hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09677.1
Complex Portal: CPX-21157
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| H2BC26 | Histone H2B type 3-B (H2B type 12) (H2B-clustered histone 26) (H2B.U histone 1) | 5 | UniProt NCBI |
| CFDP1 | Craniofacial development protein 1 (Bucentaur) | 4 | UniProt NCBI |
| RBP1 | Retinol-binding protein 1 (Cellular retinol-binding protein) (CRBP) (Cellular retinol-binding protein I) (CRBP-I) | 5 | UniProt NCBI |
| ANP32E | Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP-like protein) (LANP-L) | 5 | UniProt NCBI |
| BAHD1 | Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1) | 5 | UniProt NCBI |
| H2BC1 | Histone H2B type 1-A (Histone H2B, testis) (TSH2B.1) (hTSH2B) (Testis-specific histone H2B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-171306 | 0.0200002568185 | 0.333333333333 | H2BC1 H2BC26 | Packaging Of Telomere Ends |
| REAC:R-HSA-73927 | 0.0231414557883 | 0.333333333333 | H2BC1 H2BC26 | Depurination |
| REAC:R-HSA-110330 | 0.0231414557883 | 0.333333333333 | H2BC1 H2BC26 | Recognition and association of DNA glycosylase with site containing an affected purine |
| REAC:R-HSA-110331 | 0.0231414557883 | 0.333333333333 | H2BC1 H2BC26 | Cleavage of the damaged purine |
| REAC:R-HSA-110329 | 0.0276828753036 | 0.333333333333 | H2BC1 H2BC26 | Cleavage of the damaged pyrimidine |
| REAC:R-HSA-110328 | 0.0276828753036 | 0.333333333333 | H2BC1 H2BC26 | Recognition and association of DNA glycosylase with site containing an affected pyrimidine |
| REAC:R-HSA-73928 | 0.0276828753036 | 0.333333333333 | H2BC1 H2BC26 | Depyrimidination |
| REAC:R-HSA-73929 | 0.0288812004442 | 0.333333333333 | H2BC1 H2BC26 | Base-Excision Repair, AP Site Formation |
| REAC:R-HSA-73728 | 0.0326270815028 | 0.333333333333 | H2BC1 H2BC26 | RNA Polymerase I Promoter Opening |
| REAC:R-HSA-5334118 | 0.0339259639772 | 0.333333333333 | H2BC1 H2BC26 | DNA methylation |
| REAC:R-HSA-5625886 | 0.03659902859 | 0.333333333333 | H2BC1 H2BC26 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
| REAC:R-HSA-9670095 | 0.0379731829042 | 0.333333333333 | H2BC1 H2BC26 | Inhibition of DNA recombination at telomere |
| REAC:R-HSA-427359 | 0.0393724000146 | 0.333333333333 | H2BC1 H2BC26 | SIRT1 negatively regulates rRNA expression |
| REAC:R-HSA-68616 | 0.0407966660198 | 0.333333333333 | H2BC1 H2BC26 | Assembly of the ORC complex at the origin of replication |
| KEGG:05322 | 0.0412011786405 | 0.333333333333 | H2BC1 H2BC26 | Systemic lupus erythematosus |
| REAC:R-HSA-2299718 | 0.0452196184553 | 0.333333333333 | H2BC1 H2BC26 | Condensation of Prophase Chromosomes |
| REAC:R-HSA-5693571 | 0.0467439411123 | 0.333333333333 | H2BC1 H2BC26 | Nonhomologous End-Joining (NHEJ) |
| REAC:R-HSA-774815 | 0.0467439411123 | 0.333333333333 | H2BC1 H2BC26 | Nucleosome assembly |
| REAC:R-HSA-212300 | 0.0467439411123 | 0.333333333333 | H2BC1 H2BC26 | PRC2 methylates histones and DNA |
| REAC:R-HSA-9710421 | 0.0467439411123 | 0.333333333333 | H2BC1 H2BC26 | Defective pyroptosis |
| REAC:R-HSA-606279 | 0.0467439411123 | 0.333333333333 | H2BC1 H2BC26 | Deposition of new CENPA-containing nucleosomes at the centromere |
| REAC:R-HSA-1221632 | 0.048293243222 | 0.333333333333 | H2BC1 H2BC26 | Meiotic synapsis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| H2BC1 | CFDP1 | 0.998 | 0.138 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| H2BC26 | ANP32E | 0.998 | 0.152 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| H2BC1 | BAHD1 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| H2BC1 | ANP32E | 0.996 | 0.234 |
mutually_exclusive (P0C0S5)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| H2BC26 | CFDP1 | 0.995 | 0.214820512821 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| H2BC26 | BAHD1 | 0.968 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| H2BC26 | RBP1 | 0.951 | 0.092 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| BAHD1 | ANP32E | 0.938 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | ||
| CFDP1 | BAHD1 | 0.747 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | ||
| CFDP1 | ANP32E | 0.745 | 0.05 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| RBP1 | ANP32E | 0.083 | 0.056 | bioplex_WMM bioplex3_WMM WMM_only | |
| RBP1 | CFDP1 | 0.076 | 0.024 | bioplex3_WMM WMM_only | |
| RBP1 | BAHD1 | 0.065 | bioplex3_WMM WMM_only | ||
| H2BC1 | RBP1 | 0.005 | 0.206 | bioplex3_HCT116 WMM_only |
Related Complexes