hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09554.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RNF170 | E3 ubiquitin-protein ligase RNF170 (EC 2.3.2.27) (Putative LAG1-interacting protein) (RING finger protein 170) (RING-type E3 ubiquitin transferase RNF170) | 5 | UniProt NCBI |
| ERLIN1 | Erlin-1 (Endoplasmic reticulum lipid raft-associated protein 1) (Protein KE04) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1) (SPFH domain-containing protein 1) | 5 | UniProt NCBI |
| DUSP3 | Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR) | 5 | UniProt NCBI |
| ERLIN2 | Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (SPFH domain-containing protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6476 | 7.01606139244e-10 | 0.75 | ERLIN1 RNF170 ERLIN2 | erlin1/2-RNF170 complex |
| HP:0002061 | 0.00613143375936 | 0.75 | ERLIN1 RNF170 ERLIN2 | Lower limb spasticity |
| HP:0006986 | 0.00844485194452 | 0.5 | ERLIN2 RNF170 | Upper limb spasticity |
| HP:0003487 | 0.0124847721541 | 0.75 | ERLIN1 RNF170 ERLIN2 | Babinski sign |
| HP:0031828 | 0.0124847721541 | 0.75 | ERLIN1 RNF170 ERLIN2 | Abnormal superficial reflex |
| REAC:R-HSA-5678895 | 0.0174510452107 | 0.5 | ERLIN1 ERLIN2 | Defective CFTR causes cystic fibrosis |
| REAC:R-HSA-5619084 | 0.0253175164514 | 0.5 | ERLIN1 ERLIN2 | ABC transporter disorders |
| GO:0045541 | 0.0280843539964 | 0.5 | ERLIN1 ERLIN2 | negative regulation of cholesterol biosynthetic process |
| GO:0090206 | 0.0280843539964 | 0.5 | ERLIN1 ERLIN2 | negative regulation of cholesterol metabolic process |
| GO:0106119 | 0.0280843539964 | 0.5 | ERLIN1 ERLIN2 | negative regulation of sterol biosynthetic process |
| HP:0034353 | 0.0305087012549 | 0.75 | ERLIN1 RNF170 ERLIN2 | Appendicular spasticity |
| HP:0007256 | 0.0416942448541 | 0.75 | ERLIN1 RNF170 ERLIN2 | Abnormal pyramidal sign |
| REAC:R-HSA-382556 | 0.0444386798825 | 0.5 | ERLIN1 ERLIN2 | ABC-family proteins mediated transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ERLIN1 | RNF170 | 0.999 | 0.07 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ERLIN2 | ERLIN1 | 0.999 | 0.172 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| ERLIN1 | DUSP3 | 0.999 | 0.022 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ERLIN2 | RNF170 | 0.998 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ERLIN2 | DUSP3 | 0.995 | 0.044 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| DUSP3 | RNF170 | 0.985 | 0.036 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes