hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09570.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PLOD1 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (EC 1.14.11.4) (Lysyl hydroxylase 1) (LH1) | 5 | UniProt NCBI |
| COL4A1 | Collagen alpha-1(IV) chain [Cleaved into: Arresten] | 5 | UniProt NCBI |
| COL4A6 | Collagen alpha-6(IV) chain | 5 | UniProt NCBI |
| C1QTNF1 | Complement C1q tumor necrosis factor-related protein 1 (G protein-coupled receptor-interacting protein) (GIP) | 5 | UniProt NCBI |
| C1QTNF6 | Complement C1q tumor necrosis factor-related protein 6 | 5 | UniProt NCBI |
| COL8A2 | Collagen alpha-2(VIII) chain (Endothelial collagen) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1650814 | 6.86227830674e-05 | 0.6 | PLOD1 COL4A6 COL4A1 | Collagen biosynthesis and modifying enzymes |
| REAC:R-HSA-1474290 | 0.00018480745401 | 0.6 | PLOD1 COL4A6 COL4A1 | Collagen formation |
| REAC:R-HSA-2214320 | 0.0011839189519 | 0.4 | COL4A1 COL4A6 | Anchoring fibril formation |
| REAC:R-HSA-2243919 | 0.0018206657072 | 0.4 | COL4A1 COL4A6 | Crosslinking of collagen fibrils |
| REAC:R-HSA-3000157 | 0.00531742996423 | 0.4 | COL4A1 COL4A6 | Laminin interactions |
| REAC:R-HSA-1474244 | 0.00594422623006 | 0.6 | PLOD1 COL4A6 COL4A1 | Extracellular matrix organization |
| REAC:R-HSA-8948216 | 0.0065872694687 | 0.4 | COL4A1 COL4A6 | Collagen chain trimerization |
| KEGG:04512 | 0.00996128881886 | 0.4 | COL4A1 COL4A6 | ECM-receptor interaction |
| KEGG:04974 | 0.0105666091545 | 0.4 | COL4A1 COL4A6 | Protein digestion and absorption |
| REAC:R-HSA-2022090 | 0.0163316506439 | 0.4 | COL4A1 COL4A6 | Assembly of collagen fibrils and other multimeric structures |
| KEGG:05146 | 0.0164241113683 | 0.4 | COL4A1 COL4A6 | Amoebiasis |
| KEGG:05222 | 0.0164241113683 | 0.4 | COL4A1 COL4A6 | Small cell lung cancer |
| KEGG:04933 | 0.0168082536599 | 0.4 | COL4A1 COL4A6 | AGE-RAGE signaling pathway in diabetic complications |
| REAC:R-HSA-3000171 | 0.0170393864121 | 0.4 | COL4A1 COL4A6 | Non-integrin membrane-ECM interactions |
| REAC:R-HSA-1442490 | 0.0177620315324 | 0.4 | COL4A1 COL4A6 | Collagen degradation |
| WP:WP4658 | 0.0227605362571 | 0.4 | COL4A1 COL4A6 | Small cell lung cancer |
| REAC:R-HSA-3000178 | 0.0249357389386 | 0.4 | COL4A1 COL4A6 | ECM proteoglycans |
| KEGG:04926 | 0.0258857078716 | 0.4 | COL4A1 COL4A6 | Relaxin signaling pathway |
| REAC:R-HSA-216083 | 0.0294410858888 | 0.4 | COL4A1 COL4A6 | Integrin cell surface interactions |
| GO:0005587 | 0.0468008499735 | 0.4 | COL4A1 COL4A6 | collagen type IV trimer |
| WP:WP4239 | 0.0499562127809 | 0.4 | COL4A1 COL4A6 | Epithelial to mesenchymal transition in colorectal cancer |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| COL8A2 | C1QTNF6 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| C1QTNF1 | C1QTNF6 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PLOD1 | COL4A1 | 0.994 | 0.12 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PLOD1 | COL4A6 | 0.988 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PLOD1 | C1QTNF1 | 0.974 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PLOD1 | C1QTNF6 | 0.969 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| COL4A6 | COL8A2 | 0.958 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PLOD1 | COL8A2 | 0.944 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| COL4A1 | C1QTNF1 | 0.938 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| COL8A2 | COL4A1 | 0.858 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| COL4A6 | C1QTNF1 | 0.83 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| COL4A6 | COL4A1 | 0.676 | bioplex_WMM bioplex3_WMM WMM_only | |
| COL4A6 | C1QTNF6 | 0.063 | bioplex3_WMM WMM_only | |
| COL4A1 | C1QTNF6 | 0.063 | bioplex3_WMM WMM_only |
Related Complexes