hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09710.1
Complex Portal: CPX-13169
Confidence: Moderate High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NUP43 | Nucleoporin Nup43 (Nup107-160 subcomplex subunit Nup43) (p42) | 5 | UniProt NCBI |
| NUP133 | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | 5 | UniProt NCBI |
| SEC13 | Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein) | 5 | UniProt NCBI |
| AHCTF1 | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | 5 | UniProt NCBI |
| AAAS | Aladin (Adracalin) | 5 | UniProt NCBI |
| NUP37 | Nucleoporin Nup37 (p37) (Nup107-160 subcomplex subunit Nup37) | 5 | UniProt NCBI |
| SPAST | Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein) | 5 | UniProt NCBI |
| NUP160 | Nuclear pore complex protein Nup160 (160 kDa nucleoporin) (Nucleoporin Nup160) | 5 | UniProt NCBI |
| NUP98 | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | 5 | UniProt NCBI |
| NUP188 | Nucleoporin NUP188 (hNup188) | 5 | UniProt NCBI |
| NUP107 | Nuclear pore complex protein Nup107 (107 kDa nucleoporin) (Nucleoporin Nup107) | 5 | UniProt NCBI |
| NUP210 | Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa) | 5 | UniProt NCBI |
| SEH1L | Nucleoporin SEH1 (GATOR2 complex protein SEH1) (Nup107-160 subcomplex subunit SEH1) (SEC13-like protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3998 | 7.41879371274e-25 | 0.923076923077 | SEC13 NUP133 NUP160 AAAS NUP43 NUP98 NUP188 NUP37 NUP210 NUP107 AHCTF1 SEH1L | Prader Willi and Angelman syndrome |
| GO:0031080 | 4.27378448124e-24 | 0.692307692308 | SEC13 NUP133 NUP160 NUP43 NUP98 NUP37 NUP107 AHCTF1 SEH1L | nuclear pore outer ring |
| KEGG:03013 | 4.46641859806e-24 | 0.923076923077 | SEC13 NUP133 NUP160 AAAS NUP43 NUP98 NUP188 NUP37 NUP210 NUP107 AHCTF1 SEH1L | Nucleocytoplasmic transport |
| CORUM:87 | 1.2624989887e-23 | 0.615384615385 | SEC13 NUP133 NUP160 NUP43 NUP98 NUP37 NUP107 SEH1L | Nup 107-160 subcomplex |
| GO:0005643 | 3.17524370905e-22 | 0.923076923077 | SEC13 NUP133 NUP160 AAAS NUP43 NUP98 NUP188 NUP37 NUP210 NUP107 AHCTF1 SEH1L | nuclear pore |
| REAC:R-HSA-5619107 | 1.60589298968e-20 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| REAC:R-HSA-170822 | 1.60589298968e-20 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| REAC:R-HSA-168333 | 2.32797025689e-20 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | NEP/NS2 Interacts with the Cellular Export Machinery |
| REAC:R-HSA-168271 | 2.32797025689e-20 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-168274 | 2.32797025689e-20 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Export of Viral Ribonucleoproteins from Nucleus |
| REAC:R-HSA-159227 | 4.68386130575e-20 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-180746 | 4.68386130575e-20 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Nuclear import of Rev protein |
| REAC:R-HSA-180910 | 4.68386130575e-20 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-4085377 | 6.51506829361e-20 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-159230 | 6.51506829361e-20 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-165054 | 6.51506829361e-20 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-3301854 | 8.95600789689e-20 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-177243 | 1.21771643328e-19 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Interactions of Rev with host cellular proteins |
| REAC:R-HSA-176033 | 1.21771643328e-19 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-3232142 | 1.63882902724e-19 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | SUMOylation of ubiquitinylation proteins |
| REAC:R-HSA-168276 | 2.88603521759e-19 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-159231 | 3.78076766646e-19 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-159234 | 4.91378444435e-19 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| REAC:R-HSA-168325 | 6.33880148299e-19 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Viral Messenger RNA Synthesis |
| REAC:R-HSA-4615885 | 1.03314639584e-18 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-4570464 | 1.30630363846e-18 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-2980766 | 3.15340693386e-18 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Nuclear Envelope Breakdown |
| REAC:R-HSA-9615933 | 4.9947027917e-18 | 0.615384615385 | SEC13 NUP133 NUP160 NUP43 NUP188 NUP37 NUP107 AHCTF1 | Postmitotic nuclear pore complex (NPC) reformation |
| REAC:R-HSA-191859 | 7.033484512e-18 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | snRNP Assembly |
| REAC:R-HSA-194441 | 7.033484512e-18 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Metabolism of non-coding RNA |
| REAC:R-HSA-6784531 | 1.46853865487e-17 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | tRNA processing in the nucleus |
| GO:0005635 | 3.5499316785e-17 | 1.0 | SEC13 NUP133 NUP160 AAAS NUP43 NUP98 NUP188 NUP37 NUP210 SPAST AHCTF1 NUP107 SEH1L | nuclear envelope |
| REAC:R-HSA-3371453 | 7.36481911601e-17 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-70171 | 7.36481911601e-17 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Glycolysis |
| REAC:R-HSA-1169408 | 8.5255763836e-17 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | ISG15 antiviral mechanism |
| REAC:R-HSA-4551638 | 8.5255763836e-17 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-2995410 | 9.84607495343e-17 | 0.692307692308 | SEC13 NUP133 NUP160 NUP43 NUP188 NUP37 SPAST AHCTF1 NUP107 | Nuclear Envelope (NE) Reassembly |
| REAC:R-HSA-5619102 | 1.49645541192e-16 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | SLC transporter disorders |
| REAC:R-HSA-159236 | 1.49645541192e-16 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-3108214 | 1.71325888721e-16 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-1169410 | 1.95752576394e-16 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Antiviral mechanism by IFN-stimulated genes |
| GO:0006913 | 2.07179763993e-16 | 0.923076923077 | SEC13 NUP133 NUP160 AAAS NUP43 NUP98 NUP188 NUP37 NUP210 NUP107 AHCTF1 SEH1L | nucleocytoplasmic transport |
| GO:0051169 | 2.07179763993e-16 | 0.923076923077 | SEC13 NUP133 NUP160 AAAS NUP43 NUP98 NUP188 NUP37 NUP210 NUP107 AHCTF1 SEH1L | nuclear transport |
| REAC:R-HSA-70326 | 4.72529442294e-16 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Glucose metabolism |
| REAC:R-HSA-72202 | 4.72529442294e-16 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Transport of Mature Transcript to Cytoplasm |
| REAC:R-HSA-3371556 | 9.43905741536e-16 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Cellular response to heat stress |
| REAC:R-HSA-5578749 | 1.79413977733e-15 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Transcriptional regulation by small RNAs |
| REAC:R-HSA-72306 | 3.95469240234e-15 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | tRNA processing |
| REAC:R-HSA-9610379 | 3.95469240234e-15 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | HCMV Late Events |
| REAC:R-HSA-9705671 | 1.25124200722e-14 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| REAC:R-HSA-211000 | 2.03300931102e-14 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Gene Silencing by RNA |
| REAC:R-HSA-9609690 | 2.3764921838e-14 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | HCMV Early Events |
| REAC:R-HSA-68875 | 2.7705728767e-14 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Mitotic Prophase |
| REAC:R-HSA-162909 | 3.47074205433e-14 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Host Interactions of HIV factors |
| REAC:R-HSA-162599 | 4.99136249988e-14 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-168273 | 5.35824715211e-14 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Influenza Viral RNA Transcription and Replication |
| REAC:R-HSA-68886 | 7.92958489798e-14 | 0.846153846154 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 SPAST AHCTF1 NUP107 | M Phase |
| REAC:R-HSA-5619115 | 1.05757055223e-13 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Disorders of transmembrane transporters |
| REAC:R-HSA-9609646 | 1.12885496248e-13 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | HCMV Infection |
| REAC:R-HSA-162587 | 1.12885496248e-13 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | HIV Life Cycle |
| REAC:R-HSA-168255 | 1.65347289584e-13 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Influenza Infection |
| REAC:R-HSA-3108232 | 3.01870253849e-13 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | SUMO E3 ligases SUMOylate target proteins |
| KEGG:05014 | 3.85471900086e-13 | 0.769230769231 | SEC13 NUP133 NUP160 NUP43 NUP98 NUP188 NUP37 NUP210 NUP107 SEH1L | Amyotrophic lateral sclerosis |
| REAC:R-HSA-2990846 | 4.01977575208e-13 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | SUMOylation |
| REAC:R-HSA-913531 | 7.71552531559e-13 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Interferon Signaling |
| REAC:R-HSA-9705683 | 1.48735796828e-12 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | SARS-CoV-2-host interactions |
| REAC:R-HSA-69278 | 2.36618758562e-12 | 0.846153846154 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 SPAST AHCTF1 NUP107 | Cell Cycle, Mitotic |
| REAC:R-HSA-162906 | 6.51218026162e-12 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | HIV Infection |
| REAC:R-HSA-68882 | 7.06926091118e-12 | 0.692307692308 | SEC13 NUP133 NUP160 NUP43 NUP188 NUP37 SPAST AHCTF1 NUP107 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 7.36334463386e-12 | 0.692307692308 | SEC13 NUP133 NUP160 NUP43 NUP188 NUP37 SPAST AHCTF1 NUP107 | Mitotic Metaphase and Anaphase |
| GO:0031975 | 1.1574384006e-11 | 1.0 | SEC13 NUP133 NUP160 AAAS NUP43 NUP98 NUP188 NUP37 NUP210 SPAST AHCTF1 NUP107 SEH1L | envelope |
| GO:0031967 | 1.1574384006e-11 | 1.0 | SEC13 NUP133 NUP160 AAAS NUP43 NUP98 NUP188 NUP37 NUP210 SPAST AHCTF1 NUP107 SEH1L | organelle envelope |
| GO:0000776 | 1.48364246214e-11 | 0.692307692308 | SEC13 NUP133 NUP160 NUP43 NUP98 NUP37 NUP107 AHCTF1 SEH1L | kinetochore |
| GO:0000779 | 1.93535411059e-11 | 0.692307692308 | SEC13 NUP133 NUP160 NUP43 NUP98 NUP37 NUP107 AHCTF1 SEH1L | condensed chromosome, centromeric region |
| CORUM:1347 | 2.11387990692e-11 | 0.307692307692 | NUP107 NUP160 NUP133 NUP98 | NPC subcomplex (NUP98, NUP107, NUP133, NUP160) |
| REAC:R-HSA-1640170 | 2.3168987326e-11 | 0.846153846154 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 SPAST AHCTF1 NUP107 | Cell Cycle |
| REAC:R-HSA-71387 | 2.48008353337e-11 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Metabolism of carbohydrates |
| REAC:R-HSA-9694516 | 4.44435754086e-11 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | SARS-CoV-2 Infection |
