hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09608.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MMP9 | Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB) [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9] | 5 | UniProt NCBI |
| COL2A1 | Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin] | 5 | UniProt NCBI |
| COL14A1 | Collagen alpha-1(XIV) chain (Undulin) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04974 | 0.000381388503235 | 1.0 | COL14A1 COL2A1 | Protein digestion and absorption |
| REAC:R-HSA-8948216 | 0.000743311362176 | 1.0 | COL14A1 COL2A1 | Collagen chain trimerization |
| REAC:R-HSA-2022090 | 0.00184717145405 | 1.0 | COL14A1 COL2A1 | Assembly of collagen fibrils and other multimeric structures |
| REAC:R-HSA-1442490 | 0.0020095038205 | 1.0 | COL14A1 COL2A1 | Collagen degradation |
| REAC:R-HSA-1650814 | 0.00226581808332 | 1.0 | COL14A1 COL2A1 | Collagen biosynthesis and modifying enzymes |
| REAC:R-HSA-1474290 | 0.00436759503844 | 1.0 | COL14A1 COL2A1 | Collagen formation |
| REAC:R-HSA-1474228 | 0.00932983916662 | 1.0 | COL14A1 COL2A1 | Degradation of the extracellular matrix |
| HP:0010622 | 0.0159119894358 | 1.0 | COL14A1 COL2A1 | Neoplasm of the skeletal system |
| HPA:0200272 | 0.0351752340474 | 0.5 | COL2A1 | eye; hyaloid membrane[>=Medium] |
| HPA:0200271 | 0.0351752340474 | 0.5 | COL2A1 | eye; hyaloid membrane[>=Low] |
| REAC:R-HSA-1474244 | 0.0442193366216 | 1.0 | COL14A1 COL2A1 | Extracellular matrix organization |
| HP:0008271 | 0.0499436884913 | 0.5 | COL2A1 | Abnormal cartilage collagen |
| HP:0031520 | 0.0499436884913 | 0.5 | COL2A1 | Groin pain |
| HP:0031153 | 0.0499436884913 | 0.5 | COL2A1 | Membranous vitreous appearance |
| HP:0011860 | 0.0499436884913 | 0.5 | COL2A1 | Metaphyseal dappling |
| HP:0009290 | 0.0499436884913 | 0.5 | COL2A1 | Short distal phalanx of the 4th finger |
| HP:0009289 | 0.0499436884913 | 0.5 | COL2A1 | Aplasia/Hypoplasia of the distal phalanx of the 4th finger |
| HP:0009282 | 0.0499436884913 | 0.5 | COL2A1 | Abnormality of the distal phalanx of the 4th finger |
| HP:0008452 | 0.0499436884913 | 0.5 | COL2A1 | Wafer-thin platyspondyly |
| HP:0008142 | 0.0499436884913 | 0.5 | COL2A1 | Delayed calcaneal ossification |
| HP:0005068 | 0.0499436884913 | 0.5 | COL2A1 | Absent styloid process of ulna |
| HP:0006019 | 0.0499436884913 | 0.5 | COL2A1 | Reduced proximal interphalangeal joint space |
| HP:0005451 | 0.0499436884913 | 0.5 | COL2A1 | Decreased cranial base ossification |
| HP:0005193 | 0.0499436884913 | 0.5 | COL2A1 | Restricted large joint movement |
| HP:0100734 | 0.0499436884913 | 0.5 | COL2A1 | Abnormal vertebral epiphysis morphology |
| HP:0004605 | 0.0499436884913 | 0.5 | COL2A1 | Absent vertebral body mineralization |
| HP:0004591 | 0.0499436884913 | 0.5 | COL2A1 | Disc-like vertebral bodies |
| HP:0004557 | 0.0499436884913 | 0.5 | COL2A1 | Anterior vertebral fusion |
| HP:0004180 | 0.0499436884913 | 0.5 | COL2A1 | Short distal phalanx of the 3rd finger |
| HP:0004035 | 0.0499436884913 | 0.5 | COL2A1 | Abnormal ulnar styloid process morphology |
| HP:0003888 | 0.0499436884913 | 0.5 | COL2A1 | Flattened humeral heads |
| HP:0006172 | 0.0499436884913 | 0.5 | COL2A1 | Flattened, squared-off epiphyses of tubular bones |
| HP:0200003 | 0.0499436884913 | 0.5 | COL2A1 | Splayed epiphyses |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| COL14A1 | MMP9 | 0.973 | 0.21 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MMP9 | COL2A1 | 0.969 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| COL14A1 | COL2A1 | 0.787 | 0.258 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes