hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09496.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ATG16L2 | Protein Atg16l2 (APG16-like 2) (Autophagy-related protein 16-2) (WD repeat-containing protein 80) | 4 | UniProt NCBI |
| ATG16L1 | Autophagy-related protein 16-1 (APG16-like 1) | 5 | UniProt NCBI |
| RAB33B | Ras-related protein Rab-33B | 5 | UniProt NCBI |
| ATG12 | Ubiquitin-like protein ATG12 (Autophagy-related protein 12) (APG12-like) | 5 | UniProt NCBI |
| TECPR1 | Tectonin beta-propeller repeat-containing protein 1 | 5 | UniProt NCBI |
| ATG5 | Autophagy protein 5 (APG5-like) (Apoptosis-specific protein) | 5 | UniProt NCBI |
| ATRIP | ATR-interacting protein (ATM and Rad3-related-interacting protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4863 | 5.09349097308e-09 | 0.571428571429 | ATG12 ATG16L2 ATG5 ATG16L1 | Host pathogen interaction of human coronaviruses autophagy |
| GO:0034274 | 1.38095933257e-08 | 0.571428571429 | ATG12 ATG16L2 ATG5 ATG16L1 | Atg12-Atg5-Atg16 complex |
| KEGG:04140 | 1.39999416482e-07 | 0.714285714286 | ATG12 RAB33B ATG16L2 ATG5 ATG16L1 | Autophagy - animal |
| GO:0034045 | 1.25481586619e-06 | 0.571428571429 | ATG12 ATG16L2 ATG5 ATG16L1 | phagophore assembly site membrane |
| GO:0005776 | 3.46521130102e-06 | 0.714285714286 | ATG12 TECPR1 ATG16L2 ATG5 ATG16L1 | autophagosome |
| WP:WP2509 | 9.34907608329e-06 | 0.428571428571 | ATG12 ATG16L1 ATG5 | Nanoparticle triggered autophagic cell death |
| KEGG:04136 | 1.41786055432e-05 | 0.428571428571 | ATG12 ATG16L1 ATG5 | Autophagy - other |
| WP:WP4923 | 1.98635261751e-05 | 0.428571428571 | ATG12 ATG16L1 ATG5 | Autophagy |
| GO:0000407 | 3.29649973093e-05 | 0.571428571429 | ATG12 ATG16L2 ATG5 ATG16L1 | phagophore assembly site |
| WP:WP4577 | 5.97582627984e-05 | 0.428571428571 | ATG12 ATG16L1 ATG5 | Neurodegeneration with brain iron accumulation NBIA subtypes pathway |
| KEGG:05131 | 9.98209485344e-05 | 0.571428571429 | ATG12 ATG16L1 ATG5 TECPR1 | Shigellosis |
| WP:WP5205 | 0.000301380640239 | 0.428571428571 | ATG12 ATG16L1 ATG5 | Clock controlled autophagy in bone metabolism |
| REAC:R-HSA-8934903 | 0.00106560242715 | 0.285714285714 | ATG12 ATG5 | Receptor Mediated Mitophagy |
| KEGG:04621 | 0.00173244468583 | 0.428571428571 | ATG12 ATG16L1 ATG5 | NOD-like receptor signaling pathway |
| GO:1901096 | 0.00187892941497 | 0.428571428571 | ATG12 ATG5 TECPR1 | regulation of autophagosome maturation |
| GO:0016236 | 0.00223322150095 | 0.714285714286 | ATG12 TECPR1 ATG16L2 ATG5 ATG16L1 | macroautophagy |
| GO:0000045 | 0.00301333997974 | 0.571428571429 | ATG12 ATG16L2 ATG5 ATG16L1 | autophagosome assembly |
| GO:1905037 | 0.00355458399407 | 0.571428571429 | ATG12 ATG16L2 ATG5 ATG16L1 | autophagosome organization |
| REAC:R-HSA-1632852 | 0.00413825544794 | 0.428571428571 | ATG12 ATG16L1 ATG5 | Macroautophagy |
| REAC:R-HSA-9612973 | 0.00579605132299 | 0.428571428571 | ATG12 ATG16L1 ATG5 | Autophagy |
| REAC:R-HSA-5205685 | 0.00796834465067 | 0.285714285714 | ATG12 ATG5 | PINK1-PRKN Mediated Mitophagy |
| GO:0039689 | 0.00983221512175 | 0.285714285714 | ATG16L2 ATG16L1 | negative stranded viral RNA replication |
| REAC:R-HSA-5205647 | 0.0123178965954 | 0.285714285714 | ATG12 ATG5 | Mitophagy |
| WP:WP5420 | 0.0169268600769 | 0.428571428571 | ATG12 ATG16L1 ATG5 | ADHD and autism ASD linked metabolic pathways and SNP |
| GO:0000421 | 0.0182422971773 | 0.428571428571 | TECPR1 ATG16L2 ATG16L1 | autophagosome membrane |
| REAC:R-HSA-936440 | 0.0199798926111 | 0.285714285714 | ATG12 ATG5 | Negative regulators of DDX58/IFIH1 signaling |
| KEGG:04622 | 0.0210427715268 | 0.285714285714 | ATG12 ATG5 | RIG-I-like receptor signaling pathway |
| WP:WP3865 | 0.0251881882105 | 0.285714285714 | ATG12 ATG5 | Novel intracellular components of RIG I like receptor pathway |
| GO:0006914 | 0.0261282499937 | 0.714285714286 | ATG12 TECPR1 ATG16L2 ATG5 ATG16L1 | autophagy |
| GO:0061919 | 0.0261282499937 | 0.714285714286 | ATG12 TECPR1 ATG16L2 ATG5 ATG16L1 | process utilizing autophagic mechanism |
| GO:1904973 | 0.0294899169624 | 0.285714285714 | ATG12 ATG5 | positive regulation of viral translation |
| GO:1904971 | 0.0294899169624 | 0.285714285714 | ATG12 ATG5 | regulation of viral translation |
| WP:WP4655 | 0.0365198824686 | 0.285714285714 | ATG12 ATG5 | Cytosolic DNA sensing pathway |
| GO:0007033 | 0.0386866758686 | 0.571428571429 | ATG12 ATG16L2 ATG5 ATG16L1 | vacuole organization |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ATG5 | ATG16L1 | 1.0 | 0.128 | bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM Malo bioplex3_HCT116 fraction |
| ATG5 | TECPR1 | 0.999 | 0.09 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG5 | ATG12 | 0.999 | 0.442 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| RAB33B | ATG5 | 0.999 | 0.14 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG16L2 | ATG5 | 0.998 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RAB33B | ATG16L1 | 0.998 | 0.0448888888889 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| RAB33B | ATG12 | 0.998 | 0.118 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG12 | ATG16L1 | 0.986 | 0.162761904762 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATRIP | ATG16L1 | 0.972 | 0.082 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG16L2 | TECPR1 | 0.946 | bioplex3_WMM WMM_only | |
| ATG16L2 | ATG16L1 | 0.916 | bioplex3_WMM WMM_only | |
| TECPR1 | ATG16L1 | 0.916 | 0.056 | bioplex3_WMM WMM_only |
| ATG16L2 | ATG12 | 0.779 | bioplex3_WMM WMM_only | |
| ATG12 | TECPR1 | 0.779 | 0.134 | bioplex3_WMM WMM_only |
| ATG5 | ATRIP | 0.261 | 0.118 | bioplex3_WMM WMM_only |
| ATG12 | ATRIP | 0.248 | 0.164 | bioplex3_WMM WMM_only |
| RAB33B | ATRIP | 0.026 | 0.152 | bioplex3_WMM WMM_only |
Related Complexes