hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09710.1

Complex Portal: CPX-13169

Confidence: Moderate High

Genename	Protein Name	Uniprot Annotation Score	Links
NUP43	Nucleoporin Nup43 (Nup107-160 subcomplex subunit Nup43) (p42)	5	UniProt NCBI
NUP133	Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133)	5	UniProt NCBI
SEC13	Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein)	5	UniProt NCBI
AHCTF1	Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1)	5	UniProt NCBI
AAAS	Aladin (Adracalin)	5	UniProt NCBI
NUP37	Nucleoporin Nup37 (p37) (Nup107-160 subcomplex subunit Nup37)	5	UniProt NCBI
SPAST	Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein)	5	UniProt NCBI
NUP160	Nuclear pore complex protein Nup160 (160 kDa nucleoporin) (Nucleoporin Nup160)	5	UniProt NCBI
NUP98	Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)]	5	UniProt NCBI
NUP188	Nucleoporin NUP188 (hNup188)	5	UniProt NCBI
NUP107	Nuclear pore complex protein Nup107 (107 kDa nucleoporin) (Nucleoporin Nup107)	5	UniProt NCBI
NUP210	Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa)	5	UniProt NCBI
SEH1L	Nucleoporin SEH1 (GATOR2 complex protein SEH1) (Nup107-160 subcomplex subunit SEH1) (SEC13-like protein)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP3998	7.41879371274e-25	0.923076923077	NUP210 NUP37 NUP188 SEC13 NUP133 NUP160 AHCTF1 NUP98 NUP43 NUP107 SEH1L AAAS	Prader Willi and Angelman syndrome
GO:0031080	4.27378448124e-24	0.692307692308	NUP37 SEC13 NUP160 NUP133 AHCTF1 NUP43 NUP107 SEH1L NUP98	nuclear pore outer ring
KEGG:03013	4.46641859806e-24	0.923076923077	NUP210 NUP37 NUP188 SEC13 NUP133 NUP160 AHCTF1 NUP98 NUP43 NUP107 SEH1L AAAS	Nucleocytoplasmic transport
CORUM:87	1.2624989887e-23	0.615384615385	NUP37 SEC13 NUP160 NUP133 NUP98 NUP107 SEH1L NUP43	Nup 107-160 subcomplex
GO:0005643	3.17524370905e-22	0.923076923077	NUP210 NUP37 NUP188 SEC13 NUP133 NUP160 AHCTF1 NUP98 NUP43 NUP107 SEH1L AAAS	nuclear pore
REAC:R-HSA-5619107	1.60589298968e-20	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
REAC:R-HSA-170822	1.60589298968e-20	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Regulation of Glucokinase by Glucokinase Regulatory Protein
REAC:R-HSA-168333	2.32797025689e-20	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	NEP/NS2 Interacts with the Cellular Export Machinery
REAC:R-HSA-168271	2.32797025689e-20	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Transport of Ribonucleoproteins into the Host Nucleus
REAC:R-HSA-168274	2.32797025689e-20	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Export of Viral Ribonucleoproteins from Nucleus
REAC:R-HSA-159227	4.68386130575e-20	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Transport of the SLBP independent Mature mRNA
REAC:R-HSA-180746	4.68386130575e-20	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Nuclear import of Rev protein
REAC:R-HSA-180910	4.68386130575e-20	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Vpr-mediated nuclear import of PICs
REAC:R-HSA-4085377	6.51506829361e-20	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	SUMOylation of SUMOylation proteins
