hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09641.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FAM83G | Protein FAM83G (Protein associated with SMAD1) | 5 | UniProt NCBI |
| RAF1 | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | 5 | UniProt NCBI |
| WDR62 | WD repeat-containing protein 62 | 5 | UniProt NCBI |
| EML3 | Echinoderm microtubule-associated protein-like 3 (EMAP-3) | 5 | UniProt NCBI |
| ARAF | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | 5 | UniProt NCBI |
| PARD3 | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | 5 | UniProt NCBI |
| HDAC4 | Histone deacetylase 4 (HD4) (EC 3.5.1.98) | 5 | UniProt NCBI |
| KIF1B | Kinesin-like protein KIF1B (Klp) | 5 | UniProt NCBI |
| RASSF8 | Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1) | 4 | UniProt NCBI |
| HDAC7 | Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) | 5 | UniProt NCBI |
| AFAP1L1 | Actin filament-associated protein 1-like 1 (AFAP1-like protein 1) | 5 | UniProt NCBI |
| PTOV1 | Prostate tumor-overexpressed gene 1 protein (PTOV-1) (Activator interaction domain-containing protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2795 | 0.000374062639208 | 0.272727272727 | HDAC4 RAF1 HDAC7 | Cardiac hypertrophic response |
| WP:WP1544 | 0.00168834524022 | 0.272727272727 | HDAC4 RAF1 HDAC7 | MicroRNAs in cardiomyocyte hypertrophy |
| KEGG:04613 | 0.00822526724793 | 0.272727272727 | HDAC4 RAF1 HDAC7 | Neutrophil extracellular trap formation |
| KEGG:05034 | 0.00822526724793 | 0.272727272727 | HDAC4 RAF1 HDAC7 | Alcoholism |
| WP:WP3996 | 0.0201054514571 | 0.181818181818 | HDAC4 HDAC7 | Ethanol effects on histone modifications |
| WP:WP3414 | 0.0215858775392 | 0.181818181818 | HDAC4 HDAC7 | Initiation of transcription and translation elongation at the HIV 1 LTR |
| WP:WP4874 | 0.0231182298902 | 0.181818181818 | HDAC4 RAF1 | CAMKK2 pathway |
| REAC:R-HSA-350054 | 0.0305690780225 | 0.181818181818 | HDAC4 HDAC7 | Notch-HLH transcription pathway |
| CORUM:57 | 0.049976851631 | 0.0909090909091 | HDAC4 | HDAC4-ERK2 complex |
| CORUM:5923 | 0.049976851631 | 0.0909090909091 | RAF1 | RAF1-BRAF complex, RAS stimulated |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| PARD3 | RASSF8 | 1.0 | 0.116 |
| ARAF | RAF1 | 0.998 | 0.176 |
| HDAC7 | PTOV1 | 0.99 | 0.102 |
| HDAC4 | PTOV1 | 0.989 | 0.13 |
| PTOV1 | RAF1 | 0.987 | 0.152222222222 |
| FAM83G | HDAC7 | 0.987 | 0.066 |
| FAM83G | HDAC4 | 0.987 | 0.07 |
| PTOV1 | WDR62 | 0.985 | 0.108 |
| HDAC4 | HDAC7 | 0.985 | 0.078 |
| EML3 | HDAC4 | 0.984 | 0.08 |
| EML3 | HDAC7 | 0.984 | 0.1 |
| FAM83G | PARD3 | 0.984 | 0.062 |
| HDAC4 | RASSF8 | 0.983 | 0.126 |
| HDAC7 | ARAF | 0.982 | 0.022 |
| KIF1B | HDAC7 | 0.981 | 0.096 |
| HDAC4 | KIF1B | 0.981 | 0.116 |
| HDAC7 | WDR62 | 0.981 | 0.07 |
| HDAC4 | WDR62 | 0.981 | 0.11 |
| PARD3 | HDAC7 | 0.98 | 0.084 |
| PARD3 | HDAC4 | 0.98 | 0.106 |
| FAM83G | EML3 | 0.979 | 0.05 |
| RASSF8 | HDAC7 | 0.978 | 0.104 |
| HDAC4 | ARAF | 0.971 | 0.032 |
| KIF1B | PTOV1 | 0.968 | 0.138 |
| HDAC4 | RAF1 | 0.964 | 0.172 |
| HDAC7 | RAF1 | 0.964 | 0.122 |
| PARD3 | PTOV1 | 0.964 | 0.088 |
| PTOV1 | ARAF | 0.961 | 0.062 |
| FAM83G | RASSF8 | 0.956 | 0.074 |
| AFAP1L1 | PTOV1 | 0.953 | 0.068 |
| EML3 | WDR62 | 0.943 | 0.048 |
| FAM83G | PTOV1 | 0.943 | 0.116 |
| FAM83G | RAF1 | 0.925 | 0.056 |
| EML3 | PTOV1 | 0.921 | 0.058 |
| FAM83G | KIF1B | 0.919 | 0.112 |
| RASSF8 | PTOV1 | 0.91 | 0.136 |
| FAM83G | ARAF | 0.906 | 0.058 |
| EML3 | PARD3 | 0.734 | 0.04200968523 |
| FAM83G | WDR62 | 0.664 | 0.068 |
| ARAF | WDR62 | 0.657 | 0.062 |
| EML3 | RASSF8 | 0.539 | 0.074 |
| RAF1 | WDR62 | 0.503 | 0.074 |
| EML3 | ARAF | 0.392 | 0.136 |
| KIF1B | RASSF8 | 0.391 | 0.164 |
| EML3 | KIF1B | 0.362 | 0.092 |
| PARD3 | KIF1B | 0.304 | 0.078 |
| KIF1B | RAF1 | 0.302 | 0.148 |
| EML3 | RAF1 | 0.299 | 0.126 |
| PARD3 | RAF1 | 0.287 | 0.14 |
| RASSF8 | WDR62 | 0.241 | 0.096 |
| KIF1B | ARAF | 0.178 | 0.08 |
| PARD3 | WDR62 | 0.162 | 0.088 |
| PARD3 | ARAF | 0.13 | 0.028 |
| RASSF8 | RAF1 | 0.123 | 0.162222222222 |
| RASSF8 | ARAF | 0.083 | 0.084 |
| KIF1B | WDR62 | 0.025 | 0.124 |
| AFAP1L1 | RAF1 | 0.015 | 0.154222222222 |
Related Complexes