hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09668.1
Complex Portal: CPX-14018
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CRYZ | Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta-crystallin) | 5 | UniProt NCBI |
| CPS1 | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | 5 | UniProt NCBI |
| IARS2 | Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) | 5 | UniProt NCBI |
| TMLHE | Trimethyllysine dioxygenase, mitochondrial (EC 1.14.11.8) (Epsilon-trimethyllysine 2-oxoglutarate dioxygenase) (Epsilon-trimethyllysine hydroxylase) (TML hydroxylase) (TML-alpha-ketoglutarate dioxygenase) (TML dioxygenase) (TMLD) | 5 | UniProt NCBI |
| CLPX | ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial | 5 | UniProt NCBI |
| DARS2 | Aspartate--tRNA ligase, mitochondrial (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) | 5 | UniProt NCBI |
| TARS2 | Threonine--tRNA ligase, mitochondrial (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase-like 1) | 5 | UniProt NCBI |
| HDHD5 | Haloacid dehalogenase-like hydrolase domain-containing 5 (Cat eye syndrome critical region protein 5) | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-379726 | 3.03234516525e-05 | 0.375 | IARS2 DARS2 TARS2 | Mitochondrial tRNA aminoacylation |
| KEGG:00970 | 6.50981793488e-05 | 0.375 | IARS2 DARS2 TARS2 | Aminoacyl-tRNA biosynthesis |
| REAC:R-HSA-379724 | 0.000260330782854 | 0.375 | IARS2 DARS2 TARS2 | tRNA Aminoacylation |
| GO:0016874 | 0.0290088602918 | 0.5 | CPS1 TARS2 DARS2 IARS2 | ligase activity |
| GO:0005759 | 0.0406695841383 | 0.625 | CPS1 CLPX TMLHE DARS2 IARS2 | mitochondrial matrix |
| GO:0006418 | 0.0450022850424 | 0.375 | IARS2 DARS2 TARS2 | tRNA aminoacylation for protein translation |
| GO:0004812 | 0.0487399472212 | 0.375 | IARS2 DARS2 TARS2 | aminoacyl-tRNA ligase activity |
| GO:0016875 | 0.0487399472212 | 0.375 | IARS2 DARS2 TARS2 | ligase activity, forming carbon-oxygen bonds |
| CORUM:3991 | 0.0499436884912 | 0.125 | CLPX | ClpX complex, hexameric |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| IARS2 | TMLHE | 0.993 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| HDHD5 | DARS2 | 0.989 | 0.19 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| CPS1 | TMLHE | 0.979 | 0.038 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| IARS2 | CLPX | 0.977 | 0.178 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only treiber_WMM | |
| TARS2 | HDHD5 | 0.976 | 0.132 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| CPS1 | CLPX | 0.972 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only | |
| IARS2 | CRYZ | 0.971 | 0.138 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| CPS1 | HDHD5 | 0.967 | 0.03 | bioplex_WMM bioplex3_WMM WMM_only | |
| IARS2 | TARS2 | 0.965 | 0.346 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM | |
| HDHD5 | TMLHE | 0.965 | 0.04 | bioplex_WMM bioplex3_WMM WMM_only | |
| IARS2 | HDHD5 | 0.958 | 0.296 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| CPS1 | DARS2 | 0.945 | 0.058 | bioplex_WMM bioplex3_WMM WMM_only | |
| TARS2 | DARS2 | 0.944 | 0.26 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| IARS2 | CPS1 | 0.944 | 0.142 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| IARS2 | DARS2 | 0.937 | 0.504 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| TMLHE | DARS2 | 0.932 | 0.184 | bioplex_WMM bioplex3_WMM WMM_only | |
| CLPX | DARS2 | 0.924 | 0.164 |
structurally_consistent (Q9H0R6)
|
bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| CLPX | TMLHE | 0.921 | 0.042 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| CPS1 | TARS2 | 0.912 | 0.038 | bioplex_WMM bioplex3_WMM WMM_only | |
| TARS2 | TMLHE | 0.904 | 0.036 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| CRYZ | DARS2 | 0.625 | 0.082 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| CRYZ | CPS1 | 0.584 | 0.068 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| CLPX | HDHD5 | 0.567 | 0.088 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CRYZ | TMLHE | 0.472 | 0.116 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CRYZ | HDHD5 | 0.397 | 0.028 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| CRYZ | TARS2 | 0.303 | 0.074 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CLPX | TARS2 | 0.292 | 0.132 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CRYZ | CLPX | 0.252 | 0.088 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM fraction |
Related Complexes