hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09581.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ATG101 | Autophagy-related protein 101 | 5 | UniProt NCBI |
| ULK2 | Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) | 5 | UniProt NCBI |
| ULK1 | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | 5 | UniProt NCBI |
| FAM221B | Protein FAM221B | 5 | UniProt NCBI |
| RB1CC1 | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | 5 | UniProt NCBI |
| ATG13 | Autophagy-related protein 13 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7091 | 9.60315000334e-13 | 0.666666666667 | ATG13 ATG101 ULK1 RB1CC1 | FIP200-ULK1-ATG13-ATG101 complex |
| CORUM:6232 | 9.60315000334e-13 | 0.666666666667 | ATG13 ATG101 ULK1 RB1CC1 | ULK1-ATG13-RB1CC1-ATG101 complex |
| CORUM:7065 | 3.35999837607e-11 | 0.666666666667 | ATG13 ATG101 ULK1 RB1CC1 | WDR41-(C9orf72-SMCR8)-(FIP200-ULK1-ATG13-ATG101) complex |
| WP:WP5412 | 5.66214666683e-10 | 0.666666666667 | ATG13 ATG101 ULK1 RB1CC1 | 8q11 23 RB1CC1 copy number variation |
| WP:WP4863 | 1.73012748765e-09 | 0.666666666667 | ATG13 RB1CC1 ULK2 ULK1 | Host pathogen interaction of human coronaviruses autophagy |
| CORUM:6230 | 4.67737426163e-09 | 0.5 | ATG13 ULK2 RB1CC1 | ULK2-ATG13-RB1CC1 complex |
| CORUM:6229 | 4.67737426163e-09 | 0.5 | ATG13 ULK1 RB1CC1 | ULK1-ATG13-RB1CC1 complex |
| GO:0000407 | 1.08628542536e-08 | 0.833333333333 | ATG13 ATG101 RB1CC1 ULK2 ULK1 | phagophore assembly site |
| WP:WP4923 | 1.15639051554e-08 | 0.666666666667 | ATG13 ATG101 ULK1 RB1CC1 | Autophagy |
| KEGG:05017 | 1.30270603209e-08 | 0.833333333333 | ATG13 ATG101 RB1CC1 ULK2 ULK1 | Spinocerebellar ataxia |
| KEGG:04140 | 4.00131323611e-08 | 0.833333333333 | ATG13 ATG101 RB1CC1 ULK2 ULK1 | Autophagy - animal |
| GO:1990316 | 4.97036464355e-08 | 0.666666666667 | ATG13 ATG101 ULK1 RB1CC1 | Atg1/ULK1 kinase complex |
| WP:WP4577 | 5.15475080185e-08 | 0.666666666667 | ATG13 ATG101 ULK1 RB1CC1 | Neurodegeneration with brain iron accumulation NBIA subtypes pathway |
| GO:1903059 | 8.28303368884e-08 | 0.666666666667 | ATG13 ATG101 ULK1 RB1CC1 | regulation of protein lipidation |
| GO:0034727 | 8.28303368884e-08 | 0.666666666667 | ATG13 RB1CC1 ULK2 ULK1 | piecemeal microautophagy of the nucleus |
| GO:0050746 | 2.81924903404e-07 | 0.666666666667 | ATG13 ATG101 ULK1 RB1CC1 | regulation of lipoprotein metabolic process |
| WP:WP2059 | 4.01506707733e-07 | 0.833333333333 | ATG13 ATG101 RB1CC1 ULK2 ULK1 | Alzheimer 39 s disease and miRNA effects |
| WP:WP5124 | 4.01506707733e-07 | 0.833333333333 | ATG13 ATG101 RB1CC1 ULK2 ULK1 | Alzheimer 39 s disease |
| WP:WP5205 | 4.5793474518e-07 | 0.666666666667 | ATG13 ATG101 ULK1 RB1CC1 | Clock controlled autophagy in bone metabolism |
| GO:0016237 | 5.38102340533e-07 | 0.666666666667 | ATG13 RB1CC1 ULK2 ULK1 | microautophagy |
| GO:0034045 | 5.38102340533e-07 | 0.666666666667 | ATG13 RB1CC1 ULK2 ULK1 | phagophore assembly site membrane |
| KEGG:05016 | 6.46455868087e-07 | 0.833333333333 | ATG13 ATG101 RB1CC1 ULK2 ULK1 | Huntington disease |
| KEGG:04211 | 6.74053506358e-07 | 0.666666666667 | ATG13 ATG101 ULK1 RB1CC1 | Longevity regulating pathway |
| GO:0044804 | 9.38024124582e-07 | 0.666666666667 | ATG13 RB1CC1 ULK2 ULK1 | nucleophagy |
| KEGG:05014 | 1.58391086806e-06 | 0.833333333333 | ATG13 ATG101 RB1CC1 ULK2 ULK1 | Amyotrophic lateral sclerosis |
| KEGG:05010 | 2.01666118798e-06 | 0.833333333333 | ATG13 ATG101 RB1CC1 ULK2 ULK1 | Alzheimer disease |
| GO:0000045 | 3.28516911608e-06 | 0.833333333333 | ATG13 ATG101 RB1CC1 ULK2 ULK1 | autophagosome assembly |
| GO:1905037 | 4.04546908409e-06 | 0.833333333333 | ATG13 ATG101 RB1CC1 ULK2 ULK1 | autophagosome organization |
| KEGG:05022 | 5.40342215478e-06 | 0.833333333333 | ATG13 ATG101 RB1CC1 ULK2 ULK1 | Pathways of neurodegeneration - multiple diseases |
| KEGG:04136 | 8.04611191878e-06 | 0.5 | ATG101 ULK2 ATG13 | Autophagy - other |
| WP:WP5381 | 8.55190240716e-06 | 0.666666666667 | ATG13 ATG101 ULK1 RB1CC1 | Smith Magenis and Potocki Lupski syndrome copy number variation |
| WP:WP3844 | 1.11514262748e-05 | 0.5 | ATG13 ULK1 RB1CC1 | PI3K AKT mTOR signaling pathway and therapeutic opportunities in prostate cancer |
| GO:0010508 | 1.258414027e-05 | 0.833333333333 | ATG13 ATG101 RB1CC1 ULK2 ULK1 | positive regulation of autophagy |
| REAC:R-HSA-1632852 | 1.43305165125e-05 | 0.666666666667 | ATG13 ATG101 ULK1 RB1CC1 | Macroautophagy |
| REAC:R-HSA-9612973 | 2.2551594468e-05 | 0.666666666667 | ATG13 ATG101 ULK1 RB1CC1 | Autophagy |
| GO:0007033 | 8.18917029697e-05 | 0.833333333333 | ATG13 ATG101 RB1CC1 ULK2 ULK1 | vacuole organization |
| CORUM:6816 | 0.000102488289015 | 0.333333333333 | ATG13 ULK1 | ULK1-ATG13-ATG14-PIK3C3 complex |
| WP:WP5420 | 0.000104001340343 | 0.666666666667 | ATG13 ATG101 ULK1 RB1CC1 | ADHD and autism ASD linked metabolic pathways and SNP |
| GO:0006497 | 0.000265438603659 | 0.666666666667 | ATG13 ATG101 ULK1 RB1CC1 | protein lipidation |
| GO:0042158 | 0.000282532632952 | 0.666666666667 | ATG13 ATG101 ULK1 RB1CC1 | lipoprotein biosynthetic process |
| WP:WP5087 | 0.00042685807378 | 0.666666666667 | ATG13 RB1CC1 ULK2 ULK1 | Pleural mesothelioma |
| GO:0000422 | 0.000588161116581 | 0.666666666667 | ATG13 RB1CC1 ULK2 ULK1 | autophagy of mitochondrion |
| GO:0031331 | 0.00061299016503 | 0.833333333333 | ATG13 ATG101 RB1CC1 ULK2 ULK1 | positive regulation of cellular catabolic process |
| GO:0042157 | 0.000619048899658 | 0.666666666667 | ATG13 ATG101 ULK1 RB1CC1 | lipoprotein metabolic process |
| GO:0016236 | 0.000647964473215 | 0.833333333333 | ATG13 ATG101 RB1CC1 ULK2 ULK1 | macroautophagy |
| GO:0010506 | 0.000923996225357 | 0.833333333333 | ATG13 ATG101 RB1CC1 ULK2 ULK1 | regulation of autophagy |
| GO:0061709 | 0.00130441648129 | 0.5 | RB1CC1 ULK2 ULK1 | reticulophagy |
| WP:WP2509 | 0.0023190863075 | 0.333333333333 | ULK2 ULK1 | Nanoparticle triggered autophagic cell death |
| GO:1902554 | 0.00389790049139 | 0.666666666667 | ATG13 ATG101 ULK1 RB1CC1 | serine/threonine protein kinase complex |
| WP:WP1471 | 0.00561973689916 | 0.333333333333 | ULK2 ULK1 | Target of rapamycin signaling |
| GO:0009896 | 0.00574386107031 | 0.833333333333 | ATG13 ATG101 RB1CC1 ULK2 ULK1 | positive regulation of catabolic process |
| GO:1902911 | 0.00649203481341 | 0.666666666667 | ATG13 ATG101 ULK1 RB1CC1 | protein kinase complex |
| GO:1903008 | 0.00667678491958 | 0.666666666667 | ATG13 RB1CC1 ULK2 ULK1 | organelle disassembly |
| GO:0061919 | 0.00765815290464 | 0.833333333333 | ATG13 ATG101 RB1CC1 ULK2 ULK1 | process utilizing autophagic mechanism |
| GO:0006914 | 0.00765815290464 | 0.833333333333 | ATG13 ATG101 RB1CC1 ULK2 ULK1 | autophagy |
| GO:0031329 | 0.0194919192984 | 0.833333333333 | ATG13 ATG101 RB1CC1 ULK2 ULK1 | regulation of cellular catabolic process |
| WP:WP4963 | 0.0321785953671 | 0.333333333333 | ULK2 ULK1 | p53 transcriptional gene network |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ATG101 | ATG13 | 0.998 | 0.204 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG101 | RB1CC1 | 0.998 | 0.212 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG101 | ULK1 | 0.996 | 0.104482142857 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RB1CC1 | FAM221B | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ATG101 | FAM221B | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ATG13 | FAM221B | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RB1CC1 | ATG13 | 0.982 | 0.222 | bioplex_WMM bioplex3_WMM WMM_only |
| ULK1 | FAM221B | 0.979 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ATG101 | ULK2 | 0.975 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ULK1 | ATG13 | 0.871 | 0.146 | bioplex_WMM bioplex3_WMM WMM_only |
| ULK1 | RB1CC1 | 0.868 | 0.312 | bioplex_WMM bioplex3_WMM WMM_only |
| ULK2 | ULK1 | 0.415 | bioplex3_WMM WMM_only | |
| ULK2 | ATG13 | 0.415 | bioplex3_WMM WMM_only | |
| ULK2 | RB1CC1 | 0.25 | bioplex3_WMM WMM_only |
Related Complexes