hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09549.1
Complex Portal: CPX-14722
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ARHGEF10 | Rho guanine nucleotide exchange factor 10 | 5 | UniProt NCBI |
| ARHGEF10L | Rho guanine nucleotide exchange factor 10-like protein (GrinchGEF) | 5 | UniProt NCBI |
| EPHB2 | Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-193648 | 0.00154301186217 | 1.0 | ARHGEF10L ARHGEF10 | NRAGE signals death through JNK |
| REAC:R-HSA-204998 | 0.0027271837564 | 1.0 | ARHGEF10L ARHGEF10 | Cell death signalling via NRAGE, NRIF and NADE |
| REAC:R-HSA-9013026 | 0.0031270340064 | 1.0 | ARHGEF10L ARHGEF10 | RHOB GTPase cycle |
| REAC:R-HSA-416482 | 0.00323126847328 | 1.0 | ARHGEF10L ARHGEF10 | G alpha (12/13) signalling events |
| REAC:R-HSA-9013106 | 0.00355422444443 | 1.0 | ARHGEF10L ARHGEF10 | RHOC GTPase cycle |
| REAC:R-HSA-193704 | 0.0046153654925 | 1.0 | ARHGEF10L ARHGEF10 | p75 NTR receptor-mediated signalling |
| REAC:R-HSA-8980692 | 0.013456498798 | 1.0 | ARHGEF10L ARHGEF10 | RHOA GTPase cycle |
| REAC:R-HSA-73887 | 0.0136718027788 | 1.0 | ARHGEF10L ARHGEF10 | Death Receptor Signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ARHGEF10 | ARHGEF10L | 0.998 | 0.102 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ARHGEF10 | EPHB2 | 0.966 | 0.01 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes