hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09614.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IFIT1 | Interferon-induced protein with tetratricopeptide repeats 1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K) (P56) | 5 | UniProt NCBI |
| IFIT2 | Interferon-induced protein with tetratricopeptide repeats 2 (IFIT-2) (ISG-54 K) (Interferon-induced 54 kDa protein) (IFI-54K) (P54) | 5 | UniProt NCBI |
| IFIT3 | Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3) (CIG49) (ISG-60) (Interferon-induced 60 kDa protein) (IFI-60K) (Interferon-induced protein with tetratricopeptide repeats 4) (IFIT-4) (Retinoic acid-induced gene G protein) (P60) (RIG-G) | 5 | UniProt NCBI |
| IFNA14 | Interferon alpha-14 (IFN-alpha-14) (Interferon alpha-H) (LeIF H) (Interferon lambda-2-H) | 5 | UniProt NCBI |
| PHACTR4 | Phosphatase and actin regulator 4 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-909733 | 2.22216287327e-07 | 0.8 | IFIT3 IFNA14 IFIT1 IFIT2 | Interferon alpha/beta signaling |
| REAC:R-HSA-913531 | 1.59752917105e-05 | 0.8 | IFIT3 IFNA14 IFIT1 IFIT2 | Interferon Signaling |
| WP:WP4197 | 0.0011148137474 | 0.4 | IFIT3 IFIT1 | Immune response to tuberculosis |
| TF:M11670_1 | 0.00220577099344 | 0.6 | IFIT3 IFIT1 PHACTR4 | Factor: IRF-5; motif: NYGAAACCGAAACY; match class: 1 |
| REAC:R-HSA-1280215 | 0.00234382138907 | 0.8 | IFIT3 IFNA14 IFIT1 IFIT2 | Cytokine Signaling in Immune system |
| TF:M04020_1 | 0.00475337188383 | 0.6 | IFIT3 IFIT1 PHACTR4 | Factor: IRF8; motif: NCGAAACCGAAACT; match class: 1 |
| TF:M11665_1 | 0.00615332128452 | 0.8 | IFIT3 PHACTR4 IFIT1 IFIT2 | Factor: IRF-2; motif: NGAAASYGAAAS; match class: 1 |
| GO:0140374 | 0.00875197805683 | 0.6 | IFIT3 IFIT1 IFIT2 | antiviral innate immune response |
| TF:M04014 | 0.00911621649963 | 0.8 | IFIT3 PHACTR4 IFIT1 IFIT2 | Factor: IRF3; motif: NNRRAANGGAAACCGAAACYR |
| TF:M00772_1 | 0.0094606249379 | 0.6 | IFIT3 IFIT1 IFIT2 | Factor: IRF; motif: RRAANTGAAASYGNV; match class: 1 |
| TF:M00453_1 | 0.0152802540284 | 0.8 | IFIT3 PHACTR4 IFIT1 IFIT2 | Factor: IRF-7; motif: TNSGAAWNCGAAANTNNN; match class: 1 |
| TF:M09733_1 | 0.0158157893648 | 0.8 | IFIT3 PHACTR4 IFIT1 IFIT2 | Factor: STAT2; motif: NRGAAANNGAAACTNA; match class: 1 |
| TF:M08887_1 | 0.0224016609185 | 0.6 | IFIT3 IFIT1 IFIT2 | Factor: IRF; motif: NNGAAANTGAAANN; match class: 1 |
| GO:0009615 | 0.0320163575123 | 0.8 | IFIT3 IFNA14 IFIT1 IFIT2 | response to virus |
| KEGG:05160 | 0.0380272112444 | 0.4 | IFIT1 IFNA14 | Hepatitis C |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| IFIT1 | IFNA14 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| IFIT2 | PHACTR4 | 0.993 | 0.084 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| IFIT3 | PHACTR4 | 0.991 | 0.04 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| IFIT2 | IFIT3 | 0.988 | 0.534 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| IFIT1 | PHACTR4 | 0.988 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| IFIT1 | IFIT2 | 0.986 | 0.3 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| IFIT3 | IFNA14 | 0.967 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| IFIT1 | IFIT3 | 0.925 | 0.576 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| IFIT1 | huMAP3_02961.1 huMAP3_09614.1 huMAP3_11921.1 huMAP3_14555.1 |
| IFIT2 | huMAP3_02961.1 huMAP3_07780.1 huMAP3_09614.1 |
| IFIT3 | huMAP3_02961.1 huMAP3_09614.1 huMAP3_11921.1 |
| IFNA14 | huMAP3_04584.1 huMAP3_06996.1 huMAP3_09614.1 huMAP3_10459.1 huMAP3_11921.1 huMAP3_13851.1 |
| PHACTR4 | huMAP3_02961.1 huMAP3_07780.1 huMAP3_09614.1 huMAP3_14555.1 |