hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09690.1

Complex Portal: CPX-22454

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
STK40	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase) (Sugen kinase 495) (SgK495)	5	UniProt NCBI
ETV5	ETS translocation variant 5 (Ets-related protein ERM)	5	UniProt NCBI
ATF2	Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1)	5	UniProt NCBI
FOSB	Protein FosB (FosB proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 3) (Transcription factor AP-1 subunit FosB)	5	UniProt NCBI
DET1	DET1 homolog (De-etiolated-1 homolog)	5	UniProt NCBI
ETV1	ETS translocation variant 1 (Ets-related protein 81)	5	UniProt NCBI
CREB5	Cyclic AMP-responsive element-binding protein 5 (CREB-5) (cAMP-responsive element-binding protein 5) (cAMP-response element-binding protein A) (CRE-BPa)	5	UniProt NCBI
FOS	Protein c-Fos (Cellular oncogene fos) (Fos proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 7) (Proto-oncogene c-Fos) (Transcription factor AP-1 subunit c-Fos)	5	UniProt NCBI
JUNB	Transcription factor JunB (Transcription factor AP-1 subunit JunB)	5	UniProt NCBI
FOSL2	Fos-related antigen 2 (FRA-2)	5	UniProt NCBI
JUND	Transcription factor JunD (Transcription factor AP-1 subunit JunD)	5	UniProt NCBI
TRIB2	Tribbles homolog 2 (TRB-2)	5	UniProt NCBI
ATF7	Cyclic AMP-dependent transcription factor ATF-7 (cAMP-dependent transcription factor ATF-7) (Activating transcription factor 7) (Transcription factor ATF-A)	5	UniProt NCBI
TRIB1	Tribbles homolog 1 (TRB-1) (G-protein-coupled receptor-induced gene 2 protein) (GIG-2) (SKIP1)	5	UniProt NCBI
COP1	E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)	5	UniProt NCBI
ATF3	Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3)	5	UniProt NCBI
JUN	Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP5373	4.95395965816e-06	0.285714285714	JUN FOSB FOS JUND	Role of hypoxia angiogenesis and FGF pathway in OA chondrocyte hypertrophy
REAC:R-HSA-9031628	5.24004485356e-06	0.285714285714	FOSB TRIB1 FOS JUND	NGF-stimulated transcription
WP:WP366	7.23710980373e-06	0.357142857143	JUN FOSB ATF3 FOS JUND	TGF beta signaling pathway
KEGG:05031	1.12416279717e-05	0.285714285714	JUN FOSB CREB5 FOS	Amphetamine addiction
KEGG:04657	3.8092538857e-05	0.285714285714	JUN FOSB FOS JUND	IL-17 signaling pathway
CORUM:2694	4.44741811353e-05	0.142857142857	JUN FOS	ERG-JUN-FOS DNA-protein complex
CORUM:2695	4.44741811353e-05	0.142857142857	JUN FOS	ETS2-FOS-JUN complex
CORUM:6092	4.44741811353e-05	0.142857142857	JUN ATF3	c-Jun-ATF3 complex
CORUM:2693	4.44741811353e-05	0.142857142857	JUN FOS	NFAT-JUN-FOS DNA-protein complex
REAC:R-HSA-198725	4.55310351978e-05	0.285714285714	FOSB TRIB1 FOS JUND	Nuclear Events (kinase and transcription factor activation)
CORUM:6235	0.000133349500201	0.142857142857	JUN FOS	c-Fos-c-Jun-SAF-1 complex
GO:0035976	0.000139871762976	0.214285714286	JUN FOS JUND	transcription factor AP-1 complex
KEGG:04380	0.000190579013677	0.285714285714	JUN FOSB FOS JUND	Osteoclast differentiation
GO:0051173	0.0001993530986	0.857142857143	TRIB2 DET1 CREB5 COP1 ATF3 JUN TRIB1 JUND ATF7 FOS ETV1 ETV5	positive regulation of nitrogen compound metabolic process
CORUM:2754	0.000266552996475	0.142857142857	FOSB JUND	JUND-FOSB-SMAD3-SMAD4 complex
CORUM:2692	0.000266552996475	0.142857142857	JUN FOS	SMAD3-SMAD4-cJun-cFos complex
KEGG:05030	0.000406059345822	0.214285714286	FOSB CREB5 JUN	Cocaine addiction
CORUM:1214	0.000444011791638	0.142857142857	DET1 COP1	Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1)
REAC:R-HSA-187037	0.00048719883373	0.285714285714	FOSB TRIB1 FOS JUND	Signaling by NTRK1 (TRKA)
GO:0000981	0.000716403522792	0.642857142857	CREB5 ATF3 JUN ETV5 ATF7 FOSB FOS ETV1 JUND	DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0010604	0.000850921030799	0.857142857143	TRIB2 DET1 CREB5 COP1 ATF3 JUN TRIB1 JUND ATF7 FOS ETV1 ETV5	positive regulation of macromolecule metabolic process
GO:0000977	0.000916990234428	0.642857142857	CREB5 ATF3 JUN ETV5 ATF7 FOSB FOS ETV1 JUND	RNA polymerase II transcription regulatory region sequence-specific DNA binding
REAC:R-HSA-166520	0.000929562616243	0.285714285714	FOSB TRIB1 FOS JUND	Signaling by NTRKs
WP:WP437	0.000976690901528	0.285714285714	JUN FOSB FOS JUND	EGF EGFR signaling pathway
GO:0003700	0.00123331788004	0.642857142857	CREB5 ATF3 JUN ETV5 ATF7 FOSB FOS ETV1 JUND	DNA-binding transcription factor activity
REAC:R-HSA-9018519	0.00142940725093	0.285714285714	JUN FOSB FOS JUND	Estrogen-dependent gene expression
GO:0000785	0.00181344690089	0.642857142857	CREB5 ATF3 JUN ETV5 ATF7 FOSB FOS ETV1 JUND	chromatin
GO:0000976	0.00193052332818	0.642857142857	CREB5 ATF3 JUN ETV5 ATF7 FOSB FOS ETV1 JUND	transcription cis-regulatory region binding
GO:0001067	0.0019477802701	0.642857142857	CREB5 ATF3 JUN ETV5 ATF7 FOSB FOS ETV1 JUND	transcription regulatory region nucleic acid binding
GO:0035497	0.00195378579303	0.214285714286	ATF7 CREB5 JUN	cAMP response element binding
GO:0009893	0.0024094921579	0.857142857143	TRIB2 DET1 CREB5 COP1 ATF3 JUN TRIB1 JUND ATF7 FOS ETV1 ETV5	positive regulation of metabolic process
GO:1990837	0.00290410408744	0.642857142857	CREB5 ATF3 JUN ETV5 ATF7 FOSB FOS ETV1 JUND	sequence-specific double-stranded DNA binding
GO:0032993	0.00302953776668	0.642857142857	CREB5 ATF3 JUN ETV5 ATF7 FOSB FOS ETV1 JUND	protein-DNA complex
KEGG:04928	0.00341779792486	0.214285714286	CREB5 JUND FOS	Parathyroid hormone synthesis, secretion and action
WP:WP2840	0.00343974183373	0.214285714286	FOSB FOS JUN	Hair follicle development cytodifferentiation part 3 of 3
KEGG:04915	0.00464761969098	0.214285714286	JUN CREB5 FOS	Estrogen signaling pathway
KEGG:04668	0.00511394831728	0.214285714286	JUN CREB5 FOS	TNF signaling pathway
WP:WP2355	0.00528752378176	0.214285714286	FOSB FOS JUND	Corticotropin releasing hormone signaling pathway
GO:0043565	0.00540172587396	0.642857142857	CREB5 ATF3 JUN ETV5 ATF7 FOSB FOS ETV1 JUND	sequence-specific DNA binding
GO:0003690	0.0055305495206	0.642857142857	CREB5 ATF3 JUN ETV5 ATF7 FOSB FOS ETV1 JUND	double-stranded DNA binding
GO:0000978	0.00609807471032	0.571428571429	CREB5 ATF3 JUN ETV1 ATF7 FOSB FOS JUND	RNA polymerase II cis-regulatory region sequence-specific DNA binding
REAC:R-HSA-8939211	0.00632842100245	0.285714285714	JUN FOSB FOS JUND	ESR-mediated signaling
WP:WP4919	0.0065190163061	0.142857142857	JUN FOS	Neuroinflammation
GO:0000987	0.00715943413184	0.571428571429	CREB5 ATF3 JUN ETV1 ATF7 FOSB FOS JUND	cis-regulatory region sequence-specific DNA binding
KEGG:04926	0.00748758149237	0.214285714286	JUN CREB5 FOS	Relaxin signaling pathway
WP:WP4928	0.00897850366606	0.142857142857	JUN FOS	MAPK pathway in congenital thyroid cancer
WP:WP2435	0.00897850366606	0.142857142857	JUN FOS	Quercetin and Nf kB AP 1 induced apoptosis
REAC:R-HSA-450341	0.010724165603	0.142857142857	JUN FOS	Activation of the AP-1 family of transcription factors
WP:WP516	0.0150627036883	0.142857142857	JUND ATF3	Hypertrophy model
GO:0051171	0.015387403208	0.928571428571	TRIB2 DET1 CREB5 COP1 ATF3 JUN TRIB1 ETV5 ATF7 FOSB FOS JUND ETV1	regulation of nitrogen compound metabolic process
WP:WP712	0.0186848490128	0.142857142857	JUN FOS	Estrogen signaling pathway
KEGG:05161	0.0189814300125	0.214285714286	JUN CREB5 FOS	Hepatitis B
REAC:R-HSA-9006931	0.0195937919824	0.285714285714	JUN FOSB FOS JUND	Signaling by Nuclear Receptors
WP:WP1528	0.020640372829	0.142857142857	JUN FOS	Physiological and pathological hypertrophy of the heart
GO:0080090	0.0210317343457	0.928571428571	TRIB2 DET1 CREB5 COP1 ATF3 JUN TRIB1 ETV5 ATF7 FOSB FOS JUND ETV1	regulation of primary metabolic process
WP:WP3612	0.0226919844984	0.142857142857	JUN FOS	Photodynamic therapy induced NFE2L2 NRF2 survival signaling
KEGG:04024	0.0229942686538	0.214285714286	JUN CREB5 FOS	cAMP signaling pathway
GO:0032436	0.0232917470649	0.285714285714	TRIB2 COP1 DET1 TRIB1	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
KEGG:05207	0.0251905259219	0.214285714286	JUN CREB5 FOS	Chemical carcinogenesis - receptor activation
WP:WP289	0.0277768363491	0.214285714286	JUN FOS ATF3	Myometrial relaxation and contraction pathways
GO:0140110	0.0295551162235	0.642857142857	CREB5 ATF3 JUN ETV5 ATF7 FOSB FOS ETV1 JUND	transcription regulator activity
WP:WP4666	0.0316954449585	0.214285714286	JUN CREB5 FOS	Hepatitis B infection
WP:WP3972	0.0318561232025	0.142857142857	JUN FOS	PDGFR beta pathway
WP:WP4880	0.0397303541293	0.142857142857	JUN FOS	Host pathogen interaction of human coronaviruses interferon induction
GO:0005694	0.0416953587303	0.642857142857	CREB5 ATF3 JUN ETV5 ATF7 FOSB FOS ETV1 JUND	chromosome
WP:WP4877	0.042544943205	0.142857142857	JUN FOS	Host pathogen interaction of human coronaviruses MAPK signaling
WP:WP313	0.042544943205	0.142857142857	JUN FOS	Hepatocyte growth factor receptor signaling
KEGG:05166	0.0444106258153	0.214285714286	JUN CREB5 FOS	Human T-cell leukemia virus 1 infection
GO:0090575	0.0467055946247	0.357142857143	JUN ATF7 ATF3 FOS JUND	RNA polymerase II transcription regulator complex
GO:2000060	0.0486395171426	0.285714285714	TRIB2 COP1 DET1 TRIB1	positive regulation of ubiquitin-dependent protein catabolic process
REAC:R-HSA-2871796	0.049745617661	0.142857142857	JUN FOS	FCERI mediated MAPK activation

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
COP1	TRIB1	1.0		structurally_consistent (dimer)
JUNB	ATF7	1.0	0.136
FOS	JUND	1.0
DET1	TRIB1	1.0		structurally_consistent (Q92519)
ATF2	JUNB	1.0	0.094
JUNB	JUN	1.0	0.326120260424
STK40	DET1	0.999
FOS	JUNB	0.999
CREB5	JUN	0.999
DET1	COP1	0.999		structurally_consistent (dimer)
ATF7	JUN	0.999	0.444
JUNB	FOSL2	0.999	0.106	mutually_exclusive (P18847)
COP1	JUNB	0.999	0.068
FOSB	JUNB	0.999
COP1	JUN	0.999	0.238
ATF7	FOSL2	0.999	0.112
ETV5	COP1	0.999
JUN	FOSL2	0.999	0.32
ATF2	JUN	0.999	0.376827743417
CREB5	JUNB	0.999
JUND	JUN	0.998	0.45
ETV1	COP1	0.998
JUND	ATF7	0.998	0.126
JUND	FOSL2	0.998	0.174
STK40	TRIB1	0.998
JUNB	JUND	0.998	0.076
FOS	JUN	0.998
ATF2	JUND	0.998	0.104
TRIB2	TRIB1	0.998		structurally_consistent (dimer)
DET1	TRIB2	0.998		structurally_consistent (dimer)
FOS	ATF2	0.998
CREB5	JUND	0.998
TRIB2	COP1	0.998		structurally_consistent (Q96RU8)
ATF2	ATF7	0.997	0.244
COP1	JUND	0.997	0.088
