hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09565.1

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
VMA21	Vacuolar ATPase assembly integral membrane protein VMA21 (Myopathy with excessive autophagy protein)	5	UniProt NCBI
AQP5	Aquaporin-5 (AQP-5)	5	UniProt NCBI
ATP6V0C	V-type proton ATPase 16 kDa proteolipid subunit c (V-ATPase 16 kDa proteolipid subunit c) (Vacuolar proton pump 16 kDa proteolipid subunit c)	5	UniProt NCBI
ATP6V0A2	V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2)	5	UniProt NCBI
ATP6V0E1	V-type proton ATPase subunit e 1 (V-ATPase subunit e 1) (V-ATPase 9.2 kDa membrane accessory protein) (V-ATPase M9.2 subunit) (Vacuolar proton pump subunit e 1)	5	UniProt NCBI
TMEM199	Transmembrane protein 199	5	UniProt NCBI
ATP6V0A4	V-type proton ATPase 116 kDa subunit a 4 (V-ATPase 116 kDa isoform a 4) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4) (Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform)	5	UniProt NCBI
CCDC115	Coiled-coil domain-containing protein 115	5	UniProt NCBI
SLC14A1	Urea transporter 1 (Solute carrier family 14 member 1) (Urea transporter, erythrocyte)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0007035	1.16571800139e-10	0.666666666667	ATP6V0E1 ATP6V0C ATP6V0A2 ATP6V0A4 CCDC115 TMEM199	vacuolar acidification
GO:0051452	1.38809802007e-09	0.666666666667	ATP6V0E1 ATP6V0C ATP6V0A2 ATP6V0A4 CCDC115 TMEM199	intracellular pH reduction
GO:0051453	1.54036817355e-08	0.666666666667	ATP6V0E1 ATP6V0C ATP6V0A2 ATP6V0A4 CCDC115 TMEM199	regulation of intracellular pH
GO:0030641	1.89078424658e-08	0.666666666667	ATP6V0E1 ATP6V0C ATP6V0A2 ATP6V0A4 CCDC115 TMEM199	regulation of cellular pH
GO:0006885	2.53916490938e-08	0.666666666667	ATP6V0E1 ATP6V0C ATP6V0A2 ATP6V0A4 CCDC115 TMEM199	regulation of pH
KEGG:04966	2.95302312633e-08	0.444444444444	ATP6V0E1 ATP6V0A4 ATP6V0C ATP6V0A2	Collecting duct acid secretion
GO:0016471	2.97616055168e-08	0.555555555556	ATP6V0A4 CCDC115 ATP6V0C TMEM199 ATP6V0A2	vacuolar proton-transporting V-type ATPase complex
GO:0033176	3.80200340498e-08	0.555555555556	ATP6V0A4 CCDC115 ATP6V0C TMEM199 ATP6V0A2	proton-transporting V-type ATPase complex
REAC:R-HSA-917977	3.19610399382e-07	0.444444444444	ATP6V0E1 ATP6V0A4 ATP6V0C ATP6V0A2	Transferrin endocytosis and recycling
REAC:R-HSA-77387	3.19610399382e-07	0.444444444444	ATP6V0E1 ATP6V0A4 ATP6V0C ATP6V0A2	Insulin receptor recycling
REAC:R-HSA-1222556	4.90758223578e-07	0.444444444444	ATP6V0E1 ATP6V0A4 ATP6V0C ATP6V0A2	ROS and RNS production in phagocytes
KEGG:05110	4.93890189783e-07	0.444444444444	ATP6V0E1 ATP6V0A4 ATP6V0C ATP6V0A2	Vibrio cholerae infection
GO:0016469	1.22120697132e-06	0.555555555556	ATP6V0A4 CCDC115 ATP6V0C TMEM199 ATP6V0A2	proton-transporting two-sector ATPase complex
KEGG:04721	1.60977800925e-06	0.444444444444	ATP6V0E1 ATP6V0A4 ATP6V0C ATP6V0A2	Synaptic vesicle cycle
KEGG:05120	1.96478728772e-06	0.444444444444	ATP6V0E1 ATP6V0A4 ATP6V0C ATP6V0A2	Epithelial cell signaling in Helicobacter pylori infection
KEGG:05323	2.68254494734e-06	0.444444444444	ATP6V0E1 ATP6V0A4 ATP6V0C ATP6V0A2	Rheumatoid arthritis
REAC:R-HSA-917937	4.19823601739e-06	0.444444444444	ATP6V0E1 ATP6V0A4 ATP6V0C ATP6V0A2	Iron uptake and transport
REAC:R-HSA-74752	8.62700529853e-06	0.444444444444	ATP6V0E1 ATP6V0A4 ATP6V0C ATP6V0A2	Signaling by Insulin receptor
