hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09480.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DEFB104A | Beta-defensin 104 (Beta-defensin 4) (BD-4) (DEFB-4) (hBD-4) (Defensin, beta 104) | 5 | UniProt NCBI |
| PPY | Pancreatic polypeptide prohormone (PH) (Pancreatic polypeptide Y) (Obinepitide) [Cleaved into: Pancreatic polypeptide (HPP) (PP); Pancreatic icosapeptide (PI)] | 5 | UniProt NCBI |
| GNB2 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2) | 5 | UniProt NCBI |
| GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 5 | UniProt NCBI |
| GNA13 | Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) (G-protein subunit alpha-13) | 5 | UniProt NCBI |
| GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-428930 | 3.12154543066e-09 | 0.8 | GNB2 GNG10 GNG5 GNA13 | Thromboxane signalling through TP receptor |
| REAC:R-HSA-456926 | 7.4870963414e-09 | 0.8 | GNB2 GNG10 GNG5 GNA13 | Thrombin signalling through proteinase activated receptors (PARs) |
| REAC:R-HSA-392518 | 1.16894660556e-08 | 0.8 | GNB2 GNG10 GNG5 GNA13 | Signal amplification |
| WP:WP35 | 2.34804778155e-07 | 0.8 | GNB2 GNG10 GNG5 GNA13 | G protein signaling pathways |
| REAC:R-HSA-416482 | 2.37528501627e-07 | 0.8 | GNB2 GNG10 GNG5 GNA13 | G alpha (12/13) signalling events |
| KEGG:04371 | 7.60501177586e-07 | 0.8 | GNB2 GNG10 GNG5 GNA13 | Apelin signaling pathway |
| REAC:R-HSA-388396 | 1.57823038108e-06 | 1.0 | PPY GNA13 GNG10 GNG5 GNB2 | GPCR downstream signalling |
| REAC:R-HSA-392851 | 1.74530562074e-06 | 0.6 | GNB2 GNG10 GNG5 | Prostacyclin signalling through prostacyclin receptor |
| REAC:R-HSA-8964315 | 1.74530562074e-06 | 0.6 | GNB2 GNG10 GNG5 | G beta:gamma signalling through BTK |
| REAC:R-HSA-418217 | 2.11908198931e-06 | 0.6 | GNB2 GNG10 GNG5 | G beta:gamma signalling through PLC beta |
| REAC:R-HSA-500657 | 2.11908198931e-06 | 0.6 | GNB2 GNG10 GNG5 | Presynaptic function of Kainate receptors |
| REAC:R-HSA-8964616 | 2.54263716986e-06 | 0.6 | GNB2 GNG10 GNG5 | G beta:gamma signalling through CDC42 |
| REAC:R-HSA-372790 | 3.03512429967e-06 | 1.0 | PPY GNA13 GNG10 GNG5 GNB2 | Signaling by GPCR |
| REAC:R-HSA-392170 | 3.55148388129e-06 | 0.6 | GNB2 GNG10 GNG5 | ADP signalling through P2Y purinoceptor 12 |
| GO:0005834 | 3.60035554513e-06 | 0.8 | GNB2 GNG10 GNG5 GNA13 | heterotrimeric G-protein complex |
| REAC:R-HSA-392451 | 4.14297217289e-06 | 0.6 | GNB2 GNG10 GNG5 | G beta:gamma signalling through PI3Kgamma |
| REAC:R-HSA-202040 | 4.79663279828e-06 | 0.6 | GNB2 GNG10 GNG5 | G-protein activation |
| REAC:R-HSA-400042 | 4.79663279828e-06 | 0.6 | GNB2 GNG10 GNG5 | Adrenaline,noradrenaline inhibits insulin secretion |
| REAC:R-HSA-451326 | 4.79663279828e-06 | 0.6 | GNB2 GNG10 GNG5 | Activation of kainate receptors upon glutamate binding |
| REAC:R-HSA-418592 | 4.79663279828e-06 | 0.6 | GNB2 GNG10 GNG5 | ADP signalling through P2Y purinoceptor 1 |
