNA Double-Strand Break Repair |
| REAC:R-HSA-69242 | 0.00201875981781 | 0.6 | RFC2 RFC4 RFC5 | S Phase |
| REAC:R-HSA-69481 | 0.00201875981781 | 0.6 | RFC2 RFC4 RFC5 | G2/M Checkpoints |
| REAC:R-HSA-69306 | 0.00264594341422 | 0.6 | RFC2 RFC4 RFC5 | DNA Replication |
| GO:0140097 | 0.00729542990987 | 0.8 | RFC5 RFC2 RFC4 ATAD5 | catalytic activity, acting on DNA |
| GO:0090329 | 0.00875197805683 | 0.6 | RFC2 RFC4 RFC5 | regulation of DNA-templated DNA replication |
| REAC:R-HSA-69620 | 0.0108605941756 | 0.6 | RFC2 RFC4 RFC5 | Cell Cycle Checkpoints |
| GO:0006260 | 0.01125755688 | 0.8 | RFC5 RFC2 RFC4 ATAD5 | DNA replication |
| GO:0031391 | 0.0140440992017 | 0.4 | ATAD5 RFC4 | Elg1 RFC-like complex |
| REAC:R-HSA-73894 | 0.014302073064 | 0.6 | RFC2 RFC4 RFC5 | DNA Repair |
| GO:0051054 | 0.0172160655627 | 0.8 | RFC5 RFC2 RFC4 ATAD5 | positive regulation of DNA metabolic process |
| REAC:R-HSA-3700989 | 0.0192283148447 | 0.6 | RFC2 RFC4 RFC5 | Transcriptional Regulation by TP53 |
| WP:WP2446 | 0.0212523049113 | 0.4 | RFC5 RFC4 | Retinoblastoma gene in cancer |
| HPA:0471473 | 0.0212982616684 | 0.6 | ESF1 RFC4 RFC5 | skin 2; lymphocytes[High] |
| GO:0003678 | 0.0250826699056 | 0.6 | RFC2 RFC4 RFC5 | DNA helicase activity |
| WP:WP4932 | 0.0264781270697 | 0.4 | RFC2 RFC5 | 7q11 23 copy number variation syndrome |
| GO:2000573 | 0.0310683011928 | 0.6 | RFC2 RFC4 RFC5 | positive regulation of DNA biosynthetic process |
| GO:0005657 | 0.0417184596383 | 0.6 | RFC2 RFC4 RFC5 | replication fork |
| HPA:0461472 | 0.0423206374997 | 0.6 | ESF1 RFC4 RFC5 | skin 1; lymphocytes[>=Medium] |
| HPA:0461462 | 0.0444139015161 | 0.6 | ESF1 RFC4 RFC5 | skin 1; langerhans cells[>=Medium] |
| HPA:0460202 | 0.0460879152407 | 0.6 | ESF1 RFC4 RFC5 | skin 1; endothelial cells[>=Medium] |
| HPA:0461412 | 0.0463303695681 | 0.6 | ESF1 RFC4 RFC5 | skin 1; cells in spinous layer[>=Medium] |
| CORUM:1131 | 0.0498708842806 | 0.2 | RFC2 | RFC2-RIalpha complex |
| CORUM:1132 | 0.0498708842806 | 0.2 | RFC4 | RFC2-RIalpha complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RFC5 | RFC4 | 1.0 | 0.946 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction treiber_WMM | |
| RFC2 | RFC5 | 1.0 | 0.978 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction treiber_WMM | |
| RFC2 | RFC4 | 0.999 | 0.942 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| ATAD5 | RFC5 | 0.998 | 0.206 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| ATAD5 | RFC4 | 0.996 | 0.258 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM | |
| RFC2 | ATAD5 | 0.986 | 0.29 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| RFC4 | ESF1 | 0.956 | 0.118 | hein_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| RFC5 | ESF1 | 0.95 | 0.15 | hein_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM | |
| RFC2 | ESF1 | 0.947 | 0.188 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | |
| ATAD5 | ESF1 | 0.014 | 0.218 | bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes