hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09562.1

Complex Portal: CPX-14272

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
KIAA2013	Uncharacterized protein KIAA2013	3	UniProt NCBI
ATP6AP1	V-type proton ATPase subunit S1 (V-ATPase subunit S1) (Protein XAP-3) (V-ATPase Ac45 subunit) (V-ATPase S1 accessory protein) (Vacuolar proton pump subunit S1)	5	UniProt NCBI
VMA21	Vacuolar ATPase assembly integral membrane protein VMA21 (Myopathy with excessive autophagy protein)	5	UniProt NCBI
CALHM5	Calcium homeostasis modulator protein 5 (Protein FAM26E)	2	UniProt NCBI
ATP6V0D2	V-type proton ATPase subunit d 2 (V-ATPase subunit d 2) (Vacuolar proton pump subunit d 2)	5	UniProt NCBI
ATP6V0C	V-type proton ATPase 16 kDa proteolipid subunit c (V-ATPase 16 kDa proteolipid subunit c) (Vacuolar proton pump 16 kDa proteolipid subunit c)	5	UniProt NCBI
GPRC5A	Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1)	5	UniProt NCBI
TMEM199	Transmembrane protein 199	5	UniProt NCBI
CYBRD1	Plasma membrane ascorbate-dependent reductase CYBRD1 (EC 7.2.1.3) (Cytochrome b reductase 1) (Duodenal cytochrome b) (Ferric-chelate reductase 3)	5	UniProt NCBI
ATP6V0A4	V-type proton ATPase 116 kDa subunit a 4 (V-ATPase 116 kDa isoform a 4) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4) (Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform)	5	UniProt NCBI
CCDC115	Coiled-coil domain-containing protein 115	5	UniProt NCBI
SLC14A1	Urea transporter 1 (Solute carrier family 14 member 1) (Urea transporter, erythrocyte)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0033176	3.42862624335e-10	0.5	ATP6V0A4 ATP6V0C ATP6V0D2 ATP6AP1 TMEM199 CCDC115	proton-transporting V-type ATPase complex
GO:0007035	1.27733005709e-09	0.5	ATP6V0A4 ATP6V0C ATP6V0D2 ATP6AP1 TMEM199 CCDC115	vacuolar acidification
GO:0051452	1.51751984283e-08	0.5	ATP6V0A4 ATP6V0C ATP6V0D2 ATP6AP1 TMEM199 CCDC115	intracellular pH reduction
GO:0016469	2.37989266664e-08	0.5	ATP6V0A4 ATP6V0C ATP6V0D2 ATP6AP1 TMEM199 CCDC115	proton-transporting two-sector ATPase complex
REAC:R-HSA-917937	9.88555287361e-08	0.416666666667	ATP6V0A4 ATP6AP1 ATP6V0C CYBRD1 ATP6V0D2	Iron uptake and transport
GO:0051453	1.67835121798e-07	0.5	ATP6V0A4 ATP6V0C ATP6V0D2 ATP6AP1 TMEM199 CCDC115	regulation of intracellular pH
GO:0016471	1.86529203578e-07	0.416666666667	TMEM199 ATP6V0D2 CCDC115 ATP6V0A4 ATP6V0C	vacuolar proton-transporting V-type ATPase complex
GO:0030641	2.05942960546e-07	0.5	ATP6V0A4 ATP6V0C ATP6V0D2 ATP6AP1 TMEM199 CCDC115	regulation of cellular pH
GO:0006885	2.76417702997e-07	0.5	ATP6V0A4 ATP6V0C ATP6V0D2 ATP6AP1 TMEM199 CCDC115	regulation of pH
REAC:R-HSA-917977	1.43419085542e-06	0.333333333333	ATP6V0A4 ATP6AP1 ATP6V0C ATP6V0D2	Transferrin endocytosis and recycling
REAC:R-HSA-77387	1.43419085542e-06	0.333333333333	ATP6V0A4 ATP6AP1 ATP6V0C ATP6V0D2	Insulin receptor recycling
KEGG:05110	1.98133911025e-06	0.333333333333	ATP6V0A4 ATP6AP1 ATP6V0C ATP6V0D2	Vibrio cholerae infection
KEGG:05120	7.85882639304e-06	0.333333333333	ATP6V0A4 ATP6AP1 ATP6V0C ATP6V0D2	Epithelial cell signaling in Helicobacter pylori infection
KEGG:05323	1.07209126673e-05	0.333333333333	ATP6V0A4 ATP6AP1 ATP6V0C ATP6V0D2	Rheumatoid arthritis
GO:1904949	2.92737601591e-05	0.5	ATP6V0A4 ATP6V0C ATP6V0D2 ATP6AP1 TMEM199 CCDC115	ATPase complex
REAC:R-HSA-74752	3.84961331774e-05	0.333333333333	ATP6V0A4 ATP6AP1 ATP6V0C ATP6V0D2	Signaling by Insulin receptor
KEGG:04966	3.85714388945e-05	0.25	ATP6V0A4 ATP6V0D2 ATP6V0C	Collecting duct acid secretion
GO:0007042	5.01531664718e-05	0.333333333333	TMEM199 ATP6AP1 CCDC115 ATP6V0C	lysosomal lumen acidification
GO:0030003	6.38397202598e-05	0.583333333333	ATP6V0A4 ATP6V0C ATP6V0D2 CYBRD1 ATP6AP1 TMEM199 CCDC115	intracellular monoatomic cation homeostasis
GO:0006873	6.82896048914e-05	0.583333333333	ATP6V0A4 ATP6V0C ATP6V0D2 CYBRD1 ATP6AP1 TMEM199 CCDC115	intracellular monoatomic ion homeostasis
KEGG:00190	0.00011291543673	0.333333333333	ATP6V0A4 ATP6AP1 ATP6V0C ATP6V0D2	Oxidative phosphorylation
KEGG:04142	0.00011665955742	0.333333333333	ATP6V0A4 ATP6AP1 ATP6V0C ATP6V0D2	Lysosome
GO:0055080	0.000126832757664	0.583333333333	ATP6V0A4 ATP6V0C ATP6V0D2 CYBRD1 ATP6AP1 TMEM199 CCDC115	monoatomic cation homeostasis
GO:0035751	0.000137193142432	0.333333333333	TMEM199 ATP6AP1 CCDC115 ATP6V0C	regulation of lysosomal lumen pH
GO:0050801	0.00014319569273	0.583333333333	ATP6V0A4 ATP6V0C ATP6V0D2 CYBRD1 ATP6AP1 TMEM199 CCDC115	monoatomic ion homeostasis
KEGG:04145	0.000154648754349	0.333333333333	ATP6V0A4 ATP6AP1 ATP6V0C ATP6V0D2	Phagosome
GO:0005774	0.000158174754356	0.583333333333	ATP6V0A4 ATP6V0C ATP6V0D2 CYBRD1 ATP6AP1 TMEM199 CCDC115	vacuolar membrane
KEGG:05152	0.000231052038115	0.333333333333	ATP6V0A4 ATP6AP1 ATP6V0C ATP6V0D2	Tuberculosis
GO:0005773	0.00024536213774	0.666666666667	ATP6V0A4 VMA21 ATP6V0C ATP6V0D2 CYBRD1 ATP6AP1 TMEM199 CCDC115	vacuole
GO:0055082	0.000371056501842	0.583333333333	ATP6V0A4 ATP6V0C ATP6V0D2 CYBRD1 ATP6AP1 TMEM199 CCDC115	intracellular chemical homeostasis
WP:WP4917	0.000444083318466	0.25	ATP6V0A4 ATP6V0D2 ATP6V0C	Proximal tubule transport
REAC:R-HSA-382551	0.000476277230773	0.5	ATP6V0A4 SLC14A1 ATP6V0C ATP6V0D2 CYBRD1 ATP6AP1	Transport of small molecules
REAC:R-HSA-1222556	0.000509950447386	0.25	ATP6V0A4 ATP6V0D2 ATP6V0C	ROS and RNS production in phagocytes
REAC:R-HSA-983712	0.000629980143555	0.333333333333	ATP6V0A4 ATP6AP1 ATP6V0C ATP6V0D2	Ion channel transport
KEGG:04721	0.000732648785132	0.25	ATP6V0A4 ATP6V0D2 ATP6V0C	Synaptic vesicle cycle
GO:0019725	0.00126067414654	0.583333333333	ATP6V0A4 ATP6V0C ATP6V0D2 CYBRD1 ATP6AP1 TMEM199 CCDC115	cellular homeostasis
GO:0006879	0.00318848865688	0.333333333333	ATP6AP1 CCDC115 CYBRD1 TMEM199	intracellular iron ion homeostasis
GO:0036295	0.00347628273893	0.25	ATP6AP1 CCDC115 TMEM199	cellular response to increased oxygen levels
KEGG:05165	0.00363400593986	0.333333333333	ATP6V0A4 ATP6AP1 ATP6V0C ATP6V0D2	Human papillomavirus infection
GO:0048878	0.00426234599635	0.583333333333	ATP6V0A4 ATP6V0C ATP6V0D2 CYBRD1 ATP6AP1 TMEM199 CCDC115	chemical homeostasis
GO:0036296	0.00463290208809	0.25	ATP6AP1 CCDC115 TMEM199	response to increased oxygen levels
HP:0012345	0.00746287649073	0.25	ATP6AP1 CCDC115 TMEM199	Abnormal glycosylation
HP:0012358	0.0134884857584	0.166666666667	ATP6AP1 TMEM199	Abnormal protein O-linked glycosylation
HP:0003124	0.0146835027354	0.25	ATP6AP1 CCDC115 TMEM199	Hypercholesterolemia
GO:0007040	0.022014592736	0.333333333333	TMEM199 ATP6AP1 CCDC115 ATP6V0C	lysosome organization
GO:0080171	0.022014592736	0.333333333333	TMEM199 ATP6AP1 CCDC115 ATP6V0C	lytic vacuole organization
HP:0010837	0.0231020257076	0.166666666667	TMEM199 CCDC115	Decreased circulating ceruloplasmin concentration
HP:0033144	0.0352625662553	0.166666666667	TMEM199 CCDC115	Abnormal circulating ceruloplasmin concentration

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
VMA21	ATP6V0D2	1.0
CCDC115	ATP6V0D2	1.0		structurally_consistent (dimer)
TMEM199	ATP6V0C	1.0	0.09	structurally_consistent (dimer)
ATP6V0D2	ATP6AP1	1.0
VMA21	TMEM199	1.0	0.04
ATP6V0D2	TMEM199	1.0		structurally_consistent (P27449)
TMEM199	ATP6AP1	1.0	0.32	structurally_consistent (P27449)
CCDC115	TMEM199	0.999	0.458	structurally_consistent (dimer)
CCDC115	ATP6AP1	0.999	0.092
VMA21	ATP6V0C	0.999	0.052	structurally_consistent (dimer)
ATP6V0D2	ATP6V0C	0.999		structurally_consistent (dimer)
CCDC115	ATP6V0C	0.999	0.044
KIAA2013	VMA21	0.998	0.096	mutually_exclusive (P27449)
ATP6V0C	ATP6AP1	0.997	0.078	structurally_consistent (dimer)
CCDC115	ATP6V0A4	0.997	0.138
SLC14A1	CYBRD1	0.997	0.048
KIAA2013	CCDC115	0.997	0.078
KIAA2013	ATP6AP1	0.994	0.164
VMA21	CCDC115	0.994	0.092
VMA21	ATP6V0A4	0.994	0.056	mutually_exclusive (P27449)
KIAA2013	TMEM199	0.986	0.176
CYBRD1	GPRC5A	0.986	0.108
VMA21	ATP6AP1	0.985	0.128	structurally_consistent (P27449)
SLC14A1	TMEM199	0.985	0.058	structurally_consistent (P27449)
CYBRD1	CCDC115	0.981	0.102
SLC14A1	CCDC115	0.981	0.092
ATP6V0A4	ATP6V0C	0.98	0.086	structurally_consistent (dimer)
CYBRD1	TMEM199	0.978	0.098
KIAA2013	ATP6V0C	0.972	0.094	structurally_consistent (dimer)
TMEM199	GPRC5A	0.972	0.096
KIAA2013	ATP6V0D2	0.972		structurally_consistent (P27449)
SLC14A1	ATP6V0D2	0.972		structurally_consistent (dimer)
ATP6V0A4	ATP6V0D2	0.972
CCDC115	GPRC5A	0.971	0.07
CALHM5	ATP6V0C	0.963	0.102
SLC14A1	ATP6V0C	0.956	0.086	structurally_consistent (dimer)
CYBRD1	ATP6AP1	0.956	0.078
ATP6V0A4	TMEM199	0.954	0.116	mutually_exclusive (P27449)
GPRC5A	ATP6AP1	0.892	0.066
ATP6V0A4	ATP6AP1	0.879	0.1	structurally_consistent (P27449)
SLC14A1	ATP6AP1	0.727	0.096
CYBRD1	ATP6V0D2	0.279
CYBRD1	ATP6V0C	0.274	0.118
VMA21	GPRC5A	0.204	0.034
CYBRD1	VMA21	0.133	0.046
ATP6V0D2	GPRC5A	0.133
KIAA2013	ATP6V0A4	0.116	0.092	mutually_exclusive (P27449)
GPRC5A	ATP6V0C	0.113	0.066
KIAA2013	GPRC5A	0.064	0.022
KIAA2013	CYBRD1	0.056	0.078
SLC14A1	GPRC5A	0.043	0.084

Related Complexes

Genename	Complexes
KIAA2013	huMAP3_00308.1 huMAP3_05318.1 huMAP3_07558.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09477.1 huMAP3_09562.1 huMAP3_10511.1 huMAP3_10516.1
ATP6AP1	huMAP3_09562.1 huMAP3_10516.1 huMAP3_12042.1
VMA21	huMAP3_01342.1 huMAP3_01538.1 huMAP3_05805.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_11642.1 huMAP3_12042.1 huMAP3_13118.1 huMAP3_13872.1
CALHM5	huMAP3_00821.1 huMAP3_01934.1 huMAP3_08494.1 huMAP3_09562.1 huMAP3_11408.1 huMAP3_12042.1 huMAP3_12887.1 huMAP3_12949.1 huMAP3_13439.1 huMAP3_15220.1
ATP6V0D2	huMAP3_01501.1 huMAP3_05083.1 huMAP3_05318.1 huMAP3_05805.1 huMAP3_07329.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_08678.1 huMAP3_09477.1 huMAP3_09562.1 huMAP3_09873.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13872.1
ATP6V0C	huMAP3_03313.1 huMAP3_05083.1 huMAP3_05318.1 huMAP3_05805.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_08494.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13872.1
GPRC5A	huMAP3_01609.1 huMAP3_04056.1 huMAP3_04452.1 huMAP3_05687.1 huMAP3_05805.1 huMAP3_08151.1 huMAP3_08166.1 huMAP3_08718.1 huMAP3_09165.1 huMAP3_09440.1 huMAP3_09562.1 huMAP3_10725.1 huMAP3_12042.1
TMEM199	huMAP3_01538.1 huMAP3_04056.1 huMAP3_05805.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1
CYBRD1	huMAP3_00361.1 huMAP3_01609.1 huMAP3_05805.1 huMAP3_06790.1 huMAP3_08151.1 huMAP3_08166.1 huMAP3_09440.1 huMAP3_09562.1 huMAP3_10516.1 huMAP3_12042.1
ATP6V0A4	huMAP3_01342.1 huMAP3_01538.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13118.1 huMAP3_13872.1
CCDC115	huMAP3_01342.1 huMAP3_01538.1 huMAP3_05805.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1
SLC14A1	huMAP3_00361.1 huMAP3_00622.1 huMAP3_01538.1 huMAP3_04056.1 huMAP3_04243.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_11123.1 huMAP3_12042.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09562.1

Complex Portal: CPX-14272