hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09625.1
Complex Portal: CPX-14107
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TTC23 | Tetratricopeptide repeat protein 23 (TPR repeat protein 23) (Cervical cancer proto-oncogene 8 protein) (HCC-8) | 5 | UniProt NCBI |
| RFFL | E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) | 5 | UniProt NCBI |
| TTC23L | Tetratricopeptide repeat protein 23-like | 5 | UniProt NCBI |
| IQCE | IQ domain-containing protein E | 5 | UniProt NCBI |
| EFCAB7 | EF-hand calcium-binding domain-containing protein 7 | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4536 | 0.000181875223355 | 0.6 | TTC23 IQCE EFCAB7 | Genes related to primary cilium development based on CRISPR |
| REAC:R-HSA-5635838 | 0.0011839189519 | 0.4 | IQCE EFCAB7 | Activation of SMO |
| KEGG:04340 | 0.00447375439216 | 0.4 | IQCE EFCAB7 | Hedgehog signaling pathway |
| REAC:R-HSA-5632684 | 0.0440242300692 | 0.4 | IQCE EFCAB7 | Hedgehog 'on' state |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TTC23L | IQCE | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| RFFL | IQCE | 0.999 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 | ||
| EFCAB7 | TTC23L | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TTC23 | IQCE | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| EFCAB7 | TTC23 | 0.991 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| EFCAB7 | IQCE | 0.972 | bioplex_WMM bioplex3_WMM WMM_only | ||
| EFCAB7 | RFFL | 0.78 | bioplex3_HEK293 bioplex () bioplex3_WMM |
Related Complexes