hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09490.1
Complex Portal: CPX-19038
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NCBP1 | Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit) | 5 | UniProt NCBI |
| SRSF12 | Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19) | 5 | UniProt NCBI |
| LUC7L2 | Putative RNA-binding protein Luc7-like 2 | 5 | UniProt NCBI |
| SRRT | Serrate RNA effector molecule homolog (Arsenite-resistance protein 2) | 5 | UniProt NCBI |
| CLK2 | Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) | 5 | UniProt NCBI |
| FIP1L1 | Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) | 5 | UniProt NCBI |
| RBBP6 | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | 5 | UniProt NCBI |
| CLK1 | Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) | 5 | UniProt NCBI |
| YTHDC1 | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0043484 | 0.000790921106799 | 0.555555555556 | CLK1 SRSF12 YTHDC1 NCBP1 CLK2 | regulation of RNA splicing |
| GO:0008380 | 0.000933461830496 | 0.666666666667 | LUC7L2 NCBP1 SRSF12 CLK1 YTHDC1 CLK2 | RNA splicing |
| GO:0006396 | 0.00175183559113 | 0.777777777778 | LUC7L2 NCBP1 SRSF12 CLK1 YTHDC1 CLK2 SRRT | RNA processing |
| GO:0000245 | 0.00281552750158 | 0.444444444444 | SRSF12 YTHDC1 NCBP1 LUC7L2 | spliceosomal complex assembly |
| REAC:R-HSA-72203 | 0.0033511074443 | 0.444444444444 | SRSF12 NCBP1 FIP1L1 SRRT | Processing of Capped Intron-Containing Pre-mRNA |
| HPA:0570782 | 0.00347030524295 | 0.666666666667 | NCBP1 SRRT FIP1L1 LUC7L2 YTHDC1 CLK2 | testis; preleptotene spermatocytes[>=Medium] |
| WP:WP411 | 0.00419312016767 | 0.333333333333 | CLK1 NCBP1 CLK2 | mRNA processing |
| HPA:0570812 | 0.00580105525189 | 0.777777777778 | NCBP1 LUC7L2 FIP1L1 CLK1 YTHDC1 CLK2 SRRT | testis; spermatogonia cells[>=Medium] |
| REAC:R-HSA-77595 | 0.0135859457713 | 0.222222222222 | FIP1L1 NCBP1 | Processing of Intronless Pre-mRNAs |
| HPA:0570781 | 0.0137172856758 | 0.666666666667 | NCBP1 SRRT FIP1L1 LUC7L2 YTHDC1 CLK2 | testis; preleptotene spermatocytes[>=Low] |
| HPA:0570811 | 0.0179444989277 | 0.777777777778 | NCBP1 LUC7L2 FIP1L1 CLK1 YTHDC1 CLK2 SRRT | testis; spermatogonia cells[>=Low] |
| GO:0006376 | 0.0234426873659 | 0.333333333333 | SRSF12 YTHDC1 LUC7L2 | mRNA splice site recognition |
| REAC:R-HSA-75067 | 0.0278157587689 | 0.222222222222 | FIP1L1 NCBP1 | Processing of Capped Intronless Pre-mRNA |
| GO:0016604 | 0.0296370578408 | 0.666666666667 | LUC7L2 SRRT RBBP6 SRSF12 YTHDC1 CLK2 | nuclear body |
| HPA:0570791 | 0.035882938321 | 0.666666666667 | LUC7L2 NCBP1 SRRT FIP1L1 SRSF12 YTHDC1 | testis; round or early spermatids[>=Low] |
| REAC:R-HSA-72163 | 0.0479913936721 | 0.333333333333 | SRSF12 NCBP1 SRRT | mRNA Splicing - Major Pathway |
| HPA:0570761 | 0.0488514169774 | 0.666666666667 | LUC7L2 NCBP1 SRRT FIP1L1 SRSF12 YTHDC1 | testis; pachytene spermatocytes[>=Low] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CLK2 | CLK1 | 0.999 | 0.078 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SRRT | CLK2 | 0.997 | 0.164 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RBBP6 | YTHDC1 | 0.997 | 0.254 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CLK2 | YTHDC1 | 0.997 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SRRT | YTHDC1 | 0.996 | 0.324 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SRRT | NCBP1 | 0.996 | 0.65 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM treiber_WMM | |
| SRRT | RBBP6 | 0.994 | 0.398 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SRSF12 | LUC7L2 | 0.993 | 0.574 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM |
| NCBP1 | YTHDC1 | 0.989 | 0.118 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SRSF12 | CLK2 | 0.987 | 0.084 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM | |
| CLK2 | RBBP6 | 0.985 | 0.164 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RBBP6 | CLK1 | 0.981 | 0.138 | bioplex_WMM bioplex3_WMM WMM_only | |
| CLK2 | LUC7L2 | 0.977 | 0.12 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM |
| FIP1L1 | CLK2 | 0.969 | 0.164 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| FIP1L1 | CLK1 | 0.968 | 0.144 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| NCBP1 | CLK2 | 0.954 | 0.102 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CLK1 | YTHDC1 | 0.946 | 0.134 | bioplex_WMM bioplex3_WMM WMM_only | |
| SRRT | CLK1 | 0.943 | 0.234 | bioplex_WMM bioplex3_WMM WMM_only | |
| NCBP1 | RBBP6 | 0.938 | 0.414 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| SRRT | LUC7L2 | 0.935 | 0.828 |
mutually_exclusive (P52298)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| SRSF12 | YTHDC1 | 0.906 | 0.734 | bioplex_WMM bioplex3_WMM WMM_only | |
| FIP1L1 | LUC7L2 | 0.891 | 0.508 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM | |
| SRSF12 | RBBP6 | 0.832 | 0.16 | bioplex_WMM bioplex3_WMM WMM_only | |
| SRRT | SRSF12 | 0.769 | 0.472 | bioplex_WMM bioplex3_WMM WMM_only | |
| FIP1L1 | RBBP6 | 0.769 | 0.16 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM | |
| NCBP1 | LUC7L2 | 0.767 | 0.374 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM | |
| NCBP1 | CLK1 | 0.707 | 0.41 | bioplex_WMM bioplex3_WMM WMM_only | |
| SRSF12 | CLK1 | 0.696 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only | |
| NCBP1 | SRSF12 | 0.692 | 0.17 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FIP1L1 | SRSF12 | 0.663 | 0.684 |
mutually_exclusive (P61326)
|
bioplex_WMM bioplex3_WMM WMM_only |
| RBBP6 | LUC7L2 | 0.634 | 0.26 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| FIP1L1 | SRRT | 0.58 | 0.768 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM | |
| FIP1L1 | YTHDC1 | 0.367 | 0.428 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| FIP1L1 | NCBP1 | 0.331 | 0.4 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM | |
| CLK1 | LUC7L2 | 0.258 | 0.192 | bioplex_WMM bioplex3_WMM WMM_only | |
| LUC7L2 | YTHDC1 | 0.19 | 0.212 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes