hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09590.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RPS6KA5 | Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) | 5 | UniProt NCBI |
| MAPK4 | Mitogen-activated protein kinase 4 (MAP kinase 4) (MAPK 4) (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK) | 5 | UniProt NCBI |
| ASTL | Astacin-like metalloendopeptidase (EC 3.4.-.-) (Oocyte astacin) (Ovastacin) (ZP2-proteinase) | 5 | UniProt NCBI |
| RPS6KA4 | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3915 | 8.35699049616e-05 | 0.75 | RPS6KA5 MAPK4 RPS6KA4 | Angiopoietin like protein 8 regulatory pathway |
| WP:WP481 | 0.000165592798419 | 0.75 | RPS6KA5 MAPK4 RPS6KA4 | Insulin signaling |
| WP:WP4566 | 0.0020866894725 | 0.5 | RPS6KA5 RPS6KA4 | Translation inhibitors in chronically activated PDGFRA cells |
| GO:0044022 | 0.0028092043205 | 0.5 | RPS6KA5 RPS6KA4 | histone H3S28 kinase activity |
| WP:WP585 | 0.00324158330579 | 0.5 | RPS6KA5 RPS6KA4 | Interferon type I signaling pathways |
| WP:WP5353 | 0.00685264055756 | 0.5 | RPS6KA5 RPS6KA4 | A network map of Macrophage stimulating protein MSP signaling |
| GO:0035175 | 0.00842684400117 | 0.5 | RPS6KA5 RPS6KA4 | histone H3S10 kinase activity |
| REAC:R-HSA-437239 | 0.0105688559686 | 0.5 | RPS6KA5 RPS6KA4 | Recycling pathway of L1 |
| KEGG:04668 | 0.011104386562 | 0.5 | RPS6KA5 RPS6KA4 | TNF signaling pathway |
| WP:WP437 | 0.0259547050416 | 0.5 | RPS6KA5 MAPK4 | EGF EGFR signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ASTL | MAPK4 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MAPK4 | RPS6KA5 | 0.969 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RPS6KA5 | RPS6KA4 | 0.962 | 0.156 | bioplex_WMM bioplex3_WMM WMM_only |
| MAPK4 | RPS6KA4 | 0.953 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ASTL | RPS6KA5 | 0.396 | bioplex3_WMM WMM_only | |
| ASTL | RPS6KA4 | 0.162 | bioplex3_WMM WMM_only |
Related Complexes