hu.MAP 3.0: Complex View

Genename	Protein Name	Uniprot Annotation Score	Links
SIRT6	NAD-dependent protein deacylase sirtuin-6 (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-6) (EC 2.3.1.286) (Protein mono-ADP-ribosyltransferase sirtuin-6) (EC 2.4.2.-) (Regulatory protein SIR2 homolog 6) (hSIRT6) (SIR2-like protein 6)	5	UniProt NCBI
H2BC17	Histone H2B type 1-O (H2B-clustered histone 17) (Histone H2B.2) (Histone H2B.n) (H2B/n)	5	UniProt NCBI
GFPT2	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 2) (Glutamine:fructose-6-phosphate amidotransferase 2) (GFAT 2) (GFAT2) (Hexosephosphate aminotransferase 2)	5	UniProt NCBI
GFPT1	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 1) (Glutamine:fructose-6-phosphate amidotransferase 1) (GFAT 1) (GFAT1) (Hexosephosphate aminotransferase 1)	5	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-446210	0.000286914834749	0.5	GFPT2 GFPT1	Synthesis of UDP-N-acetyl-glucosamine
KEGG:00250	0.00116323751441	0.5	GFPT2 GFPT1	Alanine, aspartate and glutamate metabolism
KEGG:01250	0.00148789987369	0.5	GFPT2 GFPT1	Biosynthesis of nucleotide sugars
KEGG:00520	0.00247340401034	0.5	GFPT2 GFPT1	Amino sugar and nucleotide sugar metabolism
GO:0004360	0.0028092043205	0.5	GFPT2 GFPT1	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO:0070548	0.0028092043205	0.5	GFPT2 GFPT1	L-glutamine aminotransferase activity
KEGG:04931	0.0118173906169	0.5	GFPT2 GFPT1	Insulin resistance
REAC:R-HSA-446219	0.0168610262513	0.5	GFPT2 GFPT1	Synthesis of substrates in N-glycan biosythesis
REAC:R-HSA-446193	0.0267695204965	0.5	GFPT2 GFPT1	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
REAC:R-HSA-1912408	0.0290229039331	0.5	SIRT6 H2BC17	Pre-NOTCH Transcription and Translation
KEGG:05415	0.0406374666322	0.5	GFPT2 GFPT1	Diabetic cardiomyopathy
REAC:R-HSA-5693607	0.0407325822829	0.5	SIRT6 H2BC17	Processing of DNA double-strand break ends
REAC:R-HSA-1912422	0.0425656343513	0.5	SIRT6 H2BC17	Pre-NOTCH Expression and Processing
REAC:R-HSA-4085023	0.0499436884912	0.25	GFPT1	Defective GFPT1 causes CMSTA1

Protein 1	Protein 2	Score	ProteomeHD	Evidence
GFPT2	GFPT1	0.999	0.186	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM
SIRT6	GFPT1	0.991	0.14	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
SIRT6	H2BC17	0.987		bioplex3_WMM bioplex3_HCT116 WMM_only
SIRT6	GFPT2	0.977	0.032	bioplex3_HEK293 bioplex3_WMM bioplex () bioplex3_HCT116 bioplex_WMM
GFPT2	H2BC17	0.117		bioplex3_WMM WMM_only
GFPT1	H2BC17	0.061		bioplex3_WMM youn_WMM WMM_only