STK40	TRIB2	0.997
STK40	ETV5	0.996
ATF3	JUN	0.996	0.261319148936
ETV5	DET1	0.995
CREB5	ATF7	0.995
ATF2	CREB5	0.995
STK40	ETV1	0.994
TRIB1	FOSL2	0.994
COP1	ATF7	0.992	0.15
TRIB1	FOS	0.992
FOSB	JUN	0.991
STK40	COP1	0.991
STK40	FOS	0.991
TRIB1	JUNB	0.991
ATF3	FOSL2	0.99	0.114	structurally_consistent (dimer)
COP1	FOS	0.99
ATF2	FOSL2	0.989	0.092
DET1	ETV1	0.988
COP1	FOSL2	0.988	0.122
FOSB	JUND	0.986
CREB5	ATF3	0.986
FOSB	ATF2	0.985
STK40	FOSL2	0.985
FOSB	ATF7	0.983
JUNB	ATF3	0.982	0.1444	structurally_consistent (dimer)
STK40	JUND	0.975
DET1	FOS	0.975		structurally_consistent (dimer)
CREB5	FOSL2	0.974
COP1	ATF2	0.973	0.15
ATF2	ATF3	0.972	0.08
ATF7	ATF3	0.971	0.092
STK40	ATF2	0.969
FOS	ATF7	0.969
STK40	JUNB	0.967
DET1	FOSL2	0.965
FOSB	TRIB1	0.96
FOSB	COP1	0.954
STK40	ATF7	0.949
STK40	JUN	0.946
TRIB1	JUND	0.946
FOSB	STK40	0.943
TRIB1	JUN	0.929
TRIB1	ATF7	0.924
DET1	JUNB	0.92
TRIB1	ATF2	0.906
ETV5	ETV1	0.902
FOS	CREB5	0.892
FOSB	CREB5	0.877
COP1	CREB5	0.644
STK40	CREB5	0.595
FOSB	FOSL2	0.502
FOSB	ATF3	0.487
DET1	JUND	0.447
ETV5	TRIB1	0.418
ETV1	TRIB1	0.418
TRIB1	CREB5	0.389
DET1	CREB5	0.367
DET1	JUN	0.363
DET1	ATF7	0.359
DET1	ATF2	0.359
COP1	ATF3	0.198	0.148
FOSB	DET1	0.172
STK40	ATF3	0.165
TRIB1	ATF3	0.164
JUND	ATF3	0.164	0.126
DET1	ATF3	0.164
ETV1	JUN	0.042
ETV5	JUN	0.042

Related Complexes

Genename	Complexes
STK40	huMAP3_02750.1 huMAP3_04302.1 huMAP3_09617.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_10936.1 huMAP3_14027.1 huMAP3_15260.1
ETV5	huMAP3_02750.1 huMAP3_04302.1 huMAP3_09617.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_10936.1 huMAP3_14027.1 huMAP3_15260.1
ATF2	huMAP3_04647.1 huMAP3_06833.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_15260.1
FOSB	huMAP3_02665.1 huMAP3_04302.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_11678.1 huMAP3_14027.1 huMAP3_15260.1
DET1	huMAP3_02750.1 huMAP3_04302.1 huMAP3_09617.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_10936.1 huMAP3_14027.1 huMAP3_15260.1
ETV1	huMAP3_02750.1 huMAP3_04302.1 huMAP3_09617.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_10936.1 huMAP3_14027.1 huMAP3_15260.1
CREB5	huMAP3_04647.1 huMAP3_06833.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_15260.1
FOS	huMAP3_04302.1 huMAP3_09690.1 huMAP3_09842.1 huMAP3_10061.1 huMAP3_10133.1 huMAP3_12974.1 huMAP3_15260.1
JUNB	huMAP3_04647.1 huMAP3_06833.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_15260.1
FOSL2	huMAP3_06833.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_15260.1
JUND	huMAP3_04647.1 huMAP3_06833.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_15260.1
TRIB2	huMAP3_02750.1 huMAP3_04302.1 huMAP3_09617.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_10936.1 huMAP3_14027.1 huMAP3_14660.1 huMAP3_15260.1
ATF7	huMAP3_04647.1 huMAP3_06833.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_15260.1
TRIB1	huMAP3_02750.1 huMAP3_04302.1 huMAP3_09617.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_10936.1 huMAP3_11010.1 huMAP3_14027.1 huMAP3_15260.1
COP1	huMAP3_02750.1 huMAP3_04302.1 huMAP3_09617.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_10936.1 huMAP3_14027.1 huMAP3_15260.1
ATF3	huMAP3_04647.1 huMAP3_06833.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_15260.1
JUN	huMAP3_04647.1 huMAP3_06833.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_15260.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09690.1

Complex Portal: CPX-22454