hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09497.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NUP155 | Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) | 5 | UniProt NCBI |
| SENP2 | Sentrin-specific protease 2 (EC 3.4.22.-) (Axam2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Sentrin/SUMO-specific protease SENP2) | 5 | UniProt NCBI |
| SMPD4 | Sphingomyelin phosphodiesterase 4 (EC 3.1.4.12) (Neutral sphingomyelinase 3) (nSMase-3) (nSMase3) (Neutral sphingomyelinase III) | 5 | UniProt NCBI |
| NDC1 | Nucleoporin NDC1 (hNDC1) (Transmembrane protein 48) | 5 | UniProt NCBI |
| NUP35 | Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) | 5 | UniProt NCBI |
| SENP1 | Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2990846 | 1.77406446339e-07 | 0.833333333333 | NUP35 NUP155 SENP1 SENP2 NDC1 | SUMOylation |
| KEGG:03013 | 1.65053510706e-06 | 0.666666666667 | NUP35 NUP155 SENP2 NDC1 | Nucleocytoplasmic transport |
| GO:0005635 | 9.20043332604e-06 | 1.0 | NUP35 SENP2 SMPD4 NUP155 NDC1 SENP1 | nuclear envelope |
| REAC:R-HSA-9615933 | 1.42587173715e-05 | 0.5 | NUP155 NUP35 NDC1 | Postmitotic nuclear pore complex (NPC) reformation |
| REAC:R-HSA-170822 | 2.30646071149e-05 | 0.5 | NUP155 NUP35 NDC1 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| REAC:R-HSA-5619107 | 2.30646071149e-05 | 0.5 | NUP155 NUP35 NDC1 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| REAC:R-HSA-168333 | 2.57219421737e-05 | 0.5 | NUP155 NUP35 NDC1 | NEP/NS2 Interacts with the Cellular Export Machinery |
| REAC:R-HSA-168271 | 2.57219421737e-05 | 0.5 | NUP155 NUP35 NDC1 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-168274 | 2.57219421737e-05 | 0.5 | NUP155 NUP35 NDC1 | Export of Viral Ribonucleoproteins from Nucleus |
| REAC:R-HSA-180746 | 3.16323162923e-05 | 0.5 | NUP155 NUP35 NDC1 | Nuclear import of Rev protein |
| REAC:R-HSA-180910 | 3.16323162923e-05 | 0.5 | NUP155 NUP35 NDC1 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-159227 | 3.16323162923e-05 | 0.5 | NUP155 NUP35 NDC1 | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-165054 | 3.48992434538e-05 | 0.5 | NUP155 NUP35 NDC1 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-4085377 | 3.48992434538e-05 | 0.5 | NUP155 NUP35 NDC1 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-159230 | 3.48992434538e-05 | 0.5 | NUP155 NUP35 NDC1 | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-3301854 | 3.83832488858e-05 | 0.5 | NUP155 NUP35 NDC1 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-176033 | 4.20912658431e-05 | 0.5 | NUP155 NUP35 NDC1 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-177243 | 4.20912658431e-05 | 0.5 | NUP155 NUP35 NDC1 | Interactions of Rev with host cellular proteins |
| REAC:R-HSA-3232142 | 4.60302232639e-05 | 0.5 | NUP155 NUP35 NDC1 | SUMOylation of ubiquitinylation proteins |
| REAC:R-HSA-168276 | 5.46286536752e-05 | 0.5 | NUP155 NUP35 NDC1 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-159231 | 5.93019629716e-05 | 0.5 | NUP155 NUP35 NDC1 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-159234 | 6.42338853456e-05 | 0.5 | NUP155 NUP35 NDC1 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| REAC:R-HSA-168325 | 6.94313281717e-05 | 0.5 | NUP155 NUP35 NDC1 | Viral Messenger RNA Synthesis |
