hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09670.1

Complex Portal: CPX-24273

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
TUBB8	Tubulin beta-8 chain (Tubulin beta 8 class VIII)	5	UniProt NCBI
DNAJA1	DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2)	5	UniProt NCBI
CDC42EP1	Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55)	5	UniProt NCBI
TUBB	Tubulin beta chain (Tubulin beta-5 chain)	5	UniProt NCBI
CAD	Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]	5	UniProt NCBI
EML6	Echinoderm microtubule-associated protein-like 6 (EMAP-6) (Echinoderm microtubule-associated protein-like 5-like)	3	UniProt NCBI
TUBB2B	Tubulin beta-2B chain	5	UniProt NCBI
TTC5	Tetratricopeptide repeat protein 5 (TPR repeat protein 5) (Stress-responsive activator of p300) (Protein Strap)	5	UniProt NCBI
TUBA1A	Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain]	5	UniProt NCBI
TUBB4A	Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain)	5	UniProt NCBI
TUBA4B	Putative tubulin-like protein alpha-4B (EC 3.6.5.-) (Alpha-tubulin 4B)	3	UniProt NCBI
TUBA1B	Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain]	5	UniProt NCBI
TUBB6	Tubulin beta-6 chain (Tubulin beta class V)	5	UniProt NCBI
TUBB2A	Tubulin beta-2A chain (Tubulin beta class IIa)	5	UniProt NCBI
TUBB3	Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III)	5	UniProt NCBI
TBCD	Tubulin-specific chaperone D (Beta-tubulin cofactor D) (tfcD) (SSD-1) (Tubulin-folding cofactor D)	5	UniProt NCBI
ZNG1A	Zinc-regulated GTPase metalloprotein activator 1A (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 1) (COBW domain-containing protein 1) (NPC-A-6 COBW domain-containing protein 1) (NPC-A-6)	5	UniProt NCBI
CAPS	Calcyphosin (Calcyphosine)	5	UniProt NCBI
TUBA1C	Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain]	5	UniProt NCBI
ARL2	ADP-ribosylation factor-like protein 2	5	UniProt NCBI
FAS	Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)	5	UniProt NCBI
TCP11L1	T-complex protein 11-like protein 1	5	UniProt NCBI
EML2	Echinoderm microtubule-associated protein-like 2 (EMAP-2) (HuEMAP-2)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-389977	1.75679695623e-24	0.5	TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TBCD TUBB4A TUBA4B TUBB6 ARL2 TUBB2A	Post-chaperonin tubulin folding pathway
REAC:R-HSA-190840	6.93588174359e-23	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
REAC:R-HSA-190872	1.46314750269e-22	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Transport of connexons to the plasma membrane
REAC:R-HSA-9619483	5.15411658823e-21	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Activation of AMPK downstream of NMDARs
REAC:R-HSA-190861	2.06458871308e-20	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Gap junction assembly
REAC:R-HSA-5626467	3.14885817946e-20	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	RHO GTPases activate IQGAPs
REAC:R-HSA-9668328	3.14885817946e-20	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Sealing of the nuclear envelope (NE) by ESCRT-III
REAC:R-HSA-3371497	7.69256974323e-20	0.5	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1A TUBA1B DNAJA1 TUBB4A TUBA4B TUBB8 TUBB2A	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
REAC:R-HSA-8955332	7.38183136664e-19	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Carboxyterminal post-translational modifications of tubulin
REAC:R-HSA-9609736	7.38183136664e-19	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Assembly and cell surface presentation of NMDA receptors
WP:WP2359	7.91418739317e-19	0.5	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBA4B TUBB8 TUBB2B	Parkin ubiquitin proteasomal system pathway
REAC:R-HSA-190828	9.91986359415e-19	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Gap junction trafficking
REAC:R-HSA-157858	1.32165891547e-18	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Gap junction trafficking and regulation
REAC:R-HSA-9646399	1.74669262841e-18	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Aggrephagy
REAC:R-HSA-389960	3.61344247018e-18	0.409090909091	TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB6 TUBB2A	Formation of tubulin folding intermediates by CCT/TriC
WP:WP2272	5.21652149816e-18	0.454545454545	TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBB6 TUBB8 TUBB2B	Pathogenic Escherichia coli infection
REAC:R-HSA-437239	6.32729774826e-18	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Recycling pathway of L1
REAC:R-HSA-6811436	1.58969101142e-17	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	COPI-independent Golgi-to-ER retrograde traffic
REAC:R-HSA-983189	3.69232975428e-17	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Kinesins
REAC:R-HSA-389958	4.93325631813e-17	0.409090909091	TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB6 TUBB2A	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
REAC:R-HSA-380320	5.16073712857e-17	0.5	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBA4B TUBB8 TUBB2B	Recruitment of NuMA to mitotic centrosomes
REAC:R-HSA-391251	6.65829803895e-17	0.5	TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TBCD TUBB4A TUBA4B TUBB6 ARL2 TUBB2A	Protein folding
KEGG:04540	1.34367988513e-16	0.454545454545	TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBB6 TUBB8 TUBB2B	Gap junction
REAC:R-HSA-2995410	3.78927884133e-16	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Nuclear Envelope (NE) Reassembly
REAC:R-HSA-438064	4.43927369152e-16	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Post NMDA receptor activation events
REAC:R-HSA-1445148	5.18780231823e-16	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Translocation of SLC2A4 (GLUT4) to the plasma membrane
REAC:R-HSA-9663891	1.25900546976e-15	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Selective autophagy
REAC:R-HSA-8852276	1.44867699357e-15	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	The role of GTSE1 in G2/M progression after G2 checkpoint
REAC:R-HSA-442755	2.49138070415e-15	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Activation of NMDA receptors and postsynaptic events
GO:0005200	8.56682363342e-15	0.5	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBA4B TUBB8 TUBB2B	structural constituent of cytoskeleton
REAC:R-HSA-6811434	1.21066448895e-14	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	COPI-dependent Golgi-to-ER retrograde traffic
REAC:R-HSA-6807878	1.68644292662e-14	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	COPI-mediated anterograde transport
REAC:R-HSA-373760	3.1703387505e-14	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	L1CAM interactions
KEGG:04145	8.67438675081e-14	0.454545454545	TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBB6 TUBB8 TUBB2B	Phagosome
REAC:R-HSA-9648025	9.16496519844e-14	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	EML4 and NUDC in mitotic spindle formation
REAC:R-HSA-2132295	1.31268135762e-13	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	MHC class II antigen presentation
REAC:R-HSA-9609690	1.70430405051e-13	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	HCMV Early Events
GO:0005525	1.72976834894e-13	0.545454545455	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBA4B TUBB8 ARL2 TUBB2B	GTP binding
REAC:R-HSA-2500257	1.85644858065e-13	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Resolution of Sister Chromatid Cohesion
REAC:R-HSA-5617833	2.37019616867e-13	0.5	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBA4B TUBB8 TUBB2B	Cilium Assembly
REAC:R-HSA-69275	2.37019616867e-13	0.5	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBA4B TUBB8 TUBB2B	G2/M Transition
REAC:R-HSA-453274	2.66587320488e-13	0.5	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBA4B TUBB8 TUBB2B	Mitotic G2-G2/M phases
REAC:R-HSA-1632852	2.81617715044e-13	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Macroautophagy
REAC:R-HSA-8856688	2.81617715044e-13	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Golgi-to-ER retrograde transport
REAC:R-HSA-68877	3.35971787611e-13	0.5	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBA4B TUBB8 TUBB2B	Mitotic Prometaphase
REAC:R-HSA-5663220	4.54098920871e-13	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	RHO GTPases Activate Formins
GO:0005874	5.17157364282e-13	0.590909090909	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TBCD TCP11L1 TUBB4A TUBA4B TUBB8 TUBB2B	microtubule
GO:0032561	6.93568708844e-13	0.545454545455	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBA4B TUBB8 ARL2 TUBB2B	guanyl ribonucleotide binding
REAC:R-HSA-390466	6.9396802988e-13	0.409090909091	TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB6 TUBB2A	Chaperonin-mediated protein folding
KEGG:04814	7.02282083416e-13	0.454545454545	TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBB6 TUBB8 TUBB2B	Motor proteins
GO:0019001	7.38084906414e-13	0.545454545455	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBA4B TUBB8 ARL2 TUBB2B	guanyl nucleotide binding
KEGG:05130	8.46254734068e-13	0.454545454545	TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBB6 TUBB8 TUBB2B	Pathogenic Escherichia coli infection
REAC:R-HSA-9612973	8.92430135806e-13	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Autophagy
REAC:R-HSA-9609646	9.59316044034e-13	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	HCMV Infection
REAC:R-HSA-199977	1.0306688565e-12	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	ER to Golgi Anterograde Transport
REAC:R-HSA-5620924	1.14737639311e-12	0.363636363636	TUBB2A TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBB6 TUBB2B	Intraflagellar transport
REAC:R-HSA-389957	1.58773439948e-12	0.318181818182	TUBB2A TUBB3 TUBA1C TUBA1A TUBB4A TUBB6 TUBB2B	Prefoldin mediated transfer of substrate to CCT/TriC
REAC:R-HSA-983231	2.67241749545e-12	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Factors involved in megakaryocyte development and platelet production
REAC:R-HSA-112314	2.85083740198e-12	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Neurotransmitter receptors and postsynaptic signal transmission
REAC:R-HSA-948021	6.75422379714e-12	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Transport to the Golgi and subsequent modification
REAC:R-HSA-2467813	1.3372822638e-11	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Separation of Sister Chromatids
REAC:R-HSA-1852241	1.51717254135e-11	0.5	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBA4B TUBB8 TUBB2B	Organelle biogenesis and maintenance
KEGG:05132	1.85384106986e-11	0.454545454545	TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBB6 TUBB8 TUBB2B	Salmonella infection
REAC:R-HSA-6811442	2.16667456128e-11	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Intra-Golgi and retrograde Golgi-to-ER traffic
GO:0000226	2.57197422832e-11	0.636363636364	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TBCD TUBB4A TUBA4B EML2 TUBB8 ARL2 TUBB2B	microtubule cytoskeleton organization
KEGG:05012	3.40438718092e-11	0.454545454545	TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBB6 TUBB8 TUBB2B	Parkinson disease
REAC:R-HSA-112315	3.60624263944e-11	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Transmission across Chemical Synapses
KEGG:05020	4.55028052937e-11	0.454545454545	TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBB6 TUBB8 TUBB2B	Prion disease
WP:WP2059	5.41622819372e-11	0.454545454545	TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBB6 TUBB8 TUBB2B	Alzheimer 39 s disease and miRNA effects
WP:WP5124	5.41622819372e-11	0.454545454545	TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBB6 TUBB8 TUBB2B	Alzheimer 39 s disease
REAC:R-HSA-68882	9.27851349334e-11	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Mitotic Anaphase
REAC:R-HSA-2555396	9.70474632356e-11	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Mitotic Metaphase and Anaphase
KEGG:05016	1.24554724156e-10	0.454545454545	TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBB6 TUBB8 TUBB2B	Huntington disease
GO:0035639	1.360305035e-10	0.590909090909	TUBB6 TUBB2A TUBB2B TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A ARL2 CAD TUBB8 TUBA4B TUBB	purine ribonucleoside triphosphate binding
GO:0099513	1.44722392899e-10	0.590909090909	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TBCD TCP11L1 TUBB4A TUBA4B TUBB8 TUBB2B	polymeric cytoskeletal fiber
REAC:R-HSA-5610787	4.79723380024e-10	0.363636363636	TUBB2A TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBB6 TUBB2B	Hedgehog 'off' state
REAC:R-HSA-68886	6.37766438771e-10	0.5	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBA4B TUBB8 TUBB2B	M Phase
GO:0015630	6.46110315479e-10	0.727272727273	TUBB6 TUBB2A TUBB2B TUBB3 TUBA1C TUBA1A TUBA1B DNAJA1 TCP11L1 TUBB4A ARL2 TUBA4B EML2 TUBB8 TBCD TUBB	microtubule cytoskeleton
GO:0032555	7.11848287296e-10	0.590909090909	TUBB6 TUBB2A TUBB2B TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A ARL2 CAD TUBB8 TUBA4B TUBB	purine ribonucleotide binding
KEGG:05014	7.3399211222e-10	0.454545454545	TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBB6 TUBB8 TUBB2B	Amyotrophic lateral sclerosis
GO:0032553	8.83162920407e-10	0.590909090909	TUBB6 TUBB2A TUBB2B TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A ARL2 CAD TUBB8 TUBA4B TUBB	ribonucleotide binding
REAC:R-HSA-446203	1.00373589541e-09	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Asparagine N-linked glycosylation
KEGG:05010	1.18205134855e-09	0.454545454545	TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBB6 TUBB8 TUBB2B	Alzheimer disease
REAC:R-HSA-195258	1.56850932392e-09	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	RHO GTPase Effectors
REAC:R-HSA-112316	1.67697177242e-09	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Neuronal System
REAC:R-HSA-5358351	2.91065407625e-09	0.363636363636	TUBB2A TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBB6 TUBB2B	Signaling by Hedgehog
GO:0007017	2.92899657147e-09	0.636363636364	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TBCD TUBB4A TUBA4B EML2 TUBB8 ARL2 TUBB2B	microtubule-based process
GO:0017076	3.45881136417e-09	0.590909090909	TUBB6 TUBB2A TUBB2B TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A ARL2 CAD TUBB8 TUBA4B TUBB	purine nucleotide binding
GO:0099512	5.6614227549e-09	0.590909090909	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TBCD TCP11L1 TUBB4A TUBA4B TUBB8 TUBB2B	supramolecular fiber
GO:0099081	6.64358181191e-09	0.590909090909	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TBCD TCP11L1 TUBB4A TUBA4B TUBB8 TUBB2B	supramolecular polymer
KEGG:05022	8.19940564309e-09	0.454545454545	TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBB6 TUBB8 TUBB2B	Pathways of neurodegeneration - multiple diseases
GO:0005856	1.49926886115e-08	0.772727272727	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B DNAJA1 TCP11L1 TUBB4A ARL2 TUBA4B EML2 TUBB8 TBCD CDC42EP1 TUBB2B	cytoskeleton
REAC:R-HSA-69278	1.75570758145e-08	0.5	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBA4B TUBB8 TUBB2B	Cell Cycle, Mitotic
GO:0000166	2.05148075957e-08	0.590909090909	TUBB6 TUBB2A TUBB2B TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A ARL2 CAD TUBB8 TUBA4B TUBB	nucleotide binding
GO:1901265	2.09439008793e-08	0.590909090909	TUBB6 TUBB2A TUBB2B TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A ARL2 CAD TUBB8 TUBA4B TUBB	nucleoside phosphate binding
HP:0025102	2.18508180146e-08	0.181818181818	TUBA1A TUBB3 TUBB TUBB2B	Dysgenesis of the basal ganglia
GO:1901363	4.94233679981e-08	0.590909090909	TUBB6 TUBB2A TUBB2B TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A ARL2 CAD TUBB8 TUBA4B TUBB	heterocyclic compound binding
GO:0007010	6.81247447085e-08	0.681818181818	TUBB6 TUBB2A TUBB2B TUBB3 TUBA1C TUBA1A TUBA1B TBCD TUBB4A ARL2 TUBA4B EML2 TUBB8 CDC42EP1 TUBB	cytoskeleton organization
GO:0097367	7.22480650381e-08	0.590909090909	TUBB6 TUBB2A TUBB2B TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A ARL2 CAD TUBB8 TUBA4B TUBB	carbohydrate derivative binding
CORUM:6713	9.80297107667e-08	0.136363636364	TBCD TUBB ARL2	TBCD-ARL2-tubulin(beta) complex
CORUM:6703	9.80297107667e-08	0.136363636364	TBCD TUBB TUBA1A	TBCD-tubulin(alpha)-tubulin(beta) complex
CORUM:6715	9.80297107667e-08	0.136363636364	TBCD TUBB ARL2	TBCD-ARL2-tubulin(beta)-TBCE complex
REAC:R-HSA-194315	1.20694096115e-07	0.5	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBA4B TUBB8 CDC42EP1 TUBB2A	Signaling by Rho GTPases
REAC:R-HSA-9716542	1.52461474428e-07	0.5	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBA4B TUBB8 CDC42EP1 TUBB2A	Signaling by Rho GTPases, Miro GTPases and RHOBTB3
REAC:R-HSA-1640170	1.60177767918e-07	0.5	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBA4B TUBB8 TUBB2B	Cell Cycle
REAC:R-HSA-422475	1.89362145456e-07	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Axon guidance
REAC:R-HSA-9675108	2.70394675637e-07	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Nervous system development
REAC:R-HSA-9824446	3.86068588922e-07	0.5	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBA4B TUBB8 TUBB2B	Viral Infection Pathways
REAC:R-HSA-109582	4.33937591338e-07	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Hemostasis
REAC:R-HSA-2262752	5.19245194604e-07	0.5	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1A TUBA1B DNAJA1 TUBB4A TUBA4B TUBB8 TUBB2A	Cellular responses to stress
REAC:R-HSA-8953897	5.7482005853e-07	0.5	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1A TUBA1B DNAJA1 TUBB4A TUBA4B TUBB8 TUBB2A	Cellular responses to stimuli
GO:0043168	6.51643162085e-07	0.590909090909	TUBB6 TUBB2A TUBB2B TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A ARL2 CAD TUBB8 TUBA4B TUBB	anion binding
GO:0045171	8.20969065146e-07	0.318181818182	TUBB2A TUBB3 TUBB2B TUBB4A TUBB8 TUBB6 TUBB	intercellular bridge
REAC:R-HSA-199991	1.01035175314e-06	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Membrane Trafficking
GO:0099080	1.6747738282e-06	0.590909090909	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TBCD TCP11L1 TUBB4A TUBA4B TUBB8 TUBB2B	supramolecular complex
REAC:R-HSA-5653656	1.70439638674e-06	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Vesicle-mediated transport
GO:0005198	2.0479961223e-06	0.5	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBA4B TUBB8 TUBB2B	structural molecule activity
GO:0072686	2.30997658239e-06	0.363636363636	TUBB2A TUBB3 TUBB2B TUBB4A TUBB8 TUBB6 EML2 TUBB	mitotic spindle
HP:0020214	3.36420143768e-06	0.136363636364	TUBB3 TUBB2B TUBA1A	Startle-induced seizure
REAC:R-HSA-5663205	3.37006113408e-06	0.5	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBA4B TUBB8 TUBB2B	Infectious disease
GO:0000278	4.02077682853e-06	0.545454545455	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TBCD TUBB4A TUBA4B TUBB8 TUBB2B	mitotic cell cycle
REAC:R-HSA-1280218	4.15676714703e-06	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Adaptive Immune System
HP:0012502	1.3443682326e-05	0.136363636364	TUBB3 TUBB2B TUBA1A	Abnormality of the internal capsule
HP:0001477	3.35764295879e-05	0.136363636364	TUBB3 TUBB2B TUBA1A	Compensatory chin elevation
HP:0001491	3.35764295879e-05	0.136363636364	TUBB3 TUBB2B TUBA1A	Congenital fibrosis of extraocular muscles
HP:0007831	3.35764295879e-05	0.136363636364	TUBB3 TUBB2B TUBA1A	Nonprogressive restrictive external ophthalmoplegia
HP:3000072	3.35764295879e-05	0.136363636364	TUBB3 TUBB2B TUBA1A	Abnormal levator palpebrae superioris morphology
HP:0030534	3.35764295879e-05	0.136363636364	TUBB3 TUBB2B TUBA1A	Abnormal best corrected visual acuity test
HP:0025721	3.35764295879e-05	0.136363636364	TUBB3 TUBB2B TUBA1A	Limited vertical extraocular movement
HP:0012241	3.35764295879e-05	0.136363636364	TUBB3 TUBB2B TUBA1A	Levator palpebrae superioris atrophy
HP:0025309	3.35764295879e-05	0.136363636364	TUBB3 TUBB2B TUBA1A	Abnormal pupil shape
REAC:R-HSA-1266738	4.50713239916e-05	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Developmental Biology
HP:0032398	6.70873713287e-05	0.136363636364	TUBB3 TUBB2B TUBA1A	Dysgyria
CORUM:6697	7.16254081717e-05	0.0909090909091	TBCD ARL2	ARL2-TBCD complex
CORUM:6455	7.16254081717e-05	0.0909090909091	TBCD ARL2	ARL2-TBCD complex
GO:0043167	9.90301631128e-05	0.636363636364	TUBB6 TUBB2A TUBB2B TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A ARL2 CAD TUBB8 CAPS TUBA4B TUBB	ion binding
HP:0002365	0.000105983604982	0.227272727273	TUBA1A TUBB3 TUBB2A TUBB TUBB2B	Hypoplasia of the brainstem
HP:0007362	0.000105983604982	0.227272727273	TUBA1A TUBB3 TUBB2A TUBB TUBB2B	Aplasia/Hypoplasia of the brainstem
GO:0007049	0.000156349884761	0.590909090909	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TBCD TUBB4A TUBA4B TUBB8 ARL2 TUBB2B	cell cycle
HP:0000542	0.000187478449772	0.136363636364	TUBB3 TUBB2B TUBA1A	Impaired ocular adduction
HP:0008049	0.000280943438168	0.136363636364	TUBB3 TUBB2B TUBA1A	Abnormality of the extraocular muscles
HP:0011347	0.000280943438168	0.136363636364	TUBB3 TUBB2B TUBA1A	Abnormality of ocular abduction
HP:0025186	0.000280943438168	0.136363636364	TUBB3 TUBB2B TUBA1A	Marcus Gunn jaw winking synkinesis
GO:0005819	0.000376755279077	0.363636363636	TUBB2A TUBB3 TUBB2B TUBB4A TUBB8 TUBB6 EML2 TUBB	spindle
REAC:R-HSA-392499	0.000394499642692	0.545454545455	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TBCD TUBB4A TUBA4B TUBB8 ARL2 TUBB2A	Metabolism of proteins
GO:0036094	0.000432673697708	0.636363636364	TUBB6 TUBB2A TUBB2B TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A ARL2 CAD TUBB8 CAPS TUBA4B TUBB	small molecule binding
HP:0009916	0.00073365377233	0.136363636364	TUBB3 TUBB2B TUBA1A	Anisocoria
HP:0032466	0.00073365377233	0.136363636364	TUBB3 TUBB2B TUBA1A	Aplasia of the olfactory bulb
REAC:R-HSA-1643685	0.000845073617205	0.5	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBA4B TUBB8 TUBB2B	Disease
HP:0007941	0.00095281986992	0.136363636364	TUBB3 TUBB2B TUBA1A	Limited extraocular movements
HP:0002539	0.00104365731525	0.181818181818	TUBB3 TUBB2A TUBB TUBB2B	Cortical dysplasia
HP:0001338	0.00122051385898	0.181818181818	TUBA1A TUBB3 TUBB TUBB2B	Partial agenesis of the corpus callosum
HPA:0461423	0.00129542372407	0.181818181818	TUBA1C TUBB2A TUBA1A TUBA1B	skin 1; eccrine glands[High]
REAC:R-HSA-597592	0.00132532447579	0.454545454545	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1B TUBA1A TUBB4A TUBA4B TUBB8 TUBB2A	Post-translational protein modification
HP:0002363	0.00144727762047	0.272727272727	TUBB2A TUBB2B TUBA1A TBCD TUBB3 TUBB	Abnormal brainstem morphology
HPA:0471423	0.00145344625678	0.136363636364	TUBA1C TUBA1A TUBA1B	skin 2; eccrine glands[High]
HP:0030211	0.00151289496752	0.136363636364	TUBB3 TUBB2B TUBA1A	Slow pupillary light response
HP:0001180	0.00151289496752	0.136363636364	TUBB3 TUBB2B TUBA1A	Hand oligodactyly
HP:0031705	0.0018602089094	0.136363636364	TUBB3 TUBB2B TUBA1A	Compensatory head posture
HP:0031882	0.00225662254027	0.136363636364	TUBB3 TUBB2B TUBA1A	Agyria
HP:0020207	0.00225662254027	0.136363636364	TUBB3 TUBB2B TUBA1A	Reflex seizure
REAC:R-HSA-162582	0.00243161239837	0.545454545455	TUBB6 TUBB2B TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A ARL2 TUBA4B TUBB8 CDC42EP1 TUBB2A	Signal Transduction
HPA:0500703	0.00289509481829	0.227272727273	TUBA1C TUBB3 TUBA1B TUBB TUBA1A	soft tissue 1; peripheral nerve[High]
REAC:R-HSA-168256	0.00296124384533	0.5	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B TUBB4A TUBA4B TUBB8 TUBB2B	Immune System
HP:0030532	0.0032094190914	0.136363636364	TUBB3 TUBB2B TUBA1A	Visual acuity test abnormality
HP:0000473	0.00354684581936	0.181818181818	TUBB4A TUBB3 TUBB2B TUBA1A	Torticollis
HP:0030588	0.00377210554188	0.136363636364	TUBB3 TUBB2B TUBA1A	Abnormal visual field test
HP:0011006	0.00420840503714	0.181818181818	TUBB4A TUBB3 TUBB2B TUBA1A	Abnormal morphology of the musculature of the neck
HP:0000616	0.00439649880458	0.136363636364	TUBB3 TUBB2B TUBA1A	Miosis
HPA:0100212	0.00516949097168	0.545454545455	TUBB2A TUBB TUBB3 TTC5 TUBA1A TUBA1B ZNG1A TCP11L1 TUBB4A TUBA1C TUBB6 TUBB2B	cerebral cortex; neuropil[>=Medium]
HP:0011097	0.00557546581836	0.227272727273	TBCD TUBB3 TUBB2A TUBB2B TUBA1A	Epileptic spasm
HP:0007695	0.0066710601512	0.136363636364	TUBB3 TUBB2B TUBA1A	Abnormal pupillary light reflex
HPA:0461493	0.00683676231395	0.181818181818	TUBA1C TUBB2A TUBA1A TUBA1B	skin 1; vascular mural cells[High]
HPA:0100211	0.00728080461032	0.727272727273	TUBA1C TUBB2A TUBB2B TUBB3 TTC5 TUBA1A ZNG1A TUBA1B DNAJA1 TCP11L1 TUBB4A TUBB6 EML2 CAD ARL2 TUBB	cerebral cortex; neuropil[>=Low]
HPA:0500112	0.00890587534456	0.409090909091	TUBB TUBA1C TUBA1A TUBA1B DNAJA1 CAD EML2 TUBB6 ARL2	soft tissue 1; chondrocytes[>=Medium]
HP:0002536	0.00970556763077	0.272727272727	TUBB2A TTC5 TUBB2B TUBA1A TUBB3 TUBB	Abnormal cortical gyration
HPA:0500113	0.0101915673913	0.227272727273	EML2 DNAJA1 TUBA1C TUBA1A TUBA1B	soft tissue 1; chondrocytes[High]
HPA:0210000	0.0123633687397	0.863636363636	TUBA1C TUBB2A TUBB2B TUBB3 TTC5 TUBA1A ZNG1A TUBA1B DNAJA1 TCP11L1 TUBB4A ARL2 TUBB6 EML2 CAD TBCD CAPS CDC42EP1 TUBB	fallopian tube
HPA:0461482	0.0135137705706	0.181818181818	TUBA1C TUBA1A ARL2 TUBA1B	skin 1; sebaceous glands[>=Medium]
HP:0000657	0.0144020516107	0.181818181818	TUBB4A TUBB3 TUBB2B TUBA1A	Oculomotor apraxia
HP:0040327	0.014714605036	0.136363636364	TUBB3 TUBB2B TUBA1A	Abnormal morphology of the olfactory bulb
HP:0012179	0.0162303466458	0.181818181818	TUBB4A TUBB3 TUBB2B TUBA1A	Craniofacial dystonia
HP:0012165	0.0178256776946	0.136363636364	TUBB3 TUBB2B TUBA1A	Oligodactyly
HPA:0461422	0.0225220721917	0.181818181818	TUBA1C TUBB2A TUBA1A TUBA1B	skin 1; eccrine glands[>=Medium]
HPA:0470673	0.0228272878725	0.227272727273	TUBA1C TUBB2A TUBA1A ARL2 TUBA1B	skin 2; melanocytes[High]
HPA:0570763	0.0230569194696	0.318181818182	TUBB2A TUBB3 TUBB2B TUBB4A TUBB6 ARL2 TUBB	testis; pachytene spermatocytes[High]
HPA:0570732	0.0238210828948	0.727272727273	TUBB2A TUBB2B TUBB3 TUBA1C TUBA1A ZNG1A TUBA1B DNAJA1 TCP11L1 TUBB4A ARL2 TUBB6 EML2 CAD TBCD TUBB	testis; Leydig cells[>=Medium]
HPA:0471422	0.0239267911544	0.136363636364	TUBA1C TUBA1A TUBA1B	skin 2; eccrine glands[>=Medium]
GO:0031115	0.0242342063386	0.136363636364	TBCD TUBB4A EML2	negative regulation of microtubule polymerization
HPA:0461492	0.0245370596049	0.181818181818	TUBA1C TUBB2A TUBA1A TUBA1B	skin 1; vascular mural cells[>=Medium]
GO:0043228	0.025282633069	0.772727272727	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B DNAJA1 TCP11L1 TUBB4A ARL2 TUBA4B EML2 TUBB8 TBCD CDC42EP1 TUBB2B	non-membrane-bounded organelle
GO:0043232	0.025282633069	0.772727272727	TUBB6 TUBB2A TUBB TUBB3 TUBA1C TUBA1A TUBA1B DNAJA1 TCP11L1 TUBB4A ARL2 TUBA4B EML2 TUBB8 TBCD CDC42EP1 TUBB2B	intracellular non-membrane-bounded organelle
HP:0004373	0.0252935897508	0.181818181818	TUBB4A TUBB3 TUBB2B TUBA1A	Focal dystonia
HPA:0471492	0.0255921745562	0.181818181818	TUBA1C TUBB2A TUBA1A TUBA1B	skin 2; vascular mural cells[>=Medium]
HPA:0570793	0.0260354896704	0.318181818182	TUBB2B TUBB3 TUBB TUBB4A TUBB6 CDC42EP1 TUBB2A	testis; round or early spermatids[High]
GO:0006996	0.0283082933739	0.681818181818	TUBB6 TUBB2A TUBB2B TUBB3 TUBA1C TUBA1A TUBA1B TBCD TUBB4A ARL2 TUBA4B EML2 TUBB8 CDC42EP1 TUBB	organelle organization
HP:0002079	0.028345481311	0.272727272727	TUBB2A TUBB2B TUBA1A TBCD TUBB3 TUBB	Hypoplasia of the corpus callosum
HPA:0130051	0.0297891268852	0.818181818182	TUBA1C TUBB2A TUBB2B TUBB3 TTC5 TUBA1A ZNG1A TUBA1B DNAJA1 TCP11L1 TUBB4A ARL2 TUBB6 EML2 CAD TBCD CDC42EP1 TUBB	colon; glandular cells[>=Low]
HPA:0461481	0.0301441655813	0.181818181818	TUBA1C TUBA1A ARL2 TUBA1B	skin 1; sebaceous glands[>=Low]
HP:0002269	0.0311632500206	0.272727272727	TUBB2A TTC5 TUBB2B TUBA1A TUBB3 TUBB	Abnormality of neuronal migration
HPA:0470202	0.0340736902121	0.272727272727	TUBB2A TUBA1C TUBA1B TUBA1A ARL2 TUBB	skin 2; endothelial cells[>=Medium]
HPA:0471402	0.0346187727177	0.136363636364	TUBA1C TUBA1A TUBA1B	skin 2; cells in corneal layer[>=Medium]
HP:0001320	0.0358098245029	0.227272727273	TUBA1A TUBB3 TUBB2A TUBB TUBB2B	Cerebellar vermis hypoplasia
HP:0008527	0.0371793075416	0.136363636364	TUBB3 TUBB2B TUBA1A	Congenital sensorineural hearing impairment
HPA:0150051	0.0371988331876	0.818181818182	TUBA1C TUBB2A TUBB2B TUBB3 TTC5 TUBA1A ZNG1A TUBA1B DNAJA1 TCP11L1 TUBB4A ARL2 TUBB6 EML2 CAD TBCD CDC42EP1 TUBB	duodenum; glandular cells[>=Low]
HPA:0461443	0.0372448058443	0.227272727273	TUBA1C TUBB2A TUBA1B TUBB TUBA1A	skin 1; fibrohistiocytic cells[High]
HPA:0461483	0.0373518172154	0.136363636364	TUBA1C TUBA1A TUBA1B	skin 1; sebaceous glands[High]
HPA:0471472	0.0376151580007	0.272727272727	TUBB2A TUBA1C TUBA1B TUBA1A ARL2 TUBB	skin 2; lymphocytes[>=Medium]
HPA:0470672	0.0379510745119	0.272727272727	TUBB2A TUBA1C TUBA1B TUBA1A ARL2 TUBB	skin 2; melanocytes[>=Medium]
REAC:R-HSA-380259	0.0383730092424	0.136363636364	TUBB4A TUBB TUBA1A	Loss of Nlp from mitotic centrosomes
REAC:R-HSA-380284	0.0383730092424	0.136363636364	TUBB4A TUBB TUBA1A	Loss of proteins required for interphase microtubule organization from the centrosome
HPA:0330221	0.0392162229581	0.772727272727	TUBA1C TUBB2A TUBB2B TUBB3 TTC5 TUBA1A ZNG1A TUBA1B DNAJA1 TCP11L1 TUBB4A ARL2 TUBB6 EML2 CAD CDC42EP1 TUBB	oral mucosa; squamous epithelial cells[>=Low]
HPA:0330000	0.0392162229581	0.772727272727	TUBA1C TUBB2A TUBB2B TUBB3 TTC5 TUBA1A ZNG1A TUBA1B DNAJA1 TCP11L1 TUBB4A ARL2 TUBB6 EML2 CAD CDC42EP1 TUBB	oral mucosa
HPA:0210873	0.0402191766459	0.181818181818	EML2 DNAJA1 CAPS ARL2	fallopian tube; ciliated cells (ciliary rootlets)[High]
HPA:0301173	0.0405247911163	0.227272727273	DNAJA1 TUBA1C TCP11L1 TUBA1A TUBA1B	lung; alveolar cells[High]
KEGG:04210	0.0426804197121	0.136363636364	TUBA1C TUBA1A TUBA1B	Apoptosis
REAC:R-HSA-8854518	0.043807763412	0.136363636364	TUBB4A TUBB TUBA1A	AURKA Activation by TPX2
HP:0002119	0.0445380778557	0.318181818182	TUBB2A TTC5 TUBB2B TUBA1A TBCD TUBB3 TUBB	Ventriculomegaly
HPA:0471421	0.0447871795119	0.136363636364	TUBA1C TUBA1A TUBA1B	skin 2; eccrine glands[>=Low]
HP:0012469	0.0465828123726	0.181818181818	TUBB3 TUBB2A TUBB2B TUBA1A	Infantile spasms
HP:0007370	0.0475946340083	0.318181818182	TUBB2A TTC5 TUBB2B TUBA1A TBCD TUBB3 TUBB	Aplasia/Hypoplasia of the corpus callosum
HPA:0460673	0.0476196605461	0.318181818182	TUBB2A TUBA1C TUBA1A TUBA1B DNAJA1 TCP11L1 ARL2	skin 1; melanocytes[High]
GO:0031113	0.0496986001779	0.181818181818	EML2 TBCD TUBB4A ARL2	regulation of microtubule polymerization

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
ARL2	TBCD	1.0	0.2
TUBB	TUBA1C	1.0	0.974	mixed_interface
DNAJA1	TUBB	0.999	0.374
TUBB	TBCD	0.999	0.4
TCP11L1	TUBB	0.999	0.204105263158
TUBB2A	TUBB6	0.999	0.526	structurally_consistent (dimer)
CAD	TUBA1C	0.998	0.508
ARL2	TUBB	0.998	0.098
TUBB2B	TBCD	0.998	0.286	structurally_consistent (dimer)
TCP11L1	TUBB2B	0.998	0.162	structurally_consistent (dimer)
TUBB6	TUBA1C	0.998	0.968	structurally_consistent (dimer)
TUBB	CAD	0.998	0.352
TUBB8	TUBB	0.997	0.534	structurally_consistent (dimer)
TUBB2B	FAS	0.997	0.166
TUBB2A	TUBA1C	0.996	0.552
TUBB2A	CDC42EP1	0.996	0.192703448276