REAC:R-HSA-159230	6.51506829361e-20	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Transport of the SLBP Dependant Mature mRNA
REAC:R-HSA-165054	6.51506829361e-20	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Rev-mediated nuclear export of HIV RNA
REAC:R-HSA-3301854	8.95600789689e-20	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Nuclear Pore Complex (NPC) Disassembly
REAC:R-HSA-177243	1.21771643328e-19	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Interactions of Rev with host cellular proteins
REAC:R-HSA-176033	1.21771643328e-19	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Interactions of Vpr with host cellular proteins
REAC:R-HSA-3232142	1.63882902724e-19	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	SUMOylation of ubiquitinylation proteins
REAC:R-HSA-168276	2.88603521759e-19	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	NS1 Mediated Effects on Host Pathways
REAC:R-HSA-159231	3.78076766646e-19	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Transport of Mature mRNA Derived from an Intronless Transcript
REAC:R-HSA-159234	4.91378444435e-19	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Transport of Mature mRNAs Derived from Intronless Transcripts
REAC:R-HSA-168325	6.33880148299e-19	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Viral Messenger RNA Synthesis
REAC:R-HSA-4615885	1.03314639584e-18	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	SUMOylation of DNA replication proteins
REAC:R-HSA-4570464	1.30630363846e-18	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	SUMOylation of RNA binding proteins
REAC:R-HSA-2980766	3.15340693386e-18	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Nuclear Envelope Breakdown
REAC:R-HSA-9615933	4.9947027917e-18	0.615384615385	NUP37 NUP188 SEC13 NUP160 NUP133 AHCTF1 NUP43 NUP107	Postmitotic nuclear pore complex (NPC) reformation
REAC:R-HSA-191859	7.033484512e-18	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	snRNP Assembly
REAC:R-HSA-194441	7.033484512e-18	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Metabolism of non-coding RNA
REAC:R-HSA-6784531	1.46853865487e-17	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	tRNA processing in the nucleus
GO:0005635	3.5499316785e-17	1.0	NUP210 NUP37 NUP188 SEC13 NUP133 SPAST NUP160 AHCTF1 NUP98 NUP43 NUP107 SEH1L AAAS	nuclear envelope
REAC:R-HSA-3371453	7.36481911601e-17	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Regulation of HSF1-mediated heat shock response
REAC:R-HSA-70171	7.36481911601e-17	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Glycolysis
REAC:R-HSA-1169408	8.5255763836e-17	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	ISG15 antiviral mechanism
REAC:R-HSA-4551638	8.5255763836e-17	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	SUMOylation of chromatin organization proteins
REAC:R-HSA-2995410	9.84607495343e-17	0.692307692308	NUP37 NUP188 SEC13 NUP133 NUP160 AHCTF1 NUP43 NUP107 SPAST	Nuclear Envelope (NE) Reassembly
REAC:R-HSA-5619102	1.49645541192e-16	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	SLC transporter disorders
REAC:R-HSA-159236	1.49645541192e-16	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Transport of Mature mRNA derived from an Intron-Containing Transcript
REAC:R-HSA-3108214	1.71325888721e-16	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	SUMOylation of DNA damage response and repair proteins
REAC:R-HSA-1169410	1.95752576394e-16	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Antiviral mechanism by IFN-stimulated genes
GO:0006913	2.07179763993e-16	0.923076923077	NUP210 NUP37 NUP188 SEC13 NUP133 NUP160 AHCTF1 NUP98 NUP43 NUP107 SEH1L AAAS	nucleocytoplasmic transport
GO:0051169	2.07179763993e-16	0.923076923077	NUP210 NUP37 NUP188 SEC13 NUP133 NUP160 AHCTF1 NUP98 NUP43 NUP107 SEH1L AAAS	nuclear transport
REAC:R-HSA-70326	4.72529442294e-16	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Glucose metabolism
REAC:R-HSA-72202	4.72529442294e-16	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Transport of Mature Transcript to Cytoplasm
REAC:R-HSA-3371556	9.43905741536e-16	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Cellular response to heat stress
REAC:R-HSA-5578749	1.79413977733e-15	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Transcriptional regulation by small RNAs
REAC:R-HSA-72306	3.95469240234e-15	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	tRNA processing
REAC:R-HSA-9610379	3.95469240234e-15	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	HCMV Late Events
REAC:R-HSA-9705671	1.25124200722e-14	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	SARS-CoV-2 activates/modulates innate and adaptive immune responses
REAC:R-HSA-211000	2.03300931102e-14	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Gene Silencing by RNA
REAC:R-HSA-9609690	2.3764921838e-14	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	HCMV Early Events
REAC:R-HSA-68875	2.7705728767e-14	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Mitotic Prophase
REAC:R-HSA-162909	3.47074205433e-14	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Host Interactions of HIV factors
REAC:R-HSA-162599	4.99136249988e-14	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Late Phase of HIV Life Cycle
REAC:R-HSA-168273	5.35824715211e-14	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Influenza Viral RNA Transcription and Replication
REAC:R-HSA-68886	7.92958489798e-14	0.846153846154	NUP210 NUP37 NUP188 SEC13 NUP133 SPAST NUP160 AHCTF1 NUP43 NUP107 AAAS	M Phase
REAC:R-HSA-5619115	1.05757055223e-13	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Disorders of transmembrane transporters
REAC:R-HSA-9609646	1.12885496248e-13	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	HCMV Infection
REAC:R-HSA-162587	1.12885496248e-13	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	HIV Life Cycle
REAC:R-HSA-168255	1.65347289584e-13	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Influenza Infection
REAC:R-HSA-3108232	3.01870253849e-13	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	SUMO E3 ligases SUMOylate target proteins
KEGG:05014	3.85471900086e-13	0.769230769231	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 NUP98 NUP107 SEH1L NUP43	Amyotrophic lateral sclerosis
REAC:R-HSA-2990846	4.01977575208e-13	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	SUMOylation
REAC:R-HSA-913531	7.71552531559e-13	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Interferon Signaling
REAC:R-HSA-9705683	1.48735796828e-12	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	SARS-CoV-2-host interactions
REAC:R-HSA-69278	2.36618758562e-12	0.846153846154	NUP210 NUP37 NUP188 SEC13 NUP133 SPAST NUP160 AHCTF1 NUP43 NUP107 AAAS	Cell Cycle, Mitotic
REAC:R-HSA-162906	6.51218026162e-12	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	HIV Infection
REAC:R-HSA-68882	7.06926091118e-12	0.692307692308	NUP37 NUP188 SEC13 NUP133 NUP160 AHCTF1 NUP43 NUP107 SPAST	Mitotic Anaphase
REAC:R-HSA-2555396	7.36334463386e-12	0.692307692308	NUP37 NUP188 SEC13 NUP133 NUP160 AHCTF1 NUP43 NUP107 SPAST	Mitotic Metaphase and Anaphase
GO:0031975	1.1574384006e-11	1.0	NUP210 NUP37 NUP188 SEC13 NUP133 SPAST NUP160 AHCTF1 NUP98 NUP43 NUP107 SEH1L AAAS	envelope
GO:0031967	1.1574384006e-11	1.0	NUP210 NUP37 NUP188 SEC13 NUP133 SPAST NUP160 AHCTF1 NUP98 NUP43 NUP107 SEH1L AAAS	organelle envelope
GO:0000776	1.48364246214e-11	0.692307692308	NUP37 SEC13 NUP160 NUP133 AHCTF1 NUP43 NUP107 SEH1L NUP98	kinetochore
GO:0000779	1.93535411059e-11	0.692307692308	NUP37 SEC13 NUP160 NUP133 AHCTF1 NUP43 NUP107 SEH1L NUP98	condensed chromosome, centromeric region
CORUM:1347	2.11387990692e-11	0.307692307692	NUP107 NUP98 NUP133 NUP160	NPC subcomplex (NUP98, NUP107, NUP133, NUP160)
REAC:R-HSA-1640170	2.3168987326e-11	0.846153846154	NUP210 NUP37 NUP188 SEC13 NUP133 SPAST NUP160 AHCTF1 NUP43 NUP107 AAAS	Cell Cycle
REAC:R-HSA-71387	2.48008353337e-11	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Metabolism of carbohydrates
REAC:R-HSA-9694516	4.44435754086e-11	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	SARS-CoV-2 Infection
REAC:R-HSA-72203	4.59414722296e-11	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Processing of Capped Intron-Containing Pre-mRNA
GO:0046907	9.27213332445e-11	1.0	NUP210 NUP37 NUP188 SEC13 NUP133 SPAST NUP160 AHCTF1 NUP98 NUP43 NUP107 SEH1L AAAS	intracellular transport
REAC:R-HSA-141424	1.41166133156e-10	0.538461538462	NUP37 SEC13 NUP160 NUP133 AHCTF1 NUP43 NUP107	Amplification of signal from the kinetochores
REAC:R-HSA-141444	1.41166133156e-10	0.538461538462	NUP37 SEC13 NUP160 NUP133 AHCTF1 NUP43 NUP107	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
GO:0000775	3.98458204697e-10	0.692307692308	NUP37 SEC13 NUP160 NUP133 AHCTF1 NUP43 NUP107 SEH1L NUP98	chromosome, centromeric region
REAC:R-HSA-69618	4.46715765781e-10	0.538461538462	NUP37 SEC13 NUP160 NUP133 AHCTF1 NUP43 NUP107	Mitotic Spindle Checkpoint
GO:0000793	5.74252761544e-10	0.692307692308	NUP37 SEC13 NUP160 NUP133 AHCTF1 NUP43 NUP107 SEH1L NUP98	condensed chromosome
REAC:R-HSA-9648025	6.17616659209e-10	0.538461538462	NUP37 SEC13 NUP160 NUP133 AHCTF1 NUP43 NUP107	EML4 and NUDC in mitotic spindle formation
REAC:R-HSA-9679506	8.01258600153e-10	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	SARS-CoV Infections
REAC:R-HSA-2500257	1.00682422121e-09	0.538461538462	NUP37 SEC13 NUP160 NUP133 AHCTF1 NUP43 NUP107	Resolution of Sister Chromatid Cohesion
REAC:R-HSA-5663220	1.8717608466e-09	0.538461538462	NUP37 SEC13 NUP160 NUP133 AHCTF1 NUP43 NUP107	RHO GTPases Activate Formins
GO:0051649	2.40658347659e-09	1.0	NUP210 NUP37 NUP188 SEC13 NUP133 SPAST NUP160 AHCTF1 NUP98 NUP43 NUP107 SEH1L AAAS	establishment of localization in cell
REAC:R-HSA-2262752	5.64081084063e-09	0.769230769231	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 SEH1L NUP43	Cellular responses to stress
REAC:R-HSA-8953897	6.20661640576e-09	0.769230769231	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 SEH1L NUP43	Cellular responses to stimuli
REAC:R-HSA-2467813	1.96728215576e-08	0.538461538462	NUP37 SEC13 NUP160 NUP133 AHCTF1 NUP43 NUP107	Separation of Sister Chromatids
GO:0140513	2.01939993955e-08	0.923076923077	NUP210 NUP37 NUP188 SEC13 NUP133 NUP160 AHCTF1 NUP98 NUP43 NUP107 SEH1L AAAS	nuclear protein-containing complex
REAC:R-HSA-68877	2.96149696524e-08	0.538461538462	NUP37 SEC13 NUP160 NUP133 AHCTF1 NUP43 NUP107	Mitotic Prometaphase
GO:0098687	3.32907071244e-08	0.692307692308	NUP37 SEC13 NUP160 NUP133 AHCTF1 NUP43 NUP107 SEH1L NUP98	chromosomal region
GO:0006999	3.46422136935e-08	0.384615384615	AHCTF1 SEH1L NUP107 NUP133 NUP98	nuclear pore organization
REAC:R-HSA-1280215	6.01254500784e-08	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Cytokine Signaling in Immune system
REAC:R-HSA-8953854	1.68850051541e-07	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Metabolism of RNA
REAC:R-HSA-9824446	2.15326006352e-07	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Viral Infection Pathways
GO:0017056	3.02815979991e-07	0.384615384615	NUP188 NUP98 NUP107 NUP133 NUP160	structural constituent of nuclear pore
REAC:R-HSA-69620	3.64393244112e-07	0.538461538462	NUP37 SEC13 NUP160 NUP133 AHCTF1 NUP43 NUP107	Cell Cycle Checkpoints
REAC:R-HSA-195258	5.50292598703e-07	0.538461538462	NUP37 SEC13 NUP160 NUP133 AHCTF1 NUP43 NUP107	RHO GTPase Effectors
REAC:R-HSA-5663205	1.33421771934e-06	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Infectious disease
GO:0051641	2.83155234815e-06	1.0	NUP210 NUP37 NUP188 SEC13 NUP133 SPAST NUP160 AHCTF1 NUP98 NUP43 NUP107 SEH1L AAAS	cellular localization
REAC:R-HSA-194315	3.31261000601e-06	0.615384615385	NUP37 SEC13 NUP133 NUP160 AHCTF1 NUP43 NUP107 AAAS	Signaling by Rho GTPases
REAC:R-HSA-9716542	3.935826463e-06	0.615384615385	NUP37 SEC13 NUP133 NUP160 AHCTF1 NUP43 NUP107 AAAS	Signaling by Rho GTPases, Miro GTPases and RHOBTB3
HP:0031504	4.12397595916e-06	0.307692307692	NUP107 NUP160 NUP133 NUP37	Foamy urine
HP:0012579	9.19511220779e-06	0.307692307692	NUP107 NUP160 NUP133 NUP37	Minimal change glomerulonephritis
GO:0006997	1.10008102183e-05	0.461538461538	SPAST NUP107 NUP133 AHCTF1 NUP98 SEH1L	nucleus organization
HP:0001967	1.79100602237e-05	0.307692307692	NUP107 NUP160 NUP133 NUP37	Diffuse mesangial sclerosis
GO:0006810	1.98084347196e-05	1.0	NUP210 NUP37 NUP188 SEC13 NUP133 SPAST NUP160 AHCTF1 NUP98 NUP43 NUP107 SEH1L AAAS	transport
HP:0002586	2.02110603251e-05	0.307692307692	NUP107 NUP160 NUP133 NUP37	Peritonitis
REAC:R-HSA-597592	2.98907719811e-05	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Post-translational protein modification
HP:0001966	3.89748377886e-05	0.307692307692	NUP107 NUP160 NUP133 NUP37	Abnormal glomerular mesangium morphology
REAC:R-HSA-74160	4.67324464589e-05	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Gene expression (Transcription)
HP:0033072	6.26486763001e-05	0.307692307692	NUP107 NUP160 NUP133 NUP37	Abnormal macroscopic urine appearance
GO:0051234	6.48725531739e-05	1.0	NUP210 NUP37 NUP188 SEC13 NUP133 SPAST NUP160 AHCTF1 NUP98 NUP43 NUP107 SEH1L AAAS	establishment of localization
HP:0002585	0.000120933943986	0.307692307692	NUP107 NUP160 NUP133 NUP37	Abnormal peritoneum morphology
HP:0000097	0.000130354574291	0.307692307692	NUP107 NUP160 NUP133 NUP37	Focal segmental glomerulosclerosis
REAC:R-HSA-1643685	0.000150764226725	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Disease
GO:0012505	0.000224220492963	1.0	NUP210 NUP37 NUP188 SEC13 NUP133 SPAST NUP160 AHCTF1 NUP98 NUP43 NUP107 SEH1L AAAS	endomembrane system
GO:0099080	0.000264829845309	0.692307692308	NUP37 SEC13 NUP160 NUP133 AHCTF1 NUP43 NUP107 SEH1L NUP98	supramolecular complex
GO:0006405	0.000366472005037	0.384615384615	NUP188 NUP98 NUP107 NUP133 NUP160	RNA export from nucleus
CORUM:6216	0.00040971577212	0.153846153846	SEC13 SEH1L	GATOR2 complex
REAC:R-HSA-168256	0.000451020712195	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Immune System
HP:0000099	0.000459989828668	0.307692307692	NUP107 NUP160 NUP133 NUP37	Glomerulonephritis
GO:0051179	0.000476839492153	1.0	NUP210 NUP37 NUP188 SEC13 NUP133 SPAST NUP160 AHCTF1 NUP98 NUP43 NUP107 SEH1L AAAS	localization
HP:0045073	0.000485304933709	0.307692307692	NUP107 NUP160 NUP133 NUP37	Serositis
REAC:R-HSA-392499	0.000501379658429	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Metabolism of proteins
GO:0031965	0.000543492255034	0.461538461538	SPAST NUP107 NUP133 AHCTF1 NUP98 AAAS	nuclear membrane
HP:0000096	0.000627781862068	0.307692307692	NUP107 NUP160 NUP133 NUP37	Glomerular sclerosis
REAC:R-HSA-1430728	0.0006865042136	0.692307692308	NUP210 NUP37 SEC13 NUP160 NUP133 NUP188 AAAS NUP107 NUP43	Metabolism
GO:0000972	0.000960187650128	0.230769230769	NUP107 NUP133 NUP98	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
GO:0006606	0.00101853576604	0.384615384615	SEC13 NUP107 NUP188 NUP133 NUP98	protein import into nucleus
HP:0100539	0.00109519196994	0.307692307692	NUP107 NUP160 NUP133 NUP37	Periorbital edema
CORUM:6217	0.00114547798174	0.153846153846	SEC13 SEH1L	GATOR complex
CORUM:6753	0.00114547798174	0.153846153846	SEC13 SEH1L	SOG complex
GO:0050657	0.00117580772471	0.384615384615	NUP188 NUP98 NUP107 NUP133 NUP160	nucleic acid transport
GO:0050658	0.00117580772471	0.384615384615	NUP188 NUP98 NUP107 NUP133 NUP160	RNA transport
GO:0051170	0.00129097462355	0.384615384615	SEC13 NUP107 NUP188 NUP133 NUP98	import into nucleus
HP:0012116	0.0012970924159	0.307692307692	NUP107 NUP160 NUP133 NUP37	Abnormal circulating albumin concentration
HP:0003073	0.0012970924159	0.307692307692	NUP107 NUP160 NUP133 NUP37	Hypoalbuminemia
HP:0003676	0.00132343173123	0.384615384615	NUP107 NUP160 NUP133 SPAST AAAS	Progressive
GO:0051236	0.00135182953729	0.384615384615	NUP188 NUP98 NUP107 NUP133 NUP160	establishment of RNA localization
HP:0000123	0.00140783301322	0.307692307692	NUP107 NUP160 NUP133 NUP37	Nephritis
HP:0000282	0.00214738711275	0.307692307692	NUP107 NUP160 NUP133 NUP37	Facial edema
HP:0003774	0.00265542042457	0.307692307692	NUP107 NUP160 NUP133 NUP37	Stage 5 chronic kidney disease
GO:0051292	0.00328700479383	0.230769230769	AHCTF1 NUP98 NUP107	nuclear pore complex assembly
GO:0006403	0.00454246636096	0.384615384615	NUP188 NUP98 NUP107 NUP133 NUP160	RNA localization
GO:0051168	0.00487686584101	0.384615384615	NUP188 NUP98 NUP107 NUP133 NUP160	nuclear export
GO:0015931	0.00620442008194	0.384615384615	NUP188 NUP98 NUP107 NUP133 NUP160	nucleobase-containing compound transport
HP:0000095	0.0100220604573	0.307692307692	NUP107 NUP160 NUP133 NUP37	Abnormal renal glomerulus morphology
HP:0031263	0.010269095768	0.307692307692	NUP107 NUP160 NUP133 NUP37	Abnormal renal corpuscle morphology
HP:0012622	0.0110372602157	0.307692307692	NUP107 NUP160 NUP133 NUP37	Chronic kidney disease
HP:0003679	0.0137447504559	0.384615384615	NUP107 NUP160 NUP133 SPAST AAAS	Pace of progression
GO:0005694	0.016278404599	0.692307692308	NUP37 SEC13 NUP160 NUP133 AHCTF1 NUP43 NUP107 SEH1L NUP98	chromosome
GO:0046931	0.018559526455	0.230769230769	AHCTF1 NUP98 NUP107	pore complex assembly
HP:0011035	0.0216829189251	0.307692307692	NUP107 NUP160 NUP133 NUP37	Abnormal renal cortex morphology
HP:0000093	0.0225615292021	0.307692307692	NUP107 NUP160 NUP133 NUP37	Proteinuria
REAC:R-HSA-162582	0.0244930985656	0.615384615385	NUP37 SEC13 NUP133 NUP160 AHCTF1 NUP43 NUP107 AAAS	Signal Transduction
HP:0020129	0.0311277425237	0.307692307692	NUP107 NUP160 NUP133 NUP37	Abnormal urine protein level
HP:0012575	0.0322729780942	0.307692307692	NUP107 NUP160 NUP133 NUP37	Abnormal nephron morphology
HP:0000606	0.0398075436282	0.307692307692	NUP107 NUP160 NUP133 NUP37	Abnormality of the periorbital region
GO:0034504	0.0450499593655	0.384615384615	SEC13 NUP107 NUP188 NUP133 NUP98	protein localization to nucleus
HP:0000737	0.0455008743384	0.307692307692	NUP107 NUP160 NUP133 NUP37	Irritability
HP:0100720	0.0499631138006	0.153846153846	NUP107 NUP133	Hypoplasia of the ear cartilage

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
NUP160	NUP133	1.0	0.986	structurally_consistent (dimer)
NUP133	NUP107	1.0	0.962	structurally_consistent (P55735) structurally_consistent (dimer)
NUP43	NUP133	0.999	0.804	structurally_consistent (dimer)
NUP43	NUP37	0.999	0.942
NUP43	NUP107	0.999	0.818	structurally_consistent (Q8WUM0)
SEH1L	NUP133	0.999	0.78
NUP98	NUP43	0.999	0.84
SEH1L	NUP43	0.999	0.938	structurally_consistent (dimer)
NUP160	NUP43	0.999	0.83	structurally_consistent (Q9BW27)
NUP133	NUP37	0.999	0.806
NUP37	NUP107	0.999	0.822
SEC13	NUP133	0.999	0.472	structurally_consistent (dimer)
SEC13	NUP43	0.999	0.286
NUP98	NUP133	0.999	0.946
SEC13	SEH1L	0.997	0.172
SEC13	NUP107	0.997	0.448	structurally_consistent (dimer)
SEH1L	NUP37	0.997	0.83
SEC13	NUP37	0.996	0.248	structurally_consistent (dimer)
NUP98	SPAST	0.996	0.074
NUP160	NUP107	0.996	0.95
NUP43	SPAST	0.995	0.09	structurally_consistent (dimer)
