hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09681.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WIPF1 | WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) | 5 | UniProt NCBI |
| PIK3AP1 | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | 5 | UniProt NCBI |
| WIPF2 | WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein) | 5 | UniProt NCBI |
| WIPF3 | WAS/WASL-interacting protein family member 3 (Corticosteroids and regional expression protein 16 homolog) | 4 | UniProt NCBI |
| TNK2 | Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) | 5 | UniProt NCBI |
| WASL | Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP) | 5 | UniProt NCBI |
| NCK1 | SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha) | 5 | UniProt NCBI |
| ARHGEF10L | Rho guanine nucleotide exchange factor 10-like protein (GrinchGEF) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5663213 | 1.64726720638e-07 | 0.571428571429 | WIPF1 WASL WIPF3 WIPF2 | RHO GTPases Activate WASPs and WAVEs |
| REAC:R-HSA-9664422 | 1.03686148446e-06 | 0.571428571429 | WIPF1 WASL WIPF3 WIPF2 | FCGR3A-mediated phagocytosis |
| REAC:R-HSA-9664417 | 1.03686148446e-06 | 0.571428571429 | WIPF1 WASL WIPF3 WIPF2 | Leishmania phagocytosis |
| REAC:R-HSA-9664407 | 1.03686148446e-06 | 0.571428571429 | WIPF1 WASL WIPF3 WIPF2 | Parasite infection |
| REAC:R-HSA-2029482 | 1.29989157009e-06 | 0.571428571429 | WIPF1 WASL WIPF3 WIPF2 | Regulation of actin dynamics for phagocytic cup formation |
| REAC:R-HSA-2029480 | 5.03005208045e-06 | 0.571428571429 | WIPF1 WASL WIPF3 WIPF2 | Fcgamma receptor (FCGR) dependent phagocytosis |
| KEGG:05135 | 6.52549892601e-06 | 0.571428571429 | WIPF1 WASL WIPF3 WIPF2 | Yersinia infection |
| KEGG:05130 | 2.78710556251e-05 | 0.571428571429 | WIPF1 WASL WIPF3 WIPF2 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-9013148 | 3.5016953291e-05 | 0.571428571429 | WIPF1 WASL WIPF3 WIPF2 | CDC42 GTPase cycle |
| REAC:R-HSA-9658195 | 4.76192041812e-05 | 0.571428571429 | WIPF1 WASL WIPF3 WIPF2 | Leishmania infection |
| REAC:R-HSA-9824443 | 4.76192041812e-05 | 0.571428571429 | WIPF1 WASL WIPF3 WIPF2 | Parasitic Infection Pathways |
| REAC:R-HSA-9012999 | 5.40512105848e-05 | 0.714285714286 | WIPF1 ARHGEF10L WASL WIPF3 WIPF2 | RHO GTPase cycle |
| REAC:R-HSA-9013149 | 8.69731520059e-05 | 0.571428571429 | WIPF1 WASL WIPF3 WIPF2 | RAC1 GTPase cycle |
| KEGG:04144 | 0.000107023311575 | 0.571428571429 | WIPF1 WASL WIPF3 WIPF2 | Endocytosis |
| REAC:R-HSA-194315 | 0.000554819347598 | 0.714285714286 | WIPF1 ARHGEF10L WASL WIPF3 WIPF2 | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 0.000618457686161 | 0.714285714286 | WIPF1 ARHGEF10L WASL WIPF3 WIPF2 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| REAC:R-HSA-195258 | 0.00106596867098 | 0.571428571429 | WIPF1 WASL WIPF3 WIPF2 | RHO GTPase Effectors |
| HPA:0381202 | 0.00116713820823 | 0.571428571429 | WIPF1 WASL PIK3AP1 WIPF2 | placenta; hofbauer cells[>=Medium] |
| HPA:0381201 | 0.00187311663036 | 0.571428571429 | WIPF1 WASL PIK3AP1 WIPF2 | placenta; hofbauer cells[>=Low] |
| REAC:R-HSA-162582 | 0.00838328139233 | 0.857142857143 | WASL PIK3AP1 ARHGEF10L WIPF2 WIPF1 WIPF3 | Signal Transduction |
| WP:WP524 | 0.00933842806825 | 0.285714285714 | TNK2 WASL | G13 signaling pathway |
| HPA:0381193 | 0.0217996876337 | 0.428571428571 | WIPF2 PIK3AP1 WASL | placenta; cytotrophoblasts[High] |
| HPA:0381203 | 0.0217996876337 | 0.428571428571 | WIPF1 PIK3AP1 WASL | placenta; hofbauer cells[High] |
| HPA:0381221 | 0.0352622528486 | 0.428571428571 | WIPF2 PIK3AP1 WASL | placenta; syncytiotrophoblasts - microvilli[>=Low] |
| HPA:0381213 | 0.035588561295 | 0.428571428571 | WIPF2 PIK3AP1 WASL | placenta; syncytiotrophoblasts - cell body[High] |
| REAC:R-HSA-1643685 | 0.0367346572641 | 0.714285714286 | WIPF1 WIPF3 WASL PIK3AP1 WIPF2 | Disease |
| CORUM:2513 | 0.0499958217778 | 0.142857142857 | WASL | N-WASp homomer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NCK1 | WIPF2 | 0.999 | 0.1 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| NCK1 | WASL | 0.999 | 0.126 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| WIPF2 | WASL | 0.999 | 0.244 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| WIPF1 | WASL | 0.997 | 0.13 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| NCK1 | WIPF1 | 0.997 | 0.052 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () |
| WIPF3 | WASL | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NCK1 | PIK3AP1 | 0.994 | 0.056 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| WIPF1 | WIPF2 | 0.993 | 0.16 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ARHGEF10L | WASL | 0.989 | 0.1 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| NCK1 | TNK2 | 0.984 | 0.204 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () |
| PIK3AP1 | WASL | 0.977 | 0.08 | bioplex_WMM bioplex3_WMM WMM_only |
| PIK3AP1 | TNK2 | 0.972 | 0.106 | bioplex_WMM bioplex3_WMM WMM_only |
| PIK3AP1 | WIPF2 | 0.972 | 0.112 | bioplex_WMM bioplex3_WMM WMM_only |
| NCK1 | WIPF3 | 0.933 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| WIPF1 | TNK2 | 0.928 | 0.056 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| WASL | TNK2 | 0.923 | 0.108 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| WIPF2 | TNK2 | 0.914 | 0.148 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| WIPF2 | WIPF3 | 0.785 | bioplex_WMM bioplex3_WMM WMM_only | |
| WIPF1 | WIPF3 | 0.785 | bioplex_WMM bioplex3_WMM WMM_only | |
| PIK3AP1 | WIPF1 | 0.622 | 0.092 | bioplex_WMM bioplex3_WMM WMM_only |
| WIPF3 | TNK2 | 0.622 | bioplex_WMM bioplex3_WMM WMM_only | |
| PIK3AP1 | WIPF3 | 0.622 | bioplex_WMM bioplex3_WMM WMM_only | |
| PIK3AP1 | ARHGEF10L | 0.015 | 0.104 | youn_WMM WMM_only |
| NCK1 | ARHGEF10L | 0.005 | 0.074 | youn_WMM WMM_only |
Related Complexes