hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09694.1
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RNMT | mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7))-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p) | 5 | UniProt NCBI |
| RNGTT | mRNA-capping enzyme (HCAP1) (HCE) [Includes: mRNA 5'-triphosphate monophosphatase (EC 3.6.1.74) (mRNA 5'-phosphatase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)] | 5 | UniProt NCBI |
| KPNA1 | Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed] | 5 | UniProt NCBI |
| KPNA6 | Importin subunit alpha-7 (Karyopherin subunit alpha-6) | 5 | UniProt NCBI |
| SREK1IP1 | Protein SREK1IP1 (SFRS12-interacting protein 1) (SREK1-interacting protein 1) (Splicing regulatory protein of 18 kDa) (p18SRP) | 5 | UniProt NCBI |
| NUP50 | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | 5 | UniProt NCBI |
| KPNA5 | Importin subunit alpha-6 (Karyopherin subunit alpha-5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03013 | 3.86279110966e-06 | 0.571428571429 | KPNA1 KPNA6 KPNA5 NUP50 | Nucleocytoplasmic transport |
| REAC:R-HSA-162587 | 5.66464039369e-05 | 0.571428571429 | RNGTT NUP50 RNMT KPNA1 | HIV Life Cycle |
| REAC:R-HSA-168276 | 0.000100611892471 | 0.428571428571 | KPNA1 KPNA5 NUP50 | NS1 Mediated Effects on Host Pathways |
| GO:0042564 | 0.000282244947588 | 0.428571428571 | KPNA1 KPNA6 KPNA5 | NLS-dependent protein nuclear import complex |
| REAC:R-HSA-162906 | 0.000333081909557 | 0.571428571429 | RNGTT NUP50 RNMT KPNA1 | HIV Infection |
| GO:0031074 | 0.000554182028596 | 0.428571428571 | KPNA1 KPNA6 KPNA5 | nucleocytoplasmic transport complex |
| REAC:R-HSA-1169408 | 0.000589010657253 | 0.428571428571 | KPNA1 KPNA5 NUP50 | ISG15 antiviral mechanism |
| REAC:R-HSA-1169410 | 0.000766722633593 | 0.428571428571 | KPNA1 KPNA5 NUP50 | Antiviral mechanism by IFN-stimulated genes |
| REAC:R-HSA-9824446 | 0.000953213883488 | 0.714285714286 | RNGTT NUP50 RNMT KPNA5 KPNA1 | Viral Infection Pathways |
| KEGG:05164 | 0.00166242587361 | 0.428571428571 | KPNA1 KPNA6 KPNA5 | Influenza A |
| GO:0061608 | 0.00187892941497 | 0.428571428571 | KPNA1 KPNA6 KPNA5 | nuclear import signal receptor activity |
| KEGG:05207 | 0.00240757111593 | 0.428571428571 | KPNA1 KPNA6 KPNA5 | Chemical carcinogenesis - receptor activation |
| REAC:R-HSA-5663205 | 0.00262907091591 | 0.714285714286 | RNGTT NUP50 RNMT KPNA5 KPNA1 | Infectious disease |
| GO:0006607 | 0.00273674384085 | 0.428571428571 | KPNA1 KPNA6 KPNA5 | NLS-bearing protein import into nucleus |
| GO:0006606 | 0.0041654421892 | 0.571428571429 | KPNA1 KPNA6 KPNA5 NUP50 | protein import into nucleus |
| REAC:R-HSA-162599 | 0.00454464074576 | 0.428571428571 | RNGTT RNMT NUP50 | Late Phase of HIV Life Cycle |
| GO:0051170 | 0.00503558984177 | 0.571428571429 | KPNA1 KPNA6 KPNA5 NUP50 | import into nucleus |
| GO:0008139 | 0.00516068999797 | 0.428571428571 | KPNA1 KPNA6 KPNA5 | nuclear localization sequence binding |
| REAC:R-HSA-168255 | 0.00669999275154 | 0.428571428571 | KPNA1 KPNA5 NUP50 | Influenza Infection |
| GO:0140142 | 0.00979189312029 | 0.428571428571 | KPNA1 KPNA6 KPNA5 | nucleocytoplasmic carrier activity |
| REAC:R-HSA-913531 | 0.0110497496792 | 0.428571428571 | KPNA1 KPNA5 NUP50 | Interferon Signaling |
| REAC:R-HSA-167160 | 0.0123178965954 | 0.285714285714 | RNGTT RNMT | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection |
| REAC:R-HSA-77075 | 0.0123178965954 | 0.285714285714 | RNGTT RNMT | RNA Pol II CTD phosphorylation and interaction with CE |
| REAC:R-HSA-72086 | 0.0143201223364 | 0.285714285714 | RNGTT RNMT | mRNA Capping |
| REAC:R-HSA-168271 | 0.0153773615715 | 0.285714285714 | KPNA1 NUP50 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-180910 | 0.0176039638163 | 0.285714285714 | KPNA1 NUP50 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-176033 | 0.0212237900738 | 0.285714285714 | KPNA1 NUP50 | Interactions of Vpr with host cellular proteins |
| GO:0005048 | 0.0305188440994 | 0.428571428571 | KPNA1 KPNA6 KPNA5 | signal sequence binding |
| REAC:R-HSA-1643685 | 0.0367346572641 | 0.714285714286 | RNGTT NUP50 RNMT KPNA5 KPNA1 | Disease |
| KEGG:03015 | 0.0411825364664 | 0.285714285714 | RNGTT RNMT | mRNA surveillance pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| KPNA1 | KPNA6 | 1.0 | 0.458 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM boldt_WMM WMM_only |
| KPNA1 | NUP50 | 0.999 | 0.164 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM treiber_WMM |
| NUP50 | KPNA6 | 0.999 | 0.222 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| NUP50 | KPNA5 | 0.998 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| RNMT | KPNA6 | 0.998 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| SREK1IP1 | KPNA1 | 0.997 | 0.122 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| KPNA1 | RNMT | 0.997 | 0.118 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| RNMT | KPNA5 | 0.997 | 0.078 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| SREK1IP1 | KPNA6 | 0.994 | 0.1 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| KPNA1 | KPNA5 | 0.988 | 0.24 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| RNGTT | NUP50 | 0.982 | 0.206 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM |
| RNGTT | KPNA1 | 0.98 | 0.084 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| RNMT | NUP50 | 0.97 | 0.114 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| KPNA5 | KPNA6 | 0.967 | 0.23 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| SREK1IP1 | KPNA5 | 0.962 | 0.1 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RNGTT | KPNA5 | 0.612 | 0.176 | youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| RNGTT | KPNA6 | 0.559 | 0.166 | youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| SREK1IP1 | NUP50 | 0.177 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RNGTT | RNMT | 0.159 | 0.108 | youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| SREK1IP1 | RNMT | 0.002 | 0.05 | bioplex3_HCT116 WMM_only |
Related Complexes