hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09661.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DPH2 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2) (Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2) | 5 | UniProt NCBI |
| DPH1 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein 1) (Diphtheria toxin resistance protein 1) (Ovarian cancer-associated gene 1 protein) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1) | 5 | UniProt NCBI |
| FAM219B | Protein FAM219B | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5358493 | 0.000143154936711 | 0.666666666667 | DPH1 DPH2 | Synthesis of diphthamide-EEF2 |
| HP:0012712 | 0.000265674927589 | 0.666666666667 | DPH1 DPH2 | Mild hearing impairment |
| GO:0090560 | 0.00140460216025 | 0.666666666667 | DPH1 DPH2 | 2-(3-amino-3-carboxypropyl)histidine synthase activity |
| HP:0007291 | 0.00151751896202 | 0.666666666667 | DPH1 DPH2 | Posterior fossa cyst |
| HP:0004442 | 0.0024022996104 | 0.666666666667 | DPH1 DPH2 | Sagittal craniosynostosis |
| HP:0001970 | 0.00265505202111 | 0.666666666667 | DPH1 DPH2 | Tubulointerstitial nephritis |
| HP:0000805 | 0.00319841341764 | 0.666666666667 | DPH1 DPH2 | Enuresis |
| REAC:R-HSA-163841 | 0.00453384142373 | 0.666666666667 | DPH1 DPH2 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation |
| HP:0030799 | 0.00841415615575 | 0.666666666667 | DPH1 DPH2 | Scaphocephaly |
| HP:0000243 | 0.00888120343534 | 0.666666666667 | DPH1 DPH2 | Trigonocephaly |
| HP:0004482 | 0.0130706759587 | 0.666666666667 | DPH1 DPH2 | Relative macrocephaly |
| HP:0001969 | 0.0148492820647 | 0.666666666667 | DPH1 DPH2 | Abnormal tubulointerstitial morphology |
| HP:0001650 | 0.0154672949612 | 0.666666666667 | DPH1 DPH2 | Aortic valve stenosis |
| HP:0032581 | 0.0180650213362 | 0.666666666667 | DPH1 DPH2 | Abnormal renal insterstitial morphology |
| HP:0007598 | 0.0187458629677 | 0.666666666667 | DPH1 DPH2 | Bilateral single transverse palmar creases |
| GO:0017183 | 0.0210651876021 | 0.666666666667 | DPH1 DPH2 | protein histidyl modification to diphthamide |
| HP:0001800 | 0.0278951902268 | 0.666666666667 | DPH1 DPH2 | Hypoplastic toenails |
| GO:0018202 | 0.0294899169624 | 0.666666666667 | DPH1 DPH2 | peptidyl-histidine modification |
| HP:0000091 | 0.0429026841472 | 0.666666666667 | DPH1 DPH2 | Abnormal renal tubule morphology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DPH2 | FAM219B | 0.995 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| DPH2 | DPH1 | 0.99 | 0.382 | bioplex_WMM Guru bioplex3_WMM fraction |
| FAM219B | DPH1 | 0.99 | 0.082 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes