hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09630.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| STX19 | Syntaxin-19 | 5 | UniProt NCBI |
| STX11 | Syntaxin-11 | 5 | UniProt NCBI |
| STXBP1 | Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67) | 5 | UniProt NCBI |
| STXBP2 | Syntaxin-binding protein 2 (Protein unc-18 homolog 2) (Unc18-2) (Protein unc-18 homolog B) (Unc-18B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0140029 | 8.32139586928e-06 | 1.0 | STXBP2 STX11 STX19 STXBP1 | exocytic process |
| GO:0048278 | 8.32139586928e-06 | 1.0 | STXBP2 STX11 STX19 STXBP1 | vesicle docking |
| GO:0140056 | 2.14286120044e-05 | 1.0 | STXBP2 STX11 STX19 STXBP1 | organelle localization by membrane tethering |
| GO:0022406 | 3.56082257289e-05 | 1.0 | STXBP2 STX11 STX19 STXBP1 | membrane docking |
| GO:0000149 | 5.32774205779e-05 | 1.0 | STXBP2 STX11 STX19 STXBP1 | SNARE binding |
| GO:0007269 | 5.32774205779e-05 | 1.0 | STXBP2 STX11 STX19 STXBP1 | neurotransmitter secretion |
| GO:0099643 | 5.32774205779e-05 | 1.0 | STXBP2 STX11 STX19 STXBP1 | signal release from synapse |
| GO:0031629 | 8.45465618902e-05 | 0.75 | STX11 STX19 STXBP1 | synaptic vesicle fusion to presynaptic active zone membrane |
| GO:0099500 | 8.45465618902e-05 | 0.75 | STX11 STX19 STXBP1 | vesicle fusion to plasma membrane |
| GO:0006836 | 0.000141011889278 | 1.0 | STXBP2 STX11 STX19 STXBP1 | neurotransmitter transport |
| HP:0011118 | 0.000200620835246 | 0.5 | STX11 STXBP2 | Abnormality of tumor necrosis factor secretion |
| GO:0048499 | 0.000261258639543 | 0.75 | STX11 STX19 STXBP1 | synaptic vesicle membrane organization |
| GO:0045055 | 0.000280703147606 | 1.0 | STXBP2 STX11 STX19 STXBP1 | regulated exocytosis |
| HP:0011113 | 0.000334337547576 | 0.5 | STX11 STXBP2 | Abnormality of cytokine secretion |
| HP:0030783 | 0.000701980712879 | 0.5 | STX11 STXBP2 | Increased circulating interleukin 6 concentration |
| KEGG:04130 | 0.00116323751441 | 0.5 | STX11 STX19 | SNARE interactions in vesicular transport |
| HP:0004386 | 0.00151619382444 | 0.75 | STX11 STXBP2 STXBP1 | Gastrointestinal inflammation |
| HP:0002958 | 0.00183784982408 | 0.5 | STX11 STXBP2 | Immune dysregulation |
| HP:0012178 | 0.00260592941411 | 0.5 | STX11 STXBP2 | Reduced natural killer cell activity |
| HP:0012177 | 0.00260592941411 | 0.5 | STX11 STXBP2 | Abnormal natural killer cell physiology |
| GO:0006887 | 0.00273552953255 | 1.0 | STXBP2 STX11 STX19 STXBP1 | exocytosis |
| GO:0023061 | 0.00348809448709 | 1.0 | STXBP2 STX11 STX19 STXBP1 | signal release |
| HP:0002611 | 0.00400802433742 | 0.5 | STX11 STXBP2 | Cholestatic liver disease |
| HP:0012156 | 0.00454201288615 | 0.5 | STX11 STXBP2 | Hemophagocytosis |
| HP:0030356 | 0.0051092979876 | 0.5 | STX11 STXBP2 | Increased circulating interferon-gamma concentration |
| HP:0040186 | 0.0051092979876 | 0.5 | STX11 STXBP2 | Maculopapular exanthema |
| HP:4000054 | 0.0057098705025 | 0.5 | STX11 STXBP2 | Exanthem |
| HP:0012229 | 0.00701084122037 | 0.5 | STX11 STXBP2 | CSF pleocytosis |
| HP:0030782 | 0.00701084122037 | 0.5 | STX11 STXBP2 | Abnormal circulating interleukin concentration |
| HP:0030354 | 0.00771122114953 | 0.5 | STX11 STXBP2 | Abnormal circulating interferon concentration |
| HP:0030355 | 0.00771122114953 | 0.5 | STX11 STXBP2 | Abnormal circulating interferon-gamma concentration |
| GO:0016079 | 0.00951168180783 | 0.75 | STX11 STX19 STXBP1 | synaptic vesicle exocytosis |
| HP:0011112 | 0.0155098335254 | 0.5 | STX11 STXBP2 | Abnormality of serum cytokine level |
| HP:0011111 | 0.0165423111708 | 0.5 | STX11 STXBP2 | Abnormality of immune serum protein physiology |
| GO:0007268 | 0.016735764789 | 1.0 | STXBP2 STX11 STX19 STXBP1 | chemical synaptic transmission |
| GO:0098916 | 0.016735764789 | 1.0 | STXBP2 STX11 STX19 STXBP1 | anterograde trans-synaptic signaling |
| GO:0099537 | 0.0175106740088 | 1.0 | STXBP2 STX11 STX19 STXBP1 | trans-synaptic signaling |
| HP:0011900 | 0.021003726131 | 0.5 | STX11 STXBP2 | Hypofibrinogenemia |
| GO:0099536 | 0.0220295332932 | 1.0 | STXBP2 STX11 STX19 STXBP1 | synaptic signaling |
| HP:0004311 | 0.0222019103471 | 0.5 | STX11 STXBP2 | Abnormal macrophage morphology |
| HP:0011898 | 0.0222019103471 | 0.5 | STX11 STXBP2 | Abnormality of circulating fibrinogen |
| HP:0002383 | 0.0234332085093 | 0.5 | STX11 STXBP2 | Infectious encephalitis |
| HP:0003281 | 0.0234332085093 | 0.5 | STX11 STXBP2 | Increased circulating ferritin concentration |
| HP:0040133 | 0.0246976114972 | 0.5 | STX11 STXBP2 | Abnormal circulating ferritin concentration |
| WP:WP481 | 0.0255965717397 | 0.5 | STXBP1 STXBP2 | Insulin signaling |
| HP:0000967 | 0.034474601612 | 0.5 | STX11 STXBP2 | Petechiae |
| HP:0031364 | 0.0391604009626 | 0.5 | STX11 STXBP2 | Ecchymosis |
| HP:0002583 | 0.040788355352 | 0.5 | STX11 STXBP2 | Colitis |
| GO:0048787 | 0.042122686785 | 0.5 | STX11 STX19 | presynaptic active zone membrane |
| GO:0006906 | 0.0449670283878 | 0.75 | STX11 STX19 STXBP1 | vesicle fusion |
| GO:0090174 | 0.048062454325 | 0.75 | STX11 STX19 STXBP1 | organelle membrane fusion |
| GO:0032940 | 0.0497318663038 | 1.0 | STXBP2 STX11 STX19 STXBP1 | secretion by cell |
| CORUM:3196 | 0.049938562206 | 0.25 | STX11 | FHL4/STX11-ACT complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| STXBP2 | STX11 | 0.999 | 0.14 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| STX19 | STXBP2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STXBP1 | STX11 | 0.999 | 0.074 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| STX19 | STXBP1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STXBP2 | STXBP1 | 0.983 | 0.02 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only treiber_WMM |
Related Complexes