KEGG:00190	2.85056927277e-05	0.444444444444	ATP6V0E1 ATP6V0A4 ATP6V0C ATP6V0A2	Oxidative phosphorylation
KEGG:04145	3.91057568001e-05	0.444444444444	ATP6V0E1 ATP6V0A4 ATP6V0C ATP6V0A2	Phagosome
REAC:R-HSA-382551	4.14784262889e-05	0.666666666667	AQP5 ATP6V0C ATP6V0E1 ATP6V0A2 SLC14A1 ATP6V0A4	Transport of small molecules
WP:WP4917	0.000133165830465	0.333333333333	ATP6V0E1 ATP6V0C ATP6V0A4	Proximal tubule transport
REAC:R-HSA-983712	0.000142628039134	0.444444444444	ATP6V0E1 ATP6V0A4 ATP6V0C ATP6V0A2	Ion channel transport
GO:0030003	0.000338907718986	0.666666666667	ATP6V0E1 ATP6V0C ATP6V0A2 ATP6V0A4 CCDC115 TMEM199	intracellular monoatomic cation homeostasis
GO:0006873	0.000359112029499	0.666666666667	ATP6V0E1 ATP6V0C ATP6V0A2 ATP6V0A4 CCDC115 TMEM199	intracellular monoatomic ion homeostasis
GO:0030670	0.000367247519095	0.444444444444	ATP6V0E1 ATP6V0A4 ATP6V0C ATP6V0A2	phagocytic vesicle membrane
GO:1904949	0.000442390174864	0.555555555556	ATP6V0A4 CCDC115 ATP6V0C TMEM199 ATP6V0A2	ATPase complex
GO:0005773	0.000451782097262	0.777777777778	ATP6V0E1 TMEM199 ATP6V0A2 VMA21 CCDC115 ATP6V0A4 ATP6V0C	vacuole
GO:0055080	0.000611458444245	0.666666666667	ATP6V0E1 ATP6V0C ATP6V0A2 ATP6V0A4 CCDC115 TMEM199	monoatomic cation homeostasis
GO:0050801	0.000678709374776	0.666666666667	ATP6V0E1 ATP6V0C ATP6V0A2 ATP6V0A4 CCDC115 TMEM199	monoatomic ion homeostasis
GO:0005774	0.000739337478049	0.666666666667	ATP6V0E1 ATP6V0C ATP6V0A2 ATP6V0A4 CCDC115 TMEM199	vacuolar membrane
KEGG:05165	0.000943854596602	0.444444444444	ATP6V0E1 ATP6V0A4 ATP6V0C ATP6V0A2	Human papillomavirus infection
GO:1902600	0.00111503328238	0.444444444444	ATP6V0E1 ATP6V0A4 ATP6V0C ATP6V0A2	proton transmembrane transport
GO:0036295	0.00132894467527	0.333333333333	CCDC115 ATP6V0A2 TMEM199	cellular response to increased oxygen levels
GO:0055082	0.00153976470855	0.666666666667	ATP6V0E1 ATP6V0C ATP6V0A2 ATP6V0A4 CCDC115 TMEM199	intracellular chemical homeostasis
GO:0036296	0.00177138039123	0.333333333333	CCDC115 ATP6V0A2 TMEM199	response to increased oxygen levels
KEGG:04142	0.00238073539391	0.333333333333	ATP6V0A4 ATP6V0C ATP6V0A2	Lysosome
HP:0012345	0.00250410252496	0.333333333333	CCDC115 ATP6V0A2 TMEM199	Abnormal glycosylation
KEGG:05152	0.00396874980186	0.333333333333	ATP6V0A4 ATP6V0C ATP6V0A2	Tuberculosis
GO:0019725	0.00441531067767	0.666666666667	ATP6V0E1 ATP6V0C ATP6V0A2 ATP6V0A4 CCDC115 TMEM199	cellular homeostasis
GO:0045335	0.00656544696377	0.444444444444	ATP6V0E1 ATP6V0A4 ATP6V0C ATP6V0A2	phagocytic vesicle
GO:0007042	0.00778531456229	0.333333333333	CCDC115 ATP6V0C TMEM199	lysosomal lumen acidification
HP:0010837	0.0110078716337	0.222222222222	CCDC115 TMEM199	Decreased circulating ceruloplasmin concentration
GO:0048878	0.0126268944909	0.666666666667	ATP6V0E1 ATP6V0C ATP6V0A2 ATP6V0A4 CCDC115 TMEM199	chemical homeostasis
GO:0035751	0.0162365457737	0.333333333333	CCDC115 ATP6V0C TMEM199	regulation of lysosomal lumen pH
HP:0033144	0.0168068410612	0.222222222222	CCDC115 TMEM199	Abnormal circulating ceruloplasmin concentration
REAC:R-HSA-9006934	0.0199771648526	0.444444444444	ATP6V0E1 ATP6V0A4 ATP6V0C ATP6V0A2	Signaling by Receptor Tyrosine Kinases

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
TMEM199	ATP6V0C	1.0	0.09	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM
CCDC115	ATP6V0A2	1.0	0.066	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM
VMA21	ATP6V0A2	1.0	0.008	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM
VMA21	TMEM199	1.0	0.04	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM
TMEM199	ATP6V0A2	1.0	0.102	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM
CCDC115	TMEM199	0.999	0.458	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM
VMA21	ATP6V0C	0.999	0.052	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM
CCDC115	ATP6V0C	0.999	0.044	bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only
ATP6V0A2	ATP6V0C	0.998	0.066	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM
CCDC115	ATP6V0A4	0.997	0.138	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
VMA21	CCDC115	0.994	0.092	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
VMA21	ATP6V0A4	0.994	0.056	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
SLC14A1	TMEM199	0.985	0.058	bioplex3_WMM bioplex3_HCT116 WMM_only
SLC14A1	CCDC115	0.981	0.092	bioplex3_WMM bioplex3_HCT116 WMM_only
ATP6V0A4	ATP6V0C	0.98	0.086	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
CCDC115	ATP6V0E1	0.972		bioplex3_HEK293 bioplex ()
ATP6V0E1	ATP6V0A2	0.966		bioplex3_HEK293 bioplex ()
SLC14A1	ATP6V0C	0.956	0.086	bioplex3_WMM bioplex3_HCT116 WMM_only
ATP6V0A4	TMEM199	0.954	0.116	bioplex3_HEK293 bioplex3_WMM WMM_only
ATP6V0A2	AQP5	0.954		bioplex3_WMM bioplex3_HCT116 WMM_only
SLC14A1	ATP6V0A2	0.918	0.126	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
VMA21	ATP6V0E1	0.91		bioplex3_HEK293 bioplex ()
ATP6V0E1	TMEM199	0.866		bioplex3_HEK293 bioplex ()
ATP6V0A4	ATP6V0A2	0.348	0.064	bioplex3_HEK293 bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
VMA21	huMAP3_01342.1 huMAP3_01538.1 huMAP3_05805.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_11642.1 huMAP3_12042.1 huMAP3_13118.1 huMAP3_13872.1
AQP5	huMAP3_01575.1 huMAP3_03999.1 huMAP3_05374.1 huMAP3_07558.1 huMAP3_08032.1 huMAP3_08182.1 huMAP3_09324.1 huMAP3_09565.1 huMAP3_09873.1 huMAP3_10511.1 huMAP3_11642.1 huMAP3_11743.1 huMAP3_12042.1 huMAP3_12056.1
ATP6V0C	huMAP3_03313.1 huMAP3_05083.1 huMAP3_05318.1 huMAP3_05805.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_08494.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13872.1
ATP6V0A2	huMAP3_01575.1 huMAP3_02239.1 huMAP3_03999.1 huMAP3_05374.1 huMAP3_05805.1 huMAP3_07558.1 huMAP3_08032.1 huMAP3_08182.1 huMAP3_09324.1 huMAP3_09565.1 huMAP3_09873.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_11642.1 huMAP3_12042.1 huMAP3_13872.1
ATP6V0E1	huMAP3_01538.1 huMAP3_03999.1 huMAP3_07558.1 huMAP3_08032.1 huMAP3_08182.1 huMAP3_09324.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_11642.1 huMAP3_12042.1 huMAP3_13872.1
TMEM199	huMAP3_01538.1 huMAP3_04056.1 huMAP3_05805.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1
ATP6V0A4	huMAP3_01342.1 huMAP3_01538.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13118.1 huMAP3_13872.1
CCDC115	huMAP3_01342.1 huMAP3_01538.1 huMAP3_05805.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1
SLC14A1	huMAP3_00361.1 huMAP3_00622.1 huMAP3_01538.1 huMAP3_04056.1 huMAP3_04243.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_11123.1 huMAP3_12042.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09565.1