| REAC:R-HSA-72203 | 4.59414722296e-11 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0046907 | 9.27213332445e-11 | 1.0 | SEC13 NUP133 NUP160 AAAS NUP43 NUP98 NUP188 NUP37 NUP210 SPAST AHCTF1 NUP107 SEH1L | intracellular transport |
| REAC:R-HSA-141424 | 1.41166133156e-10 | 0.538461538462 | SEC13 NUP133 NUP160 NUP43 NUP37 NUP107 AHCTF1 | Amplification of signal from the kinetochores |
| REAC:R-HSA-141444 | 1.41166133156e-10 | 0.538461538462 | SEC13 NUP133 NUP160 NUP43 NUP37 NUP107 AHCTF1 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| GO:0000775 | 3.98458204697e-10 | 0.692307692308 | SEC13 NUP133 NUP160 NUP43 NUP98 NUP37 NUP107 AHCTF1 SEH1L | chromosome, centromeric region |
| REAC:R-HSA-69618 | 4.46715765781e-10 | 0.538461538462 | SEC13 NUP133 NUP160 NUP43 NUP37 NUP107 AHCTF1 | Mitotic Spindle Checkpoint |
| GO:0000793 | 5.74252761544e-10 | 0.692307692308 | SEC13 NUP133 NUP160 NUP43 NUP98 NUP37 NUP107 AHCTF1 SEH1L | condensed chromosome |
| REAC:R-HSA-9648025 | 6.17616659209e-10 | 0.538461538462 | SEC13 NUP133 NUP160 NUP43 NUP37 NUP107 AHCTF1 | EML4 and NUDC in mitotic spindle formation |
| REAC:R-HSA-9679506 | 8.01258600153e-10 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | SARS-CoV Infections |
| REAC:R-HSA-2500257 | 1.00682422121e-09 | 0.538461538462 | SEC13 NUP133 NUP160 NUP43 NUP37 NUP107 AHCTF1 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-5663220 | 1.8717608466e-09 | 0.538461538462 | SEC13 NUP133 NUP160 NUP43 NUP37 NUP107 AHCTF1 | RHO GTPases Activate Formins |
| GO:0051649 | 2.40658347659e-09 | 1.0 | SEC13 NUP133 NUP160 AAAS NUP43 NUP98 NUP188 NUP37 NUP210 SPAST AHCTF1 NUP107 SEH1L | establishment of localization in cell |
| REAC:R-HSA-2262752 | 5.64081084063e-09 | 0.769230769231 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 SEH1L | Cellular responses to stress |
| REAC:R-HSA-8953897 | 6.20661640576e-09 | 0.769230769231 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 SEH1L | Cellular responses to stimuli |
| REAC:R-HSA-2467813 | 1.96728215576e-08 | 0.538461538462 | SEC13 NUP133 NUP160 NUP43 NUP37 NUP107 AHCTF1 | Separation of Sister Chromatids |
| GO:0140513 | 2.01939993955e-08 | 0.923076923077 | SEC13 NUP133 NUP160 AAAS NUP43 NUP98 NUP188 NUP37 NUP210 NUP107 AHCTF1 SEH1L | nuclear protein-containing complex |
| REAC:R-HSA-68877 | 2.96149696524e-08 | 0.538461538462 | SEC13 NUP133 NUP160 NUP43 NUP37 NUP107 AHCTF1 | Mitotic Prometaphase |
| GO:0098687 | 3.32907071244e-08 | 0.692307692308 | SEC13 NUP133 NUP160 NUP43 NUP98 NUP37 NUP107 AHCTF1 SEH1L | chromosomal region |
| GO:0006999 | 3.46422136935e-08 | 0.384615384615 | NUP107 AHCTF1 SEH1L NUP133 NUP98 | nuclear pore organization |
| REAC:R-HSA-1280215 | 6.01254500784e-08 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Cytokine Signaling in Immune system |
| REAC:R-HSA-8953854 | 1.68850051541e-07 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Metabolism of RNA |
| REAC:R-HSA-9824446 | 2.15326006352e-07 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Viral Infection Pathways |
| GO:0017056 | 3.02815979991e-07 | 0.384615384615 | NUP188 NUP160 NUP107 NUP133 NUP98 | structural constituent of nuclear pore |
| REAC:R-HSA-69620 | 3.64393244112e-07 | 0.538461538462 | SEC13 NUP133 NUP160 NUP43 NUP37 NUP107 AHCTF1 | Cell Cycle Checkpoints |
| REAC:R-HSA-195258 | 5.50292598703e-07 | 0.538461538462 | SEC13 NUP133 NUP160 NUP43 NUP37 NUP107 AHCTF1 | RHO GTPase Effectors |
| REAC:R-HSA-5663205 | 1.33421771934e-06 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Infectious disease |
| GO:0051641 | 2.83155234815e-06 | 1.0 | SEC13 NUP133 NUP160 AAAS NUP43 NUP98 NUP188 NUP37 NUP210 SPAST AHCTF1 NUP107 SEH1L | cellular localization |
| REAC:R-HSA-194315 | 3.31261000601e-06 | 0.615384615385 | SEC13 NUP133 NUP160 AAAS NUP43 NUP37 NUP107 AHCTF1 | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 3.935826463e-06 | 0.615384615385 | SEC13 NUP133 NUP160 AAAS NUP43 NUP37 NUP107 AHCTF1 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| HP:0031504 | 4.12397595916e-06 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Foamy urine |
| HP:0012579 | 9.19511220779e-06 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Minimal change glomerulonephritis |
| GO:0006997 | 1.10008102183e-05 | 0.461538461538 | NUP98 SEH1L SPAST AHCTF1 NUP107 NUP133 | nucleus organization |
| HP:0001967 | 1.79100602237e-05 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Diffuse mesangial sclerosis |
| GO:0006810 | 1.98084347196e-05 | 1.0 | SEC13 NUP133 NUP160 AAAS NUP43 NUP98 NUP188 NUP37 NUP210 SPAST AHCTF1 NUP107 SEH1L | transport |
| HP:0002586 | 2.02110603251e-05 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Peritonitis |
| REAC:R-HSA-597592 | 2.98907719811e-05 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Post-translational protein modification |
| HP:0001966 | 3.89748377886e-05 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Abnormal glomerular mesangium morphology |
| REAC:R-HSA-74160 | 4.67324464589e-05 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Gene expression (Transcription) |
| HP:0033072 | 6.26486763001e-05 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Abnormal macroscopic urine appearance |
| GO:0051234 | 6.48725531739e-05 | 1.0 | SEC13 NUP133 NUP160 AAAS NUP43 NUP98 NUP188 NUP37 NUP210 SPAST AHCTF1 NUP107 SEH1L | establishment of localization |
| HP:0002585 | 0.000120933943986 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Abnormal peritoneum morphology |
| HP:0000097 | 0.000130354574291 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Focal segmental glomerulosclerosis |
| REAC:R-HSA-1643685 | 0.000150764226725 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Disease |
| GO:0012505 | 0.000224220492963 | 1.0 | SEC13 NUP133 NUP160 AAAS NUP43 NUP98 NUP188 NUP37 NUP210 SPAST AHCTF1 NUP107 SEH1L | endomembrane system |
| GO:0099080 | 0.000264829845309 | 0.692307692308 | SEC13 NUP133 NUP160 NUP43 NUP98 NUP37 NUP107 AHCTF1 SEH1L | supramolecular complex |
| GO:0006405 | 0.000366472005037 | 0.384615384615 | NUP188 NUP160 NUP107 NUP133 NUP98 | RNA export from nucleus |
| CORUM:6216 | 0.00040971577212 | 0.153846153846 | SEC13 SEH1L | GATOR2 complex |
| REAC:R-HSA-168256 | 0.000451020712195 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Immune System |
| HP:0000099 | 0.000459989828668 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Glomerulonephritis |
| GO:0051179 | 0.000476839492153 | 1.0 | SEC13 NUP133 NUP160 AAAS NUP43 NUP98 NUP188 NUP37 NUP210 SPAST AHCTF1 NUP107 SEH1L | localization |
| HP:0045073 | 0.000485304933709 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Serositis |
| REAC:R-HSA-392499 | 0.000501379658429 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Metabolism of proteins |
| GO:0031965 | 0.000543492255034 | 0.461538461538 | NUP98 NUP133 AAAS AHCTF1 NUP107 SPAST | nuclear membrane |
| HP:0000096 | 0.000627781862068 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Glomerular sclerosis |
| REAC:R-HSA-1430728 | 0.0006865042136 | 0.692307692308 | SEC13 NUP133 NUP160 AAAS NUP43 NUP188 NUP37 NUP210 NUP107 | Metabolism |
