hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09515.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PHF12 | PHD finger protein 12 (PHD factor 1) (Pf1) | 5 | UniProt NCBI |
| MRFAP1 | MORF4 family-associated protein 1 (Protein PGR1) (Protein associated with MRG of 14 kDa) | 5 | UniProt NCBI |
| EMSY | BRCA2-interacting transcriptional repressor EMSY | 5 | UniProt NCBI |
| KDM5A | Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A) | 5 | UniProt NCBI |
| MORF4L1 | Mortality factor 4-like protein 1 (MORF-related gene 15 protein) (MRG15) (Protein MSL3-1) (Transcription factor-like protein MRG15) | 5 | UniProt NCBI |
| GATAD1 | GATA zinc finger domain-containing protein 1 (Ocular development-associated gene protein) | 5 | UniProt NCBI |
| BRCA2 | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | 5 | UniProt NCBI |
| SIN3B | Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b) | 5 | UniProt NCBI |
| MRFAP1L1 | MORF4 family-associated protein 1-like 1 | 5 | UniProt NCBI |
| MORF4L2 | Mortality factor 4-like protein 2 (MORF-related gene X protein) (Protein MSL3-2) (Transcription factor-like protein MRGX) | 5 | UniProt NCBI |
| PALB2 | Partner and localizer of BRCA2 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:723 | 9.22394575203e-05 | 0.2 | MRFAP1 MORF4L1 | MRG15-PAM14-RB complex |
| CORUM:722 | 9.22394575203e-05 | 0.2 | MRFAP1 MORF4L1 | MRG15-PAM14-RB complex |
| CORUM:528 | 0.0032142696266 | 0.2 | MORF4L1 MORF4L2 | NuA4/Tip60-HAT complex |
| CORUM:529 | 0.00367211019763 | 0.2 | MORF4L1 MORF4L2 | NuA4/Tip60-HAT complex |
| KEGG:03440 | 0.0163216862479 | 0.2 | PALB2 BRCA2 | Homologous recombination |
| HP:0005249 | 0.0185361113698 | 0.2 | PALB2 BRCA2 | Functional intestinal obstruction |
| HP:0012334 | 0.0185361113698 | 0.2 | PALB2 BRCA2 | Extrahepatic cholestasis |
| HP:0100592 | 0.0226469783291 | 0.2 | PALB2 BRCA2 | Peritoneal abscess |
| KEGG:03460 | 0.0245273488015 | 0.2 | PALB2 BRCA2 | Fanconi anemia pathway |
| REAC:R-HSA-9709603 | 0.0278673305979 | 0.2 | PALB2 BRCA2 | Impaired BRCA2 binding to PALB2 |
| REAC:R-HSA-9701193 | 0.0302795201711 | 0.2 | PALB2 BRCA2 | Defective homologous recombination repair (HRR) due to PALB2 loss of function |
| REAC:R-HSA-9704646 | 0.0302795201711 | 0.2 | PALB2 BRCA2 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function |
| REAC:R-HSA-9704331 | 0.0302795201711 | 0.2 | PALB2 BRCA2 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function |
| REAC:R-HSA-9701192 | 0.0302795201711 | 0.2 | PALB2 BRCA2 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function |
| HP:0025318 | 0.0320940919357 | 0.2 | PALB2 BRCA2 | Ovarian carcinoma |
| REAC:R-HSA-5693554 | 0.0354011801879 | 0.2 | PALB2 BRCA2 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| HP:0030406 | 0.0374294407319 | 0.2 | PALB2 BRCA2 | Primary peritoneal carcinoma |
| HP:0003221 | 0.0431720528278 | 0.2 | PALB2 BRCA2 | Chromosomal breakage induced by crosslinking agents |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| PHF12 | GATAD1 | 1.0 | 0.168 |
| KDM5A | GATAD1 | 1.0 | 0.192 |
| EMSY | GATAD1 | 1.0 | 0.094 |
| SIN3B | GATAD1 | 1.0 | 0.216 |
| PHF12 | KDM5A | 1.0 | 0.294 |
| MORF4L2 | MRFAP1 | 1.0 | 0.198 |
| MORF4L1 | MORF4L2 | 0.999 | 0.144 |
| PHF12 | SIN3B | 0.999 | 0.444 |
| MORF4L1 | MRFAP1 | 0.999 | 0.096 |
| EMSY | SIN3B | 0.999 | 0.204 |
| PHF12 | EMSY | 0.999 | 0.646 |
| EMSY | KDM5A | 0.999 | 0.174 |
| MRFAP1 | MRFAP1L1 | 0.999 | |
| BRCA2 | PALB2 | 0.998 | |
| KDM5A | SIN3B | 0.998 | 0.324 |
| MORF4L2 | MRFAP1L1 | 0.998 | |
| MORF4L1 | GATAD1 | 0.998 | 0.114 |
| PHF12 | MORF4L1 | 0.998 | 0.044 |
| MORF4L1 | BRCA2 | 0.995 | 0.162 |
| KDM5A | MORF4L1 | 0.993 | 0.132 |
| EMSY | MORF4L1 | 0.992 | 0.026 |
| MORF4L1 | PALB2 | 0.992 | |
| MORF4L2 | PALB2 | 0.991 | |
| MORF4L1 | SIN3B | 0.983 | 0.142 |
| MORF4L1 | MRFAP1L1 | 0.975 | |
| MORF4L2 | GATAD1 | 0.964 | 0.162 |
| MORF4L2 | BRCA2 | 0.942 | 0.128 |
| PHF12 | MORF4L2 | 0.935 | 0.146 |
| KDM5A | MORF4L2 | 0.623 | 0.09 |
| SIN3B | MORF4L2 | 0.567 | 0.096 |
| EMSY | MORF4L2 | 0.407 | 0.036 |
| PHF12 | PALB2 | 0.366 | |
| MRFAP1 | PALB2 | 0.344 | |
| MRFAP1L1 | PALB2 | 0.291 | |
| PHF12 | MRFAP1L1 | 0.291 | |
| EMSY | PALB2 | 0.273 | |
| KDM5A | MRFAP1 | 0.256 | 0.032 |
| GATAD1 | MRFAP1 | 0.256 | 0.092 |
| EMSY | MRFAP1L1 | 0.245 | |
| PHF12 | MRFAP1 | 0.242 | 0.122 |
| SIN3B | MRFAP1L1 | 0.242 | |
| GATAD1 | MRFAP1L1 | 0.215 | |
| GATAD1 | PALB2 | 0.215 | |
| KDM5A | MRFAP1L1 | 0.215 | |
| KDM5A | PALB2 | 0.215 | |
| SIN3B | PALB2 | 0.165 | |
| EMSY | MRFAP1 | 0.148 | 0.038 |
| BRCA2 | MRFAP1L1 | 0.13 | |
| BRCA2 | MRFAP1 | 0.113 | 0.066 |
| SIN3B | MRFAP1 | 0.113 | 0.074 |
| PHF12 | BRCA2 | 0.092 | 0.368 |
| EMSY | BRCA2 | 0.047 | 0.1 |
| KDM5A | BRCA2 | 0.019 | 0.234 |
| GATAD1 | BRCA2 | 0.019 | 0.23 |
| SIN3B | BRCA2 | 0.016 | 0.3 |
Related Complexes