SEC13	NUP160	0.995	0.3
SEH1L	NUP107	0.995	0.802
SEH1L	NUP160	0.994	0.892
NUP160	NUP37	0.994	0.674	structurally_consistent (dimer)
SEC13	AAAS	0.993	0.118
SEC13	NUP98	0.993	0.168	structurally_consistent (P57740) structurally_consistent (dimer)
SPAST	NUP107	0.992	0.062
AHCTF1	NUP107	0.992	0.588
NUP133	AHCTF1	0.991	0.684
AHCTF1	AAAS	0.99	0.248
NUP98	SEH1L	0.989	0.85	structurally_consistent (dimer)
NUP98	NUP37	0.987	0.78	structurally_consistent (Q12769)
NUP98	NUP107	0.987	0.966	structurally_consistent (dimer)
NUP188	NUP133	0.987	0.858
SEH1L	AAAS	0.983	0.176
NUP188	NUP210	0.98	0.266
NUP188	NUP107	0.98	0.868
NUP188	AHCTF1	0.98	0.518
NUP37	SPAST	0.979	0.05
AAAS	NUP37	0.975	0.158
NUP98	NUP188	0.974	0.806
NUP188	NUP37	0.973	0.468
NUP98	NUP160	0.971	0.888	structurally_consistent (dimer)
NUP107	NUP210	0.971	0.482
NUP133	SPAST	0.969	0.072
AHCTF1	NUP210	0.966	0.062
NUP160	AHCTF1	0.963	0.66
NUP98	AHCTF1	0.959	0.65
NUP188	AAAS	0.957	0.468
AAAS	NUP107	0.957	0.382
NUP160	NUP188	0.954	0.846
AHCTF1	NUP37	0.948	0.356
NUP98	NUP210	0.944	0.396
SEH1L	NUP210	0.94	0.14
AAAS	NUP210	0.922	0.222
NUP188	NUP43	0.91	0.488
SEC13	AHCTF1	0.863	0.276
SEC13	NUP210	0.779	0.324
NUP43	AAAS	0.759	0.41
NUP160	AAAS	0.735	0.384
NUP43	AHCTF1	0.715	0.334
SEC13	SPAST	0.683	0.134
NUP98	AAAS	0.642	0.578
SEC13	NUP188	0.614	0.32
SEH1L	NUP188	0.6	0.652
NUP160	SPAST	0.565	0.064
SEH1L	AHCTF1	0.497	0.176
NUP160	NUP210	0.441	0.406
NUP37	NUP210	0.385	0.211233333333
NUP133	AAAS	0.329	0.484
NUP133	NUP210	0.302	0.186
NUP43	NUP210	0.046	0.184
AAAS	SPAST	0.009	0.044
SEH1L	SPAST	0.006	0.062	mutually_exclusive (Q8NFH3)
SPAST	NUP210	0.002	0.1

Related Complexes

Genename	Complexes
NUP43	huMAP3_06517.1 huMAP3_07705.1 huMAP3_08489.1 huMAP3_09710.1 huMAP3_09825.1 huMAP3_11762.1 huMAP3_12581.1
NUP133	huMAP3_07492.1 huMAP3_07705.1 huMAP3_08489.1 huMAP3_09710.1 huMAP3_09825.1 huMAP3_12581.1
SEC13	huMAP3_00267.1 huMAP3_06536.1 huMAP3_07705.1 huMAP3_08489.1 huMAP3_09710.1 huMAP3_09825.1 huMAP3_12394.1 huMAP3_12581.1 huMAP3_14455.1
AHCTF1	huMAP3_07492.1 huMAP3_07645.1 huMAP3_08002.1 huMAP3_09592.1 huMAP3_09710.1
AAAS	huMAP3_07492.1 huMAP3_07705.1 huMAP3_08489.1 huMAP3_09710.1 huMAP3_09825.1 huMAP3_12581.1
NUP37	huMAP3_07492.1 huMAP3_07705.1 huMAP3_08489.1 huMAP3_09710.1 huMAP3_09825.1 huMAP3_11232.1 huMAP3_12581.1
SPAST	huMAP3_07492.1 huMAP3_07705.1 huMAP3_09710.1 huMAP3_13805.1
NUP160	huMAP3_04548.1 huMAP3_06379.1 huMAP3_06517.1 huMAP3_08298.1 huMAP3_08489.1 huMAP3_09114.1 huMAP3_09710.1 huMAP3_09825.1 huMAP3_10202.1 huMAP3_11232.1 huMAP3_12581.1
NUP98	huMAP3_03647.1 huMAP3_05948.1 huMAP3_06369.1 huMAP3_06517.1 huMAP3_07705.1 huMAP3_09710.1 huMAP3_10000.1 huMAP3_12581.1
NUP188	huMAP3_05673.1 huMAP3_07492.1 huMAP3_08489.1 huMAP3_09710.1 huMAP3_09825.1
NUP107	huMAP3_07492.1 huMAP3_07705.1 huMAP3_08489.1 huMAP3_09710.1 huMAP3_09825.1 huMAP3_12581.1
NUP210	huMAP3_07492.1 huMAP3_07645.1 huMAP3_09710.1
SEH1L	huMAP3_04081.1 huMAP3_04144.1 huMAP3_07492.1 huMAP3_07705.1 huMAP3_08030.1 huMAP3_08489.1 huMAP3_09710.1 huMAP3_09825.1 huMAP3_12581.1 huMAP3_13130.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09710.1

Complex Portal: CPX-13169