| REAC:R-HSA-4615885 | 8.06503831344e-05 | 0.5 | NUP155 NUP35 NDC1 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-4570464 | 8.6685788479e-05 | 0.5 | NUP155 NUP35 NDC1 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-2980766 | 0.000113827315454 | 0.5 | NUP155 NUP35 NDC1 | Nuclear Envelope Breakdown |
| REAC:R-HSA-191859 | 0.000146098747122 | 0.5 | NUP155 NUP35 NDC1 | snRNP Assembly |
| REAC:R-HSA-194441 | 0.000146098747122 | 0.5 | NUP155 NUP35 NDC1 | Metabolism of non-coding RNA |
| GO:0031965 | 0.000149682230544 | 0.833333333333 | SENP1 NUP155 NDC1 NUP35 SMPD4 | nuclear membrane |
| REAC:R-HSA-6784531 | 0.000183939263613 | 0.5 | NUP155 NUP35 NDC1 | tRNA processing in the nucleus |
| WP:WP3998 | 0.000250309382919 | 0.5 | NUP155 NUP35 NDC1 | Prader Willi and Angelman syndrome |
| REAC:R-HSA-3371453 | 0.000305777502474 | 0.5 | NUP155 NUP35 NDC1 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-70171 | 0.000305777502474 | 0.5 | NUP155 NUP35 NDC1 | Glycolysis |
| REAC:R-HSA-4551638 | 0.000320288872929 | 0.5 | NUP155 NUP35 NDC1 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-1169408 | 0.000320288872929 | 0.5 | NUP155 NUP35 NDC1 | ISG15 antiviral mechanism |
| REAC:R-HSA-2995410 | 0.000335250637963 | 0.5 | NUP155 NUP35 NDC1 | Nuclear Envelope (NE) Reassembly |
| REAC:R-HSA-159236 | 0.00038290615081 | 0.5 | NUP155 NUP35 NDC1 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-5619102 | 0.00038290615081 | 0.5 | NUP155 NUP35 NDC1 | SLC transporter disorders |
| REAC:R-HSA-3065679 | 0.000387015749065 | 0.333333333333 | SENP2 SENP1 | SUMO is proteolytically processed |
| REAC:R-HSA-3108214 | 0.000399737323057 | 0.5 | NUP155 NUP35 NDC1 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-1169410 | 0.000417052782963 | 0.5 | NUP155 NUP35 NDC1 | Antiviral mechanism by IFN-stimulated genes |
| REAC:R-HSA-72202 | 0.000552388845795 | 0.5 | NUP155 NUP35 NDC1 | Transport of Mature Transcript to Cytoplasm |
| REAC:R-HSA-70326 | 0.000552388845795 | 0.5 | NUP155 NUP35 NDC1 | Glucose metabolism |
| REAC:R-HSA-3371556 | 0.000689296551176 | 0.5 | NUP155 NUP35 NDC1 | Cellular response to heat stress |
| GO:0005643 | 0.000719028723342 | 0.666666666667 | NUP35 NUP155 SENP2 NDC1 | nuclear pore |
| REAC:R-HSA-5578749 | 0.00084703415394 | 0.5 | NUP155 NUP35 NDC1 | Transcriptional regulation by small RNAs |
| REAC:R-HSA-3215018 | 0.000928329318648 | 0.333333333333 | SENP2 SENP1 | Processing and activation of SUMO |
| REAC:R-HSA-72306 | 0.00109225187932 | 0.5 | NUP155 NUP35 NDC1 | tRNA processing |
| REAC:R-HSA-9610379 | 0.00109225187932 | 0.5 | NUP155 NUP35 NDC1 | HCMV Late Events |
| REAC:R-HSA-9705671 | 0.00158398146364 | 0.5 | NUP155 NUP35 NDC1 | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| REAC:R-HSA-211000 | 0.00185327127259 | 0.5 | NUP155 NUP35 NDC1 | Gene Silencing by RNA |
| REAC:R-HSA-9609690 | 0.00194934586886 | 0.5 | NUP155 NUP35 NDC1 | HCMV Early Events |
| REAC:R-HSA-68875 | 0.00204866370827 | 0.5 | NUP155 NUP35 NDC1 | Mitotic Prophase |
| REAC:R-HSA-162909 | 0.00220383625716 | 0.5 | NUP155 NUP35 NDC1 | Host Interactions of HIV factors |
