hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09595.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RAD9A | Cell cycle checkpoint control protein RAD9A (hRAD9) (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A) | 5 | UniProt NCBI |
| HUS1 | Checkpoint protein HUS1 (hHUS1) | 5 | UniProt NCBI |
| RAD1 | Cell cycle checkpoint protein RAD1 (hRAD1) (Rad1-like DNA damage checkpoint protein) | 5 | UniProt NCBI |
| HUS1B | Checkpoint protein HUS1B (hHUS1B) | 3 | UniProt NCBI |
| ZBTB14 | Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 478) (Zinc finger protein 5 homolog) (ZF5) (Zfp-5) (hZF5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030896 | 1.31563155046e-10 | 0.8 | RAD9A HUS1B RAD1 HUS1 | checkpoint clamp complex |
| CORUM:267 | 2.80233355908e-09 | 0.6 | RAD9A RAD1 HUS1 | 9-1-1 complex |
| CORUM:271 | 2.80233355908e-09 | 0.6 | RAD9A RAD1 HUS1 | 9-1-1 complex |
| CORUM:275 | 2.80233355908e-09 | 0.6 | RAD9A RAD1 HUS1 | 9-1-1 complex |
| CORUM:276 | 2.80233355908e-09 | 0.6 | RAD9A RAD1 HUS1 | 9-1-1 complex |
| CORUM:2196 | 2.80233355908e-09 | 0.6 | RAD9A RAD1 HUS1 | 9-1-1-LIG1 complex |
| CORUM:2808 | 2.80233355908e-09 | 0.6 | RAD9A RAD1 HUS1 | 9-1-1-APE1 complex |
| CORUM:2809 | 2.80233355908e-09 | 0.6 | RAD9A RAD1 HUS1 | 9-1-1 complex |
| CORUM:2198 | 1.12081835382e-08 | 0.6 | RAD9A RAD1 HUS1 | 9-1-1-POLB complex |
| CORUM:6728 | 1.12081835382e-08 | 0.6 | RAD9A RAD1 HUS1 | 9-1-1-RHINO complex |
| CORUM:2197 | 1.12081835382e-08 | 0.6 | RAD9A RAD1 HUS1 | 9-1-1-FEN1 complex |
| WP:WP3875 | 6.7587434379e-08 | 0.6 | RAD9A RAD1 HUS1 | ATR signaling |
| CORUM:274 | 1.56850139259e-07 | 0.6 | RAD9A RAD1 HUS1 | 9-1-1-RAD17-RFC complex |
| CORUM:268 | 1.56850139259e-07 | 0.6 | RAD9A RAD1 HUS1 | 9-1-1-RAD17-RFC complex |
| CORUM:6733 | 1.36501667663e-05 | 0.4 | HUS1 RAD1 | 9b-1-1 complex |
| CORUM:6734 | 1.36501667663e-05 | 0.4 | HUS1B RAD1 | 9b-1b-1 complex |
| REAC:R-HSA-9709570 | 1.861537069e-05 | 0.6 | RAD9A RAD1 HUS1 | Impaired BRCA2 binding to RAD51 |
| REAC:R-HSA-5685938 | 2.03584684634e-05 | 0.6 | RAD9A RAD1 HUS1 | HDR through Single Strand Annealing (SSA) |
| GO:0000794 | 2.14197622369e-05 | 0.8 | RAD9A HUS1B RAD1 HUS1 | condensed nuclear chromosome |
| REAC:R-HSA-176187 | 2.22069549267e-05 | 0.6 | RAD9A RAD1 HUS1 | Activation of ATR in response to replication stress |
| REAC:R-HSA-5693616 | 2.84155131715e-05 | 0.6 | RAD9A RAD1 HUS1 | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-9701190 | 3.07163147334e-05 | 0.6 | RAD9A RAD1 HUS1 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function |
| REAC:R-HSA-9675136 | 3.07163147334e-05 | 0.6 | RAD9A RAD1 HUS1 | Diseases of DNA Double-Strand Break Repair |
| REAC:R-HSA-5693579 | 3.5683276241e-05 | 0.6 | RAD9A RAD1 HUS1 | Homologous DNA Pairing and Strand Exchange |
| WP:WP707 | 5.24101251737e-05 | 0.6 | RAD9A RAD1 HUS1B | DNA damage response |
| WP:WP1530 | 5.24101251737e-05 | 0.6 | RAD9A RAD1 HUS1B | miRNA regulation of DNA damage response |
| GO:0033313 | 5.37995977657e-05 | 0.6 | HUS1 RAD1 HUS1B | meiotic cell cycle checkpoint signaling |
| REAC:R-HSA-9675135 | 5.72260849506e-05 | 0.6 | RAD9A RAD1 HUS1 | Diseases of DNA repair |
| WP:WP4016 | 8.7661751387e-05 | 0.6 | RAD9A RAD1 HUS1 | DNA IR damage and cellular response via ATR |
| REAC:R-HSA-5685942 | 0.000141884912451 | 0.6 | RAD9A RAD1 HUS1 | HDR through Homologous Recombination (HRR) |
| GO:0031573 | 0.000211268761872 | 0.6 | RAD9A HUS1B HUS1 | mitotic intra-S DNA damage checkpoint signaling |
| REAC:R-HSA-69473 | 0.000327941222395 | 0.6 | RAD9A RAD1 HUS1 | G2/M DNA damage checkpoint |
| REAC:R-HSA-6804756 | 0.000351286759397 | 0.6 | RAD9A RAD1 HUS1 | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-5693607 | 0.00036336263669 | 0.6 | RAD9A RAD1 HUS1 | Processing of DNA double-strand break ends |
| KEGG:04218 | 0.000411831232455 | 0.6 | RAD9A RAD1 HUS1 | Cellular senescence |
| GO:0000077 | 0.000649914918254 | 0.8 | RAD9A HUS1B RAD1 HUS1 | DNA damage checkpoint signaling |
| GO:0000076 | 0.000783132248318 | 0.6 | RAD9A HUS1B HUS1 | DNA replication checkpoint signaling |
| GO:0031570 | 0.000904012985399 | 0.8 | RAD9A HUS1B RAD1 HUS1 | DNA integrity checkpoint signaling |
| REAC:R-HSA-5693567 | 0.000932817738425 | 0.6 | RAD9A RAD1 HUS1 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 0.00107666549853 | 0.6 | RAD9A RAD1 HUS1 | Homology Directed Repair |
| REAC:R-HSA-5633007 | 0.00176342488404 | 0.6 | RAD9A RAD1 HUS1 | Regulation of TP53 Activity |
| REAC:R-HSA-5693532 | 0.0019808748776 | 0.6 | RAD9A RAD1 HUS1 | DNA Double-Strand Break Repair |
| REAC:R-HSA-69481 | 0.00201875981781 | 0.6 | RAD9A RAD1 HUS1 | G2/M Checkpoints |
| GO:0042770 | 0.00286397125166 | 0.8 | RAD9A HUS1B RAD1 HUS1 | signal transduction in response to DNA damage |
| GO:0000075 | 0.00378855826806 | 0.8 | RAD9A HUS1B RAD1 HUS1 | cell cycle checkpoint signaling |
| GO:0044778 | 0.00468200720083 | 0.4 | HUS1 HUS1B | meiotic DNA integrity checkpoint signaling |
| GO:0000228 | 0.00469791606681 | 0.8 | RAD9A HUS1B RAD1 HUS1 | nuclear chromosome |
| GO:1901988 | 0.00893796193013 | 0.8 | RAD9A HUS1B RAD1 HUS1 | negative regulation of cell cycle phase transition |
| GO:0000793 | 0.00911621649963 | 0.8 | RAD9A HUS1B RAD1 HUS1 | condensed chromosome |
| REAC:R-HSA-69620 | 0.0108605941756 | 0.6 | RAD9A RAD1 HUS1 | Cell Cycle Checkpoints |
| REAC:R-HSA-73894 | 0.014302073064 | 0.6 | RAD9A RAD1 HUS1 | DNA Repair |
| GO:0010948 | 0.0166452738601 | 0.8 | RAD9A HUS1B RAD1 HUS1 | negative regulation of cell cycle process |
| REAC:R-HSA-3700989 | 0.0192283148447 | 0.6 | RAD9A RAD1 HUS1 | Transcriptional Regulation by TP53 |
| GO:0071479 | 0.019918492568 | 0.6 | RAD9A RAD1 HUS1 | cellular response to ionizing radiation |
| GO:0045786 | 0.0439687701346 | 0.8 | RAD9A HUS1B RAD1 HUS1 | negative regulation of cell cycle |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HUS1 | RAD1 | 1.0 | 0.666 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RAD9A | RAD1 | 1.0 | 0.186 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RAD1 | ZBTB14 | 1.0 | 0.144 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RAD9A | HUS1B | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RAD1 | HUS1B | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RAD9A | HUS1 | 0.999 | 0.272 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| HUS1B | ZBTB14 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| HUS1 | ZBTB14 | 0.994 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RAD9A | ZBTB14 | 0.993 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only |
| HUS1 | HUS1B | 0.401 | bioplex3_WMM WMM_only |
Related Complexes