hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09585.1
Complex Portal: CPX-19688
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KIFAP3 | Kinesin-associated protein 3 (KAP-3) (KAP3) (Smg GDS-associated protein) | 5 | UniProt NCBI |
| KIF3C | Kinesin-like protein KIF3C | 5 | UniProt NCBI |
| KIF3A | Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A) | 5 | UniProt NCBI |
| KIF3B | Kinesin-like protein KIF3B (HH0048) (Microtubule plus end-directed kinesin motor 3B) [Cleaved into: Kinesin-like protein KIF3B, N-terminally processed] | 5 | UniProt NCBI |
| LYG1 | Lysozyme g-like protein 1 (EC 3.2.1.-) | 3 | UniProt NCBI |
| NCKAP5 | Nck-associated protein 5 (NAP-5) (Peripheral clock protein) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5620924 | 3.60757054426e-07 | 0.666666666667 | KIF3C KIF3B KIFAP3 KIF3A | Intraflagellar transport |
| REAC:R-HSA-983189 | 4.56391388507e-07 | 0.666666666667 | KIF3C KIF3B KIFAP3 KIF3A | Kinesins |
| GO:0016939 | 1.92240082153e-06 | 0.5 | KIF3A KIFAP3 KIF3B | kinesin II complex |
| REAC:R-HSA-6811434 | 4.19553514217e-06 | 0.666666666667 | KIF3C KIF3B KIFAP3 KIF3A | COPI-dependent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-2132295 | 1.06250680796e-05 | 0.666666666667 | KIF3C KIF3B KIFAP3 KIF3A | MHC class II antigen presentation |
| KEGG:04814 | 1.11014436202e-05 | 0.666666666667 | KIF3C KIF3B KIFAP3 KIF3A | Motor proteins |
| REAC:R-HSA-8856688 | 1.43305165125e-05 | 0.666666666667 | KIF3C KIF3B KIFAP3 KIF3A | Golgi-to-ER retrograde transport |
| GO:0072383 | 1.92180881975e-05 | 0.5 | KIF3A KIFAP3 KIF3B | plus-end-directed vesicle transport along microtubule |
| GO:0005871 | 2.5973152006e-05 | 0.666666666667 | KIF3C KIF3B KIFAP3 KIF3A | kinesin complex |
| REAC:R-HSA-983231 | 3.47573058056e-05 | 0.666666666667 | KIF3C KIF3B KIFAP3 KIF3A | Factors involved in megakaryocyte development and platelet production |
| GO:0072386 | 3.84302573496e-05 | 0.5 | KIF3A KIFAP3 KIF3B | plus-end-directed organelle transport along microtubule |
| GO:0097542 | 5.85430293603e-05 | 0.666666666667 | KIF3C KIF3B KIFAP3 KIF3A | ciliary tip |
| REAC:R-HSA-5617833 | 7.32163586678e-05 | 0.666666666667 | KIF3C KIF3B KIFAP3 KIF3A | Cilium Assembly |
| REAC:R-HSA-6811442 | 7.9631941729e-05 | 0.666666666667 | KIF3C KIF3B KIFAP3 KIF3A | Intra-Golgi and retrograde Golgi-to-ER traffic |
| CORUM:905 | 0.000170782642132 | 0.333333333333 | KIF3A KIF3B | KIF3A/B-PAR-3-aPKC-PAR-6 complex |
| REAC:R-HSA-1852241 | 0.000328328901576 | 0.666666666667 | KIF3C KIF3B KIFAP3 KIF3A | Organelle biogenesis and maintenance |
| REAC:R-HSA-1445148 | 0.000366552496151 | 0.5 | KIF3A KIFAP3 KIF3B | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| WP:WP4536 | 0.000413392056955 | 0.5 | KIF3A KIFAP3 KIF3B | Genes related to primary cilium development based on CRISPR |
| GO:0005874 | 0.000636133837305 | 0.833333333333 | KIF3C NCKAP5 KIF3B KIFAP3 KIF3A | microtubule |
| GO:0005875 | 0.00353670256676 | 0.666666666667 | KIF3C KIF3B KIFAP3 KIF3A | microtubule associated complex |
| REAC:R-HSA-109582 | 0.00428563332784 | 0.666666666667 | KIF3C KIF3B KIFAP3 KIF3A | Hemostasis |
| GO:0099513 | 0.00554260195408 | 0.833333333333 | KIF3C NCKAP5 KIF3B KIFAP3 KIF3A | polymeric cytoskeletal fiber |
| REAC:R-HSA-199991 | 0.00605429919172 | 0.666666666667 | KIF3C KIF3B KIFAP3 KIF3A | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.00750133147239 | 0.666666666667 | KIF3C KIF3B KIFAP3 KIF3A | Vesicle-mediated transport |
| REAC:R-HSA-1280218 | 0.0108211006853 | 0.666666666667 | KIF3C KIF3B KIFAP3 KIF3A | Adaptive Immune System |
| GO:0047496 | 0.0203731249082 | 0.5 | KIF3A KIFAP3 KIF3B | vesicle transport along microtubule |
| GO:0099512 | 0.0229608749472 | 0.833333333333 | KIF3C NCKAP5 KIF3B KIFAP3 KIF3A | supramolecular fiber |
| GO:0099081 | 0.0244357793752 | 0.833333333333 | KIF3C NCKAP5 KIF3B KIFAP3 KIF3A | supramolecular polymer |
| TF:M01431 | 0.0385885405689 | 1.0 | KIF3A KIF3C NCKAP5 KIFAP3 LYG1 KIF3B | Factor: Barx-2; motif: TAANTAATTANTKNTN |
| GO:0003777 | 0.0421653429605 | 0.5 | KIF3C KIF3B KIF3A | microtubule motor activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| KIFAP3 | KIF3A | 1.0 | 0.47 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| KIF3B | KIF3A | 1.0 | 0.448 |
mutually_exclusive (Q92845)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| KIFAP3 | KIF3B | 1.0 | 0.376 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| KIFAP3 | KIF3C | 0.997 | 0.116 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM |
| KIF3C | KIF3A | 0.994 | 0.202 |
mutually_exclusive (Q92845)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM |
| LYG1 | KIF3A | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| KIF3C | KIF3B | 0.983 | 0.178 |
mutually_exclusive (Q92845)
|
bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| KIF3C | NCKAP5 | 0.972 |
mutually_exclusive (Q92845)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| KIFAP3 | NCKAP5 | 0.972 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| NCKAP5 | KIF3B | 0.884 |
mutually_exclusive (Q92845)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| KIF3B | LYG1 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KIFAP3 | LYG1 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KIF3C | LYG1 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes