hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09623.1
Confidence: Moderate High  
ProteinsGenename | Protein Name | Uniprot Annotation Score | Links |
---|---|---|---|
FBXO9 | F-box only protein 9 (Cross-immune reaction antigen 1) (Renal carcinoma antigen NY-REN-57) | 5 | UniProt   NCBI |
FBXO4 | F-box only protein 4 | 5 | UniProt   NCBI |
FBXL8 | F-box/LRR-repeat protein 8 (F-box and leucine-rich repeat protein 8) (F-box protein FBL8) | 3 | UniProt   NCBI |
KDM2B | Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) | 5 | UniProt   NCBI |
FBXO38 | F-box only protein 38 | 5 | UniProt   NCBI |
FBXL4 | F-box/LRR-repeat protein 4 (F-box and leucine-rich repeat protein 4) (F-box protein FBL4/FBL5) | 5 | UniProt   NCBI |
FBH1 | F-box DNA helicase 1 (hFBH1) (EC 5.6.2.4) (DNA 3'-5' helicase 1) (F-box only protein 18) | 5 | UniProt   NCBI |
FBXO44 | F-box only protein 44 (F-box protein FBX30) (F-box/G-domain protein 3) | 5 | UniProt   NCBI |
DEDD | Death effector domain-containing protein (DEDPro1) (Death effector domain-containing testicular molecule) (FLDED-1) | 5 | UniProt   NCBI |
FBXL15 | F-box/LRR-repeat protein 15 (F-box only protein 37) | 5 | UniProt   NCBI |
FBXL18 | F-box/LRR-repeat protein 18 (F-box and leucine-rich repeat protein 18) | 4 | UniProt   NCBI |
FBXO31 | F-box only protein 31 | 5 | UniProt   NCBI |
FBXO36 | F-box only protein 36 | 2 | UniProt   NCBI |
FBXL16 | F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16) | 4 | UniProt   NCBI |
FBXW9 | F-box/WD repeat-containing protein 9 (F-box and WD-40 domain-containing protein 9) | 3 | UniProt   NCBI |
CCNF | Cyclin-F (F-box only protein 1) | 5 | UniProt   NCBI |
CUL1 | Cullin-1 (CUL-1) | 5 | UniProt   NCBI |
SKP1 | S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1) | 5 | UniProt   NCBI |
FBXO22 | F-box only protein 22 (F-box protein FBX22p44) | 5 | UniProt   NCBI |
ARB2A | Cotranscriptional regulator ARB2A (ARB2 cotranscriptional regulator A) (Cotranscriptional regulator FAM172A) (Protein FAM172A) | 5 | UniProt   NCBI |
ZXDB | Zinc finger X-linked protein ZXDB | 4 | UniProt   NCBI |
KDM2A | Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A) | 5 | UniProt   NCBI |
EEF2 | Elongation factor 2 (EF-2) (EC 3.6.5.-) | 5 | UniProt   NCBI |
FBXO21 | F-box only protein 21 | 3 | UniProt   NCBI |
TTC9C | Tetratricopeptide repeat protein 9C (TPR repeat protein 9C) | 4 | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  GO:0019005 | 1.79836492791e-24 | 0.583333333333 | FBXL4 FBXL8 CCNF FBXO31 FBXO38 SKP1 FBXO4 FBXL18 FBXL16 FBXL15 FBXO44 FBH1 FBXO9 CUL1 | SCF ubiquitin ligase complex |
  GO:0031146 | 6.64697397073e-24 | 0.541666666667 | FBXL4 FBXL8 CCNF FBXO31 FBXO44 FBXO4 FBXL18 FBXL16 FBXL15 FBXO38 SKP1 FBXO9 CUL1 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
  REAC:R-HSA-8951664 | 1.40066932226e-19 | 0.625 | FBXL4 FBXL8 CCNF FBXO31 FBXO44 FBXO4 FBXL18 FBXO21 FBXL16 FBXL15 FBXO22 CUL1 SKP1 FBXO9 FBXW9 | Neddylation |
  REAC:R-HSA-983168 | 4.42007013363e-18 | 0.625 | FBXL4 FBXL8 CCNF FBXO31 FBXO44 FBXO4 FBXL18 FBXO21 FBXL16 FBXL15 FBXO22 CUL1 SKP1 FBXO9 FBXW9 | Antigen processing: Ubiquitination & Proteasome degradation |
  GO:0031461 | 3.92511869424e-17 | 0.583333333333 | FBXL4 FBXL8 CCNF FBXO31 FBXO38 SKP1 FBXO4 FBXL18 FBXL16 FBXL15 FBXO44 FBH1 FBXO9 CUL1 | cullin-RING ubiquitin ligase complex |
  REAC:R-HSA-983169 | 9.82512027699e-17 | 0.625 | FBXL4 FBXL8 CCNF FBXO31 FBXO44 FBXO4 FBXL18 FBXO21 FBXL16 FBXL15 FBXO22 CUL1 SKP1 FBXO9 FBXW9 | Class I MHC mediated antigen processing & presentation |
  GO:0000151 | 5.93870400278e-16 | 0.625 | FBXL4 FBXL8 CCNF FBXO31 FBXO38 SKP1 FBXO4 FBXL18 FBXO21 FBXL16 FBXL15 FBXO44 FBH1 FBXO9 CUL1 | ubiquitin ligase complex |
  GO:0043161 | 6.18678777796e-13 | 0.583333333333 | FBXL4 FBXL8 CCNF FBXO31 FBXO44 FBXO4 FBXL18 FBXL16 FBXL15 FBXO38 SKP1 FBXO22 FBXO9 CUL1 | proteasome-mediated ubiquitin-dependent protein catabolic process |
  REAC:R-HSA-1280218 | 1.66291069003e-12 | 0.625 | FBXL4 FBXL8 CCNF FBXO31 FBXO44 FBXO4 FBXL18 FBXO21 FBXL16 FBXL15 FBXO22 CUL1 SKP1 FBXO9 FBXW9 | Adaptive Immune System |
  GO:0006511 | 3.14536098625e-12 | 0.625 | FBXL4 FBXL8 CCNF FBXO31 FBXO44 FBXO4 FBXL18 FBXO21 FBXL16 FBXL15 FBXO38 SKP1 FBXO22 FBXO9 CUL1 | ubiquitin-dependent protein catabolic process |
  GO:0019941 | 4.00317774092e-12 | 0.625 | FBXL4 FBXL8 CCNF FBXO31 FBXO44 FBXO4 FBXL18 FBXO21 FBXL16 FBXL15 FBXO38 SKP1 FBXO22 FBXO9 CUL1 | modification-dependent protein catabolic process |
  GO:0043632 | 5.54128950138e-12 | 0.625 | FBXL4 FBXL8 CCNF FBXO31 FBXO44 FBXO4 FBXL18 FBXO21 FBXL16 FBXL15 FBXO38 SKP1 FBXO22 FBXO9 CUL1 | modification-dependent macromolecule catabolic process |
  GO:0010498 | 1.76330253529e-11 | 0.583333333333 | FBXL4 FBXL8 CCNF FBXO31 FBXO44 FBXO4 FBXL18 FBXL16 FBXL15 FBXO38 SKP1 FBXO22 FBXO9 CUL1 | proteasomal protein catabolic process |
  GO:0051603 | 6.844710547e-11 | 0.625 | FBXL4 FBXL8 CCNF FBXO31 FBXO44 FBXO4 FBXL18 FBXO21 FBXL16 FBXL15 FBXO38 SKP1 FBXO22 FBXO9 CUL1 | proteolysis involved in protein catabolic process |
  GO:0030163 | 2.23188090979e-09 | 0.625 | FBXL4 FBXL8 CCNF FBXO31 FBXO44 FBXO4 FBXL18 FBXO21 FBXL16 FBXL15 FBXO38 SKP1 FBXO22 FBXO9 CUL1 | protein catabolic process |
  GO:1990234 | 2.80437567761e-09 | 0.625 | FBXL4 FBXL8 CCNF FBXO31 FBXO38 SKP1 FBXO4 FBXL18 FBXO21 FBXL16 FBXL15 FBXO44 FBH1 FBXO9 CUL1 | transferase complex |
  GO:0140535 | 6.5117738236e-09 | 0.625 | FBXL4 FBXL8 CCNF FBXO31 FBXO38 SKP1 FBXO4 FBXL18 FBXO21 FBXL16 FBXL15 FBXO44 FBH1 FBXO9 CUL1 | intracellular protein-containing complex |
  GO:0009057 | 9.45194842971e-09 | 0.666666666667 | FBXL4 FBXL8 CCNF FBXO31 FBXO38 SKP1 FBXO4 FBXL18 FBXO21 FBXL16 FBXL15 FBXO44 FBH1 FBXO22 FBXO9 CUL1 | macromolecule catabolic process |
  REAC:R-HSA-597592 | 1.34325654687e-08 | 0.625 | FBXL4 FBXL8 CCNF FBXO31 FBXO44 FBXO4 FBXL18 FBXO21 FBXL16 FBXL15 FBXO22 CUL1 SKP1 FBXO9 FBXW9 | Post-translational protein modification |
  GO:0006508 | 2.40999759838e-07 | 0.625 | FBXL4 FBXL8 CCNF FBXO31 FBXO44 FBXO4 FBXL18 FBXO21 FBXL16 FBXL15 FBXO38 SKP1 FBXO22 FBXO9 CUL1 | proteolysis |
  GO:1901565 | 2.47685353246e-07 | 0.625 | FBXL4 FBXL8 CCNF FBXO31 FBXO44 FBXO4 FBXL18 FBXO21 FBXL16 FBXL15 FBXO38 SKP1 FBXO22 FBXO9 CUL1 | organonitrogen compound catabolic process |
  CORUM:729 | 4.71120641517e-07 | 0.125 | SKP1 FBXO31 CUL1 | Ubiquitin E3 ligase (FBXO31, SKP1A, CUL1, RBX1) |
  CORUM:6904 | 4.71120641517e-07 | 0.125 | FBXO44 CUL1 SKP1 | Ubiquitin E3 ligase (CUL1, FBXO44, RBX1, SKP1) |
  CORUM:6817 | 4.71120641517e-07 | 0.125 | FBH1 CUL1 SKP1 | Ubiquitin E3 ligase (FBXO18, SKP1A, CUL1, RBX1) |
  CORUM:2191 | 4.71120641517e-07 | 0.125 | FBH1 CUL1 SKP1 | Ubiquitin E3 ligase (FBXO18, SKP1A, CUL1, RBX1) |
  REAC:R-HSA-168256 | 1.14900157117e-06 | 0.625 | FBXL4 FBXL8 CCNF FBXO31 FBXO44 FBXO4 FBXL18 FBXO21 FBXL16 FBXL15 FBXO22 CUL1 SKP1 FBXO9 FBXW9 | Immune System |
  REAC:R-HSA-392499 | 1.36572171783e-06 | 0.625 | FBXL4 FBXL8 CCNF FBXO31 FBXO44 FBXO4 FBXL18 FBXO21 FBXL16 FBXL15 FBXO22 CUL1 SKP1 FBXO9 FBXW9 | Metabolism of proteins |
  GO:1901575 | 2.36995282846e-06 | 0.666666666667 | FBXL4 FBXL8 CCNF FBXO31 FBXO38 SKP1 FBXO4 FBXL18 FBXO21 FBXL16 FBXL15 FBXO44 FBH1 FBXO22 FBXO9 CUL1 | organic substance catabolic process |
  GO:1902494 | 4.78202400464e-05 | 0.625 | FBXL4 FBXL8 CCNF FBXO31 FBXO38 SKP1 FBXO4 FBXL18 FBXO21 FBXL16 FBXL15 FBXO44 FBH1 FBXO9 CUL1 | catalytic complex |
  GO:0009056 | 6.64806347703e-05 | 0.666666666667 | FBXL4 FBXL8 CCNF FBXO31 FBXO38 SKP1 FBXO4 FBXL18 FBXO21 FBXL16 FBXL15 FBXO44 FBH1 FBXO22 FBXO9 CUL1 | catabolic process |
  CORUM:2880 | 0.000234715819577 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (FBXW11, SKP1, CUL1) |
  CORUM:2724 | 0.000234715819577 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (NFKBIA, BTRC, CUL1, SKP1A) |
  CORUM:2725 | 0.000234715819577 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (NFKBIA, FBXW11, CUL1, SKP1A) |
  CORUM:6900 | 0.000234715819577 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (CUL1, FBXO10, SKP1) |
  CORUM:615 | 0.000234715819577 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (SKP1A, SKP2, CUL1) |
  CORUM:227 | 0.000234715819577 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (SKP1A, BTRC, CUL1) |
  CORUM:390 | 0.000234715819577 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (SKP1A, FBXW2, CUL1) |
  CORUM:4072 | 0.000234715819577 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (CUL1, RBX1, SKP1) |
  CORUM:226 | 0.000234715819577 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (SKP1A, SKP2, CUL1) |
  CORUM:6901 | 0.000468960518513 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (CUL1, FBXO6, RBX1, SKP1) |
  CORUM:2881 | 0.000468960518513 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (BTRC, CUL1, RBX1, SKP1) |
  CORUM:2773 | 0.000468960518513 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (CRY2, SKP1A, CUL1, FBXL3) |
  CORUM:6903 | 0.000468960518513 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (CUL1, FBXO27, RBX1, SKP1) |
  CORUM:2772 | 0.000468960518513 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (CRY1, SKP1A, CUL1, FBXL3) |
  CORUM:6902 | 0.000468960518513 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (CUL1, FBXO17, RBX1, SKP1) |
  CORUM:2192 | 0.000468960518513 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (NIPA, SKP1A, CUL1, RBX1) |
  CORUM:1260 | 0.000468960518513 | 0.0833333333333 | SKP1 CUL1 | Neddylin ligase (FBXO11, SKP1, CUL1, RBX1) |
  CORUM:80 | 0.000468960518513 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, RBX1) |
  CORUM:1215 | 0.000468960518513 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (FBXW7, CUL1, SKP1A, RBX1) |
  CORUM:1253 | 0.000468960518513 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (FBXW7, CUL1, SKP1A, RBX1) |
  CORUM:1052 | 0.000468960518513 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (FBXW11, SKP1A, CUL1, RBX1) |
  CORUM:1051 | 0.000468960518513 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, RBX1) |
  CORUM:2188 | 0.000780816509459 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (CDC34, NEDD8, BTRC, CUL1, SKP1A, RBX1) |
  CORUM:2189 | 0.000780816509459 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (SMAD3, BTRC, CUL1, SKP1A, RBX1) |
  CORUM:3036 | 0.000780816509459 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) |
  CORUM:3015 | 0.00117004950021 | 0.0833333333333 | SKP1 CUL1 | p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex |
  CORUM:1178 | 0.00163642570415 | 0.0833333333333 | SKP1 KDM2B | BCOR complex |
  CORUM:2715 | 0.00217971183931 | 0.0833333333333 | SKP1 CUL1 | Ubiquitin E3 ligase (CSN1, CSN8, HRT1, SKP1, SKP2, CUL1, CUL2, CUL3) |
  CORUM:781 | 0.00279967512746 | 0.0833333333333 | SKP1 CUL1 | URI complex (Unconventional prefoldin RPB5 Interactor) |
  GO:0016567 | 0.00329249728859 | 0.375 | CCNF FBXO38 FBXO4 FBXO22 FBXL15 SKP1 FBH1 FBXO9 CUL1 | protein ubiquitination |
  REAC:R-HSA-2644607 | 0.00463344224878 | 0.0833333333333 | SKP1 CUL1 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling |
  REAC:R-HSA-2644605 | 0.00463344224878 | 0.0833333333333 | SKP1 CUL1 | FBXW7 Mutants and NOTCH1 in Cancer |
  CORUM:5196 | 0.00511730766433 | 0.0833333333333 | SKP1 CUL1 | TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1) |
  GO:0032446 | 0.00988211959713 | 0.375 | CCNF FBXO38 FBXO4 FBXO22 FBXL15 SKP1 FBH1 FBXO9 CUL1 | protein modification by small protein conjugation |
  CORUM:5233 | 0.0177318158256 | 0.0833333333333 | SKP1 CUL1 | TNF-alpha/NF-kappa B signaling complex 5 |
  KEGG:03083 | 0.0186103215449 | 0.125 | SKP1 KDM2B KDM2A | Polycomb repressive complex |
  GO:0070647 | 0.0227969957811 | 0.375 | CCNF FBXO38 FBXO4 FBXO22 FBXL15 SKP1 FBH1 FBXO9 CUL1 | protein modification by small protein conjugation or removal |
  REAC:R-HSA-8854050 | 0.0258581688077 | 0.125 | SKP1 FBXL18 CUL1 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis |
  GO:0043687 | 0.039583676101 | 0.375 | CCNF FBXO38 FBXO4 FBXO22 FBXL15 SKP1 FBH1 FBXO9 CUL1 | post-translational protein modification |
  REAC:R-HSA-9708530 | 0.0421758235266 | 0.0833333333333 | SKP1 CUL1 | Regulation of BACH1 activity |
  CORUM:7185 | 0.0497620750785 | 0.0416666666667 | CCNF | CCNB1-CCNF complex |
Edges
Protein 1 | Protein 2 | Score | ProteomeHD |
---|---|---|---|
 FBXW9 |  SKP1 | 0.999 | 0.172           |
 FBXO4 |  SKP1 | 0.999 | 0.162           |
 FBXO44 |  CUL1 | 0.999 |            |
 FBXL15 |  SKP1 | 0.999 | 0.372           |
 FBXO4 |  CUL1 | 0.999 | 0.194           |
 FBXO44 |  SKP1 | 0.999 |            |
 CUL1 |  SKP1 | 0.999 | 0.302           |
 FBXL8 |  SKP1 | 0.998 | 0.142           |
 FBXO9 |  EEF2 | 0.998 | 0.252           |
 SKP1 |  FBXO22 | 0.998 | 0.054           |
 SKP1 |  FBXO9 | 0.998 | 0.134           |
 FBXL15 |  CUL1 | 0.998 | 0.2504375           |
 SKP1 |  TTC9C | 0.997 | 0.066           |
 SKP1 |  ARB2A | 0.997 | 0.152           |
 SKP1 |  FBXO38 | 0.997 | 0.252           |
 TTC9C |  FBXO38 | 0.996 | 0.044           |
 FBXO36 |  SKP1 | 0.995 |            |
 FBXO22 |  TTC9C | 0.995 | 0.074           |
 SKP1 |  KDM2A | 0.995 | 0.07           |
 DEDD |  SKP1 | 0.993 |            |
 ARB2A |  FBXO38 | 0.99 | 0.264           |
 TTC9C |  ARB2A | 0.99 | 0.02           |
 SKP1 |  FBXO21 | 0.989 | 0.226           |
 CUL1 |  FBXO9 | 0.988 | 0.146           |
 FBH1 |  SKP1 | 0.986 | 0.132           |
 FBXO31 |  SKP1 | 0.985 |            |
 KDM2B |  SKP1 | 0.982 | 0.214           |
 FBXL15 |  FBXL16 | 0.981 |            |
 FBXL8 |  FBXL15 | 0.981 | 0.06           |
 FBXL16 |  SKP1 | 0.98 |            |
 FBXL15 |  FBXO31 | 0.98 |            |
 ZXDB |  FBXO38 | 0.979 |            |
 FBXL8 |  FBXO9 | 0.978 | 0.13           |
 ZXDB |  ARB2A | 0.978 |            |
 CUL1 |  FBXO21 | 0.977 | 0.118           |
 FBXL8 |  FBXO31 | 0.976 |            |
 FBXL4 |  TTC9C | 0.976 | 0.096           |
 FBXL15 |  FBXO9 | 0.974 | 0.066           |
 FBXO31 |  FBXO9 | 0.969 |            |
 FBH1 |  TTC9C | 0.968 | 0.11           |
 FBXW9 |  TTC9C | 0.968 | 0.04           |
 FBXO21 |  FBXO9 | 0.966 | 0.086           |
 FBXO31 |  CUL1 | 0.965 |            |
 FBXL4 |  SKP1 | 0.962 | 0.18           |
 FBXL8 |  KDM2A | 0.961 | 0.036           |
 FBXL8 |  FBXL16 | 0.959 |            |
 KDM2B |  FBXL15 | 0.959 | 0.142           |
 FBXL16 |  FBXO9 | 0.959 |            |
 CCNF |  SKP1 | 0.958 |            |
 KDM2B |  FBXW9 | 0.956 | 0.114           |
 FBXW9 |  CUL1 | 0.955 | 0.054           |
 FBXL8 |  KDM2B | 0.954 | 0.056           |
 FBXL8 |  FBXW9 | 0.952 | 0.054           |
 KDM2B |  FBXO9 | 0.95 | 0.076           |
 FBH1 |  FBXO36 | 0.946 |            |
 FBXL8 |  FBH1 | 0.946 | 0.132           |
 DEDD |  FBXO36 | 0.946 |            |
 FBXL8 |  FBXO36 | 0.946 |            |
 FBXL8 |  CCNF | 0.946 |            |
 KDM2B |  FBXO36 | 0.946 |            |
 FBXO31 |  CCNF | 0.946 |            |
 FBXO36 |  CCNF | 0.946 |            |
 FBXO31 |  FBXO36 | 0.946 |            |
 FBXO36 |  KDM2A | 0.946 |            |
 FBXO4 |  FBH1 | 0.946 | 0.086           |
 FBXO4 |  CCNF | 0.946 |            |
 FBXO4 |  FBXL15 | 0.946 | 0.054           |
 FBXO4 |  FBXO31 | 0.946 |            |
 FBXO4 |  FBXO36 | 0.946 |            |
 FBXO36 |  FBXO9 | 0.946 |            |
 FBXO44 |  FBXO36 | 0.946 |            |
 FBXO4 |  FBXL8 | 0.946 | 0.064           |
 FBXL15 |  FBXO36 | 0.946 |            |
 FBXL4 |  FBXO36 | 0.946 |            |
 FBXL16 |  FBXW9 | 0.944 |            |
 FBXL15 |  FBXW9 | 0.943 | 0.104           |
 FBXO36 |  FBXL16 | 0.941 |            |
 FBXL15 |  FBXO21 | 0.937 | 0.102           |
 FBXO4 |  FBXO9 | 0.933 | 0.082           |
 FBXO36 |  FBXW9 | 0.933 |            |
 FBXO31 |  KDM2A | 0.932 |            |
 FBXL8 |  DEDD | 0.931 |            |
 FBXO4 |  DEDD | 0.931 |            |
 FBXL8 |  FBXO44 | 0.931 |            |
 FBXO4 |  FBXL4 | 0.931 | 0.092           |
 FBXL8 |  FBXL4 | 0.931 | 0.102           |
 FBXO44 |  FBXO31 | 0.931 |            |
 FBXL4 |  FBXO31 | 0.931 |            |
 FBXL15 |  CCNF | 0.931 |            |
 KDM2B |  KDM2A | 0.931 | 0.104           |
 FBXW9 |  FBXO9 | 0.93 | 0.088           |
 FBXL8 |  FBXO21 | 0.93 | 0.062           |
 SKP1 |  EEF2 | 0.925 | 0.546           |
 FBXO4 |  KDM2B | 0.923 | 0.086           |
 FBXO36 |  FBXO38 | 0.923 |            |
 FBXO31 |  FBXO21 | 0.921 |            |
 TTC9C |  FBXO9 | 0.915 | 0.06           |
 FBXO31 |  FBXW9 | 0.915 |            |
 KDM2B |  FBXO31 | 0.913 |            |
 FBXO31 |  FBXL16 | 0.909 |            |
 KDM2A |  FBXO9 | 0.909 | 0.064           |
 FBXL15 |  KDM2A | 0.909 | 0.094           |
 FBXL4 |  FBH1 | 0.906 | 0.1           |
 FBH1 |  CCNF | 0.905 |            |
 FBXO36 |  ARB2A | 0.905 |            |
 FBXO36 |  FBXO22 | 0.899 |            |
 FBH1 |  ARB2A | 0.895 | 0.108           |
 KDM2B |  FBXL16 | 0.892 |            |
 FBXW9 |  FBXO21 | 0.891 | 0.116           |
 FBXW9 |  KDM2A | 0.88 | 0.04           |
 FBXL15 |  TTC9C | 0.876 | 0.1           |
 FBH1 |  FBXO38 | 0.865 | 0.126           |
 KDM2B |  FBXO21 | 0.862 | 0.132           |
 KDM2A |  FBXO21 | 0.853 | 0.056           |
 DEDD |  FBXO38 | 0.834 |            |
 FBXL16 |  FBXO21 | 0.834 |            |
 FBH1 |  FBXO22 | 0.829 | 0.054           |
 DEDD |  ARB2A | 0.829 |            |
 CCNF |  FBXO9 | 0.826 |            |
 FBXL4 |  FBXL15 | 0.826 | 0.066           |
 FBXO9 |  FBXO38 | 0.82 | 0.076           |
 FBXL15 |  FBXO38 | 0.82 | 0.124           |
 CCNF |  FBXO22 | 0.819 |            |
 FBH1 |  EEF2 | 0.813 | 0.226714285714           |
 FBXO22 |  ARB2A | 0.813 | 0.046           |
 FBXO22 |  FBXO38 | 0.813 | 0.098           |
 FBH1 |  FBXL16 | 0.813 |            |
 FBXL16 |  CCNF | 0.813 |            |
 FBXL8 |  FBXO22 | 0.806 | 0.088           |
 FBH1 |  DEDD | 0.805 |            |
 DEDD |  FBXO9 | 0.804 |            |
 FBH1 |  FBXW9 | 0.804 | 0.128           |
 FBH1 |  FBXO9 | 0.804 | 0.094           |
 DEDD |  FBXL15 | 0.804 |            |
 FBXO31 |  ARB2A | 0.804 |            |
 FBXO31 |  FBXO38 | 0.804 |            |
 FBXO31 |  FBXO22 | 0.804 |            |
 DEDD |  FBXO22 | 0.796 |            |
 DEDD |  CCNF | 0.796 |            |
 FBH1 |  FBXO44 | 0.795 |            |
 FBXL4 |  FBXO9 | 0.795 | 0.092           |
 CCNF |  KDM2A | 0.795 |            |
 FBXO4 |  FBXO38 | 0.795 | 0.062           |
 FBXL8 |  FBXO38 | 0.795 | 0.062           |
 FBH1 |  KDM2A | 0.795 | 0.108           |
 FBXO44 |  CCNF | 0.795 |            |
 FBXL8 |  ARB2A | 0.795 | 0.082           |
 FBXL4 |  CCNF | 0.795 |            |
 DEDD |  FBXO31 | 0.793 |            |
 FBH1 |  FBXO31 | 0.793 |            |
 FBXO4 |  FBXO44 | 0.791 |            |
 FBXO4 |  KDM2A | 0.791 | 0.05           |
 FBH1 |  FBXL15 | 0.783 | 0.118           |
 KDM2B |  ARB2A | 0.78 | 0.098           |
 KDM2B |  FBXO38 | 0.78 | 0.144           |
 FBXL4 |  FBXO38 | 0.78 | 0.108           |
 FBXO4 |  FBXL16 | 0.773 |            |
 KDM2B |  FBH1 | 0.757 | 0.084           |
 KDM2B |  DEDD | 0.757 |            |
 KDM2B |  CCNF | 0.757 |            |
 FBXW9 |  CCNF | 0.757 |            |
 DEDD |  KDM2A | 0.757 |            |
 KDM2B |  FBXL4 | 0.757 | 0.06           |
 FBXO44 |  DEDD | 0.757 |            |
 FBXL4 |  DEDD | 0.757 |            |
 KDM2B |  FBXO44 | 0.757 |            |
 DEDD |  FBXL16 | 0.74 |            |
 FBXO36 |  EEF2 | 0.727 |            |
 KDM2B |  FBXO22 | 0.726 | 0.07           |
 CCNF |  ARB2A | 0.72 |            |
 CCNF |  FBXO38 | 0.72 |            |
 DEDD |  FBXW9 | 0.72 |            |
 DEDD |  EEF2 | 0.713 |            |
 CCNF |  EEF2 | 0.712 |            |
 FBXL8 |  EEF2 | 0.688 | 0.218           |
 FBXO31 |  EEF2 | 0.688 |            |
 FBXL16 |  KDM2A | 0.674 |            |
 CUL1 |  FBXO38 | 0.612 | 0.088           |
 FBXL8 |  CUL1 | 0.592 | 0.124           |
 FBXO44 |  FBXL15 | 0.572 |            |
 FBXL15 |  ARB2A | 0.561 | 0.086           |
 FBXO9 |  ARB2A | 0.561 | 0.104           |
 FBXO4 |  FBXW9 | 0.541 | 0.05           |
 FBXL8 |  TTC9C | 0.539 | 0.12           |
 FBXO22 |  FBXO9 | 0.523 | 0.044           |
 FBXL15 |  FBXO22 | 0.523 | 0.044           |
 FBXO4 |  ARB2A | 0.521 | 0.07           |
 FBXO44 |  FBXO9 | 0.521 |            |
 FBXW9 |  FBXO38 | 0.514 | 0.086           |
 FBXL4 |  ARB2A | 0.499 | 0.112           |
 FBXW9 |  FBXO22 | 0.48 | 0.042           |
 KDM2B |  EEF2 | 0.471 | 0.266714285714           |
 FBXL4 |  KDM2A | 0.466 | 0.08           |
 FBXL4 |  FBXO44 | 0.466 |            |
 FBXO4 |  FBXO22 | 0.459 | 0.044           |
 FBXO44 |  FBXO22 | 0.441 |            |
 FBXO22 |  KDM2A | 0.441 | 0.018           |
 FBXO44 |  FBXL16 | 0.435 |            |
 FBXL4 |  FBXL16 | 0.435 |            |
 DEDD |  CUL1 | 0.427 |            |
 FBXO44 |  KDM2A | 0.422 |            |
 KDM2A |  TTC9C | 0.419 | 0.014           |
 CUL1 |  ARB2A | 0.417 | 0.05           |
 FBXO36 |  FBXO21 | 0.412 |            |
 FBXW9 |  ARB2A | 0.407 | 0.196           |
 KDM2B |  CUL1 | 0.398 | 0.146           |
 FBXO44 |  FBXO38 | 0.397 |            |
 KDM2A |  FBXO38 | 0.397 | 0.096           |
 KDM2A |  EEF2 | 0.395 | 0.144           |
 KDM2B |  TTC9C | 0.391 | 0.048           |
 FBXL16 |  ARB2A | 0.389 |            |
 FBXL16 |  FBXO38 | 0.389 |            |
 FBXL4 |  FBXW9 | 0.389 | 0.116           |
 FBXO44 |  FBXW9 | 0.389 |            |
 KDM2A |  ARB2A | 0.376 | 0.014           |
 FBXO44 |  ARB2A | 0.376 |            |
 FBXL4 |  FBXO22 | 0.374 | 0.056           |
 FBXL16 |  FBXO22 | 0.371 |            |
 CUL1 |  TTC9C | 0.369 | 0.046           |
 FBXO44 |  TTC9C | 0.367 |            |
 FBXO36 |  CUL1 | 0.339 |            |
 FBXL16 |  CUL1 | 0.334 |            |
 DEDD |  FBXO21 | 0.326 |            |
 FBXO22 |  FBXO21 | 0.324 | 0.094           |
 FBH1 |  FBXO21 | 0.322 | 0.092           |
 FBH1 |  CUL1 | 0.322 | 0.146           |
 FBXO36 |  TTC9C | 0.306 |            |
 FBXO31 |  TTC9C | 0.304 |            |
 FBXW9 |  EEF2 | 0.3 | 0.124           |
 CCNF |  FBXO21 | 0.3 |            |
 CCNF |  CUL1 | 0.285 |            |
 CCNF |  TTC9C | 0.284 |            |
 CUL1 |  KDM2A | 0.271 | 0.094           |
 FBXO21 |  FBXO38 | 0.271 | 0.072           |
 FBXL4 |  FBXO21 | 0.264 | 0.08           |
 DEDD |  TTC9C | 0.249 |            |
 FBXO4 |  FBXO21 | 0.244 | 0.092           |
 FBXL16 |  TTC9C | 0.241 |            |
 FBXO4 |  TTC9C | 0.23 | 0.056           |
 FBXO44 |  FBXO21 | 0.228 |            |
 EEF2 |  FBXO38 | 0.222 | 0.150714285714           |
 FBXO21 |  ARB2A | 0.219 | 0.096           |
 TTC9C |  EEF2 | 0.181 | 0.204           |
 FBXL4 |  EEF2 | 0.161 | 0.23           |
 CUL1 |  FBXO22 | 0.16 | 0.098           |
 FBXL4 |  CUL1 | 0.14 | 0.144           |
 FBXO4 |  EEF2 | 0.078 | 0.156714285714           |
 FBXL15 |  EEF2 | 0.076 | 0.184714285714           |
 EEF2 |  ARB2A | 0.058 | 0.126           |
 FBXO22 |  EEF2 | 0.053 | 0.082           |
 FBXO44 |  EEF2 | 0.051 |            |
 TTC9C |  FBXO21 | 0.051 | 0.062           |
 FBXO21 |  EEF2 | 0.048 | 0.108           |
 CUL1 |  EEF2 | 0.043 | 0.596           |
 CUL1 |  ZXDB | 0.032 |            |
 FBXL16 |  EEF2 | 0.028 |            |
 EEF2 |  ZXDB | 0.005 |            |
 SKP1 |  ZXDB | 0.005 |            |
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