hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09598.1

Complex Portal: CPX-14564

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
NHS	Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein)	5	UniProt NCBI
WASF2	Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2)	5	UniProt NCBI
NHSL3	NHS-like protein 3	5	UniProt NCBI
BRK1	Protein BRICK1 (BRK1)	5	UniProt NCBI
ABL2	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG)	5	UniProt NCBI
SEMA6A	Semaphorin-6A (Semaphorin VIA) (Sema VIA) (Semaphorin-6A-1) (SEMA6A-1)	5	UniProt NCBI
CASKIN2	Caskin-2 (CASK-interacting protein 2)	3	UniProt NCBI
NCKAP1L	Nck-associated protein 1-like (Hematopoietic protein 1) (Membrane-associated protein HEM-1)	5	UniProt NCBI
PPFIA2	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2)	5	UniProt NCBI
RAPH1	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1)	5	UniProt NCBI
ABI1	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)	5	UniProt NCBI
NCKAP1	Nck-associated protein 1 (NAP 1) (Membrane-associated protein HEM-2) (p125Nap1)	5	UniProt NCBI
NCK1	SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)	5	UniProt NCBI
ABI2	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1)	5	UniProt NCBI
WASF1	Actin-binding protein WASF1 (Protein WAVE-1) (Verprolin homology domain-containing protein 1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1)	5	UniProt NCBI
C6orf132	Uncharacterized protein C6orf132	2	UniProt NCBI
WASF3	Actin-binding protein WASF3 (Protein WAVE-3) (Verprolin homology domain-containing protein 3) (Wiskott-Aldrich syndrome protein family member 3) (WASP family protein member 3)	5	UniProt NCBI
NHSL1	NHS-like protein 1	3	UniProt NCBI
CYFIP1	Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1)	5	UniProt NCBI
CYFIP2	Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)	5	UniProt NCBI
BAIAP2	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53)	5	UniProt NCBI
NCK2	Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)	5	UniProt NCBI
Q56UQ5	TPT1-like protein	1	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0031209	1.58709425297e-24	0.47619047619	NCKAP1 ABI1 WASF3 NCKAP1L CYFIP2 CYFIP1 ABI2 WASF2 BRK1 WASF1	SCAR complex
REAC:R-HSA-5663213	1.9656793542e-22	0.52380952381	NCKAP1 ABI1 WASF3 NCKAP1L CYFIP2 CYFIP1 BAIAP2 ABI2 WASF2 BRK1 WASF1	RHO GTPases Activate WASPs and WAVEs
REAC:R-HSA-9664407	5.17485009279e-20	0.52380952381	NCKAP1 ABI1 WASF3 NCKAP1L CYFIP2 CYFIP1 BAIAP2 ABI2 WASF2 BRK1 WASF1	Parasite infection
REAC:R-HSA-9664417	5.17485009279e-20	0.52380952381	NCKAP1 ABI1 WASF3 NCKAP1L CYFIP2 CYFIP1 BAIAP2 ABI2 WASF2 BRK1 WASF1	Leishmania phagocytosis
REAC:R-HSA-9664422	5.17485009279e-20	0.52380952381	NCKAP1 ABI1 WASF3 NCKAP1L CYFIP2 CYFIP1 BAIAP2 ABI2 WASF2 BRK1 WASF1	FCGR3A-mediated phagocytosis
REAC:R-HSA-4420097	8.11142329479e-20	0.571428571429	NCKAP1 NCK2 ABI1 WASF3 NCKAP1L CYFIP2 CYFIP1 BAIAP2 ABI2 WASF2 BRK1 WASF1	VEGFA-VEGFR2 Pathway
REAC:R-HSA-2029482	1.00899375144e-19	0.52380952381	NCKAP1 ABI1 WASF3 NCKAP1L CYFIP2 CYFIP1 BAIAP2 ABI2 WASF2 BRK1 WASF1	Regulation of actin dynamics for phagocytic cup formation
REAC:R-HSA-194138	2.48826366641e-19	0.571428571429	NCKAP1 NCK2 ABI1 WASF3 NCKAP1L CYFIP2 CYFIP1 BAIAP2 ABI2 WASF2 BRK1 WASF1	Signaling by VEGF
REAC:R-HSA-9013149	1.01016080902e-18	0.619047619048	ABI2 NCKAP1 ABI1 WASF3 NCKAP1L BRK1 CYFIP1 BAIAP2 CYFIP2 ABL2 WASF2 NHS WASF1	RAC1 GTPase cycle
REAC:R-HSA-2029480	5.19845812671e-18	0.52380952381	NCKAP1 ABI1 WASF3 NCKAP1L CYFIP2 CYFIP1 BAIAP2 ABI2 WASF2 BRK1 WASF1	Fcgamma receptor (FCGR) dependent phagocytosis
REAC:R-HSA-9013423	1.62671685619e-17	0.52380952381	ABI2 NCKAP1 ABI1 NCKAP1L BRK1 CYFIP1 BAIAP2 ABL2 WASF2 NHS WASF1	RAC3 GTPase cycle
GO:2000601	1.64688620002e-15	0.333333333333	NCKAP1 ABI2 WASF3 CYFIP1 WASF1 WASF2 BRK1	positive regulation of Arp2/3 complex-mediated actin nucleation
REAC:R-HSA-9012999	2.67670858324e-15	0.666666666667	ABI2 NCKAP1 NCK2 ABI1 WASF3 NCKAP1L BRK1 CYFIP1 BAIAP2 CYFIP2 ABL2 WASF2 NHS WASF1	RHO GTPase cycle
REAC:R-HSA-9658195	3.13689172878e-15	0.52380952381	NCKAP1 ABI1 WASF3 NCKAP1L CYFIP2 CYFIP1 BAIAP2 ABI2 WASF2 BRK1 WASF1	Leishmania infection
REAC:R-HSA-9824443	3.13689172878e-15	0.52380952381	NCKAP1 ABI1 WASF3 NCKAP1L CYFIP2 CYFIP1 BAIAP2 ABI2 WASF2 BRK1 WASF1	Parasitic Infection Pathways
KEGG:05130	5.09936817752e-15	0.52380952381	NCKAP1 NCK2 ABI1 WASF3 NCKAP1L CYFIP2 CYFIP1 BAIAP2 WASF1 WASF2 BRK1	Pathogenic Escherichia coli infection
GO:0051127	6.77632780639e-14	0.333333333333	NCKAP1 ABI2 WASF3 CYFIP1 WASF1 WASF2 BRK1	positive regulation of actin nucleation
CORUM:186	1.27243298524e-13	0.238095238095	CYFIP1 WASF2 NCKAP1 BRK1 ABI1	Wave-2 complex
REAC:R-HSA-194315	1.87229100061e-12	0.666666666667	ABI2 NCKAP1 NCK2 ABI1 WASF3 NCKAP1L BRK1 CYFIP1 BAIAP2 CYFIP2 ABL2 WASF2 NHS WASF1	Signaling by Rho GTPases
REAC:R-HSA-9716542	2.53840212894e-12	0.666666666667	ABI2 NCKAP1 NCK2 ABI1 WASF3 NCKAP1L BRK1 CYFIP1 BAIAP2 CYFIP2 ABL2 WASF2 NHS WASF1	Signaling by Rho GTPases, Miro GTPases and RHOBTB3
REAC:R-HSA-195258	1.84624071222e-11	0.52380952381	NCKAP1 ABI1 WASF3 NCKAP1L CYFIP2 CYFIP1 BAIAP2 ABI2 WASF2 BRK1 WASF1	RHO GTPase Effectors
GO:1902905	2.78607161008e-11	0.47619047619	NCKAP1 NCK2 ABI2 WASF3 NCKAP1L CYFIP1 BAIAP2 WASF1 WASF2 BRK1	positive regulation of supramolecular fiber organization
REAC:R-HSA-9006934	2.83265258738e-11	0.571428571429	NCKAP1 NCK2 ABI1 WASF3 NCKAP1L CYFIP2 CYFIP1 BAIAP2 ABI2 WASF2 BRK1 WASF1	Signaling by Receptor Tyrosine Kinases
GO:0051495	3.83189038872e-11	0.47619047619	NCKAP1 NCK2 ABI2 WASF3 NCKAP1L CYFIP1 BAIAP2 WASF1 WASF2 BRK1	positive regulation of cytoskeleton organization
REAC:R-HSA-9013404	4.70430818777e-11	0.380952380952	NCKAP1 ABI1 NCKAP1L BRK1 CYFIP1 ABI2 WASF2 NHS	RAC2 GTPase cycle
GO:0034315	1.33384791831e-10	0.333333333333	NCKAP1 ABI2 WASF3 CYFIP1 WASF1 WASF2 BRK1	regulation of Arp2/3 complex-mediated actin nucleation
KEGG:04810	1.67514360998e-10	0.428571428571	NCKAP1 ABI2 NCKAP1L CYFIP2 CYFIP1 BAIAP2 WASF1 WASF2 BRK1	Regulation of actin cytoskeleton
GO:0032956	1.9516748077e-10	0.52380952381	NCKAP1 NCK2 ABI2 WASF3 NCKAP1L CYFIP1 BAIAP2 ABL2 WASF2 BRK1 WASF1	regulation of actin cytoskeleton organization
GO:0032970	6.60575051908e-10	0.52380952381	NCKAP1 NCK2 ABI2 WASF3 NCKAP1L CYFIP1 BAIAP2 ABL2 WASF2 BRK1 WASF1	regulation of actin filament-based process
GO:0051125	6.79078026586e-10	0.333333333333	NCKAP1 ABI2 WASF3 CYFIP1 WASF1 WASF2 BRK1	regulation of actin nucleation
GO:0110053	9.7976106829e-10	0.47619047619	NCKAP1 NCK2 ABI2 WASF3 NCKAP1L CYFIP1 BAIAP2 WASF1 WASF2 BRK1	regulation of actin filament organization
GO:0008154	1.69231692036e-09	0.428571428571	NCKAP1 ABI2 NCKAP1L BRK1 NCK2 BAIAP2 ABI1 WASF3 WASF1	actin polymerization or depolymerization
GO:0034314	3.73623588021e-09	0.333333333333	NCKAP1 ABI2 WASF3 CYFIP1 WASF1 WASF2 BRK1	Arp2/3 complex-mediated actin nucleation
GO:0045010	9.05610696399e-09	0.333333333333	NCKAP1 ABI2 WASF3 CYFIP1 WASF1 WASF2 BRK1	actin nucleation
GO:0007015	1.19616320764e-08	0.52380952381	NCKAP1 NCK2 ABI1 WASF3 NCKAP1L CYFIP1 BAIAP2 ABI2 WASF2 BRK1 WASF1	actin filament organization
GO:0051493	4.19470955057e-08	0.52380952381	NCKAP1 NCK2 ABI2 WASF3 NCKAP1L CYFIP1 BAIAP2 ABL2 WASF2 BRK1 WASF1	regulation of cytoskeleton organization
WP:WP51	4.32197602292e-08	0.333333333333	NCKAP1 ABI2 CYFIP2 BAIAP2 WASF1 WASF2 BRK1	Regulation of actin cytoskeleton
GO:0030036	5.10556624611e-08	0.571428571429	ABI2 NCKAP1 NCK2 ABI1 WASF3 NCKAP1L CYFIP1 BAIAP2 ABL2 WASF2 BRK1 WASF1	actin cytoskeleton organization
GO:1902903	5.57353356955e-08	0.47619047619	NCKAP1 NCK2 ABI2 WASF3 NCKAP1L CYFIP1 BAIAP2 WASF1 WASF2 BRK1	regulation of supramolecular fiber organization
GO:0030029	1.84000926149e-07	0.571428571429	ABI2 NCKAP1 NCK2 ABI1 WASF3 NCKAP1L CYFIP1 BAIAP2 ABL2 WASF2 BRK1 WASF1	actin filament-based process
GO:0030027	2.11647179938e-07	0.380952380952	ABI1 NCKAP1 ABI2 WASF3 CYFIP1 WASF1 WASF2 BRK1	lamellipodium
KEGG:05132	1.02974557434e-06	0.333333333333	NCKAP1 ABI1 NCKAP1L CYFIP2 CYFIP1 WASF3 BRK1	Salmonella infection
REAC:R-HSA-5663205	1.89410666064e-06	0.52380952381	NCKAP1 ABI1 WASF3 NCKAP1L CYFIP2 CYFIP1 BAIAP2 ABI2 WASF2 BRK1 WASF1	Infectious disease
GO:0010638	2.33056570068e-06	0.47619047619	NCKAP1 NCK2 ABI2 WASF3 NCKAP1L CYFIP1 BAIAP2 WASF1 WASF2 BRK1	positive regulation of organelle organization
REAC:R-HSA-168249	2.52438923052e-06	0.52380952381	NCKAP1 ABI1 WASF3 NCKAP1L CYFIP2 CYFIP1 BAIAP2 ABI2 WASF2 BRK1 WASF1	Innate Immune System
GO:0010592	6.06499071235e-06	0.238095238095	ABI2 WASF2 CYFIP1 BRK1 NCKAP1	positive regulation of lamellipodium assembly
GO:0097435	6.76053518142e-06	0.52380952381	NCKAP1 NCK2 ABI1 WASF3 NCKAP1L CYFIP1 BAIAP2 ABI2 WASF2 BRK1 WASF1	supramolecular fiber organization
REAC:R-HSA-162582	1.30918064167e-05	0.666666666667	ABI2 NCKAP1 NCK2 ABI1 WASF3 NCKAP1L BRK1 CYFIP1 BAIAP2 CYFIP2 ABL2 WASF2 NHS WASF1	Signal Transduction
GO:0007010	1.36742305262e-05	0.619047619048	ABI2 NCKAP1 NCK2 ABI1 WASF3 SEMA6A NCKAP1L CYFIP1 BAIAP2 ABL2 WASF2 BRK1 WASF1	cytoskeleton organization
GO:0097581	2.07949744648e-05	0.285714285714	NCKAP1 ABI2 CYFIP1 WASF1 WASF2 BRK1	lamellipodium organization
GO:0010591	2.55219324165e-05	0.238095238095	ABI2 WASF2 CYFIP1 BRK1 NCKAP1	regulation of lamellipodium assembly
GO:1902745	3.04022028538e-05	0.238095238095	ABI2 WASF2 CYFIP1 BRK1 NCKAP1	positive regulation of lamellipodium organization
GO:0016601	3.04022028538e-05	0.238095238095	CYFIP1 NCKAP1 WASF1 BRK1 ABI2	Rac protein signal transduction
GO:0000902	4.36950022177e-05	0.47619047619	NCKAP1 CYFIP1 WASF1 PPFIA2 SEMA6A NCKAP1L BAIAP2 ABI2 WASF3 CYFIP2	cell morphogenesis
GO:0120036	5.35057346928e-05	0.571428571429	NCKAP1 CYFIP1 ABI2 PPFIA2 SEMA6A NCKAP1L BAIAP2 CYFIP2 ABL2 WASF2 BRK1 WASF1	plasma membrane bounded cell projection organization
GO:0120039	5.38528851996e-05	0.428571428571	NCKAP1 CYFIP1 WASF1 PPFIA2 SEMA6A NCKAP1L BAIAP2 ABI2 CYFIP2	plasma membrane bounded cell projection morphogenesis
GO:0031252	5.5035429067e-05	0.380952380952	ABI1 NCKAP1 ABI2 WASF3 CYFIP1 WASF1 WASF2 BRK1	cell leading edge
GO:0048858	5.90705308294e-05	0.428571428571	NCKAP1 CYFIP1 WASF1 PPFIA2 SEMA6A NCKAP1L BAIAP2 ABI2 CYFIP2	cell projection morphogenesis
GO:0030030	6.24023550202e-05	0.571428571429	NCKAP1 CYFIP1 ABI2 PPFIA2 SEMA6A NCKAP1L BAIAP2 CYFIP2 ABL2 WASF2 BRK1 WASF1	cell projection organization
CORUM:6991	6.82792716788e-05	0.0952380952381	WASF2 CYFIP1	ABI3-WAVE2-CYFIP1 complex
CORUM:7561	6.82792716788e-05	0.0952380952381	NCKAP1 WASF3	NCKAP1-WASF3 complex
CORUM:2294	6.82792716788e-05	0.0952380952381	WASF2 ABI1	ABI1-WASF2 complex
GO:0051130	8.66578010053e-05	0.52380952381	NCKAP1 NCK2 ABI2 WASF3 NCKAP1L CYFIP1 BAIAP2 ABL2 WASF2 BRK1 WASF1	positive regulation of cellular component organization
GO:1902743	0.000150687587339	0.238095238095	ABI2 WASF2 CYFIP1 BRK1 NCKAP1	regulation of lamellipodium organization
REAC:R-HSA-168256	0.000186473263887	0.571428571429	ABI2 NCKAP1 ABI1 WASF3 NCKAP1L CYFIP2 CYFIP1 BAIAP2 ABL2 WASF2 BRK1 WASF1	Immune System
GO:0030041	0.000194756689224	0.285714285714	NCKAP1 BAIAP2 NCKAP1L NCK2 WASF1 WASF3	actin filament polymerization
CORUM:7562	0.000204660259961	0.0952380952381	NCKAP1 WASF3	NCKAP1-WASF3-RAC1 complex
GO:0032989	0.000216111901415	0.428571428571	NCKAP1 CYFIP1 WASF1 PPFIA2 SEMA6A NCKAP1L BAIAP2 ABI2 CYFIP2	cellular anatomical entity morphogenesis
KEGG:04520	0.000364061664052	0.190476190476	WASF2 BAIAP2 WASF3 WASF1	Adherens junction
GO:0033043	0.000442797261156	0.52380952381	NCKAP1 NCK2 ABI2 WASF3 NCKAP1L CYFIP1 BAIAP2 ABL2 WASF2 BRK1 WASF1	regulation of organelle organization
GO:0030032	0.000456190653186	0.238095238095	ABI2 WASF2 CYFIP1 BRK1 NCKAP1	lamellipodium assembly
REAC:R-HSA-1643685	0.00049511184946	0.52380952381	NCKAP1 ABI1 WASF3 NCKAP1L CYFIP2 CYFIP1 BAIAP2 ABI2 WASF2 BRK1 WASF1	Disease
GO:0044089	0.000964426177188	0.380952380952	NCKAP1 NCK2 ABI2 NCKAP1L CYFIP1 BAIAP2 WASF2 BRK1	positive regulation of cellular component biogenesis
GO:0048812	0.00105108110725	0.380952380952	NCKAP1 ABI2 PPFIA2 SEMA6A CYFIP1 NCKAP1L BAIAP2 CYFIP2	neuron projection morphogenesis
GO:0031175	0.00155188240175	0.428571428571	NCKAP1 CYFIP1 ABI2 PPFIA2 SEMA6A NCKAP1L BAIAP2 ABL2 CYFIP2	neuron projection development
GO:0120035	0.00169226461523	0.380952380952	NCKAP1 ABI2 PPFIA2 SEMA6A CYFIP1 ABL2 WASF2 BRK1	regulation of plasma membrane bounded cell projection organization
CORUM:2300	0.00190189946027	0.0952380952381	NCKAP1 CYFIP1	Profilin 2 complex
GO:0031344	0.00214443809424	0.380952380952	NCKAP1 ABI2 PPFIA2 SEMA6A CYFIP1 ABL2 WASF2 BRK1	regulation of cell projection organization
GO:0051128	0.00279754111121	0.619047619048	NCKAP1 CYFIP1 NCK2 ABI2 WASF3 PPFIA2 SEMA6A NCKAP1L BAIAP2 ABL2 WASF2 BRK1 WASF1	regulation of cellular component organization
GO:0048666	0.00330188722277	0.428571428571	NCKAP1 CYFIP1 ABI2 PPFIA2 SEMA6A NCKAP1L BAIAP2 ABL2 CYFIP2	neuron development
GO:0120034	0.003389640287	0.238095238095	ABI2 WASF2 CYFIP1 BRK1 NCKAP1	positive regulation of plasma membrane bounded cell projection assembly
GO:0030838	0.00483207795812	0.190476190476	NCK2 NCKAP1 NCKAP1L BAIAP2	positive regulation of actin filament polymerization
GO:0008064	0.00665364144595	0.238095238095	NCK2 NCKAP1 BAIAP2 BRK1 NCKAP1L	regulation of actin polymerization or depolymerization
GO:0030832	0.00787669142364	0.238095238095	NCK2 NCKAP1 BAIAP2 BRK1 NCKAP1L	regulation of actin filament length
GO:0120025	0.00987308730007	0.52380952381	NCKAP1 ABI1 WASF3 PPFIA2 SEMA6A CYFIP1 CYFIP2 ABI2 WASF2 BRK1 WASF1	plasma membrane bounded cell projection
GO:0042995	0.0109192878451	0.52380952381	NCKAP1 ABI1 WASF3 PPFIA2 SEMA6A CYFIP1 CYFIP2 ABI2 WASF2 BRK1 WASF1	cell projection
KEGG:05231	0.012819082535	0.142857142857	WASF2 WASF3 WASF1	Choline metabolism in cancer
GO:0051258	0.0139303070315	0.285714285714	NCKAP1 BAIAP2 NCKAP1L NCK2 WASF1 WASF3	protein polymerization
KEGG:04666	0.0162849714577	0.142857142857	WASF2 WASF3 WASF1	Fc gamma R-mediated phagocytosis
GO:0031346	0.0165820137307	0.285714285714	NCKAP1 ABI2 CYFIP1 ABL2 WASF2 BRK1	positive regulation of cell projection organization
GO:0030182	0.0170761819553	0.428571428571	NCKAP1 CYFIP1 ABI2 PPFIA2 SEMA6A NCKAP1L BAIAP2 ABL2 CYFIP2	neuron differentiation
GO:0032535	0.0180558142903	0.285714285714	NCKAP1 BAIAP2 NCKAP1L SEMA6A NCK2 BRK1	regulation of cellular component size
GO:0048699	0.0272967296222	0.428571428571	NCKAP1 CYFIP1 ABI2 PPFIA2 SEMA6A NCKAP1L BAIAP2 ABL2 CYFIP2	generation of neurons
GO:0071933	0.0460629135005	0.142857142857	WASF2 WASF3 WASF1	Arp2/3 complex binding

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
WASF3	CYFIP2	1.0	0.208	structurally_consistent (dimer)
WASF2	NCKAP1	1.0	0.326
ABI2	WASF1	1.0	0.226
BRK1	WASF2	1.0	0.514	structurally_consistent (dimer)
NCKAP1	WASF1	1.0	0.16
ABI1	NHSL3	1.0
BRK1	WASF1	1.0	0.114	structurally_consistent (dimer)
ABI1	NCKAP1	1.0
BRK1	ABI1	1.0		structurally_consistent (dimer)
NCKAP1	CYFIP2	1.0	0.118
BRK1	ABI2	1.0	0.506	mutually_exclusive (Q9UPY6) structurally_consistent (dimer)
NCK1	NCK2	1.0	0.084
WASF2	NHSL3	1.0	0.112
ABI1	ABI2	1.0
CYFIP1	NHSL3	1.0	0.126
WASF2	ABI2	1.0	0.328
WASF3	ABI2	0.999	0.138	structurally_consistent (dimer)
ABI1	WASF2	0.999		mutually_exclusive (Q8WUW1)
BRK1	NHSL1	0.999
BRK1	NCKAP1	0.999	0.42
WASF2	CYFIP2	0.999	0.092	structurally_consistent (dimer)
WASF3	NCKAP1	0.999	0.132
CYFIP1	ABI2	0.999	0.398	mutually_exclusive (Q9UPY6)
NCKAP1	NHSL3	0.999	0.122
NCKAP1	ABI2	0.999	0.404
ABI1	WASF1	0.999		mutually_exclusive (Q8WUW1)
CYFIP2	WASF1	0.999	0.228	structurally_consistent (dimer)
NCK2	NHSL3	0.999	0.18
NCK2	NHSL1	0.999
WASF3	CYFIP1	0.999	0.118	structurally_consistent (dimer)
NCK2	CYFIP1	0.999	0.176
ABI1	CYFIP1	0.999
WASF3	ABI1	0.999
NCKAP1	CYFIP1	0.999	0.884	structurally_consistent (dimer)
BRK1	CYFIP1	0.999	0.768
NCK2	CYFIP2	0.999	0.084
NHSL1	NCKAP1	0.999
NHSL1	CYFIP1	0.999
NCK2	WASF2	0.999	0.088
NCKAP1L	ABI2	0.999	0.076
NHSL1	ABI2	0.999
ABI1	NHSL1	0.999
CYFIP2	NHSL3	0.999	0.09
BRK1	WASF3	0.999	0.076	structurally_consistent (dimer)
NCK2	NCKAP1	0.998	0.158
NHSL1	WASF1	0.998
NCK2	BAIAP2	0.998	0.136
NCK2	ABI1	0.998
CYFIP2	ABI2	0.998	0.074
WASF2	WASF1	0.998	0.092
ABI2	NHSL3	0.998	0.044
BAIAP2	WASF2	0.998	0.072
NCK2	ABI2	0.998	0.092
NCK1	NHSL3	0.998	0.096
WASF1	NHSL3	0.998	0.074
WASF2	CYFIP1	0.997	0.69	structurally_consistent (dimer)
BRK1	NCKAP1L	0.997	0.322
BAIAP2	NHSL3	0.997	0.096
BRK1	CYFIP2	0.997	0.144
NHS	BRK1	0.997	0.176	structurally_consistent (dimer)
BAIAP2	CYFIP1	0.997	0.076
ABI1	CYFIP2	0.997
WASF2	NHSL1	0.996
WASF3	NHSL3	0.996	0.13
BAIAP2	ABI1	0.996
CYFIP1	WASF1	0.995	0.09	structurally_consistent (dimer)
BAIAP2	ABI2	0.995	0.08640625
BAIAP2	WASF1	0.994	0.132369668246
BRK1	NHSL3	0.994	0.08
Q56UQ5	WASF2	0.993
WASF3	WASF2	0.992	0.076	mutually_exclusive (Q96F07)
WASF3	WASF1	0.992	0.166	mutually_exclusive (Q96F07)
BAIAP2	C6orf132	0.992	0.182
BAIAP2	NCKAP1	0.991	0.138
NHS	ABI2	0.989	0.078	mutually_exclusive (Q8WUW1)
NHSL1	CYFIP2	0.989
RAPH1	ABI2	0.989	0.108
NHS	NCK2	0.988	0.096
BAIAP2	WASF3	0.986	0.122
Q56UQ5	CYFIP2	0.986
Q56UQ5	ABI1	0.985
NHS	NCKAP1	0.985	0.192
NCK1	NHSL1	0.985
NCK2	CASKIN2	0.984	0.156
NHS	NHSL3	0.982	0.156
Q56UQ5	CYFIP1	0.98
RAPH1	ABI1	0.979
CASKIN2	ABI2	0.978	0.08
NHSL1	NHSL3	0.977
NCK1	NHS	0.976	0.15
BAIAP2	CYFIP2	0.973	0.064
NCK1	CYFIP1	0.972	0.198
NCK1	BAIAP2	0.971	0.084
BRK1	Q56UQ5	0.971
Q56UQ5	NCKAP1	0.97
PPFIA2	BRK1	0.97	0.124
NCK1	NCKAP1	0.969	0.166
WASF3	NHSL1	0.967
NCK2	WASF1	0.967	0.086
SEMA6A	NCK2	0.965
NCK2	ABL2	0.964	0.044
NCK1	WASF2	0.963	0.196
Q56UQ5	ABI2	0.962
NCK1	CYFIP2	0.961	0.076
NCK2	BRK1	0.959	0.212
RAPH1	BAIAP2	0.957	0.114
NHS	ABI1	0.954		mutually_exclusive (Q8WUW1)
NCK2	RAPH1	0.953	0.046
ABL2	ABI2	0.952	0.086
BRK1	BAIAP2	0.946	0.056
RAPH1	NCKAP1	0.942	0.116
RAPH1	WASF1	0.938	0.122
BAIAP2	NHSL1	0.935
NCKAP1L	CYFIP2	0.93	0.388
NCK1	ABI1	0.926
CYFIP1	CYFIP2	0.924	0.202
NHS	WASF2	0.919	0.164	mutually_exclusive (Q8WUW1)
Q56UQ5	WASF1	0.915
RAPH1	NHSL3	0.913	0.09
NCKAP1L	ABI1	0.911
NHS	WASF1	0.91	0.21	mutually_exclusive (Q8WUW1)
NCK1	ABI2	0.906	0.106
RAPH1	WASF2	0.905	0.132
C6orf132	WASF1	0.892	0.086
RAPH1	CYFIP1	0.889	0.138
NCK2	Q56UQ5	0.888
NCK2	WASF3	0.863	0.134
NCK1	CASKIN2	0.862	0.0742666666667
NHS	NHSL1	0.849
NHS	CYFIP2	0.837	0.08
BRK1	RAPH1	0.837	0.036
NCK1	BRK1	0.824	0.252
NCK1	Q56UQ5	0.817
WASF3	NCKAP1L	0.812
NCKAP1L	WASF1	0.807	0.102
NCK1	WASF1	0.799	0.084
NHS	NCKAP1L	0.795	0.144
NHS	CYFIP1	0.794	0.134
NCKAP1L	NHSL1	0.779
NCK1	ABL2	0.769	0.204
NCKAP1L	NHSL3	0.765	0.066
NHS	WASF3	0.753	0.124	mutually_exclusive (Q8WUW1)
NCK1	WASF3	0.723	0.196
WASF3	Q56UQ5	0.715
NCKAP1L	WASF2	0.713	0.22
ABL2	NHSL3	0.707	0.156
NHS	BAIAP2	0.695	0.148
CASKIN2	NHSL1	0.654
C6orf132	ABI2	0.626	0.072
C6orf132	NHSL3	0.626	0.134
NCKAP1L	CYFIP1	0.582	0.378	structurally_consistent (dimer)
CASKIN2	NHSL3	0.565	0.18
C6orf132	ABI1	0.55
CASKIN2	ABL2	0.531	0.254
NCKAP1L	NCKAP1	0.514	0.108
Q56UQ5	NHSL1	0.499
Q56UQ5	NHSL3	0.499
C6orf132	CYFIP1	0.496	0.18
C6orf132	WASF2	0.455	0.11
NCK1	SEMA6A	0.45
PPFIA2	Q56UQ5	0.415
PPFIA2	WASF3	0.415	0.082
PPFIA2	NCKAP1L	0.415	0.066
NHS	PPFIA2	0.415	0.05
CASKIN2	WASF2	0.411	0.096
BAIAP2	Q56UQ5	0.405
C6orf132	NCKAP1	0.37	0.182
CASKIN2	WASF1	0.369	0.162
RAPH1	NCKAP1L	0.362	0.044
CASKIN2	Q56UQ5	0.353
BAIAP2	NCKAP1L	0.349	0.144
ABL2	RAPH1	0.331	0.08
RAPH1	WASF3	0.327	0.17
ABL2	Q56UQ5	0.324
C6orf132	CYFIP2	0.323	0.141
CASKIN2	NCKAP1L	0.303	0.086
ABL2	WASF2	0.301	0.14
RAPH1	NHSL1	0.291
ABL2	NHSL1	0.281
CASKIN2	WASF3	0.281	0.234
CASKIN2	CYFIP2	0.279	0.116
ABL2	BAIAP2	0.279	0.166
CASKIN2	BAIAP2	0.279	0.116
NCKAP1L	Q56UQ5	0.274
CASKIN2	CYFIP1	0.265	0.172
PPFIA2	WASF1	0.25	0.078
PPFIA2	NHSL1	0.25
ABL2	ABI1	0.244
SEMA6A	RAPH1	0.242
NHS	Q56UQ5	0.239
RAPH1	CYFIP2	0.239	0.08
ABL2	NCKAP1	0.234	0.182
SEMA6A	CASKIN2	0.233
ABL2	CYFIP1	0.232	0.206
ABL2	BRK1	0.231	0.088
ABL2	WASF3	0.23	0.154
RAPH1	Q56UQ5	0.224
CASKIN2	NCKAP1	0.223	0.156
CASKIN2	ABI1	0.219
CASKIN2	RAPH1	0.215	0.1
SEMA6A	Q56UQ5	0.212
PPFIA2	NCKAP1	0.21	0.168
PPFIA2	ABI2	0.21	0.102
PPFIA2	ABI1	0.21
PPFIA2	NHSL3	0.21	0.06
PPFIA2	CYFIP2	0.21	0.066
PPFIA2	CYFIP1	0.21	0.1
SEMA6A	NHSL1	0.202
SEMA6A	BRK1	0.199
SEMA6A	WASF3	0.186
ABL2	WASF1	0.177	0.166
NHS	CASKIN2	0.175	0.116
CASKIN2	BRK1	0.166	0.06
ABL2	NCKAP1L	0.164	0.112
SEMA6A	ABL2	0.133
SEMA6A	NHSL3	0.13
NHS	ABL2	0.117	0.13
PPFIA2	WASF2	0.113	0.082
NHS	SEMA6A	0.098
NCK1	RAPH1	0.09	0.094
ABL2	CYFIP2	0.087	0.166
SEMA6A	ABI2	0.069
NHS	RAPH1	0.068	0.108
SEMA6A	WASF1	0.065
SEMA6A	WASF2	0.058
PPFIA2	BAIAP2	0.051	0.0603696682464
SEMA6A	BAIAP2	0.037
SEMA6A	ABI1	0.028
SEMA6A	CYFIP1	0.026
SEMA6A	CYFIP2	0.021
BRK1	C6orf132	0.016	0.082
SEMA6A	NCKAP1	0.012
NCK2	C6orf132	0.008	0.078
RAPH1	C6orf132	0.004	0.072
NCK1	C6orf132	0.003	0.09

Related Complexes

Genename	Complexes
NHS	huMAP3_00870.1 huMAP3_01805.1 huMAP3_08747.1 huMAP3_09119.1 huMAP3_09598.1 huMAP3_10500.1 huMAP3_13345.1
WASF2	huMAP3_02474.1 huMAP3_09598.1 huMAP3_13345.1
NHSL3	huMAP3_02474.1 huMAP3_09598.1 huMAP3_13345.1
BRK1	huMAP3_01979.1 huMAP3_03690.1 huMAP3_09598.1 huMAP3_13345.1 huMAP3_13550.1
ABL2	huMAP3_01805.1 huMAP3_09598.1 huMAP3_13345.1 huMAP3_14607.1
SEMA6A	huMAP3_00870.1 huMAP3_01805.1 huMAP3_07569.1 huMAP3_08747.1 huMAP3_09119.1 huMAP3_09598.1 huMAP3_10500.1
CASKIN2	huMAP3_01805.1 huMAP3_07820.1 huMAP3_09598.1 huMAP3_13345.1 huMAP3_14886.1 huMAP3_15130.1
NCKAP1L	huMAP3_02474.1 huMAP3_03690.1 huMAP3_09598.1 huMAP3_13345.1 huMAP3_13550.1
PPFIA2	huMAP3_01979.1 huMAP3_03690.1 huMAP3_09598.1 huMAP3_13345.1 huMAP3_13550.1
RAPH1	huMAP3_02072.1 huMAP3_02474.1 huMAP3_09598.1 huMAP3_10837.1 huMAP3_13345.1
ABI1	huMAP3_02474.1 huMAP3_09598.1 huMAP3_13345.1
NCKAP1	huMAP3_02474.1 huMAP3_09598.1 huMAP3_13345.1
NCK1	huMAP3_00870.1 huMAP3_01805.1 huMAP3_05139.1 huMAP3_06440.1 huMAP3_07569.1 huMAP3_08747.1 huMAP3_09119.1 huMAP3_09598.1 huMAP3_09681.1 huMAP3_10500.1 huMAP3_13345.1 huMAP3_14886.1
ABI2	huMAP3_02474.1 huMAP3_09598.1 huMAP3_13345.1
WASF1	huMAP3_02474.1 huMAP3_09598.1 huMAP3_13345.1
C6orf132	huMAP3_02072.1 huMAP3_04246.1 huMAP3_09598.1 huMAP3_10837.1 huMAP3_12520.1 huMAP3_13303.1 huMAP3_13410.1
WASF3	huMAP3_02474.1 huMAP3_09598.1 huMAP3_13345.1
NHSL1	huMAP3_02474.1 huMAP3_09598.1 huMAP3_13345.1
CYFIP1	huMAP3_02474.1 huMAP3_09598.1 huMAP3_13345.1
CYFIP2	huMAP3_02474.1 huMAP3_09598.1 huMAP3_13345.1
BAIAP2	huMAP3_02072.1 huMAP3_04246.1 huMAP3_09598.1 huMAP3_10837.1 huMAP3_13345.1
NCK2	huMAP3_00870.1 huMAP3_01805.1 huMAP3_07569.1 huMAP3_08747.1 huMAP3_09119.1 huMAP3_09598.1 huMAP3_10500.1 huMAP3_13345.1 huMAP3_14886.1
Q56UQ5	huMAP3_02474.1 huMAP3_09598.1 huMAP3_13345.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09598.1

Complex Portal: CPX-14564