hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09689.1
Complex Portal: CPX-12018
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SGO1 | Shugoshin 1 (Serologically defined breast cancer antigen NY-BR-85) (Shugoshin-like 1) | 5 | UniProt NCBI |
| USP12 | Ubiquitin carboxyl-terminal hydrolase 12 (EC 3.4.19.12) (Deubiquitinating enzyme 12) (Ubiquitin thioesterase 12) (Ubiquitin-hydrolyzing enzyme 1) (Ubiquitin-specific-processing protease 12) | 5 | UniProt NCBI |
| WDR20 | WD repeat-containing protein 20 (Protein DMR) | 5 | UniProt NCBI |
| FERMT2 | Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1) | 5 | UniProt NCBI |
| WDR48 | WD repeat-containing protein 48 (USP1-associated factor 1) (WD repeat endosomal protein) (p80) | 5 | UniProt NCBI |
| PHLPP1 | PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) | 5 | UniProt NCBI |
| USP46 | Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.4.19.12) (Deubiquitinating enzyme 46) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6634 | 7.02338504734e-09 | 0.428571428571 | USP12 WDR48 WDR20 | WDR20-USP12-UAF1 complex |
| CORUM:6635 | 7.02338504734e-09 | 0.428571428571 | WDR20 USP46 WDR48 | WDR20-USP46-UAF1 complex |
| CORUM:6636 | 2.05265451394e-05 | 0.285714285714 | USP12 WDR48 | USP12-UAF1 complex |
| CORUM:6637 | 2.05265451394e-05 | 0.285714285714 | WDR48 USP46 | USP46-UAF1 complex |
| CORUM:6521 | 0.000430566012817 | 0.285714285714 | WDR48 PHLPP1 | Akt-PHLPP1-PHLPP2-FANCI-FANCD2-USP1-UAF1 complex |
| REAC:R-HSA-5689880 | 0.0116239984871 | 0.428571428571 | USP12 WDR48 WDR20 | Ub-specific processing proteases |
| REAC:R-HSA-5688426 | 0.0315073113812 | 0.428571428571 | USP12 WDR48 WDR20 | Deubiquitination |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| WDR20 | WDR48 | 1.0 | 0.144 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 gupta_WMM boldt_WMM | |
| WDR20 | USP46 | 1.0 | 0.232 |
mutually_exclusive (O75317)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM |
| WDR20 | FERMT2 | 0.999 | 0.186 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| WDR48 | USP46 | 0.998 | 0.224 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM | |
| WDR48 | USP12 | 0.997 | 0.082 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM gupta_WMM WMM_only boldt_WMM |
| WDR20 | USP12 | 0.994 | 0.152 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| PHLPP1 | USP46 | 0.984 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SGO1 | USP12 | 0.981 | 0.108 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SGO1 | WDR20 | 0.969 | 0.086 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PHLPP1 | WDR20 | 0.967 | 0.118 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SGO1 | USP46 | 0.957 | 0.0853333333333 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PHLPP1 | WDR48 | 0.924 | 0.166 | bioplex_WMM bioplex3_WMM WMM_only | |
| USP46 | USP12 | 0.9 | 0.17 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| SGO1 | WDR48 | 0.876 | 0.066 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PHLPP1 | FERMT2 | 0.675 | 0.256 | bioplex3_WMM WMM_only | |
| USP46 | FERMT2 | 0.53 | 0.142 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| WDR48 | FERMT2 | 0.504 | 0.084 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| FERMT2 | USP12 | 0.399 | 0.084 | bioplex3_WMM gupta_WMM WMM_only | |
| PHLPP1 | USP12 | 0.267 | 0.054 | bioplex3_WMM WMM_only |
Related Complexes