| GO:0000972 | 0.000960187650128 | 0.230769230769 | NUP98 NUP133 NUP107 | transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery |
| GO:0006606 | 0.00101853576604 | 0.384615384615 | NUP188 SEC13 NUP107 NUP133 NUP98 | protein import into nucleus |
| HP:0100539 | 0.00109519196994 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Periorbital edema |
| CORUM:6217 | 0.00114547798174 | 0.153846153846 | SEC13 SEH1L | GATOR complex |
| CORUM:6753 | 0.00114547798174 | 0.153846153846 | SEC13 SEH1L | SOG complex |
| GO:0050657 | 0.00117580772471 | 0.384615384615 | NUP188 NUP160 NUP107 NUP133 NUP98 | nucleic acid transport |
| GO:0050658 | 0.00117580772471 | 0.384615384615 | NUP188 NUP160 NUP107 NUP133 NUP98 | RNA transport |
| GO:0051170 | 0.00129097462355 | 0.384615384615 | NUP188 SEC13 NUP107 NUP133 NUP98 | import into nucleus |
| HP:0012116 | 0.0012970924159 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Abnormal circulating albumin concentration |
| HP:0003073 | 0.0012970924159 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Hypoalbuminemia |
| HP:0003676 | 0.00132343173123 | 0.384615384615 | NUP107 AAAS NUP160 NUP133 SPAST | Progressive |
| GO:0051236 | 0.00135182953729 | 0.384615384615 | NUP188 NUP160 NUP107 NUP133 NUP98 | establishment of RNA localization |
| HP:0000123 | 0.00140783301322 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Nephritis |
| HP:0000282 | 0.00214738711275 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Facial edema |
| HP:0003774 | 0.00265542042457 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Stage 5 chronic kidney disease |
| GO:0051292 | 0.00328700479383 | 0.230769230769 | AHCTF1 NUP107 NUP98 | nuclear pore complex assembly |
| GO:0006403 | 0.00454246636096 | 0.384615384615 | NUP188 NUP160 NUP107 NUP133 NUP98 | RNA localization |
| GO:0051168 | 0.00487686584101 | 0.384615384615 | NUP188 NUP160 NUP107 NUP133 NUP98 | nuclear export |
| GO:0015931 | 0.00620442008194 | 0.384615384615 | NUP188 NUP160 NUP107 NUP133 NUP98 | nucleobase-containing compound transport |
| HP:0000095 | 0.0100220604573 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Abnormal renal glomerulus morphology |
| HP:0031263 | 0.010269095768 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Abnormal renal corpuscle morphology |
| HP:0012622 | 0.0110372602157 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Chronic kidney disease |
| HP:0003679 | 0.0137447504559 | 0.384615384615 | NUP107 AAAS NUP160 NUP133 SPAST | Pace of progression |
| GO:0005694 | 0.016278404599 | 0.692307692308 | SEC13 NUP133 NUP160 NUP43 NUP98 NUP37 NUP107 AHCTF1 SEH1L | chromosome |
| GO:0046931 | 0.018559526455 | 0.230769230769 | AHCTF1 NUP107 NUP98 | pore complex assembly |
| HP:0011035 | 0.0216829189251 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Abnormal renal cortex morphology |
| HP:0000093 | 0.0225615292021 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Proteinuria |
| REAC:R-HSA-162582 | 0.0244930985656 | 0.615384615385 | SEC13 NUP133 NUP160 AAAS NUP43 NUP37 NUP107 AHCTF1 | Signal Transduction |
| HP:0020129 | 0.0311277425237 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Abnormal urine protein level |
| HP:0012575 | 0.0322729780942 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Abnormal nephron morphology |
| HP:0000606 | 0.0398075436282 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Abnormality of the periorbital region |
| GO:0034504 | 0.0450499593655 | 0.384615384615 | NUP188 SEC13 NUP107 NUP133 NUP98 | protein localization to nucleus |
| HP:0000737 | 0.0455008743384 | 0.307692307692 | NUP107 NUP37 NUP133 NUP160 | Irritability |
| HP:0100720 | 0.0499631138006 | 0.153846153846 | NUP107 NUP133 | Hypoplasia of the ear cartilage |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| NUP160 | NUP133 | 1.0 | 0.986 |
structurally_consistent (dimer)
|
| NUP133 | NUP107 | 1.0 | 0.962 |
structurally_consistent (P55735)
structurally_consistent (dimer) |
| NUP43 | NUP133 | 0.999 | 0.804 |
structurally_consistent (dimer)
|
| NUP43 | NUP37 | 0.999 | 0.942 | |
| NUP43 | NUP107 | 0.999 | 0.818 |
structurally_consistent (Q8WUM0)
|
| SEH1L | NUP133 | 0.999 | 0.78 | |
| NUP98 | NUP43 | 0.999 | 0.84 | |
| SEH1L | NUP43 | 0.999 | 0.938 |
structurally_consistent (dimer)
|
| NUP160 | NUP43 | 0.999 | 0.83 |
structurally_consistent (Q9BW27)
|
| NUP133 | NUP37 | 0.999 | 0.806 | |
| NUP37 | NUP107 | 0.999 | 0.822 | |
| SEC13 | NUP133 | 0.999 | 0.472 |
structurally_consistent (dimer)
|
| SEC13 | NUP43 | 0.999 | 0.286 | |
| NUP98 | NUP133 | 0.999 | 0.946 | |
| SEC13 | SEH1L | 0.997 | 0.172 | |
| SEC13 | NUP107 | 0.997 | 0.448 |
structurally_consistent (dimer)
|
| SEH1L | NUP37 | 0.997 | 0.83 | |
| SEC13 | NUP37 | 0.996 | 0.248 |
structurally_consistent (dimer)
|
| NUP98 | SPAST | 0.996 | 0.074 | |
| NUP160 | NUP107 | 0.996 | 0.95 | |
| NUP43 | SPAST | 0.995 | 0.09 |
structurally_consistent (dimer)
|
| SEC13 | NUP160 | 0.995 | 0.3 | |
| SEH1L | NUP107 | 0.995 | 0.802 | |
| SEH1L | NUP160 | 0.994 | 0.892 | |
| NUP160 | NUP37 | 0.994 | 0.674 |
structurally_consistent (dimer)
|
| SEC13 | AAAS | 0.993 | 0.118 | |
| SEC13 | NUP98 | 0.993 | 0.168 |
structurally_consistent (P57740)
structurally_consistent (dimer) |
| SPAST | NUP107 | 0.992 | 0.062 | |
| AHCTF1 | NUP107 | 0.992 | 0.588 | |
| NUP133 | AHCTF1 | 0.991 | 0.684 | |
| AHCTF1 | AAAS | 0.99 | 0.248 | |
| NUP98 | SEH1L | 0.989 | 0.85 |
structurally_consistent (dimer)
|
| NUP98 | NUP37 | 0.987 | 0.78 |
structurally_consistent (Q12769)
|
| NUP98 | NUP107 | 0.987 | 0.966 |
structurally_consistent (dimer)
|
| NUP188 | NUP133 | 0.987 | 0.858 | |
| SEH1L | AAAS | 0.983 | 0.176 | |
| NUP188 | NUP210 | 0.98 | 0.266 | |
| NUP188 | NUP107 | 0.98 | 0.868 | |
| NUP188 | AHCTF1 | 0.98 | 0.518 | |
| NUP37 | SPAST | 0.979 | 0.05 | |
| AAAS | NUP37 | 0.975 | 0.158 | |
| NUP98 | NUP188 | 0.974 | 0.806 | |
| NUP188 | NUP37 | 0.973 | 0.468 | |
| NUP98 | NUP160 | 0.971 | 0.888 |
structurally_consistent (dimer)
|
| NUP107 | NUP210 | 0.971 | 0.482 | |
| NUP133 | SPAST | 0.969 | 0.072 | |
| AHCTF1 | NUP210 | 0.966 | 0.062 | |
| NUP160 | AHCTF1 | 0.963 | 0.66 | |
| NUP98 | AHCTF1 | 0.959 | 0.65 | |
| NUP188 | AAAS | 0.957 | 0.468 | |
| AAAS | NUP107 | 0.957 | 0.382 | |
| NUP160 | NUP188 | 0.954 | 0.846 | |
| AHCTF1 | NUP37 | 0.948 | 0.356 | |
| NUP98 | NUP210 | 0.944 | 0.396 | |
| SEH1L | NUP210 | 0.94 | 0.14 | |
| AAAS | NUP210 | 0.922 | 0.222 | |
| NUP188 | NUP43 | 0.91 | 0.488 | |
| SEC13 | AHCTF1 | 0.863 | 0.276 | |
| SEC13 | NUP210 | 0.779 | 0.324 | |
| NUP43 | AAAS | 0.759 | 0.41 | |
| NUP160 | AAAS | 0.735 | 0.384 | |
| NUP43 | AHCTF1 | 0.715 | 0.334 | |
| SEC13 | SPAST | 0.683 | 0.134 | |
| NUP98 | AAAS | 0.642 | 0.578 | |
| SEC13 | NUP188 | 0.614 | 0.32 | |
| SEH1L | NUP188 | 0.6 | 0.652 | |
| NUP160 | SPAST | 0.565 | 0.064 | |
| SEH1L | AHCTF1 | 0.497 | 0.176 | |
| NUP160 | NUP210 | 0.441 | 0.406 | |
| NUP37 | NUP210 | 0.385 | 0.211233333333 | |
| NUP133 | AAAS | 0.329 | 0.484 | |
| NUP133 | NUP210 | 0.302 | 0.186 | |
| NUP43 | NUP210 | 0.046 | 0.184 | |
| AAAS | SPAST | 0.009 | 0.044 | |
| SEH1L | SPAST | 0.006 | 0.062 |
mutually_exclusive (Q8NFH3)
|
| SPAST | NUP210 | 0.002 | 0.1 |
Related Complexes