hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09671.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MMGT1 | ER membrane protein complex subunit 5 (Membrane magnesium transporter 1) (Transmembrane protein 32) | 5 | UniProt NCBI |
| RABL3 | Rab-like protein 3 | 5 | UniProt NCBI |
| OSBPL8 | Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) | 5 | UniProt NCBI |
| VDAC3 | Voltage-dependent anion-selective channel protein 3 (VDAC-3) (hVDAC3) (Outer mitochondrial membrane protein porin 3) | 5 | UniProt NCBI |
| PHB2 | Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity) | 5 | UniProt NCBI |
| PIP4P1 | Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 1 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase I) (Transmembrane protein 55B) | 5 | UniProt NCBI |
| FAM8A1 | Protein FAM8A1 (Autosomal highly conserved protein) | 4 | UniProt NCBI |
| TMUB1 | Transmembrane and ubiquitin-like domain-containing protein 1 (Dendritic cell-derived ubiquitin-like protein) (DULP) (Hepatocyte odd protein shuttling protein) (Ubiquitin-like protein SB144) [Cleaved into: iHOPS] | 5 | UniProt NCBI |
| CAV1 | Caveolin-1 | 5 | UniProt NCBI |
| PHB1 | Prohibitin 1 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8949215 | 8.52274449062e-05 | 0.3 | VDAC3 PHB1 PHB2 | Mitochondrial calcium ion transport |
| CORUM:6289 | 0.000307240465423 | 0.2 | PHB2 PHB1 | prohibitin 2 complex, mitochondrial |
| REAC:R-HSA-8949664 | 0.0121516690115 | 0.2 | PHB2 PHB1 | Processing of SMDT1 |
| WP:WP5038 | 0.0166734771023 | 0.2 | PHB2 PHB1 | Mitochondrial immune response to SARS CoV 2 |
| GO:0035632 | 0.0210690324038 | 0.2 | PHB2 PHB1 | mitochondrial prohibitin complex |
| CORUM:550 | 0.0499436884912 | 0.1 | CAV1 | NOS3-CAV1-NOSTRIN complex |
| CORUM:2462 | 0.0499436884912 | 0.1 | CAV1 | Caveolin-1 homodimer complex |
| CORUM:5714 | 0.0499436884912 | 0.1 | CAV1 | NOS3-CAV1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PHB1 | PHB2 | 1.0 | 0.974 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| VDAC3 | FAM8A1 | 0.999 | 0.098 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PHB1 | VDAC3 | 0.999 | 0.562 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| CAV1 | RABL3 | 0.998 | 0.064 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| PHB2 | VDAC3 | 0.998 | 0.47 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| FAM8A1 | TMUB1 | 0.996 | 0.074 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PHB1 | MMGT1 | 0.996 | 0.554 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| PHB2 | TMUB1 | 0.995 | 0.11 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| PIP4P1 | TMUB1 | 0.994 | 0.068 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| MMGT1 | TMUB1 | 0.992 | 0.142 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| RABL3 | VDAC3 | 0.991 | 0.054 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM |
| TMUB1 | OSBPL8 | 0.991 | 0.05 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PHB1 | TMUB1 | 0.989 | 0.088 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| VDAC3 | TMUB1 | 0.988 | 0.02 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| PHB1 | RABL3 | 0.985 | 0.084 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| RABL3 | TMUB1 | 0.985 | 0.08 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| RABL3 | MMGT1 | 0.984 | 0.118 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| FAM8A1 | OSBPL8 | 0.981 | 0.152 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MMGT1 | FAM8A1 | 0.98 | 0.236 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| RABL3 | OSBPL8 | 0.979 | 0.132 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| MMGT1 | PIP4P1 | 0.968 | 0.278 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| RABL3 | FAM8A1 | 0.968 | 0.294 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PIP4P1 | OSBPL8 | 0.966 | 0.124 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PIP4P1 | FAM8A1 | 0.963 | 0.13 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PHB1 | FAM8A1 | 0.962 | 0.1 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PHB2 | RABL3 | 0.952 | 0.142 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM |
| CAV1 | MMGT1 | 0.952 | 0.112 | hein_WMM bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM |
| PHB2 | MMGT1 | 0.944 | 0.388 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM |
| MMGT1 | OSBPL8 | 0.927 | 0.084 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| CAV1 | PIP4P1 | 0.927 | 0.104 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PHB2 | FAM8A1 | 0.908 | 0.184 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CAV1 | TMUB1 | 0.902 | 0.184586387435 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PHB2 | PIP4P1 | 0.889 | 0.116 | hein_WMM bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
| PHB1 | PIP4P1 | 0.878 | 0.122 | hein_WMM bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
| CAV1 | PHB1 | 0.797 | 0.442 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| CAV1 | PHB2 | 0.751 | 0.166 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| VDAC3 | PIP4P1 | 0.72 | 0.0703243243243 | bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM |
| MMGT1 | VDAC3 | 0.683 | 0.154 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| CAV1 | FAM8A1 | 0.612 | 0.178124848973 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| CAV1 | OSBPL8 | 0.417 | 0.166 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| CAV1 | VDAC3 | 0.34 | 0.188 | hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| PHB1 | OSBPL8 | 0.157 | 0.118 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| RABL3 | PIP4P1 | 0.086 | 0.26 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| VDAC3 | OSBPL8 | 0.014 | 0.058 | bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only |
| PHB2 | OSBPL8 | 0.009 | 0.154 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
Related Complexes