| REAC:R-HSA-162599 | 0.00247941542207 | 0.5 | NUP155 NUP35 NDC1 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-168273 | 0.00253713376791 | 0.5 | NUP155 NUP35 NDC1 | Influenza Viral RNA Transcription and Replication |
| GO:0017056 | 0.00295184433846 | 0.5 | NUP155 NUP35 NDC1 | structural constituent of nuclear pore |
| GO:0031967 | 0.00310405054115 | 1.0 | NUP35 SENP2 SMPD4 NUP155 NDC1 SENP1 | organelle envelope |
| GO:0031975 | 0.00310405054115 | 1.0 | NUP35 SENP2 SMPD4 NUP155 NDC1 SENP1 | envelope |
| REAC:R-HSA-5619115 | 0.00316393974757 | 0.5 | NUP155 NUP35 NDC1 | Disorders of transmembrane transporters |
| REAC:R-HSA-162587 | 0.00323172543915 | 0.5 | NUP155 NUP35 NDC1 | HIV Life Cycle |
| REAC:R-HSA-9609646 | 0.00323172543915 | 0.5 | NUP155 NUP35 NDC1 | HCMV Infection |
| REAC:R-HSA-168255 | 0.00365870216205 | 0.5 | NUP155 NUP35 NDC1 | Influenza Infection |
| REAC:R-HSA-597592 | 0.00433380037126 | 0.833333333333 | NUP35 NUP155 SENP1 SENP2 NDC1 | Post-translational protein modification |
| REAC:R-HSA-3108232 | 0.00445044283113 | 0.5 | NUP155 NUP35 NDC1 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-913531 | 0.00604240808777 | 0.5 | NUP155 NUP35 NDC1 | Interferon Signaling |
| REAC:R-HSA-9705683 | 0.00748536008797 | 0.5 | NUP155 NUP35 NDC1 | SARS-CoV-2-host interactions |
| KEGG:05014 | 0.0106340043214 | 0.5 | NUP155 NUP35 NDC1 | Amyotrophic lateral sclerosis |
| REAC:R-HSA-162906 | 0.0121264165673 | 0.5 | NUP155 NUP35 NDC1 | HIV Infection |
| REAC:R-HSA-68882 | 0.0124562827139 | 0.5 | NUP155 NUP35 NDC1 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.012623409261 | 0.5 | NUP155 NUP35 NDC1 | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-71387 | 0.0187811350588 | 0.5 | NUP155 NUP35 NDC1 | Metabolism of carbohydrates |
| REAC:R-HSA-392499 | 0.0215959266916 | 0.833333333333 | NUP35 NUP155 SENP1 SENP2 NDC1 | Metabolism of proteins |
| REAC:R-HSA-9694516 | 0.0227330941007 | 0.5 | NUP155 NUP35 NDC1 | SARS-CoV-2 Infection |
| REAC:R-HSA-72203 | 0.0229811698012 | 0.5 | NUP155 NUP35 NDC1 | Processing of Capped Intron-Containing Pre-mRNA |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NDC1 | SMPD4 | 0.998 | 0.148 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| NDC1 | NUP35 | 0.997 | 0.27 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| NUP155 | NUP35 | 0.991 | 0.476 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| NUP155 | NDC1 | 0.986 | 0.408 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| SMPD4 | SENP1 | 0.982 | 0.066 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| SENP2 | NDC1 | 0.98 | 0.086 | hein_WMM youn_WMM gupta_WMM WMM_only |
| NUP35 | SMPD4 | 0.975 | 0.434 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| SENP2 | SMPD4 | 0.973 | 0.048 | hein_WMM youn_WMM gupta_WMM WMM_only |
| NDC1 | SENP1 | 0.969 | 0.092 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| SENP2 | SENP1 | 0.961 | 0.094 | hein_WMM bioplex3_WMM youn_WMM WMM_only |
| SENP2 | NUP155 | 0.959 | 0.15 | hein_WMM youn_WMM gupta_WMM WMM_only |
| NUP155 | SMPD4 | 0.958 | 0.454 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| SENP2 | NUP35 | 0.951 | 0.214 | hein_WMM youn_WMM gupta_WMM WMM_only |
| NUP35 | SENP1 | 0.918 | 0.228 | hein_WMM bioplex3_WMM youn_WMM WMM_only |
| NUP155 | SENP1 | 0.888 | 0.156 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes