hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09600.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UQCRH | Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein) | 5 | UniProt NCBI |
| MT-CYB | Cytochrome b (Complex III subunit 3) (Complex III subunit III) (Cytochrome b-c1 complex subunit 3) (Ubiquinol-cytochrome-c reductase complex cytochrome b subunit) | 5 | UniProt NCBI |
| UQCR10 | Cytochrome b-c1 complex subunit 9 (Complex III subunit 9) (Complex III subunit X) (Cytochrome c1 non-heme 7 kDa protein) (Ubiquinol-cytochrome c reductase complex 7.2 kDa protein) | 5 | UniProt NCBI |
| UQCRQ | Cytochrome b-c1 complex subunit 8 (Complex III subunit 8) (Complex III subunit VIII) (Ubiquinol-cytochrome c reductase complex 9.5 kDa protein) (Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C) | 5 | UniProt NCBI |
| UQCRC1 | Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1) | 5 | UniProt NCBI |
| COX7A2L | Cytochrome c oxidase subunit 7A-related protein, mitochondrial (COX7a-related protein) (Cytochrome c oxidase subunit VIIa-related protein) (EB1) | 4 | UniProt NCBI |
| UQCRC2 | Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2) | 5 | UniProt NCBI |
| MT-CO3 | Cytochrome c oxidase subunit 3 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide III) | 5 | UniProt NCBI |
| UQCRB | Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (QP-C) (Ubiquinol-cytochrome c reductase complex 14 kDa protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04260 | 2.72459845369e-15 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | Cardiac muscle contraction |
| WP:WP111 | 4.44073224517e-14 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | Electron transport chain OXPHOS system in mitochondria |
| REAC:R-HSA-611105 | 1.02240114482e-13 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | Respiratory electron transport |
| KEGG:00190 | 1.23889969397e-13 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | Oxidative phosphorylation |
| KEGG:04932 | 3.15558911241e-13 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | Non-alcoholic fatty liver disease |
| REAC:R-HSA-163200 | 4.33630636944e-13 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| WP:WP4396 | 4.93694422163e-13 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | Nonalcoholic fatty liver disease |
| WP:WP4921 | 1.02752951578e-12 | 0.714285714286 | UQCRH UQCRQ UQCRC1 MT-CYB UQCR10 | Mitochondrial complex III assembly |
| KEGG:05415 | 2.15982375943e-12 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | Diabetic cardiomyopathy |
| KEGG:05208 | 4.53372178345e-12 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | Chemical carcinogenesis - reactive oxygen species |
| REAC:R-HSA-1428517 | 4.73062610759e-12 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | The citric acid (TCA) cycle and respiratory electron transport |
| KEGG:04714 | 5.03439681856e-12 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | Thermogenesis |
| GO:0070469 | 8.74570132675e-12 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | respirasome |
| GO:0005746 | 8.74570132675e-12 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | mitochondrial respirasome |
| GO:0070069 | 1.22794481412e-11 | 0.857142857143 | UQCR10 UQCRC1 UQCRH UQCRQ MT-CO3 MT-CYB | cytochrome complex |
| KEGG:05012 | 1.45211767151e-11 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | Parkinson disease |
| KEGG:05020 | 1.7833665418e-11 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | Prion disease |
| KEGG:05016 | 3.64330709843e-11 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | Huntington disease |
| GO:0006122 | 8.73008139488e-11 | 0.714285714286 | UQCRH UQCRQ UQCRC1 MT-CYB UQCR10 | mitochondrial electron transport, ubiquinol to cytochrome c |
| GO:0006119 | 9.34173200582e-11 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | oxidative phosphorylation |
| KEGG:05014 | 1.28858507535e-10 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | Amyotrophic lateral sclerosis |
| GO:0005750 | 1.49641459906e-10 | 0.714285714286 | UQCRH UQCRQ UQCRC1 MT-CYB UQCR10 | mitochondrial respiratory chain complex III |
| GO:0045275 | 1.49641459906e-10 | 0.714285714286 | UQCRH UQCRQ UQCRC1 MT-CYB UQCR10 | respiratory chain complex III |
| KEGG:05010 | 1.81130942353e-10 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | Alzheimer disease |
| GO:0009060 | 4.96806299631e-10 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | aerobic respiration |
| KEGG:05022 | 7.26931749373e-10 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | Pathways of neurodegeneration - multiple diseases |
| GO:0008121 | 9.2094208532e-10 | 0.571428571429 | UQCRH UQCRC1 MT-CYB UQCR10 | ubiquinol-cytochrome-c reductase activity |
| GO:0015453 | 1.04452075302e-09 | 0.857142857143 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB | oxidoreduction-driven active transmembrane transporter activity |
| GO:0045333 | 1.22050153576e-09 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | cellular respiration |
| GO:0016679 | 4.60395405777e-09 | 0.571428571429 | UQCRH UQCRC1 MT-CYB UQCR10 | oxidoreductase activity, acting on diphenols and related substances as donors |
| GO:0019646 | 5.63577767821e-09 | 0.857142857143 | UQCR10 UQCRC1 UQCRH UQCRQ MT-CO3 MT-CYB | aerobic electron transport chain |
| GO:0098803 | 7.16433362003e-09 | 0.857142857143 | UQCR10 UQCRC1 UQCRH UQCRQ MT-CO3 MT-CYB | respiratory chain complex |
| GO:0015980 | 8.76668742926e-09 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | energy derivation by oxidation of organic compounds |
| GO:0042775 | 9.02363054154e-09 | 0.857142857143 | UQCR10 UQCRC1 UQCRH UQCRQ MT-CO3 MT-CYB | mitochondrial ATP synthesis coupled electron transport |
| GO:0042773 | 9.02363054154e-09 | 0.857142857143 | UQCR10 UQCRC1 UQCRH UQCRQ MT-CO3 MT-CYB | ATP synthesis coupled electron transport |
| GO:0022904 | 1.71681656462e-08 | 0.857142857143 | UQCR10 UQCRC1 UQCRH UQCRQ MT-CO3 MT-CYB | respiratory electron transport chain |
| GO:0015078 | 1.83648616726e-08 | 0.857142857143 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB | proton transmembrane transporter activity |
| GO:0009055 | 2.54425790718e-08 | 0.857142857143 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB | electron transfer activity |
| GO:0022900 | 2.88469823397e-08 | 0.857142857143 | UQCR10 UQCRC1 UQCRH UQCRQ MT-CO3 MT-CYB | electron transport chain |
| GO:0015399 | 1.39386944178e-07 | 0.857142857143 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB | primary active transmembrane transporter activity |
| GO:0006091 | 1.59608931467e-07 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | generation of precursor metabolites and energy |
| GO:0098800 | 3.24442854958e-07 | 0.857142857143 | UQCR10 UQCRC1 UQCRH UQCRQ MT-CO3 MT-CYB | inner mitochondrial membrane protein complex |
| GO:0022853 | 3.82117336424e-07 | 0.857142857143 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB | active monoatomic ion transmembrane transporter activity |
| GO:0005743 | 4.82408178268e-07 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | mitochondrial inner membrane |
| GO:0019866 | 7.20471992479e-07 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | organelle inner membrane |
| KEGG:01100 | 2.22932395196e-06 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | Metabolic pathways |
| GO:0031966 | 5.15102136807e-06 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | mitochondrial membrane |
| GO:0005740 | 8.14468871125e-06 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | mitochondrial envelope |
| GO:0022804 | 1.4171153104e-05 | 0.857142857143 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB | active transmembrane transporter activity |
| GO:0098798 | 1.79728096133e-05 | 0.857142857143 | UQCR10 UQCRC1 UQCRH UQCRQ MT-CO3 MT-CYB | mitochondrial protein-containing complex |
| GO:1990204 | 2.50587434005e-05 | 0.714285714286 | UQCRH UQCRQ UQCRC1 MT-CYB UQCR10 | oxidoreductase complex |
| GO:0022890 | 5.20876851769e-05 | 0.857142857143 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB | inorganic cation transmembrane transporter activity |
| REAC:R-HSA-1430728 | 7.38712706808e-05 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | Metabolism |
| GO:0008324 | 8.66684976201e-05 | 0.857142857143 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB | monoatomic cation transmembrane transporter activity |
| GO:0015318 | 0.000160710926303 | 0.857142857143 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB | inorganic molecular entity transmembrane transporter activity |
| GO:0031967 | 0.000194627304791 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | organelle envelope |
| GO:0031975 | 0.000194627304791 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | envelope |
| GO:0015075 | 0.000249052318126 | 0.857142857143 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB | monoatomic ion transmembrane transporter activity |
| HP:0003287 | 0.000572900170312 | 0.571428571429 | UQCRH MT-CO3 MT-CYB UQCRQ | Abnormality of mitochondrial metabolism |
| GO:0016491 | 0.000868117651073 | 0.857142857143 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB | oxidoreductase activity |
| HP:0012103 | 0.000958141441811 | 0.571428571429 | UQCRH MT-CO3 MT-CYB UQCRQ | Abnormality of the mitochondrion |
| HP:0003200 | 0.00124752252588 | 0.428571428571 | MT-CO3 MT-CYB UQCRQ | Ragged-red muscle fibers |
| GO:1902495 | 0.00127236559123 | 0.714285714286 | UQCRH UQCRQ UQCRC1 MT-CYB UQCR10 | transmembrane transporter complex |
| HP:0001271 | 0.00156347848785 | 0.428571428571 | MT-CO3 MT-CYB UQCRC1 | Polyneuropathy |
| GO:1990351 | 0.00188817498962 | 0.714285714286 | UQCRH UQCRQ UQCRC1 MT-CYB UQCR10 | transporter complex |
| GO:0005739 | 0.00195755801633 | 1.0 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB UQCRQ | mitochondrion |
| GO:0022857 | 0.00370746489181 | 0.857142857143 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB | transmembrane transporter activity |
| HP:0001112 | 0.00598974417902 | 0.285714285714 | MT-CO3 MT-CYB | Leber optic atrophy |
| GO:0005215 | 0.00729549474285 | 0.857142857143 | UQCR10 UQCRC1 UQCRH COX7A2L MT-CO3 MT-CYB | transporter activity |
| HP:0007768 | 0.00748547207011 | 0.285714285714 | MT-CO3 MT-CYB | Central retinal vessel vascular tortuosity |
| HP:0000631 | 0.00748547207011 | 0.285714285714 | MT-CO3 MT-CYB | Retinal arterial tortuosity |
| HP:0001941 | 0.00979738131748 | 0.571428571429 | UQCRH MT-CO3 MT-CYB UQCRQ | Acidosis |
| HP:0000576 | 0.0109736833289 | 0.285714285714 | MT-CO3 MT-CYB | Centrocecal scotoma |
| HP:0004360 | 0.0124114275939 | 0.571428571429 | UQCRH MT-CO3 MT-CYB UQCRQ | Abnormality of acid-base homeostasis |
| HP:0001427 | 0.0174461853129 | 0.285714285714 | MT-CO3 MT-CYB | Mitochondrial inheritance |
| GO:0098796 | 0.0206938362537 | 0.857142857143 | UQCR10 UQCRC1 UQCRH UQCRQ MT-CO3 MT-CYB | membrane protein complex |
| HP:0200125 | 0.0225866527703 | 0.285714285714 | MT-CO3 MT-CYB | Mitochondrial respiratory chain defects |
| HP:0002401 | 0.0283864349721 | 0.285714285714 | MT-CO3 MT-CYB | Stroke-like episode |
| HP:0001716 | 0.0419603197237 | 0.285714285714 | MT-CO3 MT-CYB | Wolff-Parkinson-White syndrome |
| HP:0005116 | 0.0419603197237 | 0.285714285714 | MT-CO3 MT-CYB | Arterial tortuosity |
| HP:0007763 | 0.0457644476584 | 0.285714285714 | MT-CO3 MT-CYB | Retinal telangiectasia |
| HP:0011017 | 0.0478764522021 | 0.571428571429 | UQCRH MT-CO3 MT-CYB UQCRQ | Abnormal cellular physiology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| UQCRB | UQCRC1 | 0.999 | 0.986 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM |
| UQCRC2 | UQCRC1 | 0.999 | 0.958 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only |
| UQCRC2 | UQCRQ | 0.999 | 0.96 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM fraction boldt_WMM |
| UQCRQ | UQCRC1 | 0.998 | 0.962 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM |
| UQCRC2 | UQCRB | 0.997 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction boldt_WMM |
| UQCRH | UQCRC1 | 0.997 | 0.876 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM |
| UQCRH | UQCR10 | 0.997 | 0.932 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM |
| UQCRB | UQCRQ | 0.996 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction |
| UQCRH | UQCRQ | 0.995 | 0.612 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM |
| COX7A2L | UQCRQ | 0.995 | 0.726 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM |
| MT-CYB | UQCRQ | 0.995 | 0.77 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction |
| UQCRH | COX7A2L | 0.995 | 0.21 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM |
| UQCR10 | UQCRQ | 0.994 | 0.766 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM |
| UQCRH | UQCRB | 0.992 | 0.964 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| COX7A2L | UQCRB | 0.989 | 0.882 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| UQCR10 | UQCRC1 | 0.989 | 0.758 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only |
| UQCRH | MT-CYB | 0.988 | 0.194 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction |
| UQCRC2 | MT-CO3 | 0.986 | 0.598 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| UQCRC2 | UQCR10 | 0.984 | 0.58 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only |
| COX7A2L | MT-CYB | 0.983 | 0.652 | bioplex_WMM bioplex3_WMM WMM_only |
| MT-CYB | UQCRB | 0.981 | 0.814 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| UQCRC2 | COX7A2L | 0.979 | 0.828 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt_WMM WMM_only |
| COX7A2L | UQCRC1 | 0.979 | 0.584 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| UQCRH | UQCRC2 | 0.978 | 0.686 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM |
| MT-CYB | UQCR10 | 0.966 | 0.612 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| UQCRB | UQCR10 | 0.965 | 0.914 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| UQCRC2 | MT-CYB | 0.958 | 0.78 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM fraction |
| UQCRH | MT-CO3 | 0.958 | 0.222 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| COX7A2L | MT-CO3 | 0.952 | 0.198 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| MT-CYB | UQCRC1 | 0.944 | 0.762 | bioplex_WMM bioplex3_WMM WMM_only |
| COX7A2L | UQCR10 | 0.925 | 0.53 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt_WMM WMM_only |
| MT-CO3 | UQCRC1 | 0.903 | 0.618 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| MT-CO3 | UQCRQ | 0.902 | 0.694 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| MT-CO3 | UQCR10 | 0.89 | 0.57 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| MT-CO3 | UQCRB | 0.823 | 0.666 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MT-CO3 | MT-CYB | 0.133 | 0.578 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes