hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09560.1
Complex Portal: CPX-22751
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DYNC1I2 | Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2) | 5 | UniProt NCBI |
| DYNLT1 | Dynein light chain Tctex-type 1 (Protein CW-1) (T-complex testis-specific protein 1 homolog) | 5 | UniProt NCBI |
| PCBP4 | Poly(rC)-binding protein 4 (Alpha-CP4) | 4 | UniProt NCBI |
| DYNC1LI2 | Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC-2) (LIC53/55) | 5 | UniProt NCBI |
| DYNC2I2 | Cytoplasmic dynein 2 intermediate chain 2 (Dynein 2 intermediate chain 2) (WD repeat-containing protein 34) | 5 | UniProt NCBI |
| C2CD2 | C2 domain-containing protein 2 (Transmembrane protein 24-like) | 3 | UniProt NCBI |
| DYNC1H1 | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | 5 | UniProt NCBI |
| DYNC1LI1 | Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) (DLIC-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4532 | 5.57915398033e-14 | 0.75 | DYNLT1 DYNC2I2 DYNC1I2 DYNC1LI1 DYNC1H1 DYNC1LI2 | Intraflagellar transport proteins binding to dynein |
| GO:0005868 | 5.60867694166e-12 | 0.75 | DYNLT1 DYNC2I2 DYNC1I2 DYNC1LI1 DYNC1H1 DYNC1LI2 | cytoplasmic dynein complex |
| GO:0030286 | 1.14315920869e-10 | 0.75 | DYNLT1 DYNC2I2 DYNC1I2 DYNC1LI1 DYNC1H1 DYNC1LI2 | dynein complex |
| KEGG:04962 | 1.65353041647e-07 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Vasopressin-regulated water reabsorption |
| WP:WP5085 | 3.04756518364e-07 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Vasopressin regulated water reabsorption |
| KEGG:04814 | 4.24558203212e-07 | 0.625 | DYNC1LI1 DYNLT1 DYNC1H1 DYNC1I2 DYNC1LI2 | Motor proteins |
| GO:0005875 | 4.33968859688e-07 | 0.75 | DYNLT1 DYNC2I2 DYNC1I2 DYNC1LI1 DYNC1H1 DYNC1LI2 | microtubule associated complex |
| REAC:R-HSA-9646399 | 7.87322279848e-07 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Aggrephagy |
| GO:0045504 | 9.10136169988e-07 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC2I2 | dynein heavy chain binding |
| REAC:R-HSA-6811436 | 1.78693125766e-06 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-3371497 | 2.09967265566e-06 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand |
| KEGG:05132 | 2.16017111801e-06 | 0.625 | DYNC1LI1 DYNLT1 DYNC1H1 DYNC1I2 DYNC1LI2 | Salmonella infection |
| WP:WP4352 | 2.81343449223e-06 | 0.625 | DYNC1LI1 DYNLT1 DYNC1H1 DYNC1I2 DYNC2I2 | Ciliary landscape |
| REAC:R-HSA-9663891 | 9.3792090956e-06 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Selective autophagy |
| KEGG:04145 | 2.14237071886e-05 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Phagosome |
| REAC:R-HSA-141444 | 2.14810904075e-05 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 2.14810904075e-05 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Amplification of signal from the kinetochores |
| REAC:R-HSA-6807878 | 2.55163225974e-05 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | COPI-mediated anterograde transport |
| REAC:R-HSA-69620 | 2.78130741896e-05 | 0.625 | DYNC1LI1 PCBP4 DYNC1H1 DYNC1I2 DYNC1LI2 | Cell Cycle Checkpoints |
| REAC:R-HSA-69618 | 4.10552092745e-05 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-9648025 | 4.92719380171e-05 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | EML4 and NUDC in mitotic spindle formation |
| GO:0007018 | 5.22137331801e-05 | 0.75 | DYNLT1 DYNC2I2 DYNC1I2 DYNC1LI1 DYNC1H1 DYNC1LI2 | microtubule-based movement |
| REAC:R-HSA-2132295 | 5.66828303964e-05 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | MHC class II antigen presentation |
| REAC:R-HSA-9609690 | 6.27645062694e-05 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | HCMV Early Events |
| REAC:R-HSA-2500257 | 6.48960058064e-05 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-1632852 | 7.63750276844e-05 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Macroautophagy |
| REAC:R-HSA-8856688 | 7.63750276844e-05 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Golgi-to-ER retrograde transport |
| REAC:R-HSA-5663220 | 9.20763585551e-05 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | RHO GTPases Activate Formins |
| REAC:R-HSA-9612973 | 0.000119991173414 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Autophagy |
| REAC:R-HSA-9609646 | 0.000123441958688 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | HCMV Infection |
| REAC:R-HSA-199977 | 0.000126966247042 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | ER to Golgi Anterograde Transport |
| CORUM:6038 | 0.000143457417375 | 0.25 | DYNC1H1 DYNC1LI1 | Dynein complex |
