hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09629.1
Complex Portal: CPX-12610
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBL4A | Ubiquitin-like protein 4A (Ubiquitin-like protein GDX) | 5 | UniProt NCBI |
| APOL2 | Apolipoprotein L2 (Apolipoprotein L-II) (ApoL-II) | 5 | UniProt NCBI |
| TBX3 | T-box transcription factor TBX3 (T-box protein 3) | 5 | UniProt NCBI |
| PDE12 | 2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4) | 5 | UniProt NCBI |
| DNAJB2 | DnaJ homolog subfamily B member 2 (Heat shock 40 kDa protein 3) (Heat shock protein J1) (HSJ-1) | 5 | UniProt NCBI |
| GET4 | Golgi to ER traffic protein 4 homolog (Conserved edge-expressed protein) (Transmembrane domain recognition complex 35 kDa subunit) (TRC35) | 5 | UniProt NCBI |
| GET3 | ATPase GET3 (EC 3.6.-.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase) (Guided entry of tail-anchored proteins factor 3, ATPase) (Transmembrane domain recognition complex 40 kDa ATPase subunit) (hARSA-I) (hASNA-I) | 5 | UniProt NCBI |
| BAG6 | Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) | 5 | UniProt NCBI |
| TRAFD1 | TRAF-type zinc finger domain-containing protein 1 (Protein FLN29) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9609523 | 7.28267215104e-06 | 0.428571428571 | GET4 BAG6 GET3 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane |
| KEGG:03060 | 1.41786055432e-05 | 0.428571428571 | GET4 BAG6 GET3 | Protein export |
| CORUM:6862 | 2.05265451394e-05 | 0.285714285714 | GET4 BAG6 | Bag6-Ubl4A-Trc35 Complex |
| GO:0006620 | 0.00122180600483 | 0.428571428571 | GET4 BAG6 GET3 | post-translational protein targeting to endoplasmic reticulum membrane |
| GO:0071816 | 0.00228108846854 | 0.428571428571 | GET4 BAG6 GET3 | tail-anchored membrane protein insertion into ER membrane |
| REAC:R-HSA-9609507 | 0.00520230847661 | 0.428571428571 | GET4 BAG6 GET3 | Protein localization |
| GO:0045047 | 0.0109646664486 | 0.428571428571 | GET4 BAG6 GET3 | protein targeting to ER |
| GO:0045048 | 0.0122273067778 | 0.428571428571 | GET4 BAG6 GET3 | protein insertion into ER membrane |
| GO:0072599 | 0.0150353457168 | 0.428571428571 | GET4 BAG6 GET3 | establishment of protein localization to endoplasmic reticulum |
| GO:0051205 | 0.0281770340738 | 0.428571428571 | GET4 BAG6 GET3 | protein insertion into membrane |
| GO:0071818 | 0.0294899169624 | 0.285714285714 | GET4 BAG6 | BAT3 complex |
| GO:0036506 | 0.0294899169624 | 0.285714285714 | GET4 BAG6 | maintenance of unfolded protein |
| GO:1904378 | 0.0294899169624 | 0.285714285714 | GET4 BAG6 | maintenance of unfolded protein involved in ERAD pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| UBL4A | GET4 | 1.0 | 0.522 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM |
| UBL4A | BAG6 | 1.0 | 0.302 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () Malo bioplex3_HCT116 fraction boldt_WMM |
| GET4 | BAG6 | 1.0 | 0.46 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM |
| GET3 | GET4 | 1.0 | 0.128 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM | |
| UBL4A | GET3 | 0.999 | 0.146 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM | |
| GET3 | BAG6 | 0.998 | 0.094 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM | |
| UBL4A | APOL2 | 0.996 | 0.032 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| UBL4A | TRAFD1 | 0.987 | 0.038 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | |
| DNAJB2 | GET4 | 0.984 | 0.148109589041 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GET3 | DNAJB2 | 0.973 | 0.086 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PDE12 | GET4 | 0.972 | 0.096 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| UBL4A | TBX3 | 0.971 | 0.112 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| DNAJB2 | BAG6 | 0.971 | 0.03 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| TBX3 | BAG6 | 0.964 | 0.156 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| GET3 | TRAFD1 | 0.957 | 0.038 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| APOL2 | BAG6 | 0.953 | 0.024 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| UBL4A | DNAJB2 | 0.95 | 0.02 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| TRAFD1 | BAG6 | 0.882 | 0.038 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | |
| PDE12 | BAG6 | 0.877 | 0.128 |
mutually_exclusive (P11441)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () |
| TRAFD1 | GET4 | 0.783 | 0.026 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| TRAFD1 | DNAJB2 | 0.681 | 0.01 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | |
| UBL4A | PDE12 | 0.518 | 0.328 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| TBX3 | GET4 | 0.192 | 0.116 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| APOL2 | GET3 | 0.079 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| TBX3 | DNAJB2 | 0.072 | 0.044 | bioplex3_WMM WMM_only | |
| APOL2 | TRAFD1 | 0.055 | 0.01 | bioplex_WMM bioplex3_WMM WMM_only | |
| APOL2 | GET4 | 0.051 | 0.028 | bioplex_WMM bioplex3_WMM WMM_only | |
| APOL2 | TBX3 | 0.034 | 0.064 | hein_WMM WMM_only | |
| GET3 | PDE12 | 0.034 | 0.05 | bioplex_WMM bioplex3_WMM WMM_only | |
| APOL2 | DNAJB2 | 0.034 | 0.022 | bioplex_WMM bioplex3_WMM WMM_only | |
| APOL2 | PDE12 | 0.031 | 0.036 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PDE12 | DNAJB2 | 0.01 | 0.056 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TRAFD1 | PDE12 | 0.008 | 0.022 | bioplex_WMM bioplex3_WMM WMM_only |
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