hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09489.1
Complex Portal: CPX-11240
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KLHL28 | Kelch-like protein 28 (BTB/POZ domain-containing protein 5) | 2 | UniProt NCBI |
| KLHL12 | Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR) | 5 | UniProt NCBI |
| KLHL20 | Kelch-like protein 20 (Kelch-like ECT2-interacting protein) (Kelch-like protein X) | 5 | UniProt NCBI |
| IPP | Actin-binding protein IPP (Intracisternal A particle-promoted polypeptide) (IPP) (Kelch-like protein 27) | 4 | UniProt NCBI |
| CCIN | Calicin | 4 | UniProt NCBI |
| NUDCD3 | NudC domain-containing protein 3 | 5 | UniProt NCBI |
| KLHL13 | Kelch-like protein 13 (BTB and kelch domain-containing protein 2) | 5 | UniProt NCBI |
| KLHL26 | Kelch-like protein 26 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0031463 | 0.0487399472212 | 0.375 | KLHL12 KLHL20 KLHL13 | Cul3-RING ubiquitin ligase complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| IPP | KLHL28 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| NUDCD3 | KLHL28 | 0.999 |
structurally_consistent (Q53HC5)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| KLHL13 | KLHL28 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| KLHL26 | KLHL28 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NUDCD3 | KLHL26 | 0.998 | 0.068 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| IPP | KLHL20 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| KLHL20 | KLHL26 | 0.988 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NUDCD3 | KLHL20 | 0.985 |
structurally_consistent (Q53HC5)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| KLHL12 | KLHL26 | 0.98 | 0.164 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| IPP | KLHL26 | 0.976 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| IPP | NUDCD3 | 0.973 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CCIN | NUDCD3 | 0.954 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| KLHL26 | KLHL13 | 0.945 | 0.088 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| KLHL12 | KLHL28 | 0.676 |
mutually_exclusive (Q13618)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| IPP | KLHL13 | 0.501 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KLHL20 | KLHL28 | 0.496 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| KLHL12 | IPP | 0.464 |
mutually_exclusive (Q13618)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| KLHL12 | KLHL13 | 0.428 | 0.174 |
mutually_exclusive (Q13618)
|
bioplex_WMM bioplex3_WMM WMM_only |
| NUDCD3 | KLHL13 | 0.296 | 0.038 | bioplex_WMM bioplex3_WMM WMM_only | |
| KLHL12 | NUDCD3 | 0.267 | 0.156 | bioplex_WMM bioplex3_WMM WMM_only | |
| KLHL12 | KLHL20 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| KLHL20 | KLHL13 | 0.041 |
structurally_consistent (Q9P2J3)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| KLHL12 | CCIN | 0.004 | bioplex3_HCT116 WMM_only |
Related Complexes