hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09538.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| INCENP | Inner centromere protein | 5 | UniProt NCBI |
| AURKC | Aurora kinase C (EC 2.7.11.1) (Aurora 3) (Aurora/IPL1-related kinase 3) (ARK-3) (Aurora-related kinase 3) (Aurora/IPL1/Eg2 protein 2) (Serine/threonine-protein kinase 13) (Serine/threonine-protein kinase aurora-C) | 5 | UniProt NCBI |
| CDCA8 | Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0032133 | 1.92240082153e-06 | 1.0 | INCENP CDCA8 AURKC | chromosome passenger complex |
| CORUM:1120 | 1.02521027753e-05 | 0.666666666667 | INCENP CDCA8 | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5) |
| GO:0051256 | 1.58598067776e-05 | 1.0 | INCENP CDCA8 AURKC | mitotic spindle midzone assembly |
| CORUM:1118 | 2.05032700758e-05 | 0.666666666667 | INCENP CDCA8 | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) |
| CORUM:1119 | 2.05032700758e-05 | 0.666666666667 | INCENP CDCA8 | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) |
| GO:0000022 | 2.11464090368e-05 | 1.0 | INCENP CDCA8 AURKC | mitotic spindle elongation |
| GO:0051255 | 2.11464090368e-05 | 1.0 | INCENP CDCA8 AURKC | spindle midzone assembly |
| GO:0051231 | 2.74903317479e-05 | 1.0 | INCENP CDCA8 AURKC | spindle elongation |
| GO:0051233 | 0.000575182325801 | 1.0 | INCENP CDCA8 AURKC | spindle midzone |
| GO:0032467 | 0.000575182325801 | 1.0 | INCENP CDCA8 AURKC | positive regulation of cytokinesis |
| GO:0051781 | 0.000949666005835 | 1.0 | INCENP CDCA8 AURKC | positive regulation of cell division |
| GO:0008608 | 0.0018839528051 | 1.0 | INCENP CDCA8 AURKC | attachment of spindle microtubules to kinetochore |
| GO:0090307 | 0.00345936027834 | 1.0 | INCENP CDCA8 AURKC | mitotic spindle assembly |
| REAC:R-HSA-4615885 | 0.00585997836812 | 0.666666666667 | INCENP CDCA8 | SUMOylation of DNA replication proteins |
| GO:0032465 | 0.00597828207479 | 1.0 | INCENP CDCA8 AURKC | regulation of cytokinesis |
| GO:0051310 | 0.0116771431902 | 1.0 | INCENP CDCA8 AURKC | metaphase chromosome alignment |
| GO:0051303 | 0.0128843147861 | 1.0 | INCENP CDCA8 AURKC | establishment of chromosome localization |
| GO:0050000 | 0.0150763323228 | 1.0 | INCENP CDCA8 AURKC | chromosome localization |
| GO:0051225 | 0.0165038110528 | 1.0 | INCENP CDCA8 AURKC | spindle assembly |
| GO:0051302 | 0.0201788647033 | 1.0 | INCENP CDCA8 AURKC | regulation of cell division |
| GO:0007052 | 0.0225051619375 | 1.0 | INCENP CDCA8 AURKC | mitotic spindle organization |
| REAC:R-HSA-141424 | 0.0284248695791 | 0.666666666667 | INCENP CDCA8 | Amplification of signal from the kinetochores |
| REAC:R-HSA-141444 | 0.0284248695791 | 0.666666666667 | INCENP CDCA8 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| GO:0005875 | 0.0290879429506 | 1.0 | INCENP CDCA8 AURKC | microtubule associated complex |
| GO:1903490 | 0.0294899169624 | 0.666666666667 | INCENP CDCA8 | positive regulation of mitotic cytokinesis |
| HPA:0030432 | 0.0366451526634 | 0.666666666667 | INCENP CDCA8 | appendix; germinal center cells[>=Medium] |
| HPA:0031293 | 0.0370192963486 | 0.666666666667 | INCENP CDCA8 | appendix; endocrine cells[High] |
| REAC:R-HSA-69618 | 0.0392065258044 | 0.666666666667 | INCENP CDCA8 | Mitotic Spindle Checkpoint |
| GO:1902425 | 0.0393180950424 | 0.666666666667 | INCENP CDCA8 | positive regulation of attachment of mitotic spindle microtubules to kinetochore |
| GO:1902423 | 0.0393180950424 | 0.666666666667 | INCENP CDCA8 | regulation of attachment of mitotic spindle microtubules to kinetochore |
| GO:1902412 | 0.0393180950424 | 0.666666666667 | INCENP CDCA8 | regulation of mitotic cytokinesis |
| REAC:R-HSA-9648025 | 0.0429286997388 | 0.666666666667 | INCENP CDCA8 | EML4 and NUDC in mitotic spindle formation |
| GO:1902850 | 0.043021407985 | 1.0 | INCENP CDCA8 AURKC | microtubule cytoskeleton organization involved in mitosis |
| HPA:0131293 | 0.0448972088574 | 0.666666666667 | INCENP CDCA8 | colon; endocrine cells[High] |
| REAC:R-HSA-2500257 | 0.049233254294 | 0.666666666667 | INCENP CDCA8 | Resolution of Sister Chromatid Cohesion |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| INCENP | AURKC | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CDCA8 | INCENP | 0.998 | 0.606 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
Related Complexes