| REAC:R-HSA-997272 | 5.51556094215e-06 | 0.6 | GNB2 GNG10 GNG5 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| REAC:R-HSA-420092 | 5.51556094215e-06 | 0.6 | GNB2 GNG10 GNG5 | Glucagon-type ligand receptors |
| REAC:R-HSA-1296041 | 5.51556094215e-06 | 0.6 | GNB2 GNG10 GNG5 | Activation of G protein gated Potassium channels |
| REAC:R-HSA-1296059 | 5.51556094215e-06 | 0.6 | GNB2 GNG10 GNG5 | G protein gated Potassium channels |
| KEGG:05163 | 6.93652868949e-06 | 0.8 | GNB2 GNG10 GNG5 GNA13 | Human cytomegalovirus infection |
| GO:1905360 | 7.73614931468e-06 | 0.8 | GNB2 GNG10 GNG5 GNA13 | GTPase complex |
| REAC:R-HSA-163359 | 9.10580767182e-06 | 0.6 | GNB2 GNG10 GNG5 | Glucagon signaling in metabolic regulation |
| REAC:R-HSA-397795 | 9.10580767182e-06 | 0.6 | GNB2 GNG10 GNG5 | G-protein beta:gamma signalling |
| REAC:R-HSA-1296065 | 9.10580767182e-06 | 0.6 | GNB2 GNG10 GNG5 | Inwardly rectifying K+ channels |
| CORUM:7166 | 1.36501667663e-05 | 0.4 | GNB2 GNG5 | GNAS-L-GNB2-GNG5 complex |
| CORUM:7188 | 1.36501667663e-05 | 0.4 | GNB2 GNG10 | GNAS-L-GNB2-GNG10 complex |
| REAC:R-HSA-991365 | 1.69745830215e-05 | 0.6 | GNB2 GNG10 GNG5 | Activation of GABAB receptors |
| REAC:R-HSA-977444 | 1.69745830215e-05 | 0.6 | GNB2 GNG10 GNG5 | GABA B receptor activation |
| REAC:R-HSA-432040 | 1.861537069e-05 | 0.6 | GNB2 GNG10 GNG5 | Vasopressin regulates renal water homeostasis via Aquaporins |
| REAC:R-HSA-381676 | 2.03584684634e-05 | 0.6 | GNB2 GNG10 GNG5 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| REAC:R-HSA-9660821 | 2.03584684634e-05 | 0.6 | GNB2 GNG10 GNG5 | ADORA2B mediated anti-inflammatory cytokines production |
| REAC:R-HSA-418597 | 2.03584684634e-05 | 0.6 | GNB2 GNG10 GNG5 | G alpha (z) signalling events |
| REAC:R-HSA-6814122 | 2.03584684634e-05 | 0.6 | GNB2 GNG10 GNG5 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| REAC:R-HSA-418594 | 2.04162706146e-05 | 0.8 | PPY GNG10 GNG5 GNB2 | G alpha (i) signalling events |
| REAC:R-HSA-9634597 | 2.22069549267e-05 | 0.6 | GNB2 GNG10 GNG5 | GPER1 signaling |
| REAC:R-HSA-445717 | 2.22069549267e-05 | 0.6 | GNB2 GNG10 GNG5 | Aquaporin-mediated transport |
| REAC:R-HSA-977443 | 3.31378787787e-05 | 0.6 | GNB2 GNG10 GNG5 | GABA receptor activation |
| REAC:R-HSA-76002 | 3.79352838038e-05 | 0.8 | GNB2 GNG10 GNG5 GNA13 | Platelet activation, signaling and aggregation |
| CORUM:7037 | 4.09448956317e-05 | 0.4 | GNB2 GNG5 | GNAI1-GNB2-GNG5 complex |
| CORUM:7077 | 4.09448956317e-05 | 0.4 | GNB2 GNG10 | GNAI1-GNB2-GNG10 complex |
| KEGG:04727 | 4.44119474406e-05 | 0.6 | GNB2 GNG10 GNG5 | GABAergic synapse |
| KEGG:05032 | 4.64569454207e-05 | 0.6 | GNB2 GNG10 GNG5 | Morphine addiction |
| REAC:R-HSA-500792 | 4.70861772628e-05 | 0.8 | PPY GNG10 GNG5 GNB2 | GPCR ligand binding |
| KEGG:04713 | 5.76252819292e-05 | 0.6 | GNB2 GNG10 GNG5 | Circadian entrainment |
| GO:0031234 | 6.39580887555e-05 | 0.8 | GNB2 GNG10 GNG5 GNA13 | extrinsic component of cytoplasmic side of plasma membrane |
| REAC:R-HSA-4086398 | 7.27326653199e-05 | 0.6 | GNB2 GNG10 GNG5 | Ca2+ pathway |
| KEGG:04724 | 7.89847986766e-05 | 0.6 | GNB2 GNG10 GNG5 | Glutamatergic synapse |
| KEGG:04726 | 8.81816836153e-05 | 0.6 | GNB2 GNG10 GNG5 | Serotonergic synapse |
| KEGG:04725 | 0.000105044972713 | 0.6 | GNB2 GNG10 GNG5 | Cholinergic synapse |
| REAC:R-HSA-9009391 | 0.000117314199984 | 0.6 | GNB2 GNG10 GNG5 | Extra-nuclear estrogen signaling |
| REAC:R-HSA-9662851 | 0.000117314199984 | 0.6 | GNB2 GNG10 GNG5 | Anti-inflammatory response favouring Leishmania parasite infection |
| REAC:R-HSA-9664433 | 0.000117314199984 | 0.6 | GNB2 GNG10 GNG5 | Leishmania parasite growth and survival |
| REAC:R-HSA-422356 | 0.00013544954428 | 0.6 | GNB2 GNG10 GNG5 | Regulation of insulin secretion |
| REAC:R-HSA-1296071 | 0.000141884912451 | 0.6 | GNB2 GNG10 GNG5 | Potassium Channels |
| REAC:R-HSA-373080 | 0.00015535926553 | 0.6 | GNB2 GNG10 GNG5 | Class B/2 (Secretin family receptors) |
| REAC:R-HSA-418346 | 0.00018480745401 | 0.6 | GNB2 GNG10 GNG5 | Platelet homeostasis |
| KEGG:04926 | 0.000188471529119 | 0.6 | GNB2 GNG10 GNG5 | Relaxin signaling pathway |
| KEGG:04728 | 0.000193785633278 | 0.6 | GNB2 GNG10 GNG5 | Dopaminergic synapse |
| KEGG:05200 | 0.000202734552549 | 0.8 | GNB2 GNG10 GNG5 GNA13 | Pathways in cancer |
| REAC:R-HSA-111885 | 0.000235592298974 | 0.6 | GNB2 GNG10 GNG5 | Opioid Signalling |
| KEGG:04723 | 0.0002524957978 | 0.6 | GNB2 GNG10 GNG5 | Retrograde endocannabinoid signaling |
| REAC:R-HSA-390466 | 0.000305650569508 | 0.6 | GNB2 GNG10 GNG5 | Chaperonin-mediated protein folding |
| WP:WP3929 | 0.000343547971734 | 0.6 | GNB2 GNG10 GNG5 | Chemokine signaling pathway |
| GO:0019897 | 0.000365836607157 | 0.8 | GNB2 GNG10 GNG5 GNA13 | extrinsic component of plasma membrane |
| REAC:R-HSA-163685 | 0.000375711265178 | 0.6 | GNB2 GNG10 GNG5 | Integration of energy metabolism |
| REAC:R-HSA-391251 | 0.000388335652279 | 0.6 | GNB2 GNG10 GNG5 | Protein folding |
| REAC:R-HSA-418555 | 0.000388335652279 | 0.6 | GNB2 GNG10 GNG5 | G alpha (s) signalling events |
| KEGG:04062 | 0.000403047923682 | 0.6 | GNB2 GNG10 GNG5 | Chemokine signaling pathway |
| KEGG:05034 | 0.000496659427831 | 0.6 | GNB2 GNG10 GNG5 | Alcoholism |
| WP:WP4223 | 0.000617085733732 | 0.6 | GNB2 GNG10 GNG5 | Ras signaling |
| KEGG:05167 | 0.000712153738972 | 0.6 | GNB2 GNG10 GNG5 | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:04014 | 0.000935536894331 | 0.6 | GNB2 GNG10 GNG5 | Ras signaling pathway |
| GO:0007186 | 0.00102823006223 | 1.0 | PPY GNA13 GNG10 GNG5 GNB2 | G protein-coupled receptor signaling pathway |
| KEGG:05170 | 0.00107946278271 | 0.6 | GNB2 GNG10 GNG5 | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-416476 | 0.00112769600133 | 0.6 | GNB2 GNG10 GNG5 | G alpha (q) signalling events |
| REAC:R-HSA-9658195 | 0.0012622367962 | 0.6 | GNB2 GNG10 GNG5 | Leishmania infection |
| REAC:R-HSA-9824443 | 0.0012622367962 | 0.6 | GNB2 GNG10 GNG5 | Parasitic Infection Pathways |
| REAC:R-HSA-3858494 | 0.0012622367962 | 0.6 | GNB2 GNG10 GNG5 | Beta-catenin independent WNT signaling |
| REAC:R-HSA-109582 | 0.00129857214677 | 0.8 | GNB2 GNG10 GNG5 GNA13 | Hemostasis |
| REAC:R-HSA-112314 | 0.0019808748776 | 0.6 | GNB2 GNG10 GNG5 | Neurotransmitter receptors and postsynaptic signal transmission |
| GO:0009898 | 0.00206012733421 | 0.8 | GNB2 GNG10 GNG5 GNA13 | cytoplasmic side of plasma membrane |
| GO:0019898 | 0.00206012733421 | 0.8 | GNB2 GNG10 GNG5 GNA13 | extrinsic component of membrane |
| WP:WP3932 | 0.00295696208302 | 0.6 | GNB2 GNG10 GNG5 | Focal adhesion PI3K Akt mTOR signaling pathway |
| REAC:R-HSA-8939211 | 0.00317982187903 | 0.6 | GNB2 GNG10 GNG5 | ESR-mediated signaling |
| KEGG:04151 | 0.00349664244214 | 0.6 | GNB2 GNG10 GNG5 | PI3K-Akt signaling pathway |
| WP:WP4172 | 0.00385309020299 | 0.6 | GNB2 GNG10 GNG5 | PI3K Akt signaling pathway |
| REAC:R-HSA-112315 | 0.0041994817849 | 0.6 | GNB2 GNG10 GNG5 | Transmission across Chemical Synapses |
| GO:0098562 | 0.00469791606681 | 0.8 | GNB2 GNG10 GNG5 GNA13 | cytoplasmic side of membrane |
| REAC:R-HSA-9006931 | 0.00755035935577 | 0.6 | GNB2 GNG10 GNG5 | Signaling by Nuclear Receptors |
| REAC:R-HSA-162582 | 0.00823431736973 | 1.0 | PPY GNA13 GNG10 GNG5 GNB2 | Signal Transduction |
| REAC:R-HSA-195721 | 0.0130852308339 | 0.6 | GNB2 GNG10 GNG5 | Signaling by WNT |
| REAC:R-HSA-112316 | 0.0132169246876 | 0.6 | GNB2 GNG10 GNG5 | Neuronal System |
| GO:0003924 | 0.0180995584082 | 0.8 | GNB2 GNG10 GNG5 GNA13 | GTPase activity |
| WP:WP536 | 0.0360146352745 | 0.4 | GNB2 GNG5 | Calcium regulation in cardiac cells |
| WP:WP289 | 0.0492060648012 | 0.4 | GNB2 GNG5 | Myometrial relaxation and contraction pathways |
| CORUM:7210 | 0.0498708842806 | 0.2 | GNB2 | GNAS-L-GNB2-GNG13 complex |
| CORUM:7189 | 0.0498708842806 | 0.2 | GNG10 | GNAS-L-GNB3-GNG10 complex |
| CORUM:7167 | 0.0498708842806 | 0.2 | GNG5 | GNAS-L-GNB3-GNG5 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GNG5 | GNB2 | 0.999 | 0.138 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM |
| GNA13 | GNG10 | 0.997 | 0.238 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| GNA13 | GNG5 | 0.997 | 0.08 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| GNG10 | GNB2 | 0.996 | 0.196 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| DEFB104A | GNB2 | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM | |
| GNG10 | GNG5 | 0.976 | 0.1 | bioplex_WMM bioplex3_WMM WMM_only |
| GNA13 | GNB2 | 0.972 | 0.312 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| PPY | GNG10 | 0.97 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GNA13 | PPY | 0.039 | bioplex3_HCT116 WMM_only | |
| GNA13 | DEFB104A | 0.012 | bioplex3_HEK293 bioplex () bioplex_WMM |
Related Complexes