| CORUM:6039 | 0.000239030245992 | 0.25 | DYNC1H1 DYNC1LI1 | Dynein-dynactin complex |
| REAC:R-HSA-948021 | 0.000265948733232 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-2467813 | 0.000348181384989 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Separation of Sister Chromatids |
| REAC:R-HSA-6811442 | 0.000421277670154 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| REAC:R-HSA-68877 | 0.000438960882413 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 0.000749055316945 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.000762505701986 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Mitotic Metaphase and Anaphase |
| CORUM:6236 | 0.00157457895347 | 0.25 | DYNLT1 DYNC2I2 | Dynein-2 complex, cytoplasmic |
| REAC:R-HSA-1640170 | 0.00178497530737 | 0.625 | DYNC1LI1 PCBP4 DYNC1H1 DYNC1I2 DYNC1LI2 | Cell Cycle |
| REAC:R-HSA-446203 | 0.00192825651353 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Asparagine N-linked glycosylation |
| REAC:R-HSA-195258 | 0.00230324362175 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | RHO GTPase Effectors |
| REAC:R-HSA-68886 | 0.00662679219127 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | M Phase |
| GO:0007017 | 0.0144794406787 | 0.75 | DYNLT1 DYNC2I2 DYNC1I2 DYNC1LI1 DYNC1H1 DYNC1LI2 | microtubule-based process |
| REAC:R-HSA-69278 | 0.0220129016806 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Cell Cycle, Mitotic |
| REAC:R-HSA-5617833 | 0.0241789966573 | 0.375 | DYNC2I2 DYNC1I2 DYNC1H1 | Cilium Assembly |
| REAC:R-HSA-199991 | 0.0307022914608 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Membrane Trafficking |
| WP:WP4906 | 0.0376097283422 | 0.25 | DYNLT1 DYNC2I2 | 3q29 copy number variation syndrome |
| REAC:R-HSA-5653656 | 0.0379039189287 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Vesicle-mediated transport |
| REAC:R-HSA-194315 | 0.0443350038176 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 0.0482664296552 | 0.5 | DYNC1LI2 DYNC1LI1 DYNC1I2 DYNC1H1 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DYNC1I2 | DYNC1LI2 | 1.0 | 0.586 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| DYNC1I2 | DYNC1LI1 | 1.0 | 0.63 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| DYNC1LI1 | DYNLT1 | 1.0 | 0.256 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta () boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| DYNC1LI2 | DYNLT1 | 1.0 | 0.236 | hein_WMM bioplex_WMM bioplex3_WMM gupta () boldt youn_WMM Malo gupta_WMM fraction boldt_WMM | |
| DYNC1I2 | DYNLT1 | 1.0 | 0.71 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta () boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | |
| DYNC1LI2 | DYNC1LI1 | 0.999 | 0.296 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM | |
| DYNC1LI2 | DYNC1H1 | 0.999 | 0.488 | hein_WMM bioplex_WMM bioplex3_WMM boldt hein () Malo gupta_WMM fraction boldt_WMM | |
| DYNC1H1 | DYNLT1 | 0.999 | 0.502 | hein_WMM bioplex_WMM bioplex3_WMM gupta () boldt Malo gupta_WMM fraction boldt_WMM | |
| DYNC1H1 | DYNC1LI1 | 0.999 | 0.618 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| DYNC1I2 | DYNC1H1 | 0.999 | 0.922 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| DYNC1I2 | C2CD2 | 0.995 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DYNLT1 | C2CD2 | 0.994 | 0.056 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DYNC1LI2 | C2CD2 | 0.987 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DYNC2I2 | DYNC1I2 | 0.981 | 0.046 |
mutually_exclusive (Q9NP97)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM |
| PCBP4 | DYNC1LI1 | 0.978 | 0.172 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DYNC1H1 | C2CD2 | 0.976 | 0.149184931507 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PCBP4 | DYNC1I2 | 0.969 | 0.05 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DYNC1LI1 | C2CD2 | 0.968 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DYNC2I2 | DYNC1LI2 | 0.953 | 0.058 | hein_WMM bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only | |
| PCBP4 | DYNLT1 | 0.952 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PCBP4 | DYNC1H1 | 0.918 | 0.19 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PCBP4 | DYNC1LI2 | 0.876 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DYNC2I2 | DYNC1H1 | 0.874 | 0.198 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM | |
| DYNC2I2 | DYNC1LI1 | 0.818 | 0.082 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM | |
| DYNC2I2 | DYNLT1 | 0.671 | 0.098 |
structurally_consistent (Q8WW35)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta () boldt gupta_WMM boldt_WMM |
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