TUBB2A	TUBB8	0.996	0.33	structurally_consistent (dimer)
TUBB6	TUBB	0.996	0.982	mutually_exclusive (Q9BQE3)
TUBB3	TUBB6	0.996	0.308	mutually_exclusive (Q9BQE3)
TUBB2A	TUBB4A	0.996	0.684	structurally_consistent (dimer)
TUBA1B	TUBB	0.995
TCP11L1	TUBB3	0.995	0.086
CAPS	TUBB2B	0.995	0.09
TUBB2A	FAS	0.995	0.204	structurally_consistent (P04350) structurally_consistent (dimer)
TUBB3	TUBB	0.995	0.394	mutually_exclusive (Q9BQE3)
TUBB2A	TBCD	0.995	0.148
TUBB4A	TBCD	0.993	0.3
TCP11L1	TTC5	0.993	0.04
TUBA1B	TUBA1C	0.993		structurally_consistent (dimer)
DNAJA1	TUBA1B	0.993		mutually_exclusive (P68366)
TUBA1C	TUBB4A	0.993	0.918
TUBB2A	TUBB	0.993	0.626	structurally_consistent (dimer)
CDC42EP1	TUBB4A	0.993	0.284
TUBB	TUBB4A	0.992	0.938	structurally_consistent (dimer)
TUBB6	TUBB4A	0.992	0.798
TUBB	FAS	0.992	0.112	mutually_exclusive (P04350)
TUBB3	TUBA1C	0.992	0.404	structurally_consistent (dimer)
ARL2	TUBB2B	0.991	0.244	structurally_consistent (dimer)
TUBB3	TUBA1A	0.991		structurally_consistent (dimer)
TCP11L1	TUBB4A	0.991	0.138
TCP11L1	TUBA1C	0.991	0.382
TUBB2A	TTC5	0.991	0.188	structurally_consistent (dimer)
TUBB2A	EML2	0.99		structurally_consistent (dimer)
TUBB2B	TTC5	0.99	0.184
TUBB2A	TUBB3	0.99	0.38	structurally_consistent (dimer)
TUBB2A	ARL2	0.989	0.164
TUBB	EML2	0.989
TUBB4A	TUBB2B	0.988	0.650344827586
DNAJA1	TUBB3	0.988	0.32
CDC42EP1	TUBB	0.988	0.358
ZNG1A	TUBB	0.988	0.229222222222
TUBB6	EML2	0.987		structurally_consistent (Q3ZCM7)
TUBB	TTC5	0.985	0.236
TUBB3	CAD	0.984	0.332
TUBB3	EML2	0.984		structurally_consistent (dimer)
TUBB2A	TCP11L1	0.983	0.106	structurally_consistent (dimer)
EML2	TUBB2B	0.982		structurally_consistent (dimer)
TUBA1A	TUBB4A	0.982
TUBB3	TUBB2B	0.979	0.398	structurally_consistent (dimer)
TUBB8	TUBB2B	0.979	0.284	structurally_consistent (dimer)
TUBA1A	TUBB	0.979
TUBA1B	TUBB6	0.977
TUBB6	TUBB2B	0.976	0.63	structurally_consistent (dimer)
ZNG1A	TUBA1A	0.975
TUBB6	FAS	0.975	0.224768
TUBB8	TUBB6	0.973	0.546	structurally_consistent (dimer)
CDC42EP1	TUBB2B	0.973	0.146
ZNG1A	TUBA1C	0.973	0.178
TUBB8	TUBA1A	0.971		structurally_consistent (dimer)
TUBB3	EML6	0.97
TUBB8	TUBB4A	0.969	0.554	structurally_consistent (dimer)
DNAJA1	TUBA1A	0.968
ZNG1A	TUBB3	0.967	0.144
TUBA1A	TUBA1B	0.967
TUBB2A	TUBA1A	0.966		structurally_consistent (dimer)
TUBB6	TTC5	0.966	0.198
TUBB8	TUBB3	0.965	0.304
TUBB8	CDC42EP1	0.965	0.146
TUBA1A	TUBA1C	0.965
ARL2	EML2	0.963
TUBB8	ZNG1A	0.962	0.328
TCP11L1	ZNG1A	0.961	0.02
EML2	FAS	0.957
FAS	TBCD	0.956	0.149666666667
CAPS	TUBB6	0.956	0.3
EML6	TUBB2B	0.953
CAPS	TUBB	0.952	0.306608695652
TUBA1C	TUBB2B	0.95	0.55
DNAJA1	TUBB8	0.95	0.30875
TUBB3	FAS	0.948	0.22
TUBB4A	FAS	0.947	0.164609230769	structurally_consistent (dimer)
TUBB2A	CAPS	0.947	0.138	structurally_consistent (dimer)
CDC42EP1	TUBB3	0.945	0.186
TCP11L1	CDC42EP1	0.943	0.106
TUBB2A	TUBB2B	0.94	0.47	structurally_consistent (dimer)
TCP11L1	EML2	0.938
TCP11L1	TUBB6	0.938	0.152
ARL2	TTC5	0.934	0.064
TUBB3	TUBB4A	0.933	0.454	structurally_consistent (dimer)
TCP11L1	ARL2	0.932	0.052
CDC42EP1	TTC5	0.93	0.078
TUBB8	TBCD	0.927	0.31
CDC42EP1	TUBA1A	0.925
TUBA1A	TTC5	0.92
ARL2	TUBB4A	0.919	0.188
TCP11L1	TUBA1A	0.916
TUBB3	CAPS	0.915	0.142
TUBA1C	TTC5	0.913	0.236
CDC42EP1	TUBA1C	0.908	0.292290196078
EML2	TBCD	0.906
ARL2	FAS	0.906	0.166
ZNG1A	TUBB4A	0.901	0.168442211055
TUBB3	TUBA1B	0.9		structurally_consistent (dimer)
TTC5	FAS	0.899	0.11
ZNG1A	FAS	0.899	0.172
TUBB	TUBB2B	0.895	0.719
ARL2	TUBB8	0.888	0.362	structurally_consistent (dimer)
CDC42EP1	TUBB6	0.886	0.226042553191
EML2	TUBB4A	0.884
EML2	TTC5	0.884
DNAJA1	TUBA1C	0.883	0.406
DNAJA1	TUBB6	0.867	0.298
DNAJA1	TUBB4A	0.866	0.22
TUBB2A	TUBA1B	0.864
TUBB2A	ZNG1A	0.863	0.118
TUBB8	CAPS	0.859	0.174
TUBB8	TUBA1C	0.853	0.398
TUBA1C	EML2	0.838
CAPS	TUBB4A	0.812	0.18
EML6	EML2	0.81
TUBA1A	TUBB6	0.805
TCP11L1	TBCD	0.792	0.048	structurally_consistent (Q9BVA1)
TUBB3	TTC5	0.775	0.170162601626
TCP11L1	TUBB8	0.764	0.184
TUBB8	TTC5	0.759	0.172	mutually_exclusive (Q13885)
TUBB3	TBCD	0.752	0.13	structurally_consistent (Q9BVA1)
CDC42EP1	TUBA1B	0.751
ARL2	TUBB3	0.742	0.343173015
TUBA1B	CAD	0.74
TTC5	TBCD	0.739	0.036
CDC42EP1	ZNG1A	0.735	0.094
TUBB2A	DNAJA1	0.722	0.16
ARL2	TUBB6	0.716	0.1803
TUBA1A	CAD	0.692
ZNG1A	TUBB6	0.667	0.196
TUBB4A	TTC5	0.614	0.312888888889
TCP11L1	FAS	0.604	0.112
TUBB8	EML6	0.599
TUBB2A	CAD	0.591	0.314
ARL2	CDC42EP1	0.586	0.082
ZNG1A	CAD	0.577	0.064
ZNG1A	TUBB2B	0.547	0.166
TCP11L1	DNAJA1	0.51	0.084
DNAJA1	CAD	0.506	0.23
CDC42EP1	EML2	0.497
TUBB8	CAD	0.494	0.222
TUBB8	TUBA1B	0.467
CAD	TUBB2B	0.445	0.324
DNAJA1	TUBB2B	0.435	0.302
TUBA1B	TUBB4A	0.432
TUBA1A	CAPS	0.429
TUBA1A	TUBB2B	0.415
TCP11L1	CAD	0.395	0.058
EML6	CAPS	0.378
TUBB8	EML2	0.359		structurally_consistent (dimer)
CAD	TUBB4A	0.353	0.294
EML6	TUBB6	0.307
ARL2	CAPS	0.303	0.062
DNAJA1	CDC42EP1	0.301	0.174
ARL2	EML6	0.3
TUBA1B	TBCD	0.288
CAPS	TUBA1C	0.269	0.342
CAPS	EML2	0.252
CDC42EP1	TBCD	0.247	0.12
TUBB6	TBCD	0.243	0.252
DNAJA1	EML2	0.242
DNAJA1	ZNG1A	0.241	0.064
TUBA1A	TBCD	0.226
CAD	EML2	0.215
EML6	TBCD	0.195
TCP11L1	EML6	0.182
EML6	FAS	0.176
CAPS	TBCD	0.169	0.118
ARL2	TUBA1A	0.167
EML6	TTC5	0.157
CDC42EP1	CAD	0.156	0.164
DNAJA1	TTC5	0.154	0.128
TUBB8	FAS	0.144	0.19
CAPS	TTC5	0.137	0.072
EML6	TUBB	0.129
TCP11L1	CAPS	0.127	0.1
TUBA1B	TUBB2B	0.12
ZNG1A	TBCD	0.113	0.086
TUBA1A	FAS	0.113
TUBB6	CAD	0.102	0.272
TUBA1C	TBCD	0.096	0.43
DNAJA1	FAS	0.084	0.12
EML6	TUBB4A	0.079
ARL2	DNAJA1	0.079	0.094
TUBB2A	EML6	0.075
CAPS	FAS	0.066	0.048	structurally_consistent (Q13885)
EML6	TUBA1A	0.059
CDC42EP1	CAPS	0.053	0.06
DNAJA1	TBCD	0.051	0.226
CAD	TBCD	0.05	0.418
CDC42EP1	EML6	0.049
ZNG1A	TTC5	0.046	0.072
CAD	TTC5	0.044	0.1
EML6	TUBA1C	0.044
DNAJA1	EML6	0.031
TUBA1B	TTC5	0.029
TUBA1B	FAS	0.027
EML6	TUBA1B	0.026
TUBA1C	FAS	0.02	0.184
ZNG1A	TUBA1B	0.02
DNAJA1	CAPS	0.019	0.14
TUBA1A	EML2	0.018		structurally_consistent (Q13885)
TUBA1B	EML2	0.016		structurally_consistent (Q13509)
ARL2	CAD	0.016	0.07
CDC42EP1	FAS	0.015	0.174
TCP11L1	TUBA1B	0.015
CAD	FAS	0.01	0.086
TUBA1B	CAPS	0.009
EML6	CAD	0.007
ARL2	ZNG1A	0.006	0.07
CAPS	CAD	0.005	0.1
ZNG1A	EML2	0.004
ARL2	TUBA1C	0.003	0.208346153846
ARL2	TUBA1B	0.001

Related Complexes

Genename	Complexes
TUBB8	huMAP3_01878.1 huMAP3_06977.1 huMAP3_07762.1 huMAP3_08179.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_12871.1
DNAJA1	huMAP3_01335.1 huMAP3_02724.1 huMAP3_03106.1 huMAP3_04859.1 huMAP3_07544.1 huMAP3_07762.1 huMAP3_07864.1 huMAP3_08179.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10363.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_11156.1
CDC42EP1	huMAP3_01878.1 huMAP3_06500.1 huMAP3_07544.1 huMAP3_08179.1 huMAP3_08981.1 huMAP3_09233.1 huMAP3_09670.1 huMAP3_09835.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_11719.1
TUBB	huMAP3_03106.1 huMAP3_04859.1 huMAP3_06977.1 huMAP3_07544.1 huMAP3_07762.1 huMAP3_07864.1 huMAP3_08179.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10665.1
CAD	huMAP3_03106.1 huMAP3_04859.1 huMAP3_07544.1 huMAP3_07762.1 huMAP3_07864.1 huMAP3_08179.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10103.1 huMAP3_10475.1 huMAP3_10665.1
EML6	huMAP3_02722.1 huMAP3_08179.1 huMAP3_08402.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_14043.1 huMAP3_14311.1 huMAP3_14884.1
TUBB2B	huMAP3_06977.1 huMAP3_08179.1 huMAP3_08402.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_14311.1
TTC5	huMAP3_06977.1 huMAP3_07544.1 huMAP3_07762.1 huMAP3_07864.1 huMAP3_08179.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_14311.1 huMAP3_14884.1
TUBA1A	huMAP3_02724.1 huMAP3_05787.1 huMAP3_06977.1 huMAP3_07544.1 huMAP3_07864.1 huMAP3_08179.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_11156.1
TUBB4A	huMAP3_05787.1 huMAP3_06500.1 huMAP3_07544.1 huMAP3_07762.1 huMAP3_07864.1 huMAP3_08179.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10665.1
TUBA4B	huMAP3_03106.1 huMAP3_04859.1 huMAP3_07544.1 huMAP3_07762.1 huMAP3_07864.1 huMAP3_08179.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10665.1
TUBA1B	huMAP3_02724.1 huMAP3_03810.1 huMAP3_06559.1 huMAP3_07544.1 huMAP3_07864.1 huMAP3_07938.1 huMAP3_08094.1 huMAP3_08179.1 huMAP3_09191.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10656.1 huMAP3_10665.1 huMAP3_11156.1 huMAP3_14584.1
TUBB6	huMAP3_03106.1 huMAP3_04859.1 huMAP3_06977.1 huMAP3_07544.1 huMAP3_07762.1 huMAP3_07864.1 huMAP3_08179.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_14311.1
TUBB2A	huMAP3_00118.1 huMAP3_05787.1 huMAP3_06977.1 huMAP3_07544.1 huMAP3_07762.1 huMAP3_08179.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_14311.1
TUBB3	huMAP3_02722.1 huMAP3_06977.1 huMAP3_07864.1 huMAP3_08179.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10665.1
TBCD	huMAP3_06977.1 huMAP3_07544.1 huMAP3_07762.1 huMAP3_07864.1 huMAP3_08179.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_14311.1
ZNG1A	huMAP3_02366.1 huMAP3_06317.1 huMAP3_07602.1 huMAP3_07625.1 huMAP3_08149.1 huMAP3_08516.1 huMAP3_08572.1 huMAP3_09070.1 huMAP3_09287.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10548.1 huMAP3_10665.1
CAPS	huMAP3_03106.1 huMAP3_03532.1 huMAP3_04859.1 huMAP3_06197.1 huMAP3_07544.1 huMAP3_07762.1 huMAP3_07864.1 huMAP3_08179.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_11669.1 huMAP3_12525.1 huMAP3_13292.1 huMAP3_14468.1 huMAP3_14491.1 huMAP3_14682.1
TUBA1C	huMAP3_03385.1 huMAP3_04456.1 huMAP3_04912.1 huMAP3_05787.1 huMAP3_06977.1 huMAP3_08094.1 huMAP3_08574.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_11156.1
ARL2	huMAP3_01239.1 huMAP3_07544.1 huMAP3_07762.1 huMAP3_07864.1 huMAP3_08179.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10142.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_13133.1 huMAP3_14311.1 huMAP3_14884.1
FAS	huMAP3_06977.1 huMAP3_07544.1 huMAP3_07762.1 huMAP3_07864.1 huMAP3_08179.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_12841.1 huMAP3_14311.1
TCP11L1	huMAP3_00374.1 huMAP3_05787.1 huMAP3_06064.1 huMAP3_07544.1 huMAP3_07625.1 huMAP3_07762.1 huMAP3_08179.1 huMAP3_08262.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10547.1 huMAP3_10665.1 huMAP3_11283.1 huMAP3_14236.1
EML2	huMAP3_04397.1 huMAP3_04859.1 huMAP3_06977.1 huMAP3_07762.1 huMAP3_08321.1 huMAP3_09233.1 huMAP3_09670.1 huMAP3_09835.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_14043.1 huMAP3_14311.1 huMAP3_14884.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09670.1

Complex Portal: CPX-24273