hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09688.1
Complex Portal: CPX-11369
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CHSY1 | Chondroitin sulfate synthase 1 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 1) (Chondroitin synthase 1) (ChSy-1) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1) (N-acetylgalactosaminyltransferase 1) | 5 | UniProt NCBI |
| CHPF2 | Chondroitin sulfate glucuronyltransferase (EC 2.4.1.226) (CSGlcA-T) (Chondroitin glucuronyltransferase) (Chondroitin polymerizing factor 2) (ChPF-2) (Chondroitin synthase 3) (ChSy-3) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase) | 5 | UniProt NCBI |
| CHSY3 | Chondroitin sulfate synthase 3 (EC 2.4.1.175) (EC 2.4.1.226) (Carbohydrate synthase 2) (Chondroitin glucuronyltransferase 3) (Chondroitin synthase 2) (ChSy-2) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3) (N-acetylgalactosaminyltransferase 3) | 5 | UniProt NCBI |
| TIMP3 | Metalloproteinase inhibitor 3 (Protein MIG-5) (Tissue inhibitor of metalloproteinases 3) (TIMP-3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00532 | 3.91004404658e-07 | 0.75 | CHPF2 CHSY1 CHSY3 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |
| REAC:R-HSA-2022870 | 9.53498684462e-07 | 0.75 | CHPF2 CHSY1 CHSY3 | Chondroitin sulfate biosynthesis |
| GO:0050510 | 1.53784171933e-06 | 0.75 | CHPF2 CHSY1 CHSY3 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity |
| WP:WP5395 | 2.94331624137e-06 | 0.75 | CHPF2 CHSY1 CHSY3 | Glycosaminoglycan synthesis in fibroblasts |
| GO:0047238 | 7.68841921772e-06 | 0.75 | CHPF2 CHSY1 CHSY3 | glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity |
| REAC:R-HSA-1793185 | 2.12537496865e-05 | 0.75 | CHPF2 CHSY1 CHSY3 | Chondroitin sulfate/dermatan sulfate metabolism |
| GO:0030206 | 0.000174830724535 | 0.75 | CHPF2 CHSY1 CHSY3 | chondroitin sulfate biosynthetic process |
| GO:0030204 | 0.000215165225046 | 0.75 | CHPF2 CHSY1 CHSY3 | chondroitin sulfate metabolic process |
| REAC:R-HSA-1630316 | 0.000301178051097 | 0.75 | CHPF2 CHSY1 CHSY3 | Glycosaminoglycan metabolism |
| GO:0050650 | 0.000510886175237 | 0.75 | CHPF2 CHSY1 CHSY3 | chondroitin sulfate proteoglycan biosynthetic process |
| GO:0050654 | 0.000591522022343 | 0.75 | CHPF2 CHSY1 CHSY3 | chondroitin sulfate proteoglycan metabolic process |
| GO:0015020 | 0.000777349058504 | 0.75 | CHPF2 CHSY1 CHSY3 | glucuronosyltransferase activity |
| GO:0008376 | 0.00140301566648 | 0.75 | CHPF2 CHSY1 CHSY3 | acetylgalactosaminyltransferase activity |
| REAC:R-HSA-71387 | 0.00382744839761 | 0.75 | CHPF2 CHSY1 CHSY3 | Metabolism of carbohydrates |
| GO:0030166 | 0.0079870728422 | 0.75 | CHPF2 CHSY1 CHSY3 | proteoglycan biosynthetic process |
| GO:1903510 | 0.0079870728422 | 0.75 | CHPF2 CHSY1 CHSY3 | mucopolysaccharide metabolic process |
| GO:0006024 | 0.0106287970558 | 0.75 | CHPF2 CHSY1 CHSY3 | glycosaminoglycan biosynthetic process |
| GO:0006023 | 0.0112187083505 | 0.75 | CHPF2 CHSY1 CHSY3 | aminoglycan biosynthetic process |
| GO:0006029 | 0.0137962469792 | 0.75 | CHPF2 CHSY1 CHSY3 | proteoglycan metabolic process |
| GO:0030203 | 0.0218982649712 | 0.75 | CHPF2 CHSY1 CHSY3 | glycosaminoglycan metabolic process |
| GO:0006022 | 0.0291371139957 | 0.75 | CHPF2 CHSY1 CHSY3 | aminoglycan metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CHSY1 | CHSY3 | 1.0 |
mutually_exclusive (Q9P2E5)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CHPF2 | CHSY1 | 0.99 | 0.264 |
mutually_exclusive (Q70JA7)
structurally_consistent (dimer) |
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| CHPF2 | TIMP3 | 0.964 | 0.124 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CHPF2 | CHSY3 | 0.961 |
mutually_exclusive (Q86X52)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TIMP3 | CHSY3 | 0.069 | bioplex3_WMM WMM_only | ||
| TIMP3 | CHSY1 | 0.065 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes