hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09675.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ST3GAL4 | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (Alpha 2,3-ST 4) (Beta-galactoside alpha-2,3-sialyltransferase 4) (EC 2.4.3.2) (EC 2.4.3.4) (Alpha 2,3-sialyltransferase IV) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (Gal-beta-1,4-GlcNAc-alpha-2,3-sialyltransferase) (N-acetyllactosaminide alpha-2,3-sialyltransferase) (EC 2.4.3.6) (SAT-3) (ST-4) (ST3Gal IV) (ST3GalIV) (ST3GalA.2) (STZ) (Sialyltransferase 4C) (SIAT4-C) | 5 | UniProt NCBI |
| C1GALT1C1 | C1GALT1-specific chaperone 1 (C38H2-like protein 1) (C38H2-L1) (Core 1 beta1,3-galactosyltransferase 2) (C1Gal-T2) (C1GalT2) (Core 1 beta3-Gal-T2) (Core 1 beta3-galactosyltransferase-specific molecular chaperone) | 5 | UniProt NCBI |
| PCSK9 | Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-913709 | 0.00735562020533 | 0.666666666667 | ST3GAL4 C1GALT1C1 | O-linked glycosylation of mucins |
| WP:WP2846 | 0.0165527833611 | 0.333333333333 | PCSK9 | PCSK9 mediated LDL receptor degradation |
| WP:WP3408 | 0.0165527833611 | 0.333333333333 | PCSK9 | Evolocumab mechanism to reduce LDL cholesterol |
| REAC:R-HSA-5173105 | 0.019882541548 | 0.666666666667 | ST3GAL4 C1GALT1C1 | O-linked glycosylation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| C1GALT1C1 | ST3GAL4 | 0.978 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PCSK9 | ST3GAL4 | 0.975 | 0.124 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| PCSK9 | C1GALT1C1 | 0.055 | 0.08 | bioplex3_WMM WMM_only |
Related Complexes