hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09525.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GNL3L | Guanine nucleotide-binding protein-like 3-like protein | 5 | UniProt NCBI |
| RFC3 | Replication factor C subunit 3 (Activator 1 38 kDa subunit) (A1 38 kDa subunit) (Activator 1 subunit 3) (Replication factor C 38 kDa subunit) (RF-C 38 kDa subunit) (RFC38) | 5 | UniProt NCBI |
| DIDO1 | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | 5 | UniProt NCBI |
| SKIC2 | Superkiller complex protein 2 (Ski2) (EC 3.6.4.13) (Helicase-like protein) (HLP) | 5 | UniProt NCBI |
| EME1 | Crossover junction endonuclease EME1 (EC 3.1.22.-) (MMS4 homolog) (hMMS4) | 5 | UniProt NCBI |
| SKIC3 | Superkiller complex protein 3 (Ski3) (Tetratricopeptide repeat protein 37) (TPR repeat protein 37) (Tricho-hepatic-enteric syndrome protein) (Thespin) | 5 | UniProt NCBI |
| USP36 | Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1168 | 6.1565588648e-05 | 0.285714285714 | SKIC2 SKIC3 | SKI complex |
| HP:0025156 | 0.000499829101057 | 0.285714285714 | SKIC2 SKIC3 | Dependency on intravenous nutrition |
| HP:0030056 | 0.00249743559672 | 0.285714285714 | SKIC2 SKIC3 | Uncombable hair |
| HP:0002041 | 0.00349561220575 | 0.285714285714 | SKIC2 SKIC3 | Intractable diarrhea |
| REAC:R-HSA-429958 | 0.00455853850403 | 0.285714285714 | SKIC2 SKIC3 | mRNA decay by 3' to 5' exoribonuclease |
| HP:0009886 | 0.0109736833289 | 0.285714285714 | SKIC2 SKIC3 | Trichorrhexis nodosa |
| HPA:0100123 | 0.014905435517 | 0.571428571429 | GNL3L EME1 RFC3 DIDO1 | cerebral cortex; glial cells[High] |
| HP:0005263 | 0.0199339480346 | 0.285714285714 | SKIC2 SKIC3 | Gastritis |
| HP:0040130 | 0.0199339480346 | 0.285714285714 | SKIC2 SKIC3 | Abnormal serum iron concentration |
| HP:0003139 | 0.0254041861805 | 0.285714285714 | SKIC2 SKIC3 | Panhypogammaglobulinemia |
| KEGG:03018 | 0.0265381810008 | 0.285714285714 | SKIC2 SKIC3 | RNA degradation |
| GO:0070478 | 0.0294899169624 | 0.285714285714 | SKIC2 SKIC3 | nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay |
| GO:0055087 | 0.0294899169624 | 0.285714285714 | SKIC2 SKIC3 | Ski complex |
| HP:0011877 | 0.0315332858987 | 0.285714285714 | SKIC2 SKIC3 | Increased mean platelet volume |
| HP:0011031 | 0.0348446257606 | 0.285714285714 | SKIC2 SKIC3 | Abnormality of iron homeostasis |
| HP:0002224 | 0.0383203414044 | 0.285714285714 | SKIC2 SKIC3 | Woolly hair |
| HP:0011472 | 0.0383203414044 | 0.285714285714 | SKIC2 SKIC3 | Abnormal small intestinal villus morphology |
| HP:0011473 | 0.0383203414044 | 0.285714285714 | SKIC2 SKIC3 | Villous atrophy |
| HP:0002884 | 0.0383203414044 | 0.285714285714 | SKIC2 SKIC3 | Hepatoblastoma |
| HP:0011876 | 0.0419603197237 | 0.285714285714 | SKIC2 SKIC3 | Abnormal platelet volume |
| HP:0025129 | 0.0457644476584 | 0.285714285714 | SKIC2 SKIC3 | Abnormal small intestinal mucosa morphology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SKIC3 | SKIC2 | 0.999 | 0.914 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction |
| SKIC3 | GNL3L | 0.993 | 0.014 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| SKIC2 | GNL3L | 0.991 | 0.016 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| USP36 | GNL3L | 0.985 | 0.062 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only treiber_WMM |
| RFC3 | GNL3L | 0.984 | 0.066 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only treiber_WMM |
| DIDO1 | GNL3L | 0.981 | 0.048 | hein_WMM bioplex3_WMM youn_WMM WMM_only |
| RFC3 | USP36 | 0.973 | 0.064 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only treiber_WMM |
| EME1 | GNL3L | 0.971 | 0.072 | hein_WMM bioplex3_WMM WMM_only |
| RFC3 | SKIC2 | 0.966 | 0.0546666666667 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| SKIC3 | RFC3 | 0.931 | 0.016 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| RFC3 | EME1 | 0.835 | 0.088 | hein_WMM bioplex3_WMM WMM_only |
| SKIC3 | EME1 | 0.791 | 0.056 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| SKIC3 | USP36 | 0.616 | 0.026 | hein_WMM youn_WMM WMM_only |
| SKIC3 | DIDO1 | 0.445 | 0.048 | hein_WMM youn_WMM WMM_only |
| DIDO1 | USP36 | 0.317 | 0.07 | bioplex3_WMM youn_WMM WMM_only |
| RFC3 | DIDO1 | 0.253 | 0.056 | hein_WMM bioplex3_WMM youn_WMM WMM_only |
| EME1 | USP36 | 0.152 | 0.11 | hein_WMM bioplex3_WMM WMM_only |
| SKIC2 | USP36 | 0.066 | 0.028 | hein_WMM bioplex3_WMM WMM_only |
| EME1 | DIDO1 | 0.063 | 0.122 | hein_WMM WMM_only |
| EME1 | SKIC2 | 0.054 | 0.052 | bioplex_WMM bioplex3_WMM WMM_only |
| SKIC2 | DIDO1 | 0.008 | 0.052 | youn_WMM WMM_only |
Related Complexes